- |||||||||| tranexamic acid oral / Generic mfg., doxycycline / Generic mfg.
An Uncommon Cause of Gross Hematuria With Underlying Fibrinolysis Induced by Pulmonary Artery Leiomyosarcoma (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1077;
In our case presentation, the patient’s hematuria rapidly, but temporarily, resolved with two courses of doxycycline...His bleeding stopped after initiation of tranexamic acid...Diagnosis of renal AV fistulas often require a high-index of suspicion, as their symptoms can vary widely from asymptomatic to gross hematuria, flank pain, and an abdominal mass. Renal artery angiogram is diagnostic gold standard and is required for selective embolization of the fistula as was performed in our patient with a rare underlying malignancy.
- |||||||||| doxycycline / Generic mfg.
Intu Deficiency in Renal Tubules Delays Kidney Repair yet Suppresses Renal Fibrosis After Kidney Injury (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1047;
Methods We have established an inducible Intu knockout mouse model that was exposed to doxycycline to ablate Intu specifically from kidney tubules (iRT-Intu-KO)...Conclusion Knockout of Intu suppressed kidney recovery and weakened fibrosis, associated with centrosome orientation abnormality and senescence inhibition. These findings suggest that planar cell polarity may contribute to tubular repair after kidney injury, shedding light on new strategies for improving kidney repair and recovery.
- |||||||||| doxycycline / Generic mfg.
TGFβR1 Activation in Tubular Epithelial Cell Recruits Leukocytes That Deliver Lethal Hit in a Model of AKI (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_995;
We have previously shown that ligand-independent activation of TGFβR1 in proximal tubules (doxycycline inducible transgenic Pax8Tgfbr1) results in rapid epithelial cell injury and death, as well as immune cell infiltration...Conclusion TGFβR1 in mPTECs promotes the recruitment of leukocytes by the secretion of key chemokines and facilitating vascular permeability. Activated leukocytes subsequently contribute to an injurious interplay triggering cell death pathways in mPTECs.
- |||||||||| doxycycline / Generic mfg.
Successful Outcome of AKI in a Patient With Leptospirosis and COVID-19 Infection (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_909;
Doxycycline 200mg added...Discussion Our case demonstrates successful resolution of the severe ARDS, AKI, with complete restoration of the kidney function under steroid therapy. Further trials are needed to elaborate recommendations on steroid therapy during co-existing covid-19 and leptospirosis.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice. (Pubmed Central) - Oct 13, 2022
In further in vivo studies utilizing doxycycline-inducible Tat transgenic (iTat-tg) mice, 14 days of Tat expression significantly reduced the recognition index by 31.7% in the final phase of novel object recognition (NOR) and potentiated cocaine-CPP 2.7-fold compared to responses of vehicle-treated control iTat-tg mice...Systemic administration (i.p.) of SRI-32743 prior to behavioral testing ameliorated Tat-induced impairment of NOR (at a dose of 10 mg/kg) and the Tat-induced potentiation of cocaine-CPP (at doses of 1 or 10 mg/kg). These findings demonstrate that Tat and cocaine interactions with DAT may be regulated by compounds interacting at the DAT allosteric modulatory sites, suggesting a potential therapeutic intervention for HIV-infected patients with concurrent cocaine abuse.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Letter in reply: more power to ivermectin multidrug therapy. (Pubmed Central) - Oct 13, 2022
These findings demonstrate that Tat and cocaine interactions with DAT may be regulated by compounds interacting at the DAT allosteric modulatory sites, suggesting a potential therapeutic intervention for HIV-infected patients with concurrent cocaine abuse. No abstract available
- |||||||||| doxycycline / Generic mfg.
Journal: Childhood granulomatous periorificial dermatitis showing a good response to doxycycline. (Pubmed Central) - Oct 12, 2022
We put forward that research into the pathogenesis of persisting complaints after antibiotic treatment for Lyme borreliosis in humans should be a top priority, but future studies should most definitely also focus on explanations other than persistent B. burgdorferi sensu lato infection after antibiotic treatment. No abstract available
- |||||||||| doxycycline / Generic mfg.
Journal: Occam vs Hickam. (Pubmed Central) - Oct 12, 2022
Additional CSF testing revealed probable Lyme meningitis. The patient responded to a course of oral doxycycline, with rapid resolution of his diplopia, abduction deficits, and disc edema.
- |||||||||| doxycycline / Generic mfg.
