- |||||||||| Retrospective data, Review, Journal: Antimicrobial resistance in Vibrio cholerae O1/O139 clinical isolates: a systematic review and meta-analysis. (Pubmed Central) - Sep 12, 2022
: Temporal changes in antibiotic resistance rate found in this study demonstrated the critical continuous surveillance of antibiotic resistance. Also, ciprofloxacin, azithromycin, gentamicin, cephalexin, imipenem, ofloxacin, and norfloxacin were found to be the best antibiotics against V. cholera, with the highest and the lowest effectiveness resistance rate.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Pharmacologic Enhancement of Rotator Cuff Repair: A Narrative Review. (Pubmed Central) - Sep 11, 2022
The purpose of this study is to review the current understanding of Matrix Metalloproteinases (MMPs), Doxycycline, Testosterone, Estrogen, Growth hormone/ IGF-1, Vitamin D, and Vitamin C as a means to mitigate deleterious effects and propagate factors that support healing following RCR...Patients with Vitamin D deficiency have shown to have increased fatty infiltration in rotator cuff muscle while Vitamin C functions as an antioxidant that increases collagen and fibroblast proliferation. As manipulation of pharmacologic factors shows potential for enhancing healing following RCRs, future studies are needed to establish a viable augmentation strategy to improve patient outcomes.
- |||||||||| NOCARDIA TSUKAMURELLA: AN ATYPICAL PNEUMONIA (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4194;
The symptoms can very easily resemble TB therefore a high clinical suspicion should be present for proper diagnosis and to save from prolonged course of unnecessary RIPE therapy, and its associated high risk side effect profile. Additionally, more research into learning about this pathogen is required to better understand, diagnose and thereby treat this infection effectively.
- |||||||||| doxycycline / Generic mfg., amiodarone / Generic mfg.
ATYPICAL PRESENTATION OF STAPHYLOCOCCUS AUREUS PNEUMONIA (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4193;
Diseases that present with ground-glass opacification of the lung on CT are numerous. In cases with multiple confounding factors, it is important to broaden the range of differentials and correlate radiological findings with the overall clinical picture.
- |||||||||| Mycamine (micafungin) / Astellas
NECROTIZING PNEUMONIA SECONDARY TO CANDIDA INFECTION IN A PATIENT WITH HISTORY OF ALCOHOL ABUSE REQUIRING LOBECTOMY AND ANTIFUNGAL THERAPY (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4189;
Cardiothoracic surgery consulted for surgical biopsy of abscess [Fig 3] and he eventually required lobectomy.Biopsy revealed pulmonary parenchyma with necrosis and abscess formation containing Candida albicans [Fig 4].Patient started on fluconazole but was later transitioned to micafungin with improvement of leukocytosis and overall condition.Patient weaned off ventilator and tracheostomy was performed... We discuss the pathological findings and the clinical course of a case of necrotizing Candida pneumonia.The infection was severe but full recovery was achieved in the patient.Candida albicans is a rare but significant cause of necrotizing pneumonia secondary to aspiration pneumonia in alcoholics and should be considered as one of the causes of necrotizing pneumonia in the lung.If suspected early lobectomy and start of antifungal therapy should be started for best prognosis and chance of recovery.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
A UNIQUE CASE: ACUTE EOSINOPHILIC PNEUMONIA SECONDARY TO DAPTOMYCIN: A COVID-19 PNEUMONIA MIMIC (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3987;
The differential in a patient with acute hypoxic respiratory failure is numerous, especially during the COVID19 pandemic. During these challenging times, it is important to think of atypical causes, such as AEP to improve the patient's clinical status.
- |||||||||| doxycycline / Generic mfg.
