- |||||||||| doxycycline / Generic mfg.
Journal: Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance. (Pubmed Central) - Aug 11, 2022
To study HORMAD1-driven genetic dependencies, we generated a SUM159 cell line model with doxycycline-inducible HORMAD1 that replicated genomic instability phenotypes seen in HORMAD1-positive TNBC (1)...Our data confirms that out-of-context somatic expression of HORMAD1 can lead to genomic instability and reveals that HORMAD1 expression induces dependencies upon replication stress tolerance pathways, such as translesion synthesis. Our data also suggest that HORMAD1 expression could be a patient selection biomarker for agents targeting replication stress.
- |||||||||| Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
Journal: Case Report: Treatment of Severe Neuroretinitis and other Sequelae Associated with Cat Scratch Disease. (Pubmed Central) - Aug 11, 2022
Oral prednisone and topical difluprednate are recommended to quell initial inflammation during the first few weeks. The anti-inflammatory effects of doxycycline and topical ketorolac used for longer duration may be beneficial in preventing tissue damage without systemic immunosuppression and result in better visual outcomes.
- |||||||||| Journal: The pathogenic characterization of Citrobacter freundii and its activation on immune related genes in Macrobrachium nipponense. (Pubmed Central) - Aug 11, 2022
The expression level of MyD88, α2M, CDSP, and Relish were detected in hepatopancreas, hemolymph, gills and intestine tissues by quantitive real-time PCR (qRT-PCR), and clear transcriptional activation of these genes were observed in M. nipponense after C. freundii infection. These results revealed pathogenicity of C. freundii and its activation of host immune response, which will provide a scientific reference for the breeding and disease prevention in M. nipponense culture.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: A tough synthetic hydrogel with excellent post-loading of drugs for promoting the healing of infected wounds in vivo. (Pubmed Central) - Aug 10, 2022
In a rat model of methicillin-resistant Staphylococcus aureus (MRSA)-infected full-thickness skin defect wound, the DOX-loaded hydrogel showed good therapeutic effect. It could significantly promote the wound closure, increased the collagen coverage area, down-regulate the expressions of pro-inflammatory TNF-α and IL-1β factors, and up-regulate the expressions of anti-inflammatory IL-4 factor and CD31 neovascularization factor.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: Analysis of serological treatment response to doxycycline versus benzathine penicillin in syphilis infections, a retrospective single-centre study. (Pubmed Central) - Aug 10, 2022
It could significantly promote the wound closure, increased the collagen coverage area, down-regulate the expressions of pro-inflammatory TNF-α and IL-1β factors, and up-regulate the expressions of anti-inflammatory IL-4 factor and CD31 neovascularization factor. Doxycycline had a slightly lower, though not statistically different, success rate when compared with penicillin in treating primary syphilis, but had a lower success rate in attaining resolution in late and undetermined syphilis infection.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg., acyclovir / Generic mfg.
Journal: Changing Spectrum of Acute Encephalitis Syndrome in India and a Syndromic Approach. (Pubmed Central) - Aug 10, 2022
If smear or antigen for malaria is positive, should receive antimalarial, if negative doxycycline and ceftriaxone should be started pending serological confirmation of scrub typhus, leptospira, or dengue. A syndromic approach of AES based on the prevalent infection in a geographical region may be developed, which may be cost-effective.
- |||||||||| Gatiflox (gatifloxacin) / Orient Europharma
Journal: Antibiotic resistance status of helicobacter pylori strains isolated from initial eradication patients in Ningbo, China, from 2017 to 2021. (Pubmed Central) - Aug 9, 2022
A syndromic approach of AES based on the prevalent infection in a geographical region may be developed, which may be cost-effective. With the increasing resistance rate and multiple resistance of H. pylori to commonly used antibiotics, drug susceptibility testing is imperative to permit individualized therapy, and a regimen containing the combination of amoxicillin, furazolidone, tetracycline, doxycycline, or rifampicin is reasonable for initial empirical eradication therapy.
- |||||||||| Applying citizen science to recalcitrant global problems (Grand Horizon B (Marriott Marquis Chicago)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_7995;
It has also been a real force multiplier for my research. I’ll focus on the features of DPAL that other educators could replicate to engage wider circles of citizen scientists in attacking other big problems, like environmental lead and the opioid crisis.
- |||||||||| Journal: Dolichoectasia: a brain arterial disease with an elusive treatment. (Pubmed Central) - Aug 7, 2022
I’ll focus on the features of DPAL that other educators could replicate to engage wider circles of citizen scientists in attacking other big problems, like environmental lead and the opioid crisis. These cases exemplify the challenges of treating people with dolichoectasia and highlight the need for better evidence regarding the best possible treatment for this population.
- |||||||||| doxycycline / Generic mfg.
Journal: Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC-derived neurons. (Pubmed Central) - Aug 7, 2022
The characterization of our cell lines revealed that the presence of mHTTEx1 in hiPSC-derived neurons alters the synaptic protein appearance, decreases synaptic contacts, and causes a delay in the development of a mature neuronal activity pattern, recapitulating some of the developmental alterations observed in HD models, nonetheless in a shorted time window. Our data support the notion that HD has a neurodevelopmental component and is not solely a degenerative disease.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: MicroRNA-101a enhances trabecular bone accrual in male mice. (Pubmed Central) - Aug 6, 2022
We also examined skeletal phenotypes of an inducible miR-101a transgene under direct control of doxycycline administration...Hence, miR-101a upregulation during osteoblast maturation and the concomitant reduction in Ezh2 mediated H3K27me3 levels may contribute to the enhanced trabecular bone parameters in male mice. However, the sex-specific effect of miR-101a indicates that more intricate epigenetic mechanisms mediate physiological control of bone formation and homeostasis.