Journal: Study on antibacterial effect of halicin (SU3327) against Enterococcus faecalis and Enterococcus faecium. (Pubmed Central) - Oct 12, 2022
In addition, the synergistic antibacterial effect between halicin and doxycycline (DOX) against Enterococcus was observed through the checkerboard method, and it was observed that halicin and DOX could significantly synergistically inhibit biofilm formation and eradicate preformed biofilms at sub-MICs...Moreover, the mouse subcutaneous model and H&E staining showed that the combination of halicin and DOX could effectively reduce the bacterial load and inflammatory infiltration without obvious side effects. In nutshell, these results demonstrate the potential of halicin in combination with DOX as a novel therapy against infections by enterococcus.
- |||||||||| doxycycline / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma. (Pubmed Central) - Oct 12, 2022
Recurrent tumor cells were found to be sensitive to treatment with an MGMT inhibitor and doxorubicin. These findings suggest that recurrence-specific targeting coupled with DNA repair inhibition comprises a potential therapeutic strategy in patients affected by medulloblastoma relapse.
- |||||||||| doxycycline / Generic mfg.
Journal: Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea. (Pubmed Central) - Oct 12, 2022
Interestingly, we provided evidence showing that doxycycline can improve the symptoms of rosacea patients possibly by targeting amino acid metabolic pathway. These findings reveal that abnormal amino acid metabolism promotes neurovascular reactivity in rosacea, and raise the possibility of targeting dysregulated metabolism as a promising strategy for clinical treatment.
- |||||||||| Journal: Co-infections of Aeromonas veronii and Nocardia seriolae in largemouth bass (Micropterus salmoides). (Pubmed Central) - Oct 11, 2022
In addition, the coinfection of A. veronii and N. seriolae induce quick and higher mortality in comparison with those challenged by single bacteria. These results revealed that both A. veronii and N. seriolae participated in the disease outbreaks of the M. salmoides, and concurrent of those two bacteria synergistically exacerbate the disease severity.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg., minocycline / Generic mfg.
Review, Journal: Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review. (Pubmed Central) - Oct 11, 2022
Given the unclear long-term benefits, common side effects, and increasing antibiotic resistance seen globally, the existing literature is not sufficient to conclude that antibiotics are useful in long-term MGD management. A survival-analysis of a single round of antibiotics, in addition to the effects of repeated rounds of treatment, on DED parameters could provide useful insights.
- |||||||||| albendazole / Generic mfg., doxycycline / Generic mfg., ivermectin topical / Generic mfg.
Journal: Filariasis diagnosed by real-time ultrasound scanning as filarial dance sign - A case report. (Pubmed Central) - Oct 11, 2022
Doxycycline, albendazole, diethylcarbamazine, and ivermectin are among the treatments available...Using pulsed-wave doppler mode, the characteristic movement profile of adult worms in pulsed-wave doppler mode can be distinguished from other movements (e.g., blood in venous vessels). Ultrasound is the imaging modality of choice to detect filarial worms/microfilaria in the lymphatic system, which produces the classic twirling of microfilaria in the lymphatic system, known as the "filarial dance sign".
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: The use of mucoadhesive oral patches containing epigallocatechin-3-gallate to treat periodontitis: an in vivo study. (Pubmed Central) - Oct 11, 2022
Periodontitis was then treated with MOP (control), a mucoadhesive oral patch containing doxycycline (MOP-doxy) or MOP-EGCG for 1 h/day for 21 days...MOP-EGCG extract significantly reduced the expression of RANKL and increased the expression of OPG and RANK (p < 0.05) when compared to the MOP-doxy and MOP groups. MOP-EGCG extract reduced the expression of RANKL and increased the expression of OPG and RANK, thus suggesting that MOP-EGCG can inhibit the loss of alveolar bone in periodontitis.
- |||||||||| doxycycline / Generic mfg.
Journal: Clinical Efficacy Analysis of Biofeedback Electrical Stimulation Combined with Doxycycline in the Treatment of Type IIIA Chronic Prostatitis. (Pubmed Central) - Oct 11, 2022
After treatment, the overall efficiency of patients in the electrical stimulation group was significantly higher than that of the drug group (P < 0.05). Biofeedback electrical stimulation combined with doxycycline in the treatment of type IIIA chronic prostatitis can synergistically improve the patient's inflammation level, urinary dysfunction, relieve pelvic floor tension myalgia, and improve their quality of life, opening up new avenues for the rehabilitation of patients with type IIIA chronic prostatitis.
