- |||||||||| doxycycline / Generic mfg.
Targeting Hyperglucagonemia Reverses Glucagon Resistance (In Person in Atlanta B404) - Jul 16, 2022 - Abstract #ENDO2022ENDO_2408;
Using mice with doxycycline induction of Rheb (activator of mTORC1 signaling) (aRheb Tg ) and inducible Cre-mediated deletion of the mTORC1 inhibitor, TSC2, in alpha-cells (iaTSC2 KO ), we showed that induction of hyperglucagonemia is associated with two phases: Acute phase characterized by impaired glucose tolerance because of increased gluconeogenesis and glucose output by the liver...These studies uncovered the acute versus chronic effects of hyperglucagonemia on glucose homeostasis and further demonstrate that glucagon resistance is a reversible process. These observations provide insight into the impact of glucagon in the pathogenesis of hyperglycemia and the physiological effects of administration of dual GLP1/Glucagon receptor agonists.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Aromatase interacting partner in Breast (AIPB) regulates estradiol in human breast () - Jul 16, 2022 - Abstract #ENDO2022ENDO_1187;
We observed a significant decrease in estradiol upon induction with doxycycline. We concluded that there is potential for future advancements in the early prediction of breast cancer with the identification of AIPB expression from breast tissue.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
AIPB is a Biomarker for ER+/PR+/Her2- Breast Cancers () - Jul 16, 2022 - Abstract #ENDO2022ENDO_1142;
However, the estrogenic effect of the cells was reduced after stimulation of the promoter. In summary, our preliminary results suggest AIPB to be a potential biomarker with a potential for cell therapy-mediated decrease of estradiol in some tumorigenic breast tissues.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Neurological Manifestations of Scrub Typhus. (Pubmed Central) - Jul 16, 2022
A very careful search for the eschar is essential; however, the absence of the skin lesion cannot exclude the diagnosis of scrub typhus. Neurological manifestations mostly respond to doxycycline therapy.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model. (Pubmed Central) - Jul 15, 2022
We used hcrt-tTA;TetO DTA mice (NT1 mice) that lose their HCRT neurons upon dietary doxycycline removal to examine in detail the effect of sex on NT1 symptoms and sleep-wake characteristics...During the dark phase, fast-δ (2.5-4 Hz) in non-rapid-eye-movement (NREM) sleep and θ (6-10 Hz) EEG spectral power in REM sleep were lower in females compared to males. We demonstrate that biologically driven sex-related differences exist in the symptomatology of NT1 mice which calls for including both sexes in future research.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline sclerotherapy of cervical spine aneurysmal bone cysts: single-institution 13-year experience. (Pubmed Central) - Jul 15, 2022
We demonstrate that biologically driven sex-related differences exist in the symptomatology of NT1 mice which calls for including both sexes in future research. Doxycycline sclerotherapy is a viable standalone treatment for cervical spine ABCs because it is safe and effective while avoiding the morbidity associated with open surgical treatments.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: Bowel perforation following percutaneous sclerotherapy of an intra-abdominal lymphatic malformation. (Pubmed Central) - Jul 15, 2022
Sclerotherapy has been described as durable and effective with a low complication rate. We describe a serious complication from sclerotherapy of a lymphatic malformation extending from the mesentery through the bowel wall, highlighting the spectrum of this pathology and the need for multidisciplinary management of complex cases.
- |||||||||| amikacin sulfate / Generic mfg., doxycycline / Generic mfg., erythromycin / Generic mfg.
Retrospective data, Journal: Bacteria isolated from equine uteri in The United Arab Emirates: A retrospective study. (Pubmed Central) - Jul 15, 2022
Decreasing susceptibility of trimethoprim-sulphonamide between two time periods was seen for E. coli. Compared to other studies UAE-based mares had a high incidence of P. aeruginosa and K. pneumoniae isolates, whereas E. coli was represented far less frequently as an isolate.
- |||||||||| doxycycline / Generic mfg.
Journal: Drug Eluting Embolization Particles for Permanent Contraception. (Pubmed Central) - Jul 15, 2022
We found that fiber microparticles with bolus release doxycycline effectively elicited acute trauma and those formulated with highly loaded phenyl benzoate caused sustained inflammation in the target organs. The demonstrated potency of these electrospun microparticles, as well as their embolic size and shape, suggests potential for proximal agglomeration and inflammatory activity in the fallopian tubes following transcervical delivery.
