doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Synthesis of Controlled-Release Calcium Peroxide Nanoparticles Coated with Dextran for Removal of Doxycycline from Aqueous System. (Pubmed Central) -  Sep 24, 2022   
    The characterization of nCPs and dextran-coated nCPs was performed using X-ray diffractometry (XRD), field emission scanning electron microscopy (FESEM), fourier transform infrared spectroscopy (FTIR), Brunauer, Emmett and Teller analysis (BET), dynamic light scattering (DLS) and thermogravimetric analysis (TGA) techniques. This work suggests that dextran-coated nCPs are beneficial in wastewater treatment practice in terms of the long-term efficacy of DOX degradation potential.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Effect of Doxycycline-Release Anastomotic Augmentation Ring on Porcine Colorectal Anastomosis. (Pubmed Central) -  Sep 24, 2022   
    This pilot study shows that doxycycline-release AAR is feasible and safe. While burst pressure and collagen content did not change significantly with doxycycline treatment, upregulating genes related to the inflammatory process for pathogen and debris clearance in AAR may improve the early stage of colorectal anastomotic healing.
  • ||||||||||  Xerava (eravacycline) / SOM Biotech, Ewha Womans University, PAION, Innoviva
    Preclinical, Journal:  In Vitro Susceptibility Testing of Eravacycline against Nontuberculous Mycobacteria. (Pubmed Central) -  Sep 24, 2022   
    In this study, the in vitro activity of eravacycline, a new tetracycline derivative, was tested against 110 clinical isolates of NTM...massiliense (5), M. chelonae (10), M. immunogenum (3), M. fortuitum group (20) including 12 doxycycline-resistant isolates, and M. mucogenicum group (10) including three doxycycline-resistant isolates...MICs for tigecycline were generally within 1 to 2 dilutions of the 100%-inhibition eravacycline MIC values...While there was no trailing observed in most SGM, the eravacycline MICs were higher (MIC range of >8 μg/mL), except for M. kansasii and M. marinum which had MIC values of 1 μg/mL. This study supports further evaluation of eravacycline, including clinical trials for the development of RGM treatment regimens, especially for M. abscessus.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  MMP-2 inhibition prevents platelet activation in ischemia/reoxygenation conditions. (Pubmed Central) -  Sep 24, 2022   
    This patient received early treatment with antibiotics, which may have contributed to the early recovery of renal function and removal of L. interrogans from kidney tissue. The inhibition of platelet MMP-2 by doxycycline attenuated platelet activation and protected platelets by preserving their aggregation ability.
  • ||||||||||  Review, Journal:  Gradual Drug Release Membranes and Films Used for the Treatment of Periodontal Disease. (Pubmed Central) -  Sep 24, 2022   
    Some of the drugs released by the films and membranes in the selected articles include doxycycline, tetracycline, metronidazole, levofloxacin, and minocycline, all used with good outcome regarding their bactericide effect; BMP-2, Zinc-hydroxyapatite nanoparticles with regenerative effect. The conclusion derived from the selected studies was that gradual drug release in the periodontal pockets is a promising strategy as an adjuvant for the treatment of periodontal disease.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Expression of microRNA let-7 in cleavage embryos modulates cell fate determination and formation of mouse blastocysts. (Pubmed Central) -  Sep 24, 2022   
    The biased development towards the inner cell mass with forced expression of let-7 was reproduced in 2-cell chimeric embryos consisting of one wildtype blastomere and one GFP mRNA-injected blastomere from another 2-cell embryo carrying a doxycycline inducible let-7 g gene...In conclusion, a high level of let-7 at the 2-cell stage favored the formation of the inner cell mass, while a low level of let-7 at the 4-cell to 8-cell stage enhanced blastocyst formation. Tead4 mediated the action of let-7 on the inner cell mass cell fate determination.
  • ||||||||||  Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Combo-PEP: Multipurpose Prevention of Post-Exposure Prophylaxis Regimens (clinicaltrials.gov) -  Sep 22, 2022   
    P4,  N=37, Completed, 
    Drugs like teicoplanin, chloramphenicol, doxycycline, amikacin, and levofloxacin can treat MRSA infections. Recruiting --> Completed | N=20 --> 37 | Trial completion date: Apr 2023 --> May 2022 | Trial primary completion date: Apr 2023 --> May 2022
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Human Granulocytic Anaplasmosis. (Pubmed Central) -  Sep 21, 2022   
    Start it empirically if symptoms and risk factors suggest HGA. PCR is the confirmatory test of choice.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Journal, Combination therapy:  Combination therapy for Mycoplasma genitalium, and new insights into the utility of parC mutant detection to improve cure. (Pubmed Central) -  Sep 20, 2022   
    However, in the context of a high prevalence of the parC S83I mutation (23%) in macrolide-resistant infections, doxycycline + moxifloxacin cured only 85%. Infections that were wild-type for S83/D87 experienced high cure following doxycycline + moxifloxacin, supporting the use of a parC-resistance/susceptibility testing strategy in clinical care.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Management of lymphocele following anterior lumbar interbody fusion, case report and review of literature. (Pubmed Central) -  Sep 20, 2022   
    After percutaneous drainage by interventional radiology (IR), output remained high at 1 liter (L) per day, necessitating sclerotherapy with doxycycline and ethanol...In mild cases, drainage alone or nonsurgical chemical sclerotherapy may suffice. In symptomatic refractory cases, localization of the site with lymphangiogram or US-guided injection of methylene blue dye allows for easier identification and definitive management with either transabdominal laparoscopic fenestration or retroperitoneal surgical exploration and ligation.