- |||||||||| doxycycline / Generic mfg.
When a Sweet Rash Leads To a Sour Diagnosis (Exhibit Hall (Upper Concourse); Monitor 06) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_944;
It was thought that he had an atypical presentation of Kawasaki Disease, and he was treated with IVIG in addition to doxycycline for empiric coverage of possible infection...This case highlights that immunodeficiency should be considered in cases of SS even in older children. Immunologists play a role in the evaluation of these children.
- |||||||||| doxycycline / Generic mfg.
126 - Towards a New Standard for Managing Lymphedema Associated with Lymphatic Filariasis: Lessons from the LEDoxy and TAKeOFF Studies (Convention Center - Room 618/619/620 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_3023;
This symposium will present the results and implications of 5 coordinated clinical trials aimed at 1) defining and quantifying the long-term (2-year) outcomes of WHO’s current hygiene-focused recommendations for managing lymphedema (LE) and elephantiasis (E) in individuals with lymphatic filariasis and 2) testing the potential of 6-weeks of doxycycline as an adjunct to the current hygiene-based treatment regimen [since earlier studies had shown its potential effectiveness]...To create WHO guidelines requires greater rigor in data collection, and the present trials of 1514 people whose 2-year hygiene-based LE management was studied in detail will provide the documentation and insight to subsequently identify the best indicators for monitoring both patient and program success. Finally, since patient self-care is at the core of the hygiene strategy for LE management, the symposium will identify what is required of patients (understanding, training, resources) to be successful and also what is required of health systems both to facilitate patient compliance and success as well as to integrate this program with other similar activities that target disabling and stigmatizing diseases involving the skin.
- |||||||||| albendazole / Generic mfg., doxycycline / Generic mfg.
Pre-clinical development of Corallopyronin A - a novel antibiotic active against Wolbachia endosymbionts of filarial nematodes (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2656;
We have funding to complete the pre-clinical phase and to prepare and submit a clinical trial application for a first-in-human phase 1 study (planned for 2024) to the German regulatory agency BfArM. CorA would be a first-in-class antibiotic with a novel mode of action to treat filarial infections in support of the UN Sustainable Development Goals.
- |||||||||| doxycycline / Generic mfg.
Effect of filarial lymphedema treatment with doxycycline on immune activation and exhaustion frequencies in blood (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2649;
Current treatment (200 µg/kg ivermectin (IVM) and 400 mg albendazole (ALB)) acts on microfilariae, the larval stage that is also responsible for transmission, but does not affect the adult worm...Interestingly, the opposite is observed in the Ghanaian samples when examining paired values from pre- and 6 months post-treatment. Clearer conclusions as to the nature of these differing results will be able to be drawn after unblinding of the study participants (anticipated July 2022).
- |||||||||| Characterization of Klebsiella pneumoniae strains from hospitalized patients in Bangladesh (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2607;
In this study, the plan is also to compare the community acquired and hospital acquired Kpn isolates. While the study is ongoing, including WGS for all isolates, initial clinical and phenotypic findings suggest further analysis which can be useful for future approach of vaccine development.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Retrospective Molecular Analysis of Sexually Transmitted Infections (STI) for the Detection of Mycoplasma genitalium in Ghana (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2255;
A low occurrence of M. genitalium and subsequently low rate of macrolide-resistance was recorded in this study, comparable to earlier work conducted in Ghana. This retrospective study design had significant limitations that could be improved upon by conducting prospective sexually transmitted infection surveillance to better estimate the incidence and prevalence of MG in Ghana.
- |||||||||| Krintafel (tafenoquine) / GSK, Medicines for Malaria Venture
Antimalarial Susceptibility of Plasmodium falciparum field isolates from Busia County in Kenya (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1496;
Artemisinin, Artesunic acid and Amodiaquine posted a median (IC50) of 2.384 ng/ml (95%Cl,1.385 to 4.072), 4.169 ng/ml (95%Cl,1.748 to 5.912) and 0.8535 ng/ml (95%Cl,0.4478 to 1.597) respectively. Malaria field isolates from Busia County were susceptible to the antimalarials hence it calls for continued surveillance to detect any emerging drug resistance.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Flea-borne Typhus Causing Fatal Hemophagocytic Lymphohistiocytosis (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_1377;
She was diagnosed with euglycemic diabetic ketoacidosis and was started on ceftriaxone, IV fluids, and insulin drip...She was intubated and started on norepinephrine and broad-spectrum antibiotics including doxycycline...Autopsy revealed hemophagocytic histiocytes in lymph nodes and bone marrow. With these findings, the cause of death was ascribed to HLH due to FBT.
