doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  Nuvocid (oritavancin) / Melinta Therap, Cubicin (daptomycin) / Merck (MSD)
    Journal:  Eradication of Staphylococcus aureus Biofilm Infection by Persister Drug Combination. (Pubmed Central) -  Oct 29, 2022   
    Our study demonstrates an important treatment principle, the Yin-Yang model, for persistent infections by targeting both growing and non-growing heterogeneous bacterial populations, utilizing persister drugs for the more effective eradication of persistent and biofilm infections. Our findings have implications for the improved treatment of other persistent and biofilm infections in general.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Role of Scl39a13/ZIP13 in cardiovascular homeostasis. (Pubmed Central) -  Oct 28, 2022   
    We found that the expression level of Zip13 mRNA was diminished in both primary neonatal cardiomyocytes and mouse heart tissues treated with the cardiotoxic agent doxycycline...These results indicate the physiological importance of ZIP13-it maintains cardiovascular homeostasis by resolving inflammation and stress response. Our findings suggest that optimizing ZIP13 expression and/or function may improve cardiovascular disease management.
  • ||||||||||  doxycycline / Generic mfg.
    Variants of the transcription factor ONECUT2 regulate gene expression in Hodgkin Lymphoma cells (Great Hall) -  Oct 27, 2022 - Abstract #ISHL2022ISHL_56;    
    ONECUT2 acts as a transcription factors in HL-cells and both variants have different effects on gene expression. The high expression of both ONECUT2 variants in HL might qualify this transcription factor as a possible candidate for targeted therapy of HL.Our work is supported by Mitteldeutsche Kinderkrebsforschung
  • ||||||||||  Preclinical evaluation of novel repurposed drug combinations in Hodgkin lymphoma (Great Hall) -  Oct 27, 2022 - Abstract #ISHL2022ISHL_46;    
    On the contrary Eprosartan (Epro) Metformin (Met) Clofibrate (Clof) and Ornidazole (Orni) increased antibody dependent cellular phagocytosis (ADCP) in in-vitro assays.This project shows that combinations of repurposed non-oncological drugs at safe doses have a direct cytotoxic effect against HL and a potentially beneficial impact on key immune response mechanisms. Taken together our results justify further evaluation of combinations of these clinically known drugs with chemotherapy or checkpoint blockade in cases of HL without other treatment options.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Promotion effect on liver tumor progression of microcystin-LR at environmentally relevant levels in female krasV12 transgenic zebrafish. (Pubmed Central) -  Oct 26, 2022   
    In this study, the hepatocellular promoting effect of MC-LR was described in Kras transgenic zebrafish, a doxycycline (DOX) inducible HCC model...Furthermore, the mRNA expression and protein abundance of β-Catenin in Wnt signaling pathway were significantly up-regulated following exposure to MC-LR. In short, our results suggested that MC-LR significantly inhibited the activity of PP2A, which in turn activated Wnt signaling, eventually resulting in progression of liver tumor in transgenic zebrafish.
  • ||||||||||  doxycycline / Generic mfg.
    Doxycycline. (Twitter) -  Oct 26, 2022   
  • ||||||||||  Journal:  Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh. (Pubmed Central) -  Oct 25, 2022   
    Antibiotic usage was mainly advised by veterinary practitioners (45-71%, depending on production type), followed by feed dealers (21-40%) and farmers (7-13%). Improvement of chicken health through good farming practices along with changes in key stakeholders (feed dealers and practitioners) attitudes towards antibiotic recommendations to farmers, may help to reduce the levels of antibiotic usage and thus contribute to mitigate antimicrobial resistance.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  A quantitative metric of pioneer activity reveals that HNF4A has stronger in vivo pioneer activity than FOXA1. (Pubmed Central) -  Oct 25, 2022   
    Improvement of chicken health through good farming practices along with changes in key stakeholders (feed dealers and practitioners) attitudes towards antibiotic recommendations to farmers, may help to reduce the levels of antibiotic usage and thus contribute to mitigate antimicrobial resistance. Our results suggest that relative binding affinities are reasonable measures of pioneer activity and support the model wherein most TFs have some degree of context-dependent pioneer activity.
  • ||||||||||  doxycycline / Generic mfg.
    PRMT1-mediated arginine methylation of Neurogenin 3 is required for pancreatic endocrine development from hESCs (Poster Gallery) -  Oct 24, 2022 - Abstract #IDF2022IDF_899;    
    However, the role of methylation of NGN3 is poorly understood.MethodWe generated inducible PRMT1-knockout (P-iKO) human embryonic stem cells (hESCs) and differentiated them toward pancreatic ECs with doxycycline treatment...PRMT1 KO EPs failed EC development, especially in insulin and somatostatin expression, and showed NGN3 stabilization. Our findings demonstrate that arginine 65 methylation of NGN3 is a key molecular switch in hESCs in vitro, permitting the differentiation into pancreatic endocrine lineages.
  • ||||||||||  tamoxifen / Generic mfg., doxycycline / Generic mfg.
