- |||||||||| montelukast / Generic mfg.
Clinical, Journal: Montelukast as an effective adjuvant in the treatment of moderate acne vulgaris. (Pubmed Central) - Oct 5, 2022
In addition, the two groups were significantly different with regard to the percentage of decrease in the total lesion count, inflammatory lesions, and IGA (p = 0.033, 0.003, and 0.044, respectively). Thus, montelukast can be used as an adjuvant therapy besides other treatments of acne, especially for inflammatory lesions.
- |||||||||| temozolomide / Generic mfg., doxycycline / Generic mfg.
Journal: Atypical induction of HIF-1α expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells. (Pubmed Central) - Oct 4, 2022
Densely cultured GBM cells showed enhanced viability and resistance to temozolomide (TMZ) compared to GBM cells at a low density...Silencing Notch1 signaling using a doxycycline-inducible Notch1 RNA-interfering system or treatment with chetomin, a HIF pathway inhibitor, retarded tumor development with a significant anti-cancer effect in a murine U251-xenograft model...Collectively, these findings highlight the critical role of cell-to-cell contact-dependent signaling in GBM progression. They provide a rationale for targeting HIF-1α signaling even in a non-hypoxic microenvironment.
- |||||||||| doxycycline / Generic mfg.
Journal, IO biomarker: An Alternate Approach to Generate Induced Pluripotent Stem Cells with Precise CRISPR/Cas9 Tool. (Pubmed Central) - Oct 4, 2022
The generated iPSCs showed their potential to make embryoid bodies and differentiate into the derivatives of all three germ layers. Collectively, our data emphasize the exploitation of CASH-1 by CRISPR/Cas9 tool for therapeutic and biotechnological applications including but not limited to reprogramming of engineered cells into iPSCs.
- |||||||||| doxycycline / Generic mfg.
Doxycycline-induced gastric mucosal injury () - Oct 4, 2022 - Abstract #AGW2022AGW_609;
Esophageal injuries are more common and present with deep ulceration, whereas gastric injuries present with superficial necrosis and erosions. The mechanism of injury is poorly understood, with the localized nature of the injury suggesting it may be related to direct caustic effects from tablet stasis, similar to in the esophagus.
- |||||||||| albendazole / Generic mfg., doxycycline / Generic mfg.
Journal: Topical interferon in recurrent inflammatory macular edema following a cat bite. (Pubmed Central) - Oct 4, 2022
Interruption of interferon therapy due to COVID-lock down resulted in recurrence of the CME, which again responded well to interferon monotherapy. Topical interferon may have a role in the treatment of inflammatory macular edema and can serve as a, safer, economical and non-invasive treatment option compared to intravitreal steroids and anti-VEGFs.
- |||||||||| Review, Journal: The perspective of antibiotic therapeutic challenges of brucellosis in the Middle East and North African (MENA) countries: Current situation and therapeutic management. (Pubmed Central) - Sep 30, 2022
However, several studies proved that brucellae are still in-vitro susceptible to the majority of antibiotic compounds and combinations in current recommended WHO treatment regimens, e.g. levofloxacin, tetracyclines, doxycycline, streptomycin, ciprofloxacin, chloramphenicol, gentamicin, tigecycline, and trimethoprim/sulfamethoxazole. The current review presents an overview on resistance development of brucellae and highlights the current knowledge on effective antibiotics regimens for treating human brucellosis.
- |||||||||| doxycycline / Generic mfg.
Journal: PRC2-indepdendent actions of H3.3K27M in embryonic stem cell differentiation. (Pubmed Central) - Sep 30, 2022
We developed Doxycycline (Dox)-inducible mouse embryonic stem cells (ESCs) carrying a single extra copy of WT-H3.3, H3.3K27M and H3.3K27L, all fused to HA...Differentiated cells carrying either H3.3K27M or H3.3K27L retain expression of ESC-active genes, in expense of expression of genes related to neuronal differentiation. Taken together, our data suggest that a modifiable H3.3K27 is required for proper histone incorporation and cellular maturation, independent of PRC2 activity.
- |||||||||| doxycycline / Generic mfg.
PK/PD data, Journal, Combination therapy: PK/PD integration of florfenicol alone and in combination with doxycycline against Riemerella anatipestifer. (Pubmed Central) - Sep 30, 2022
For strains with a MIC ≤ 16 μg/ml, the magnitude of the AUC/MIC and C/MIC required for a 3 logCFU/ml of bacterial killing was 34.84 h and 4.74 in the presence of DOX at 0.5 MIC, respectively. These data suggest that combination of FF with DOX enhanced the activity against RA strains with various susceptibilities to FF and DOX.
