doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Doxycycline: the universal treatment for anogenital chlamydia. (Pubmed Central) -  Jul 28, 2022   
    The results of this study indicate that S. aureus from raw milk may constitute a risk concerning food poisoning, and more attention must be given to awareness and hygienic measures in the food industry. No abstract available
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Colorimetric assay for tetracyclines based on europium ion-induced aggregation of gold nanoparticles. (Pubmed Central) -  Jul 28, 2022   
    The whole process takes only 5 min, and as low as 20 nM OTC, 14 nM tetracycline (TC), and 20 nM doxycycline (DC) could be sensitively detected, respectively. The proposed method was also featured as good repeatability and specificity, and was applied to the detection of OTC in lake water with satisfactory recovery.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Journal:  Partial masculinization of Aedes aegypti females by conditional expression of Nix. (Pubmed Central) -  Jul 28, 2022   
    While the conditional expression of Nix produced intersex phenotypes, the level of expression was insufficient to program full conversion. Modifications that increase both the level of activation (no tet) and the level of repression (with tet) will be necessary, as such this study represents one step forward in the development of genetic strategies to control vector-borne diseases via sex ratio distortion.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. (Pubmed Central) -  Jul 27, 2022   
    We demonstrate the utility of this system for intracranial expression of shRNAs in a glioblastoma model. Additionally, we leverage this platform to target the redundant RAF signaling node in a mouse model of KRAS-mutant cancer and show that robust combinatorial synthetic lethality efficiently abolishes tumor growth.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Effect of Doxycycline Use in the Early Broiler Production Cycle on the Microbiome. (Pubmed Central) -  Jul 27, 2022   
    Moreover, Chao1, ACE, and Shannon indices showed the antibiotic treatment significantly altered the microbiota, and this change persisted throughout the rearing period. Further research is required to investigate the effect of these changes on bird performance, susceptibility to infections and Campylobacter carriage.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Urogenital Ureaplasma urealyticum can cause invasive infection in immunosuppressed patients (Pubmed Central) -  Jul 27, 2022   
    Repeated cultures were negative, which prolonged the time to diagnosis and accurate treatment. Uu was detected with 16S rRNA PCR assays during the course of the disease but was interpreted as non-pathogenic Finally, Uu was suspected as the causing agent, treatment with doxycycline was initiated, and the patient recovered after nine months of disease.
  • ||||||||||  Krintafel (tafenoquine) / GSK, Medicines for Malaria Venture
    Journal:  Survey and Analysis of Chemoprophylaxis Policies for Domestic Travel in Malaria-Endemic Countries. (Pubmed Central) -  Jul 26, 2022   
    The few positive recommendations for domestic travel were dominated by the suppressive prophylaxis options of daily doxycycline or atovaquone-proguanil or weekly mefloquine. The incomplete protection afforded by these strategies, along with impractical dosing in connection with the typically brief domestic travel, may in part explain the broad lack of policies and practices across malaria-endemic nations regarding chemoprophylaxis.
  • ||||||||||  ampicillin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Resistance and Pathogenicity of Salmonella Thompson Isolated from Incubation End of a Poultry Farm. (Pubmed Central) -  Jul 26, 2022   
    Additionally, the bacterial inoculation experiment with 1-day-old chicks revealed that clinical S. Thompson was highly pathogenic to newborn chicks after yolk sac inoculation. This study highlighted that the S. Thompson isolated from poultry embryos and the S. Thompson causing human foodborne diarrhea in some parts of China belong to the same cgMLST typology (cgST-12774) and showed the pathogenicity of this clinical S. Thompson to chicks.
  • ||||||||||  spironolactone / Generic mfg.