- |||||||||| ceftriaxone / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
Journal: Systemic Brucellosis with Arrhythmogenic Cardiac Inflammatory Pseudotumor. (Pubmed Central) - Aug 6, 2022
In the case of travelers, the possibility of regionally specific illnesses, especially infections, must be taken into consideration as possible causes of arrhythmias. Cardiac magnetic resonance imaging may be useful in patients with 'idiopathic ventricular tachycardias' to detect non-apparent myocardial lesions which may result from the underlying cause of the arrhythmia.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Preclinical, Journal: Rapid and efficient generation of cartilage pellets from mouse induced pluripotent stem cells by transcriptional activation of BMP-4 with shaking culture. (Pubmed Central) - Aug 6, 2022
Here, we established a tetracycline (tet) controlled bone morphogenetic protein-4 (BMP-4) expressing iPSC (iPSC-Tet/BMP-4) line in which transcriptional activation of BMP-4 was associated with enhanced chondrogenesis...Of note, transcriptional activation of BMP-4 by addition of tet (doxycycline) greatly enhanced the expression of these genes...The regenerated cartilage expressed the neomycin resistance gene, indicating that the newly formed cartilage was generated by the transplanted iPSCs-Tet/BMP-4. Thus, our culture system could be a useful tool for further investigation of the mechanism of BMP-4 in regulating iPSC differentiation toward the chondrogenic lineage, and should facilitate research in cartilage development, repair, and osteoarthritis.
- |||||||||| doxycycline / Generic mfg.
Journal: Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia. (Pubmed Central) - Aug 5, 2022
Doxycycline (DOX) was given to EKI mice to induce endothelial TXNIP overexpression...This was associated with increased NLRP3 and reduced Akt and eNOS activation. In conclusion, deletion of endothelial TXNIP is protective against and overexpression of endothelial TXNIP induces endothelial dysfunction; thus, endothelial TXNIP plays a critical role in modulating endothelial dysfunction.
- |||||||||| doxycycline / Generic mfg.
Journal: Investigation of the Relationship between Chronic Endometritis Manifestations under Hysteroscope and CD138 Expression. (Pubmed Central) - Aug 3, 2022
According to the results of CD138 IHC, positive patients were given antibiotic treatment (doxycycline 100 mg BID orally for 14 days), and hysteroscopy was performed again after treatment to check the efficacy of antibiotics...Cases of diffuse endometrial hyperemia under hysteroscope had the lowest positive rate of CD138, and the effect of antibiotic treatment on these patients was poor. The positive rate of CD138 in patients with endometrial micropolyps and endometrial stroma edema and hyperplasia under hysteroscope was high, and the effect of antibiotic treatment was better.
- |||||||||| doxycycline / Generic mfg.
p16 Regulates Transcription Factor Sp1 Function to Affect Outcome in Oropharyngeal Cancer (Henry B. Gonzalez Convention Center, Room 303) - Aug 1, 2022 - Abstract #ASTRO2022ASTRO_2020;
This increase of HUWE1 expression then leads to down-regulation of homologous recombination, sensitizing cells to DNA damage. Clinical data shows the combined expression of p16, Sp1 and HUWE1 are highly correlated and that the combination of p16 and Sp1 may be an effective biomarker in OPC.
- |||||||||| doxycycline / Generic mfg.
TRIBBLES1 (TRIB1) Pseudokinase Induces Treatment Resistance in GBM by Promoting Survival of Tumor Cells through the Akt Pathway (Henry B. Gonzalez Convention Center, Exhibit Hall 1) - Aug 1, 2022 - Abstract #ASTRO2022ASTRO_666;
Our data suggest that heightened expression of TRIB1 in GBM cells contributes to RT/TMZ resistance by activating the prosurvival Akt signaling cascades. Therefore, targeting TRIB1 mediated Akt activation could provide a therapeutic benefit over targeting Akt directly, which may reduce Akt’s oncogenic signal without risking the toxicity associated with available Akt- specific inhibitors.
- |||||||||| doxycycline / Generic mfg.
Doxycycline (Twitter) - Jul 31, 2022
- |||||||||| doxycycline / Generic mfg.
Doxycycline (Twitter) - Jul 31, 2022
- |||||||||| Avastin (bevacizumab) / Roche
Journal: PRIDE complex-like skin rash associated with bevacizumab. (Pubmed Central) - Jul 30, 2022
After dose modification to 5 mg/kg body weight, 6 cycles were administered with no further rash and resolution of oedema. There is no need to halt bevacizumab therapy, although it can be continued at a lesser dose as it may be a dose-dependent complication.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2. (Pubmed Central) - Jul 29, 2022
Cell-cell fusion by the transient transfection of viral fusogens in the presence of doxycycline results in the expression of the reporter enzyme secreted alkaline phosphatase (SEAP) and the fluorescent nuclear localization marker EYFPNuc...Parallel quantification of secNLuc enabled the detection of cytotoxic compounds or insufficient transfection efficacy. In conclusion, the SRFIA reported here is well suited for high-throughput screening for new antiviral agents and essentially will be applicable to all viral fusogens causing cell-cell fusion in Vero cells.
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