doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Identification of NRAS Downstream Genes with CRISPR Activation Screening. (Pubmed Central) -  Nov 16, 2022   
    We previously established that NRAS expression and proliferative activity can be controlled with doxycycline and named as THP-1 B11...The knockdown of DOHH, HIST1H2AC, and TAF6 was found to reduce proliferation in THP-1 cells, indicating that they are involved in the downstream proliferation of NRAS. These molecules are expected to be new therapeutic targets for NRAS-mutant leukemia cells.
  • ||||||||||  doxycycline / Generic mfg., irinotecan / Generic mfg.
    The role of SMARCAL1 as a synthetic lethal vulnerability in ATRX-deficient gliomas (West/Central Hall) -  Nov 16, 2022 - Abstract #SNO2022SNO_1598;    
    Based on these data, we hypothesize that SMARCAL1 activity is critical for resolving ALT-associated replication stress in ATRX-deficient malignant gliomas. We therefore propose that SMARCAL1 functions as a synthetic lethal vulnerability in ATRX-deficient ALT-positive gliomas and that SMARCAL1 inhibition is a viable therapeutic strategy in these tumors.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Ydj1 interaction at nucleotide-binding-domain of yeast Ssa1 impacts Hsp90 collaboration and client maturation. (Pubmed Central) -  Nov 16, 2022   
    Further proteomic analysis showed that pathways involved in signaling, signal transduction, and protein phosphorylation are markedly downregulated in the A1-T175N upon repressing Sti1 expression using doxycycline regulatable promoter...Overall, our data suggest that Ydj1 competes with Hsp90 for binding to Hsp70, and thus regulates Hsp90 interaction with the nucleotide-binding domain of Hsp70. The study thus provides new insight into the Hsp70-mediated regulation of Hsp90 and broadens our understanding of the intricate complexities of the Hsp70-Hsp90 network.
  • ||||||||||  ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
    Journal:  Hyperammonaemia syndrome in disseminated Ureaplasma parvum infection. (Pubmed Central) -  Nov 16, 2022   
    This occurred in the context of immunosuppression for chronic graft versus host disease and six years following an allogeneic stem cell transplant for diffuse large B-cell lymphoma. Following treatment of U. parvum septic arthritis with ciprofloxacin and doxycycline, the patient experienced a full neurological recovery, and continues on suppressive doxycycline therapy with no recurrence of symptoms to date.
  • ||||||||||  prednisolone / Generic mfg., doxycycline / Generic mfg., cyclosporine / Generic mfg.
    Journal:  Negative-pressure wound therapy as an adjunct to treating pyoderma gangrenosum. (Pubmed Central) -  Nov 15, 2022   
    After multidisciplinary discussion, involving breast surgeons, oncology, dermatology and tissue viability, doxycycline was commenced alongside a portable negative-pressure device with twice weekly tissue viability input. The introduction of this device resulted in a rapid reduction in the wound size and facilitated healing with an excellent outcome.
  • ||||||||||  doxycycline / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Dynamics of subclinical pneumonia in male dairy calves in relation to antimicrobial therapy and production outcomes. (Pubmed Central) -  Nov 15, 2022   
    Initial therapy with tulathromycin and subsequently doxycycline appeared ineffective, resulting in a increase to 43.8% of calves having pneumonia in wk 4...At wk 4, the outbreak became more clinical, and treatment with amoxicillin resulted in a cure risk of 52.7%...This study documents the consequences of subclinical pneumonia upon arrival and pneumonia developed later in the production cycle on production outcomes in a veal calf setting. Both qTUS and nBAL diagnostics provide important information, offering potential for better control and prevention of bovine respiratory disease in dairy calves.
  • ||||||||||  ciprofloxacin oral / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Noncontiguous multifocal Brucella spondylodiscitis with paravertebral abscess: a case report. (Pubmed Central) -  Nov 12, 2022   
    Nonetheless, the principal challenge to an efficient management is establishing the diagnosis of Brucella in the first place. In endemic countries, a strong suspicion of spinal involvement of brucellosis should be elicited in front of back pain presentations-even in the absence of fever and other related symptoms.
  • ||||||||||  Mycoplasma Pneumoniae-associated Vasoplegic Shock and Perimyocarditis in an Adolescent (Anaheim Convention Center, Hall A, Board # 082) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2238;    
    Cardiovascular complications caused by MP are uncommon, and although MP-induced perimyocarditis is known, presentation with vasoplegic shock may pose challenges to management. Aggressive treatment with appropriate vasoactive and inotropic medications, judicious use of IVIG and/or corticosteroid, along with appropriate antibiotic use while keeping MRMP in mind, are key to improved outcome of this potentially life-threatening condition.
  • ||||||||||  Tubo-ovarian Abscess in a Non-sexually Active Adolescent Female: an Uncommon Diagnosis (Anaheim Convention Center, Hall A, Board # 186) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2156;    
    This case highlights that early recognition is key to diagnosis and appropriate management of TOA in a non-sexually active adolescent female. A multi-disciplinary approach is critical to optimize therapeutic options including antibiotics, surgery, and IR drainage.
  • ||||||||||  Associations Between Antibiotic Subtype and Childhood Disease (Anaheim Marriott, Marquis Ballroom Center, Board # 048) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2046;    
    Additionally, there was no significant association between the use of antibiotics and the development of eczema. As the prevalence of atopic and allergic diseases continues to increase, it is important to understand how different antibiotic subtypes influence gut dysbiosis and to update pediatric best practices regarding antibiotic use accordingly.
  • ||||||||||  doxycycline / Generic mfg.