A RARE CASE OF DISSEMINATED MYCOBACTERIUM AS THE CAUSE OF RECURRENT PNEUMOTHORAX (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3974;
Although rare, disseminated MAC can be a fatal culprit leading to PTX in HIV patients. Due to the high mortality, the prompt diagnosis leading to appropriate treatment is necessary for improved patient outcome.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie, Akis (diclofenac injection) / IBSA Institute Biochemical SA
BUT WHAT ABOUT THE RASH? (Convention Center Exhibit Hall: Rapid Area 4B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3523;
CASE PRESENTATION: A 74-year-old woman with Crohn's disease (on weekly adalimumab); pulmonary hypertension (RVSP 76 mmHg); OHS/OSA, on home BPAP 17/7 cmH2O; and morbid obesity presented with a one-week history of skin lesions...She was hypoxic during the visit and given doxycycline for empiric treatment of pneumonia...Labs were significant for a leukocytosis of 19.3 with left shift, lactate of 3.5, serum creatinine of 1.9 (likely higher than patient's previous baseline of 1.7 with previous history of recurrent AKIs on CKD), elevated inflammatory markers, and normal ALT/AST...She was treated empirically with vancomycin, piperacillin-tazobactam, valacyclovir, and amphotericin B, the latter given the concern of blastomycosis... Prompt recognition of multiorgan failure secondary to blastomycosis is important for early treatment and improved survival in immunocompromised patients
- |||||||||| doxycycline / Generic mfg.
TORSION: A RARE CAUSE OF CHEST PAIN IN AN ACTIVE DUTY SERVICE MEMBER (Convention Center Exhibit Hall: Rapid Area 4A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3464;
This case represents an extremely rare cause of chest pain and dyspnea which was initially diagnosed as pneumonia with delay in definitive treatment. While pulmonary sequestration is a rare congenital abnormality that does not always have clinical significance, a high index of suspicion should be maintained in patients presenting with symptoms out of proportion to the typical presentation of a more common diagnosis.
- |||||||||| prednisone / Generic mfg., doxycycline / Generic mfg.
A TRACHEAL FIBROEPITHELIAL POLYP (Convention Center Exhibit Hall: Rapid Area 3B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3442;
She presented one month later for persistent cough and was prescribed doxycycline and a short course of prednisone and discharged home. Due to the rarity of this lesion, no guidelines exist regarding follow up, however, reported case reports encourage a repeat bronchoscopy for surveillance after removal.
- |||||||||| hydroxychloroquine / Generic mfg., ceftriaxone / Generic mfg., doxycycline / Generic mfg.
A SUBTLE PRESENTATION OF INFECTIVE ENDOCARDITIS WITH COXIELLA BURNETII AND CUTIBACTERIUM COINFECTION (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3393;
Clinicians should consider chronic Q fever in patients with structural heart disease from rural, farming communities. Both chronic Q fever and Cutibacterium acnes can present inconspicuously, leading to missed diagnosis and consequences of recurrent surgical intervention and mortality.
- |||||||||| doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
UNDERSTANDING THE NEED FOR A BROAD DIFFERENTIAL DIAGNOSIS: A CASE OF PNEUMONIC TULAREMIA (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3387;
Ultimately, the patient was extubated, transitioned to oral doxycycline, and discharged home. In the above case, we illustrate the gradual onset and rapid patient deterioration when treatment is delayed; yet, there is rapid recovery once appropriate treatment is used.
- |||||||||| Omnicef (cefdinir) / Abbott
A REMINDER OF THE IMMUNOSUPPRESSION CONFERRED BY PROLONGED HYPERGLYCEMIA: A CASE OF NOCARDIA FARCINICA PNEUMONIA (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3385;
She was prescribed a short course of prednisone and doxycycline for presumed upper respiratory tract infection...Her presenting complaints improved over the next 48 hours, and she was discharged to complete a course of cefdinir...Five days after percutaneous biopsy the patient was readmitted for initiation of antibiotics and intravenous trimethoprim-sulfamethoxazole and ceftriaxone were started... This rare case of N. farcinica pneumonia, involving a patient with immunocompromising risk factors notably without exposure to immunosuppressive therapy reminds us of the severity and risk posed by prolonged hyperglycemia in patients with poorly controlled diabetes mellitus.
- |||||||||| doxycycline / Generic mfg.
LEPTOSPIROSIS CAUSING PULMONARY HEMORRHAGE AND MULTIORGAN SYSTEM FAILURE (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3346;
Clinical suspicion should be high in patients presenting after potential exposure to infected soil. Appropriate timing of serology testing is crucial in making the diagnosis.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
HYPERAMMONEMIA POSTLUNG TRANSPLANTATION: AN UNCOMMON BUT LIFE-THREATENING COMPLICATION (Convention Center Exhibit Hall: Rapid Area 1A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3315;
Clinical signs of hyperammonemia should be promptly recognized in post lung transplant patients and managed aggressively given high mortality rates without treatment. A multi-pronged treatment approach with Intermittent high flux hemodialysis, bowel decontamination and agents targeting the urea cycle should be used to rapidly decrease the ammonia levels.
