- |||||||||| dexamethasone / Generic mfg., doxycycline / Generic mfg., promethazine / Generic mfg.
onchocerciasis : forgotten but not quite gone (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3962;
He denied the use of traditional medication but reports self-medication on drugs he believed to relieve his itch, especially dexamethasone...The patient was started on ivermectin 1.2mg stat, doxycycline 100mg OD, and betamethasone ointment with promethazine 25mg nocte... To avert missed diagnoses, it
- |||||||||| doxycycline / Generic mfg.
Chronic erythema migrans (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3928;
It is important to consider erythema migrans in cases of atypical erythematous unilateral rashes especially in areas where Lyme. Testing is non invasive and response to treatment is often rapid with minimal side effects and the potential consequences of not treating are catastrophic.
- |||||||||| Rituxan (rituximab) / Roche
Experience of managing a patient with blastomycosis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3908;
From the anamnesis it is known that the man came from Jordan 2 years ago, after he was subsequently diagnosed with diffuse large cell lymphoma, and therefore received 4 courses of RCHOP chemotherapy...The treatment included desensitizing infusion therapy with hepatoprotectors and antihistamines, antibiotic therapy (doxycycline 100 mg 2 times a day 20 days) , and antifungal therapy (nystatin 500 mg 3 times a day, 30 days, terbinafine 250 mg 2 times a day, 20 days)... thus, blastomycosis is a rare disease from the group of deep mycoses, usually found in immunocompromised patients and in late stages leads to damage to internal organs, as well as the nervous system.
- |||||||||| doxycycline / Generic mfg.
Efficiency of Doxycycline in Hailey-Hailey Disease (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3658;
Doxycycline appears to be an interesting therapeutic option, especially since it is inexpensive, well tolerated and easy to manage in routine practice. Large series studies are necessary to evaluate its effectiveness and define precise therapeutic modalities.
- |||||||||| Vulvar ulcers: a rare presentation of a potentially fatal disease (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3311;
Histopathological analysis confirmed the diagnosis of a neutrophilic dermatosis and, in the setting of persistent hematologic abnormalities, prompt investigation for an underlying malignancy was warranted. APL is a subtype of acute myeloid leukemia and mostly presents with pancytopenia or a life-threatening coagulopathy.
- |||||||||| Spikevax (elasomeran) / Moderna
facial lesions after hyaluronic acid fillers and Covid-19 vaccine: case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2847;
There is no established clear line of treatment, but options include oral or intralesional corticosteroids, alone or combined with 5-Fluorouracil, macrolides, tetracyclines, and hyaluronidase...We aim to present a case of delayed inflammatory reaction to hyaluronic acid fillers following the first dose of the Moderna Covid-19 vaccine, which was refractory to several treatments, but showed a rapid and sustained response to doxycycline... We present a case of delayed inflammatory reaction to hyaluronic acid dermal fillers following Covid-19 vaccination, resistant to treatment with oral corticosteroids and lisinopril, with an excellent response maintained with oral doxycycline.
- |||||||||| isotretinoin / Generic mfg.
Severe epidermal growth factor receptor inhibitors- induced papulo-pustular eruption with good response to low-dose isotretinoin and low-dose systemic corticotherapy (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2648;
We present a case of delayed inflammatory reaction to hyaluronic acid dermal fillers following Covid-19 vaccination, resistant to treatment with oral corticosteroids and lisinopril, with an excellent response maintained with oral doxycycline. We report the case of a 71 years old male patient, known with advanced colorectal cancer (extension to the upper bladder wall, multiple associated loco-regional adenopathies, multiple liver metastases) , under treatment with panitumumab, a humanized monoclonal antibody that inhibits EGFR...He was diagnosed with grade 3 papulopustular eruption secondary to epidermal growth factor receptor inhibitors treatments and recommended oral antibiotherapy with doxycycline 200 mg daily, topical low-potency corticosteroids along with general measures like avoidance of frequent washing with hot water using hard soaps, detergents, solvents, or disinfectants, limitation of sun exposure, usage of broad-spectrum sunscreen and emollients twice daily...Therefore, under the close surveillance of the liver tests and of the lipidogram, and with the oncologist
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Opdivo (nivolumab) / BMS, Xolair (omalizumab) / Roche, Novartis
Omalizumab and dupilumab (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2629;
The patient was initially treated with oral prednisolone 0.5mg/kg, doxycycline 100mg twice daily and topical clobetasol propionate...Despite treatment with oral prednisolone, mycophenolate mofetil, IVIg and rituximab her condition continued to progress... Given the many inherent risks and complications associated with immunosuppression in this patient group, targeted therapies such as dupilumab and omalizumab may provide a safe and efficacious option, either as single agents or in severe refractory cases such as this one, as combination therapy.