  • ||||||||||  doxycycline / Generic mfg.
    Unchecked Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility (S103BC) -  Sep 18, 2022 - Abstract #AHA2022AHA_6789;    
    Similarly, high-dose doxycycline inducible cardiomyocyte-specific overexpression of both proteins (inducible double transgenic) in the adult heart results in reversible widespread cardiomyocyte mitosis, cardiac enlargement, and contractile failure, while low-dose transient induction also results in significant cardiomyocyte proliferation and lower ejection fraction that is reversible after doxycycline is removed. Collectively, these results demonstrate that cytokinesis failure mediates cardiomyocyte multinucleation and cell cycle exit of postnatal cardiomyocytes but may be a protective mechanism to preserve the contractile function of the myocardium.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Prevalence and Antimicrobial Susceptibility of Bovine Mycoplasma Species in Egypt. (Pubmed Central) -  Sep 17, 2022   
    All molecularly confirmed mycoplasma isolates (n = 5) were positive for the gyrA gene (100%); meanwhile, three isolates (60%) were positive for the parC gene. In conclusion, our findings revealed alarming resistance to enrofloxacin and doxycycline antibiotics; thus, antimicrobial usage must be restricted and molecular techniques can help in the rapid detection of the resistant strains.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels and Neonate Growth in Mice. (Pubmed Central) -  Sep 15, 2022   
    However, whether Cx43 is required for adipocyte remodeling and breastmilk production to support neonates' growth has not been established. In this study, we used doxycycline-inducible adipocyte-specific Cx43-deleted mice and demonstrated that adipocyte Cx43 played a vital role in determining the carbohydrate levels in breastmilk, which may subsequently affect neonates' growth.
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  UiO-66-NH based fluorescent sensing for detection of tetracyclines in milk. (Pubmed Central) -  Sep 14, 2022   
    The proposed UiO-66-NH sensor had good sensitivity and selectivity, and under the optimal conditions possessed detection limits of 0.449, 0.431, and 0.163 μM for tetracycline (TET), oxytetracycline (OTC), and doxycycline (DOX), respectively. Besides, the UiO-66-NH sensor was successfully applied to the quantitative detection of TCs in milk samples with reasonable recoveries of 93.26-115.17%, and the detection results achieved from the as-fabricated fluorescence sensing assay were consistent with those of high-performance liquid chromatography (HPLC), indicating the potential applicability of the UiO-66-NH sensor for detecting TCs in actual food samples.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  Downregulation of Bdnf Expression in Adult Mice Causes Body Weight Gain. (Pubmed Central) -  Sep 14, 2022   
    Thus, we exploited mutant mice in which the Bdnf expression level is regulated by the tetracycline-dependent transcriptional silencer (tTS)-tetracycline operator sequence (tetO) system...We demonstrated that changes in Bdnf expression influenced body weight during not only the developmental stage but also the adult stage of mice. Although it is still unclear whether acquired Bdnf loss of function in rodents mimics the pathology of MDD, our findings may bridge the mechanistic gap between MDDs and body weight gain in line with BDNF dysfunction.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties. (Pubmed Central) -  Sep 13, 2022   
    The data are correlated according to a statistical multivariate approach based on Principal Component Analysis and their mucoadhesion properties are also tested by Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the different P407 formulations are able to influence the release pathway of two antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate) largely used in oral diseases.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Oligomeropathies, inflammation and prion protein binding. (Pubmed Central) -  Sep 13, 2022   
    This review summarizes our studies with β-amyloid or α-synuclein oligomers, also considering the potential curative role of doxycycline, a well-known antibiotic with anti-amyloidogenic and anti-inflammatory activities. These actions are analyzed in terms of the therapeutic prospects.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model. (Pubmed Central) -  Sep 13, 2022   
    Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a positive allosteric modulator (PAM) of neuropeptide PACAP receptor 1 (PAC1-R), we use virtual and laboratory screening to search for novel small molecule PAMs of PAC1-R...Moreover, both SPAM1 and DOX block the decrease of PAC1-R level in mouse brain tissues induced by MPTP. The successful screening of SPAM1 offers a novel drug for the treatment of neurodegenerative disease targeting the PAC1-R.