- |||||||||| Tetralysal (lymecycline) / Galderma
Maculopapular cutaneous mastocytosis mimicking seborrhoeic folliculitis () - Jul 15, 2022 - Abstract #BAD2022BAD_756;
This had been widely investigated and managed as follicular eruption with long-term antibiotics in the past (lymecycline and doxycycline)...Urgent skin biopsies were carried out using lidocaine without adrenaline...He was started on fexofenadine 180 mg twice daily with topical mometasone furoate 0·1% cream, which resulted in a slight improvement...Gastrointestinal symptoms are second only to pruritus and seen in 60–80% of patients with systemic disease. This case report highlights the importance of re-evaluation, a high degree of clinical suspicion and clinicopathological correlation in arriving at a diagnosis of a rare skin disease with variable presentations as they are often misdiagnosed and underdiagnosed.
- |||||||||| doxycycline / Generic mfg.
Journal: A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells. (Pubmed Central) - Jul 13, 2022
This tool also allows modulation with RNA-binding proteins in a separate plasmid. In addition to its use with a variety of different miRNAs and their respective targets, it can be adapted to different cell lines, provided these are amenable to transfection.
- |||||||||| doxycycline / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Clinical, radiological and pathological characteristics of moderate to fulminant psittacosis pneumonia. (Pubmed Central) - Jul 12, 2022
In conclusion, mNGS may be a promising approach for clinical diagnosis of psittacosis. For patients with a history of exposure to birds, hyperpyrexia, nonproductive cough, multiple elevated inflammatory markers, and air-space consolidation in lung, psittacosis pneumonia should be considered, especially when beta-lactam antibiotics showed limited efficacy.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Journal: Sodium-glucose cotransporter 2 inhibitor-associated severe epididymo-orchitis. (Pubmed Central) - Jul 12, 2022
Initially, he had failed treatment of epididymo-orchitis with oral levofloxacin for 3 weeks, followed by 2 weeks of doxycycline therapy...Adequate wound care and regular follow-up demonstrated resolution of infection. This case highlights the risk of severe urogenital infection associated with the use of SGLT2 inhibitors in the setting of uncontrolled T2DM.
- |||||||||| doxycycline / Generic mfg.
Trial initiation date: ORBS: Ocular Rosacea Biome Study (clinicaltrials.gov) - Jul 12, 2022
P4, N=50, Not yet recruiting,
This case highlights the risk of severe urogenital infection associated with the use of SGLT2 inhibitors in the setting of uncontrolled T2DM. Initiation date: Jun 2022 --> Sep 2022
- |||||||||| clindamycin phosphate / Generic mfg., doxycycline / Generic mfg.
Review, Journal: Blood Culture-Negative Infective Endocarditis by Mycoplasma hominis: Case Report and Literature Review. (Pubmed Central) - Jul 11, 2022
Among published cases of IE by this microorganism, 72.7% were male, with a mean age of 45 years and a history of valve surgery; the diagnosis was by culture (54.5%) or molecular technique (45.5%), and the prognosis was favorable in 72.7% of cases. The most frequently prescribed antibiotics were doxycycline, quinolones, and clindamycin.
- |||||||||| doxycycline / Generic mfg.