    Enrollment closed:  FASCE: Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman. (clinicaltrials.gov) -  Jul 26, 2022   
    P3,  N=158, Active, not recruiting, 
    This study highlighted that the S. Thompson isolated from poultry embryos and the S. Thompson causing human foodborne diarrhea in some parts of China belong to the same cgMLST typology (cgST-12774) and showed the pathogenicity of this clinical S. Thompson to chicks. Recruiting --> Active, not recruiting
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
    115 - Ditching the Dogma: Antimicrobial Stewardship Myth Busters (145 AB) -  Jul 23, 2022 - Abstract #IDWeek2022IDWEEK_270;    
    Urine bacteriology should be ordered. CME Credits : Maximum of 1.25 hours of AMA PRA Category 1 Credit™ MOC Credits : Maximum of 1.25 hours of MOC Credit CNE Credits : Maximum of 1.25 hours of ANCC Credit ACPE Credits : ACPE 1.25 contact hours of pharmacy CE ACPE Number : JA0007082-0000-22-002-L01-P Learning Objectives: At the conclusion of this session, participants will be able to: understand the role of bacteriocidal antibiotic agents in the treatment of bloodstream infections; understand the role of trimethoprim-sulfamethoxazole in the treatment of beta-hemolytic infections; understand the role of doxycycline in children less than 8 years of age
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  The doxycycline paradox in primary mitochondrial diseases. (Pubmed Central) -  Jul 23, 2022   
    The overall results of the current work demonstrate that diospyric acid (7), 28-hydroxy-β-amyrin (8) and oleanolic acid (9) are the major bioactive constituents of Donella welwitschia towards Gram-negative bacteria expressing MDR phenotypes. No abstract available
  • ||||||||||  Humira (adalimumab) / Eisai, AbbVie
    SCREENING FOR LATENT TUBERCULOSIS IN INFLAMMATORY BOWEL DISEASE – WILL IT BE ENOUGH? (Science Lounge) -  Jul 20, 2022 - Abstract #UEGW2022UEGW_2692;    
    In 2019, after the appearance of a vulvar ulcer (biopsies with epithelioid granulomas), azathioprine was suspended...Antibiotic therapy with ceftriaxone and doxycycline was started...Therefore, the diagnosis of tuberculosis with pulmonary, peritoneal and genital involvement was made, with adalimumab being suspended and anti-bacillary drugs started.When using anti-TNF alpha drugs, the reactivation of tuberculosis is a great concern, however, although screening for latent tuberculosis is in general use, it is not always possible to prevent the reactivation or new onset of tuberculosis. Therefore, it is essential to make clinicians aware to the emergence of exuberant and disseminated tuberculosis despite previous negative screenings.
  • ||||||||||  moxidectin / Generic mfg.
    Journal:  Application of Moxidectin and Ultrasound-Aided Injection of Melarsomine During the American Heartworm Society Recommended Treatment Protocol in Dirofilaria immitis Infected Dogs. (Pubmed Central) -  Jul 20, 2022   
    The American Heartworm Society (AHS) recommends the three-dose alternate melarsomine therapeutic regimen, together with a macrocyclic lactone (ML) to reduce new infections and eliminate susceptible larvae and doxycycline against Wolbachia bacteria...Microfilaremic dogs were pretreated with prednisolone and clopidogrel for 1 week before the first moxidectin application...On the first day, dexamethasone and chloropyramine were used to avoid potential adverse effects caused by the destroyed microfilariae...From the 60th day, dalteparin was applied for 10 days to decrease the chance of pulmonary thromboembolism...All dogs recovered clinically by the 120th day and no microfilaremia was seen that time. An antigen test performed in 37/44 animals on the 271st day was also negative in all cases.
  • ||||||||||  hydroxychloroquine / Generic mfg., ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Cerebral Whipple's disease presenting with an epileptic seizure: reminder of a rare disease with variable manifestations (A8) -  Jul 18, 2022 - Abstract #EAN2022EAN_1573;    
    Intravenous treatment with ceftriaxone during two weeks followed by oral doxycycline combined with hydroxychloroquine resulted in a progressive reduction of the lesions on brain MRI at 1, 3 and 6 months after treatment initiation (Fig. This case clearly shows the clinical subtleness and the clinico-radiological paradox by which cerebral Whipple's disease can present itself.
  • ||||||||||  atorvastatin / Generic mfg., mebendazole / Generic mfg., doxycycline / Generic mfg.
    Enrollment change, Trial withdrawal, Real-world evidence, Real-world:  METRICS: Study of the Safety, Tolerability and Efficacy of Metabolic Combination Treatments on Cancer (clinicaltrials.gov) -  Jul 18, 2022   
    P3,  N=0, Withdrawn, 
    This case clearly shows the clinical subtleness and the clinico-radiological paradox by which cerebral Whipple's disease can present itself. N=207 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  Preclinical, Journal:  In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates. (Pubmed Central) -  Jul 17, 2022   
    The results demonstrated the suitability and application scope in food and environment safety. Our results supported the current usage of macrolides, rifabutin, and aminoglycosides in the regimens for MAC infection, and also demonstrated the low resistance rate against new drugs, such as clofazimine, tedizolid, and bedaquiline, suggesting the possible implementation of these drugs in MAC treatment.
  • ||||||||||  doxycycline / Generic mfg., sirolimus / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Preclinical, Journal:  Characterisation of 3D Bioprinted Human Breast Cancer Model for In Vitro Drug and Metabolic Targeting. (Pubmed Central) -  Jul 17, 2022   
    Our results provide additional steps in the direction of representing in vivo 3D situations in in vitro studies. Future use of these models could help to reduce the number of animal experiments and increase the success rate of clinical phase trials.