- |||||||||| doxycycline / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC. (Pubmed Central) - Sep 29, 2022
We found that doxycycline-driven SNAI1 expression in the epithelial -like TNBC cell line MDA-MB-468 results in CD73 upregulation by direct binding to the CD73 proximal promoter...Our data are validated in TNBC samples by showing a positive correlation between the mRNA expression of CD73 and SNAI1. Overall, our results reveal a new CD73 regulation mechanism in TNBC that participates in TNBC-mediated immunosuppression and paves the way for developing new treatment opportunities for CD73-positive TNBC.
- |||||||||| doxycycline / Generic mfg., fluticasone / Generic mfg., itraconazole / Generic mfg.
Journal: The efficacy of itraconazole, fluticasone and doxycycline in chronic rhinosinusitis. (Pubmed Central) - Sep 29, 2022
Overall, our results reveal a new CD73 regulation mechanism in TNBC that participates in TNBC-mediated immunosuppression and paves the way for developing new treatment opportunities for CD73-positive TNBC. There were no significant differences between the clinical condition of patients receiving intranasal fluticasone, intranasal fluticasone in combination with doxycycline or itraconazole.
- |||||||||| etomoxir (MIQ-001) - Meta / IQ
Preclinical, Journal, Residual disease: In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence. (Pubmed Central) - Sep 29, 2022
Here, we characterize metabolic reprogramming related to tumor dormancy and recurrence in a doxycycline-induced Her2+/Neu model of breast cancer with varying times to recurrence using longitudinal fluorescence microscopy...Consequently, when fast-recurrence tumors receive treatment with a fatty acid inhibitor, Etomoxir, tumors report an increase in glucose uptake and lipid synthesis during regression...We show that metabolic reprogramming reports on tumor recurrence characteristics, particularly at time points that are essential for actionable targets. The temporal characteristics of metabolic reprogramming will be critical in determining the use of an appropriate timing for potential therapies; namely, the notion that metabolic-targeted inhibition during regression reports long-term therapeutic benefit.
- |||||||||| Journal: In-silico validation of the proposed treatment strategy of periodontitis. (Pubmed Central) - Sep 29, 2022
The temporal characteristics of metabolic reprogramming will be critical in determining the use of an appropriate timing for potential therapies; namely, the notion that metabolic-targeted inhibition during regression reports long-term therapeutic benefit. Based upon molecular docking results, it can be concluded that the proposed treatment strategy would be a suitable approach for periodontitis and all the selected therapeutic agents have potential similar to the standard drugs, thereby constituting a reliable system for periodontitis.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline Suppresses Vasculogenic Mimicry in Human Pterygium Fibroblasts. (Pubmed Central) - Sep 29, 2022
Furthermore, doxycycline impaired the expression of MMP-9, MMP-2 and VEGF which may related to pterygium VM formation. Doxycycline decelerated pterygium progression might be through inhibiting VM formation according to the downregulation of MMP-9, MMP-2 and VEGF, which may provide the basis of further studies involving doxycycline for pterygium treatment.
- |||||||||| Journal: Challenging diagnosis and successful treatment of localised Mycobacterium avium subsp. hominissuis glossitis in a dog on long-term immunomodulatory therapy. (Pubmed Central) - Sep 29, 2022
The results of several biopsies taken over 7 months indicated persistent pyogranulomatous and necrotising glossitis despite ongoing antimicrobial treatment, first with amoxicillin/clavulanic acid and then pradofloxacin...Therapy was initiated with rifampicin, clarithromycin and doxycycline, leading to complete remission of the lesions...This report describes challenges in the diagnosis and therapy of a localised Mah infection in an iatrogenically immunocompromised dog. Successful treatment was only achieved with a specific combination of antibiotics administered long-term.
- |||||||||| clarithromycin / Generic mfg., doxycycline / Generic mfg.
Retrospective data, Journal: Diagnosis and therapy of Mycobacterium marinum: a single-center 21-year retrospective analysis. (Pubmed Central) - Sep 29, 2022
Our retrospective analysis of M. marinum infections at a German tertiary referral center revealed a considerable diagnostic delay and the relevance of microbiological culture, PCR and histology for diagnosis. Monotherapy with clarithromycin (rather than doxycycline) appeared as a reasonable treatment option while immunosuppressed or -compromised patients and those with extended disease received combination therapy.
- |||||||||| metformin / Generic mfg., doxycycline / Generic mfg.