- |||||||||| dexamethasone / Generic mfg., doxycycline / Generic mfg.
Bullous pemphigoid in association with urothelial carcinoma (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2597;
In some cases, BP may occur before or after the diagnosis of bladder cancer. Some studies suggest that common genetic and immunological factors may play a role in their pathogenesis and may be involved in the development of both conditions.
- |||||||||| valacyclovir / Generic mfg., doxycycline / Generic mfg.
Genital bullous pemphigoid : A rare case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2575;
Based on the clinical diagnosis of herpes genitalis, he was treated with oral valacyclovir with resolution of lesions after few days...The patient was then started on oral doxycycline 100mg twice daily with topical antibiotics and oral antihistamines... We are reporting the first case of adult GBP with the diagnosis confirmed by both direct and indirect immunofluorescence.
- |||||||||| Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly
Pemphigoid nodularis induced by gliptins (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2543;
More than 50 cases of pemphigoid nodularis have been reported so far, but only in few of them a particular trigger could be identified in contrast to BP in general which can be precipitated by various physical or chemical agents, and medications, DPP-4i among them. A few cases of pemphigoid nodularis under gliptins were found in the literature, which may support linagliptin as a possible
- |||||||||| Advantan (methylprednisolone aceponate) / Bayer
Lupus erythematosus tumidus (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2537;
A few cases of pemphigoid nodularis under gliptins were found in the literature, which may support linagliptin as a possible Description of patients Patient 1 Patient 2 Sex / Age Male / 30 yo Male / 53 yo Medical history of interest Hepatomegaly Hypertension, dyslipidemia, smoking Time from outbreak to diagnosis 6 months 2 years Geographical location Central Asia North-Western region of Russia Season N/A Spring-Summer Trigger factors Sun exposure, doxycycline (2 months) Sun exposure, alcohol, ACE inhibitor (3 years) Previous diagnoses Dermatitis, JLIS, Rosacea, cutaneous sarcoidosis Dermatitis, Urticaria, Rosacea Clinical manifestation 3 round shape urticarial-like erythematous-violaceous plaques (oedematous erythema) with clearly defined boundaries Multiple annular and semi annular urticarial-like erythematous- violaceus plaques (oedematous erythema) and succulent papules Localisation Face Face, neck, chest, back Itch No Yes Indirect immunofluorescence ANA < 160 dsDNA
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Rosacea-like skin reaction under treatment with dupilumab for atopic dermatitis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2247;
It is possible that Th2 pathway inhibition by dupilumab may promote Demodex proliferation, which could lead to increased IL- 17-mediated inflammation. Rosacea disease is dominated by TH1/Th17 cells, often accompanied by infiltration of macrophages and mast cells4 In our case, systemic therapy with an IL-13 inhibitor could be continued without worsening of the skin reaction.
- |||||||||| Erbitux (cetuximab) / Eli Lilly
Cetuximab-Induced Papulopustular Exanthema: A Case Report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2068;
During the first few weeks of treatment with EGFR inhibitors, papulopustular exanthema is the earliest and very common cutaneous side effect. The recognition and prompt management of cutaneous adverse effects may prevent severe, extensive symptoms, the need for dose reduction, or antitumor therapy interruption.