- |||||||||| Nuzyra (omadacycline) / Paratek
MYCOBACTERIUM ABSCESSUS SKIN INFECTION AFTER TATTOOING IN A LUNG TRANSPLANT RECIPIENT (Convention Center Exhibit Hall: Rapid Area 1A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3311;
In the case of tattoo related NTM exposure, the lack of standardized safety with ink handling that drives infections. NTM can be difficult to diagnose, making clinician suspicion and early treatment key to successful eradication.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
CAVITARY LUNG DISEASE: UNDERESTIMATED NOCARDIA (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3103;
Immunocompromised patients presenting with cavitary lesions require intense work-up and close monitoring for decompensation. Nocardia should be high on the differential for subacute cavitary lung lesions.
- |||||||||| A RARE CAUSE OF MULTIFOCAL PNEUMONIA AND CONSTRICTIVE PERICARDITIS: COXSACKIEVIRUS A (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3037;
We report a case of 30-year-old man who presented with multifocal pneumonia and subsequently developed constrictive pericarditis due to Coxsackievirus A. CASE PRESENTATION: A 30-year-old man without medical history was seen in Emergency Department(ED) for fever, cough and dyspnea and discharged with 5-day course of Azithromycin for community acquired pneumonia...He was started on intravenous(IV) Ceftriaxone and doxycycline...Our patient was initially treated with Colchicine and ibuprofen. We highlight a rare case of multifocal pneumonia and constrictive pericarditis caused by coxsackievirus A. It also sheds light on diagnostic and treatment approach.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice. (Pubmed Central) - Sep 10, 2022
Rosmarinic acid, salvianolic acid C, salvianolic acid B, or doxycycline as a positive control was provided daily through intraperitoneal injection...Our present study on mice demonstrated that rosmarinic acid inhibited multiple pathological processes, which were the key features important in abdominal aortic aneurysm formation. Further study on rosmarinic acid, the novel candidate for aneurysmal therapy, should be undertaken to determine its potential for clinical use.
- |||||||||| tetracycline / Generic mfg.
Journal: Tetracycline-induced mitohormesis mediates disease tolerance against influenza. (Pubmed Central) - Sep 10, 2022
Tolerance to IFV infection is associated with the induction of genes involved in lung epithelial cell and cilia function, and with down-regulation of inflammatory and immune gene sets in lungs, liver, and kidneys. Mitohormesis induced by non-antimicrobial tetracyclines and the ensuing IFN response may dampen excessive inflammation and tissue damage during viral infections, opening innovative therapeutic avenues.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: Atypical pneumonia caused by Chlamydia Psittaci during the COVID-19 pandemic. (Pubmed Central) - Sep 10, 2022
Mitohormesis induced by non-antimicrobial tetracyclines and the ensuing IFN response may dampen excessive inflammation and tissue damage during viral infections, opening innovative therapeutic avenues. This retrospective study, with the highest number of C. psittaci pneumonia enrolled cases in China so far, suggests that human psittacosis may be underdiagnosed and misdiagnosed clinically, especially in the midst of the COVID-19 pandemic.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Doxycycline as an antimalarial: Impact on travellers' diarrhoea and doxycycline resistance among various stool bacteria - Prospective study and literature review. (Pubmed Central) - Sep 10, 2022
Our findings suggest that new therapeutic strategies are warranted to combat MDR pathogens due to the emergence of many PMB clinical strains. Our prospective data and the literature review together suggest the following: 1) doxycycline does not prevent TD; 2) doxycycline use favours acquisition of doxy/tetracycline-co-resistant intestinal bacteria; 3) although doxycycline does not predispose to travel-related ESBL-PE acquisition per se, it selects ESBL-PE strains co-resistant to doxycycline; 4) doxycycline resistance rates are high among stool bacteria in general with no evidence of any tendency to decrease.
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