    Tularemia During Pregnancy and the Neonatal Period: A Systematic Literature Review (Anaheim Convention Center, Hall A, Board # 123) -  Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_1999;    
    However, further research is needed to establish whether these outcomes were attributable to the infection. Possible evidence of F. tularensis in placental and fetal tissues might suggest that tularemia is transmissible from mother to fetus.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes. (Pubmed Central) -  Nov 10, 2022   
    Here, the disruptive effects of four commonly used antibiotics, namely doxycycline (DC), enrofloxacin (ENR), florfenicol (FF) and sulfamethazine (SMT) on lipid metabolism were investigated in zebrafish (Danio rerio) larvae and murine preadipocyte cell line...Reporter gene assays showed that only SMT inhibited the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ). The above experimental results and clustering analysis demonstrate that the four antibiotics exerted disruption on lipid metabolism through different mechanisms, and one of the mechanisms for SMT may be inhibition of PPARγ transcriptional activity.
  • ||||||||||  mebendazole / Generic mfg., doxycycline / Generic mfg.
    Journal:  A large case series of travel-related Mansonella perstans (vector-borne filarial nematode): a TropNet study in Europe. (Pubmed Central) -  Nov 9, 2022   
    Lack of specific symptoms, together with the inconstant positivity of parasitological and antibody-based assays in the infected population, makes the clinical suspicion and screening for mansonellosis particularly difficult. Prospective studies evaluating prevalence of infection in migrants from endemic areas, infection-specific morbidity, presence of Wolbachia endosymbionts in M. perstans populations from different geographical areas and efficacy of treatment regimens are absolutely needed to optimize the clinical management of infection.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Gastrointestinal tract and neuroendocrine system responses of young turkeys to the early administration of antibiotics or feeding a diet containing a coccidiostat. (Pubmed Central) -  Nov 9, 2022   
    Group ENR was treated with enrofloxacin for the first 5 d of life, group DOX received doxycycline for 5 d and group MON was administered monensin for 84 d. CON birds served as a control group without any antibiotic treatment or MON administration...Early DOX use increased plasma cortisol concentrations (P < 0.001) and decreased plasma serotonin levels (P = 0.006) in 56-day-old turkeys. Over the entire experiment (up to 12 wk of age), the use of MON improved the BW gain of turkeys (P = 0.055) and feed conversion (P = 0.016), compared with the DOX treatment.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Opinion among veterinarians on equine Lyme disease - results of a questionnaire study (Pubmed Central) -  Nov 9, 2022   
    The opinion on the clinical relevance of Equine Lyme Borreliosis among german equine veterinarians vary considerably. Uniform diagnostic guidelines and, possibly, recommendations for therapy would serve to counteract the existing uncertainty concerning this disease within the equine veterinary community.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Genetically Inducing Renal Lymphangiogenesis Attenuates Hypertension in Mice. (Pubmed Central) -  Nov 9, 2022   
    Uniform diagnostic guidelines and, possibly, recommendations for therapy would serve to counteract the existing uncertainty concerning this disease within the equine veterinary community. These findings demonstrate that augmenting renal lymphangiogenesis can treat HTN in male and female mice by improving renal immune cell trafficking and sodium handling.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Ehrlichiosis and Anaplasmosis: An Update. (Pubmed Central) -  Nov 8, 2022   
    Protection through vaccines for ehrlichiosis or anaplasmosis remains elusive. This review provides practicing veterinarians with the most current information about the transmission, diagnosis, and management of ehrlichiosis and anaplasmosis in dogs and cats.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Emerging Spotted Fever Rickettsioses in the United States. (Pubmed Central) -  Nov 8, 2022   
    Therefore, therapy with doxycycline must be initiated and continued based on the clinician's index of suspicion...Veterinarians should keep in mind that novel and well characterized species of SFG Rickettsia are important causes of emerging infectious disease. Veterinarians can play an important role in detecting, defining, and preventing illness in their canine patients and their human companions.
  • ||||||||||  doxycycline / Generic mfg.
    Review, Journal:  Hemotropic Mycoplasma. (Pubmed Central) -  Nov 8, 2022   
    Prompt treatment of clinical disease with supportive care and at least 2 weeks of doxycycline is usually successful. Transmission pathways have not been confirmed, but indirect, via vectors, and direct via bites/fights/predation are likely.
  • ||||||||||  Journal:  Antibiotic consumption in the public sector of the Limpopo province, South Africa, 2014-2018. (Pubmed Central) -  Nov 8, 2022   
    While ABC remained relatively stable throughout the study, there was an increase in broad-spectrum ABC that requires further investigation. This study contributes ABC surveillance data in Southern Africa, described by ATC classification, which is essential for monitoring and evaluating antibiotic stewardship programmes.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Doxycycline for the treatment of breast cancer-related lymphedema. (Pubmed Central) -  Nov 8, 2022   
    However, our patients reported improvements in quality-of-life measures using a validated lymphedema patient-reported outcome instrument. Our results suggest that doxycycline may be of use in patients with breast cancer-related lymphedema; however, larger and more rigorous studies are needed.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Depression-related phenotypes at early stages of Aβ and tau accumulation in inducible Alzheimer's disease mouse model: task-oriented and concept-driven interpretations. (Pubmed Central) -  Nov 8, 2022   
    Conditional doxycycline-dependent transgenic mouse models reproducing amyloidosis (TetOffAPPsi) and/or tau (TetOffTauP301L) pathology starting at middle age (6 months) were used in this study...In addition, factor loadings varied between genotypes, indicating that genotype-specific between-task correlations need to be considered for interpretations of findings in any single task. In general, this study demonstrates that utilization of multiple tasks to characterize behavioral phenotypes, an approach that is finally gaining more widespread adoption, requires a step of data integration across different behavioral tests for appropriate interpretations.