Biomarker, Clinical, Review, Journal: Immunologic and imaging signatures in post tuberculosis lung disease. (Pubmed Central) - Sep 29, 2022
It is likely that an integrated antifibrotic strategy that could simultaneously target inflammatory and pro-fibrotic pathways will probably emerge as a successful way to treat this complex condition. In a disease spectrum as wide as PTLD, a single immunologic or radiographic marker may not be sufficient and a combination is more likely to be a successful surrogate that could aid in the development of successful HDTs.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: A novel Candida glabrata doxycycline-inducible system for in vitro/in vivo use. (Pubmed Central) - Sep 29, 2022
Here we report a Tet-on gene expression system which can be used in vitro and in vivo in any C. glabrata genetic background. This system was used in a mice model of systemic infection to demonstrate that the general amino acid permease Gap1 is important for C. glabrata virulence.
- |||||||||| doxycycline / Generic mfg.
Journal: Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs. (Pubmed Central) - Sep 29, 2022
This system was used in a mice model of systemic infection to demonstrate that the general amino acid permease Gap1 is important for C. glabrata virulence. These results indicate that FOP-ML faithfully recapitulated the phenotype of primary monocytes of FOP and the combination with resFOP-ML is a useful tool to investigate molecular events at the initial inflammation stage of HO in FOP.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
DOES WINTER MEAN YOU ARE LESS LIKELY TO CATCH LEGIONNAIRES DISEASE? (Convention Center Exhibit Hall: Poster Area) - Sep 28, 2022 - Abstract #CHEST2022CHEST_4524;
However, during December 2021, Kentucky had several days of > 70°F weather with increased humidity index. She was an already immunosuppressed host, which concomitantly increased her risk of Legionella infection.
- |||||||||| doxycycline / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date, Surgery: MMMMODCS: Modulation of Microbiota Metabolism in Cardiac Surgery Patients (clinicaltrials.gov) - Sep 28, 2022
P=N/A, N=60, Recruiting,
Due to the presence of resistance and virulence genes, multi-antimicrobial resistance, and biofilm-forming capacity, the results of this study suggest a risk to the public health as these pathogens are associated with foodborne diseases, which emphasizes the hazard of resistance gene propagation in the environment. Not yet recruiting --> Recruiting | Trial completion date: Dec 2021 --> May 2023 | Trial primary completion date: Nov 2021 --> Nov 2022
- |||||||||| doxycycline / Generic mfg.
TERT acts via FOXO1 to alter redox metabolism in brain tumors (West/Central Hall) - Sep 28, 2022 - Abstract #SNO2022SNO_1150;
Our results indicate that doxycycline-inducible TERT silencing significantly reduces lactate production from [U-2H]-pyruvate in tumor-bearing mice...Furthermore, [U-2H]-pyruvate reports on early response to treatment with TERT inhibitors or with radiochemotherapy in mice bearing orthotopic patient-derived gliomas at early timepoints before radiographic alterations can be visualized by magnetic resonance imaging. Collectively, our studies integrate a mechanistic understanding of TERT biology with innovative imaging that has the potential to improve assessment of tumor burden and treatment response for glioma patients.
- |||||||||| doxycycline / Generic mfg.
Telomerase inhibition is an effective therapeutic strategy in TERT promoter-mutant glioblastomas models with low tumor burden (West/Central Hall) - Sep 28, 2022 - Abstract #SNO2022SNO_641;
Lastly, we used a doxycycline inducible CRISPR interference system to knock down TERT expression in vivo early and late in the tumor formation process...In vivo, tumor formation is only inhibited when TERT knockdown is induced shortly after tumor implantation, but not when tumor burden is high. This work supports the idea that telomerase inhibition would be a suitable therapeutic strategy for glioblastoma patients with low tumor burden, for example in the adjuvant setting after surgical debulking and chemoradiation.
- |||||||||| doxycycline / Generic mfg., irinotecan / Generic mfg.
The role of SMARCAL1 as a synthetic lethal vulnerability in ATRX-deficient gliomas (West/Central Hall) - Sep 28, 2022 - Abstract #SNO2022SNO_563;
Based on these data, we hypothesize that SMARCAL1 activity is critical for resolving ALT-associated replication stress in ATRX-deficient malignant gliomas. We therefore propose that SMARCAL1 functions as a synthetic lethal vulnerability in ATRX-deficient ALT-positive gliomas and that SMARCAL1 inhibition is a viable therapeutic strategy in these tumors.
- |||||||||| doxycycline / Generic mfg.
The molecular network of CAMTA-1 in glioma cells (West/Central Hall) - Sep 28, 2022 - Abstract #SNO2022SNO_411;
We established glioma cell lines with a doxycycline-inducible overexpression of CAMTA1...We identified an interaction of CAMTA1 overexpression with changes in the differential expression of Zink finger (ZNF) genes located on 19q. We will present novel data on a potential molecular interaction between chromosomes 1p and 19q.
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