doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Retrospective data, Journal:  Effectiveness of antibiotic treatment in children with Lyme neuroborreliosis - a retrospective study. (Pubmed Central) -  Jun 10, 2022   
    In this large retrospective study, no difference in clinical outcome was found, independent of age, when comparing children who received ceftriaxone with those who received doxycycline, supporting an equal effectiveness for treatment of LNB pediatric patients. However, future randomized comparative treatment studies are warranted for evaluation of efficacy of antibiotic treatment in pediatric LNB patients.
  • ||||||||||  doxycycline / Generic mfg.
    Journal, PARP Biomarker, IO biomarker:  CD38-Induced Apoptosis and Mitochondrial Damage is Restored by Nicotinamide in Prostate Cancer. (Pubmed Central) -  Jun 10, 2022   
    In this study, we generated stable LNCaP95 cell clones expressing varying levels of CD38 upon induction by doxycycline...We also found that NAM demonstrated biphasic effect on mitochondria function, a finding that can be explained by the dual role of NAM as both a precursor of NAD and also as a suppressor of a number of NAD-dependent enzymes. Collectively, these findings provide additional insight supporting the functional relevance of CD38 loss in prostate cancer by linking cell-autonomous regulation of mitochondrial function and prostate cancer.
  • ||||||||||  Aphthasol (amlexanox) / Abeona Therap, Esteve, Lamprene (clofazimine) / Novartis
    Review, Journal:  Recurrent Aphthous Stomatitis: A Comprehensive Review and Recommendations on Therapeutic Options. (Pubmed Central) -  Jun 9, 2022   
    This review will summarize current treatment options for RAS with discussion of prevention, topical measures, natural treatments, systemic therapies, and new potential therapies. Furthermore, this review will provide recommendations on therapeutic options for RAS based on disease severity and patient circumstances.
  • ||||||||||  temozolomide / Generic mfg., doxycycline / Generic mfg.
    Journal, PD(L)-1 Biomarker, IO biomarker:  ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma. (Pubmed Central) -  Jun 8, 2022   
    In conclusion, Ag NP-antibiotic combinations can result in enhanced antimicrobial action against P. aeruginosa, MRSA and S. aureus clinical isolates in planktonic and biofilm forms and can be used in the context of CRS with confirmed infection. ATRX loss activates a BRD-dependent immune-suppressive transcriptome and immune escape mechanism in IDH1R132H/p53mut astrocytoma cells.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Celebrating 20 years of the UK Dermatology Clinical Trials Network: Part 1 - developing and delivering high quality independent clinical trials. (Pubmed Central) -  Jun 8, 2022   
    Trials have covered a range of interventions from drugs such as doxycycline (BLISTER), silk clothing for eczema (CLOTHES) and surgical interventions for hidradenitis suppurativa (THESEUS)...Genuine partnership with patients and carers has been a strong feature of the network since its inception. The UK DCTN is proud of its first 20 years of collaborative work and aims to remain at the forefront of independent dermatological health technology assessment as well as expanding into areas including diagnostics, AI, efficient studies and innovative designs.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Characterization of polymethylmethacrylate microspheres loaded with silver and doxycycline for dental materials applications. (Pubmed Central) -  Jun 8, 2022   
    The UK DCTN is proud of its first 20 years of collaborative work and aims to remain at the forefront of independent dermatological health technology assessment as well as expanding into areas including diagnostics, AI, efficient studies and innovative designs. PMMA microspheres containing DOX and AgSO offer a sustained antimicrobial activity for dental applications and promising potential for the biomedical field.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain. (Pubmed Central) -  Jun 8, 2022   
    Brains are then perfusion-fixed and processed for immunofluorescence and other downstream applications in order to interpret changes to stem cell activation, proliferation, lineage commitment, migration to various brain niches, and differentiation to mature cell types. Using this system, any rtTA mouse can be mated to oTet-Cre and a Rosa reporter to conduct doxycycline-inducible "pulse-chase" lineage tracing experiments using markers of stem cells.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Clinical Features and Follow-Up of Prurigo Pigmentosa: A Case Series. (Pubmed Central) -  Jun 8, 2022   
    Doxycycline 200 mg daily for two weeks led to a complete response in all six medically treated patients...Young women are most commonly affected, and ketosis stemming from decreased calorie intake may be the etiological factor in the majority of the patients. Dermatologists should be familiar with early signs of PP in order to minimize unnecessary therapies, recurrences and long-lasting hyperpigmentation.
  • ||||||||||  MULTIDRUG RESISTANT SEROTYPE 16F LINEAGES IN INFANTS IN SOUTH AFRICA (E-Poster Gallery) -  Jun 7, 2022 - Abstract #ISPPD2022ISPPD_573;    
    Conclusions Multidrug resistance (MDR) serotype 16F lineages pose a challenge to effective prevention and treatment of IPD. Monitoring resistance, judicious antibiotic use and vaccine strategies that protect against a wide range of serotypes/lineages remain essential.
  • ||||||||||  Apretude (cabotegravir extended-release injectable suspension) / ViiV Healthcare
    Enrollment change:  Parrying the Pitfalls of PrEP: Project PEACH (clinicaltrials.gov) -  Jun 7, 2022   
    P4,  N=200, Recruiting, 
    Further surveillance and sequencing is required to determine if MDR ST180-clade II is increasing over time. N=300 --> 200
  • ||||||||||  doxycycline / Generic mfg.