- |||||||||| Olumiant (baricitinib) / Eli Lilly, Rinvoq (upadacitinib) / AbbVie
Association between atopic dermatitis and hidradenitis suppurativa: a series of 3 cases (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2057;
In our 3 patients, severity of AD and HS seem to correlate, which may have significant clinical implications. Each of these diseases brings substantial burden on the patients, and their simultaneous occurrence has even more profound effect on the patients
- |||||||||| Extensive pyogenic granuloma on the scalp due to the use of amivantanab (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2029;
Each of these diseases brings substantial burden on the patients, and their simultaneous occurrence has even more profound effect on the patients A 36-year-old female patient with T4N2M1c lung adenocarcinoma (metastases to the central nervous system and bones)
- |||||||||| Erbitux (cetuximab) / Eli Lilly, Vectibix (panitumumab) / Amgen
The Double Trouble: Acne and Pyogenic Granuloma in EGFR Inhibitor Treatment (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2008;
They can significantly impact patient quality of life, leading to physical discomfort, psychological distress, and treatment interruptions. The skin adverse reactions during EGFR inhibitors treatment, appear to be mechanism-based linked to the inhibition of EGFR action but the exact pathophysiology remains elusive.
- |||||||||| doxycycline / Generic mfg.
Doxycycline induced generalized morbilliform rash simulating viral exanthem. (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1939;
To differentiate between its two most common causes (drug-induced and viral) , most often remains a diagnostic challenge. History, clinical, and histopathological findings may help to arrive at the correct diagnosis but are usually inadequate in distinguishing between these two.
- |||||||||| Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie
Follicular occlusion triad : Case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1807;
Clinicians should pay more attention to FOT and provide patients with more education on their lifestyle. Due to the paucity of cases reported, there are no treatment guidelines yet, and management often requires a multidisciplinary approach encompassing both medical and surgical specialties.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg., isotretinoin / Generic mfg.
Ten-Ten pulse therapy in treatment of Acne Vulgaris (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1767;
Introduction & Objectives: Introduction: Tetracycline group of drugs have been the principal oral therapy for acne vulgaris for many years...Oral isotretinoin is recommended for severe nodulocystic acne which is usually associated with higher incidence of adverse effects... ** Doxycycline and isotretenoin are the good old drugs for the management of moderate, severe and very severe acne but can
- |||||||||| doxycycline / Generic mfg., isotretinoin / Generic mfg.
Follicular Dowling degos disease with Hidradenitis suppurativa (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1741;
Our case series reports this rare association. gene mutation studies are advised in such cases to confirm the variant of Dowling degos disease associated with hidradenitis suppurativa, same could not be done in our patients due to lack of resources.
- |||||||||| Rinvoq (upadacitinib) / AbbVie
Response to Upadacitinib in Hidradenitis suppurativa (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1705;
P2
Among the latter, the only ones currently approved for HS are adalimumab (anti-TNF) , secukinumab and bimekizumab (anti IL-17)... This study assesses the therapeutic potential of Upadacitinib in hidradenitis suppurativa, bringing new alternatives for its management in daily practice.
- |||||||||| Hidradenitis Suppurativa: Current Trends of Treatment In A Country With Limited Healthcare Facilities. (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1632;
Identifying and addressing barriers to achieving expertise in the treatment of HS can help provide access to high- quality care for patients with hidradenitis suppurativa. Future changes to health care in this country will undoubtedly result from the provision of health insurance, the training of dermatologists to become clinical and surgical experts in this area, and the assurance of the accessibility and affordability of newer treatment modalities.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Effective Treatment of COVID-19 Infection with Repurposed Drugs: Case Reports. (Pubmed Central) - Aug 4, 2024
Multidrug therapy is effective because of the differing mechanisms of action of these drugs, and it may also mitigate the emergence of drug-resistant SARS-CoV-2 strains. The medicines were lopinavir/ritonavir (Kaletra), bamlanivimab (monoclonal antibody), glycopyrrolate-formoterol (Bevespi), ciclesonide (Alvesco), famotidine (Pepcid), and diphenhydramine (Benadryl).