Journal: Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection? (Pubmed Central) - Jul 10, 2022
16S rRNA amplicon sequencing revealed significantly lower bacterial diversity in the stool of ceftriaxone-treated mice, in comparison to doxycycline-treated and azithromycin-treated mice. These findings suggest that doxycycline may have a low propensity to promote C. difficile colonization because it causes relatively limited alteration of the indigenous microbiota that provide colonization resistance and because it provides inhibitory activity against some C. difficile strains.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis. (Pubmed Central) - Jul 10, 2022
Here, we generated doxycycline-inducible Epfn-expressing mouse iPSCs (Epfn-iPSCs)...Simultaneous LDN-193189 treatment and Epfn activation largely reversed the perturbations in ameloblast induction, with partial recovery of p-Smad1/5/8 expression, suggesting that Epfn activation promotes ameloblast induction from mouse iPSCs partially by upregulating BMP-Smad activity. These results reveal the potential regulatory networks between Epfn and the BMP-Smad pathway and suggest that Epfn is a promising target for inducing the differentiation of ameloblasts, which can be used in enamel and tooth regeneration.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Journal: Identifying patient-level risk factors associated with non-β-lactam resistance outcomes in invasive MRSA infections in the United States using chain graphs. (Pubmed Central) - Jul 9, 2022
Only levofloxacin susceptibility was associated with healthcare-associated infections...Patients with positive blood culture had significantly increased MIC of chloramphenicol, erythromycin, gentamicin, lincomycin and mupirocin, and decreased daptomycin and rifampicin MICs...The differences in resistance phenotypes between patients with previous healthcare use or positive blood cultures, or from different states, may be useful to inform first-choice antibiotics to treat clinical MRSA cases. Additionally, we demonstrated multilevel PGMs are useful to quantify and visualize interactions among multiple resistance outcomes and their explanatory variables.
- |||||||||| doxycycline / Generic mfg.
Journal: The great imitator, revisited. (Pubmed Central) - Jul 8, 2022
The patient was started on a course of doxycycline 100 mg tablets, twice daily for 4 weeks. At follow up, there was complete remission.
- |||||||||| norfloxacin / Generic mfg., doxycycline / Generic mfg.
Journal: Copper exposure effects on antibiotic degradation in swine manure vary between mesophilic and thermophilic conditions. (Pubmed Central) - Jul 8, 2022
The results showed that Cu promoted the dissipation of norfloxacin and sulfamethazine (SMZ) in solid swine manure under mesophilic conditions at initial concentrations ranging from 407.8 to 1353.0 mg·kg but insignificantly influenced or even inhibited their dissipation under thermophilic conditions...In the presence of Cu, the heat-resistant SMZ-degrading inoculum failed to enhance SMZ removal in manure suspensions. Our findings can help to answer why Cu has varied effects on antibiotic degradation during manure composting.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Stably Integrating an Inducible CRISPR-Cas9 to Protect Against Viral Infections in Vitro. (Pubmed Central) - Jul 8, 2022
The A549 lung adenocarcinoma cell line was genetically modified to express a doxycycline-inducible Cas9, and a guide RNA targeting a luciferase reporter plasmid. This investigation revealed a robust inducible Cas9 system that successfully reduced the expression of the luciferase viral reporter by up to 98% and by 75% on average.
- |||||||||| tetracycline / Generic mfg.
Review, Journal: Tetracyclines-An Important Therapeutic Tool for Dermatologists. (Pubmed Central) - Jul 2, 2022
The side effects have been thoroughly studied over the years, the most characteristic and important ones in daily dermatological practice being: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, and idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss the instances where the efficacy and safety of tetracyclines have been highlighted over the past few years.
- |||||||||| ampicillin / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Characterization of Clinical Salmonella entericas Trains in Huzhou, China. (Pubmed Central) - Jul 2, 2022
Our results highlight a serovar shift and a concerning number of multidrug-resistant (MDR) strains. Continued surveillance of Salmonella and their MDR profiles and efforts to control the rapid increase in antimicrobial resistance among Salmonella in Huzhou are needed.
- |||||||||| Aphthasol (amlexanox) / Abeona Therap, Esteve
Retrospective data, Review, Journal: Efficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis. (Pubmed Central) - Jul 1, 2022
Honey, lnsulin liposome gel, laser, amlexanox, glycyrrhiza and triamcinolone had better efficacy performance...Doxycycline and penicillin had a high risk of adverse events...The rank possibility of size-reducing effect and symptom-reducing effect supported the short-term effect of laser and the long-term effect of probiotics. We recommend the use of laser as a short-term intervention during the exacerbation phase of RAS and probiotics as a long-term intervention during the exacerbation and remission phases of RAS.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Drugs for sexually transmitted infections. (Pubmed Central) - Jul 1, 2022
We recommend the use of laser as a short-term intervention during the exacerbation phase of RAS and probiotics as a long-term intervention during the exacerbation and remission phases of RAS. No abstract available
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