- |||||||||| Trikafta (elexacaftor/tezacaftor/ivacaftor) / Vertex
Functional analysis of elexacaftor/tezacaftor/ivacaftor-refractory class II mutations by yeast phenomic profiling (Exhibition Hall) - Oct 8, 2022 - Abstract #NACFC2022NACFC_1190;
For the phenotypic profiling,we use custom growth curve technology and quantitative high-throughputcell array phenotyping to quantify differences in Yor1 function and thus todiscover evolutionarily conserved genetic, molecular, and cellular path-ways predicted to influence analogous CFTR mutations in CF cell models.CRISPR genome editing was used to construct the relevant YOR1 mutantalleles analogous to F508del (F670del-Yor1) and some not approved forELX/TEZ/IVA: N1303 K (N1307K-Yor1), R560 T (R722T-Yor1), R560 K(R722K-Yor1), and A559 T (A721T-Yor1).A background strain, constructed by chromosomal integration topermit tetracycline-repressible (Tet-OFF) Yor1 expression, was confirmedphenotypically by titratable oligomycin sensitivity with addition ofdoxycycline. Results from ongoing yeast phenomic profiling studies tofunctionally distinguish F508del from alleles refractory to ELX/TEZ/IVAtherapy will be presented.
- |||||||||| Kineret (anakinra) / SOBI
Preclinical, Journal: Murine typhus complicated by sHLH mimicking adult-onset Still's disease. (Pubmed Central) - Oct 7, 2022
It is important to consider murine typhus in patients returning from endemic areas, such as La Reunion or other tropical areas, when they present fever of unknown origin with non-specific clinical features. Moreover, this case illustrates the effectiveness of IL-1 blockers as a treatment for symptomatic sHLH without severity criteria, regardless of the aetiology.
- |||||||||| Journal: Antimicrobial resistance and genomic investigation of non-typhoidal Salmonella isolated from outpatients in Shaoxing city, China. (Pubmed Central) - Oct 7, 2022
Furthermore, the phylogenomic analysis showed that all isolates of the same serovar are very close to each other and clustered together in the same clade. Together, we showed a high incidence of MDR among the studied isolates which is alarming for public health services and is a major threat to the currently available treatments to deal with human salmonellosis; hence, efforts should be gathered to further introduce WGS in routinely monitoring of AMR Salmonella in the medical field in order to enhance the effectiveness of surveillance systems and to limit the spread of MDR clones.
- |||||||||| Invirase (saquinavir) / Roche
Preclinical, Review, Journal: Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies. (Pubmed Central) - Oct 7, 2022
From evaluated structures, saquinavir, ritonavir, eucalyptus, Tinospora cordifolia, aloe, green tea, curcumin, pyrazole, and triazole derivatives in in silico studies and doxycycline, chlorpromazine, and heparin from in vitro and human monoclonal antibodies from in vivo studies showed promised results regarding efficacy. It seems that due to the nature of COVID-19 disease, finding some drugs with multitarget antiviral actions and anti-inflammatory potential is valuable and some herbal medicines have this potential.
- |||||||||| Journal: COVID-19 Vaccination Outcomes and Antibiotic Crisis and Overuse During the COVID-19 Pandemic in Bosnia and Herzegovina. (Pubmed Central) - Oct 7, 2022
Out of all patients, 312 (78.0%) have received antibiotics and 3 (0.75%) antivirotics such as favipiravir as therapy for the treatment of COVID-19...The most prescribed antibiotic was doxycycline 172 (43.0%), followed by ceftriaxone 139 (34.7%) and azithromycin 108 (27.0%)...The outcome of such malpractice could lead to antimicrobial resistance which will be seen in further years. Governmental agencies should advise physicians to change these trends.
- |||||||||| tetracycline / Generic mfg.
Journal: New method for morphological identification and simultaneous quantification of multiple tetracyclines by a white fluorescent probe. (Pubmed Central) - Oct 6, 2022
In addition, the selective and competitive experiments have been carried out on the pollutants widely present in water, and the results have also confirmed that other pollutants could not interfere with the detection of the above 4 tetracyclines. It is undeniable that this work will conveniently and visually reveal the existence information and geographical distribution characteristics of different tetracycline antibiotics in the environment and their action mechanism on organisms.
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