    CITED1 Regulates the Activity of Signaling Pathways that Control Macrophage M1 Polarization (Exhibit and Poster Hall) -  Jun 4, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_2970;    
    To test this, CITED1 doxycycline-inducible RAW 264.7 cells were pretreated with doxycycline prior to M1 polarization (IFNγ)...Additionally, 20 genes overlapped with our prior Cn transcriptome profiling. Collectively, these data suggest that CITED1 influences M1-associated gene expression observed in M1-polarized macrophages in a complex way.
  • ||||||||||  Nuzyra (omadacycline) / Paratek
    Comparative In Vitro Activities of Omadacycline Against Mycoplasma Genitalium (Exhibit and Poster Hall) -  Jun 4, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_2809;    
    One clinical isolated detected at UAB in 2019 had elevated MICs to AZI (2), LEV (16), MOX (2), DOX (2) and TET (16), but MICs for OMC (0.125), and MIN (0.5) remained low. These data suggest that OMC may be a potential treatment alternative and warrants further investigation for MG infections that do not respond to other agents.
  • ||||||||||  The Prevalence And Antibiograms Of Methicillin-resistant Staphylococcus Aureus (mrsa) Isolates From The Anterior Nares Of Apparently Healthy Medical Students In Dominica (Exhibit and Poster Hall) -  Jun 4, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_2744;    
    However, susceptibility was observed to gentamycin (92%), cotrimoxazole (sulfamethoxazole-trimethoprim) (77%), levofloxacin (69%), vancomycin (65%), doxycycline (65%), and tetracycline (62%)...The MRSA prevalence rate of 88.5% observed in the nasal cavities of the medical students is alarming and highlights the need for further investigation to confirm the mechanisms of resistance due to the detection of vancomycin-resistance, and for infection control measures to prevent MRSA transmission from medical students within the community or to vulnerable patients in clinical settings. Interestingly, findings from the isolates’ antibiotic susceptibilities suggest possible treatment of potential patients infected with the nasal MRSA strains with some common antibiotics in the country’s formulary.
  • ||||||||||  gepotidacin (GSK2140944) / GSK
    Activity of Gepotidacin Combined with Marketed Antibiotics Against Neisseria Gonorrhoeae (Exhibit and Poster Hall) -  Jun 4, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_2665;    
    GW broth supported the growth of all study isolates with good correlation to AD MICs. Checkerboard results showed synergy with one combination (gepotidacin/azithromycin) against one isolate (WHO M), no antagonism and lower MICs for select agents against select isolates when tested in combination.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Neoehrlichiosis as a cause of feaver of unknown origin (Pubmed Central) -  Jun 4, 2022   
    Through open biopsy of the femoral shaft and microbiological analysis, a diagnosis of neoehrlichiosis could be established. After initiation of treatment with doxycycline, the symptoms quickly resolved resulting in a complete recovery.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Sonosynthesis of nanobiotics with antimicrobial and antioxidant properties. (Pubmed Central) -  Jun 4, 2022   
    In this study, we demonstrate that acoustic cavitation produced by high-frequency ultrasound transforms the antibiotic doxycycline into carrier-free nanobiotics...coli) bacterial strains. Our results highlight the feasibility of the ultrasound-based approach for engineering drug molecules into a nanosized formulation with controlled and multiple bio-functionalities.
  • ||||||||||  doxycycline / Generic mfg., spironolactone / Generic mfg.
    Trial completion date, Trial primary completion date, HEOR:  Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne (clinicaltrials.gov) -  Jun 3, 2022   
    P4,  N=400, Recruiting, 
    The use of synthesized nanodrugs in this study had promising therapeutic results. Trial completion date: Dec 2026 --> Jul 2026 | Trial primary completion date: Dec 2025 --> Jul 2025
  • ||||||||||  ketorolac / Generic mfg., doxycycline / Generic mfg.
    Hip Injury - Hiking (31A) -  Jun 2, 2022 - Abstract #ACSM2022ACSM_1322;    
    Cystic lesions within the right femoral head decreased in size. May represent healed areas of osseous erosion or areas of previous avascular necrosis.
  • ||||||||||  doxycycline / Generic mfg.
    New trial:  Brimonidine in Rosacea (clinicaltrials.gov) -  Jun 2, 2022   
    P=N/A,  N=45, Not yet recruiting, 
  • ||||||||||  doxycycline / Generic mfg.
    Trial completion date:  RosaC-RF : Bipolar Radiofrequency vs Doxycycline in Rosacea (clinicaltrials.gov) -  Jun 1, 2022   
    P=N/A,  N=20, Completed, 
    May represent healed areas of osseous erosion or areas of previous avascular necrosis. Trial completion date: Jun 2019 --> Jun 2021
  • ||||||||||  Enrollment change, Trial termination, Trial primary completion date:  Antimicrobial Therapy for Ulcerative Colitis (UC) (clinicaltrials.gov) -  Jun 1, 2022   
    P2,  N=20, Terminated, 
    Recruiting --> Completed N=40 --> 20 | Recruiting --> Terminated | Trial primary completion date: Jul 2021 --> May 2022; There is no feasibility to conduct the study
  • ||||||||||  doxycycline / Generic mfg.
    New P4 trial:  Subantimicrobial Doxycycline in Acne (clinicaltrials.gov) -  Jun 1, 2022   
    P4,  N=22, Completed,