- |||||||||| doxycycline / Generic mfg.
Journal: Pharmacological approach using Doxycycline and Tocopherol in rotenone induced oxidative stress, neuroinflammation and Parkinson's like symptoms. (Pubmed Central) - Aug 1, 2024
and TNF-?) and activity of MAO-A, MAO-B.ResultDoxycycline and tocopherol in combination significantly attenuated behavioral, neurotransmitters and biochemical alterations induced by rotenone in experimental rats as compared to alone treatment with DOX and TOCO. Similarly, DOX and TOCO combination significantly reduced the level of inflammatory markers, prevented the biochemical changes, decreased MAO-A and MAO-B and improved complex-I, complex-IV, cAMP levels significantly.ConclusionThe current study revealed that a combination of doxycycline with tocopherol contributed to the prevention of PD like symptoms in rats by antioxidant, anti-inflammatory, MAO inhibitory and neuromodulatory mechanisms.
- |||||||||| Mycamine (micafungin) / Astellas
MULTIFOCAL OR PNEUMONIC-TYPE ADENOCARCINOMA OF LUNG: EARLY RECOGNITION FOR EARLY INTERVENTION (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5489;
A high index of suspicion is necessary to facilitate early diagnosis and treatment. PADC often presents with pneumonia-like signs and symptoms along with imaging that is suggestive of pneumonia, but does not improve with antibiotics or steroids.
- |||||||||| AN UNUSUAL CASE PRESENTATION OF BRUCELLOSIS (Convention Center Exhibit Hall: Rapid Fire Area 1D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5414;
This condition can have atypical clinical presentations and manifest in patients without the typical epidemiological risk factors. Prompt diagnosis and timely appropriate treatment can preclude any unwanted clinical sequelae and potential complications.
- |||||||||| cefepime hydrochloride / Generic mfg., ceftriaxone / Generic mfg., doxycycline / Generic mfg.
REFRACTORY PNEUMONIA FROM FOREIGN-BODY OBSTRUCTION (Convention Center Exhibit Hall: Rapid Fire Area 2D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5368;
Management included fluid resuscitation with 3L crystalloid and empiric community-acquired pneumonia antibiotics, including ceftriaxone and doxycycline...Antibiotics were escalated to Cefepime for refractory pneumonia and shock.Due to increased oxygen and pressors requirements, patient was upgraded to the ICU for close monitoring, and diagnostic bronchoscopy was performed, Bronchoscopy revealed a foreign body lodged on the left main bronchus with surrounding granulation tissue... This case underscores the importance of considering foreign body aspiration in the differential diagnosis of refractory obstructive pneumonia, even in the absence of overt clinical or historical evidence.
- |||||||||| NEISSERIA GONORRHOEAE PRESENTING AS ENDOCARDITIS AND SEPTIC SHOCK (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5282;
This case highlights the challenges of diagnosing and managing endocarditis caused by N gonorrhoeae. Endocarditis should be considered as a possible manifestation of gonococcal bacteremia and there should a high degree of clinical suspicion for endocarditis in a patient with no other identified source of infection.
- |||||||||| vancomycin / Generic mfg., doxycycline / Generic mfg., meropenem / Generic mfg.
FROM RASH TO RECOVERY: A TALE OF TRIUMPH OVER PURPURA FULMINANS SECONDARY TO SEPTIC SHOCK (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5236;
This case of PF with underlying E.coli septic shock exemplifies the pivotal role of timely diagnosis, interdisciplinary management approach, and aggressive targeted therapies necessary in such cases. It aims to spread awareness of the severity of PF and advocate for preparedness amongst clinicians to improve patient outcomes in similar cases.
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