    THE ORCHESTRATION OF BH3-ONLY PROTEINS CONTROLS BAK/BAX DEPENDENT HEPATOCYTE APOPTOSIS () -  Oct 23, 2022 - Abstract #AASLD2022AASLD_2202;    
    On the other hand, serum ALT levels of the Bcl-xL(-/-) Mcl-1(+/-) Bak-/- Bax(-/-) (15±4 IU/L) mice were significantly lower than those of Bcl-xL(-/-) Mcl-1(+/-) Bim-/- Bid-/- Puma-/- mice, and serum ALT level of Bim-/- Bid-/- Puma-/- Bcl-xL flox/flox Mcl-1flox/flox tamoxifen-inducible Albumin Cre mice elevated after tamoxifen injection(3920±2593 IU/L)...In Vitro study, we immortalized Bim-/- Bid-/- Puma-/- Bcl-xL flox/flox Mcl-1flox/flox mouse primary hepatocyte and doxycycline-dependent Cre recombinase was expressed by Lentivirus vector... Bim, Bid, Puma, and Noxa participates in Bak/Bax dependent hepatocyte apoptosis.
  • ||||||||||  Lynparza (olaparib) / Merck (MSD), AstraZeneca
    OLAPARIB ENHANCES THE ANTI-VIRAL EFFECT OF CRISPR/Cas9 THERAPY TARGETING HBV GENOME VIA NHEJ-MEDIATED DNA REPAIR MACHINERY () -  Oct 23, 2022 - Abstract #AASLD2022AASLD_662;    
    Four days after HBV infection, Cas9 expression was induced by doxycycline (DOX) administration...Treatment of entecavir, interferon α, Bay41-4109 (Capsid Assembly Modulator) did not alter the efficacy of CRISPR/Cas9 treatment in HepG2-hNTCP-iCas9 cells... Inhibition of NHEJ-mediated DNA repair machinery with olaparib enhances the efficacy of CRISPR/Cas9 treatment targeting HBV genome.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo. (Pubmed Central) -  Oct 22, 2022   
    HEK293 cells expressing tau P301L under a tetracycline-inducible system (HEK T-Rex) were employed to produce different tau assemblies whose proteotoxic potential was evaluated using C. elegans...We investigated the applicability of this approach for testing compounds acting against oligomeric tau toxicity, using doxycycline (Doxy) as a prototype drug...These effects translated into a dose-dependent protective action in C. elegans. These findings confirm the validity of the combined HEK T-Rex cells and the C. elegans-based approach as a platform for pharmacological screening.
  • ||||||||||  vancomycin / Generic mfg., doxycycline / Generic mfg.
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  Evaluating the Use of ProKera Plus® in the Management of Bacterial Corneal Ulcers (clinicaltrials.gov) -  Oct 21, 2022   
    P=N/A,  N=3, Active, not recruiting, 
    These findings confirm the validity of the combined HEK T-Rex cells and the C. elegans-based approach as a platform for pharmacological screening. Recruiting --> Active, not recruiting | N=24 --> 3 | Trial completion date: Nov 2023 --> Nov 2022 | Trial primary completion date: Nov 2023 --> Nov 2022
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  A Machine Learning Framework for Predicting Entrapment Efficiency in Niosomal Particles. (Pubmed Central) -  Oct 21, 2022   
    The veracity of this test was evaluated by entrapment efficiency results of 7 niosomal formulations containing doxycycline hyclate prepared in the laboratory...The hydrophilic-lipophilic balance (HLB) was identified as the most influential parameter, and the entrapment efficiency change curve was plotted versus the HLB value. This study uses machine learning methods to synthesize niosomal systems with optimal entrapment efficiency at a lower cost and time.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans. (Pubmed Central) -  Oct 21, 2022   
    In this paper, using a doxycycline-mediated HSP90 strain and an HSP90-overexpressing strain of C. albicans, we demonstrated that the curcumin triggered a decrease in Hsp90 by affecting it at the post-transcriptional level...We also found that curcumin can not only decrease the transcriptional expression of CDR1, but also inhibit the efflux pump activity of Cdr1. Hence, we conclude that disruption of HSP90 by curcumin could impair cell growth, stress responses and efflux pump activity of C. albicans.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  The "steric-like" inhibitory effect and mechanism of doxycycline on florfenicol metabolism: Interaction risk. (Pubmed Central) -  Oct 20, 2022   
    The findings of this study showed that DOX inhibits FF metabolism in two ways. Firstly, DOX significantly inhibits the expression of CYP3A29, leading to the slower metabolism of FF; secondly, DOX affects the binding of FF to R106 and R372 by competing for the R372 and/or by a "steric-like effect", thus slowing down FF metabolism, which may increase the residual concentration of FF in edible tissues of food producing animals.
  • ||||||||||  Review, Journal:  State of the Science in Tracheal Stents: A Scoping Review. (Pubmed Central) -  Oct 19, 2022   
    Though most studies are still preclinical, awareness of tracheal stent developments is important in contextualizing novel stent concepts and clinical trials. Laryngoscope, 132:2111-2123, 2022.
  • ||||||||||  dapsone / Generic mfg.
    Review, Journal:  Topical dapsone in the treatment of acne: a systematic review. (Pubmed Central) -  Oct 19, 2022   
    Laryngoscope, 132:2111-2123, 2022. Dapsone gel offers a safe and promising alternative therapy for patients with difficult to treat acne or those who experience adverse effects to first-line therapies.