- |||||||||| glumetinib (SCC244) / HaiHe Biopharma
Preclinical, Journal: Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice. (Pubmed Central) - Feb 27, 2023 The cells were cultured with pro-HGF, and inhibitory effect of MET inhibitor (SCC244) and HAI-2 was evaluated by phosphorylation of MET and cell proliferation...Although in vivo analysis also showed apparent downregulation of MET phosphorylation and growth inhibition in combined treatment, statistical significance was not observed compared with single use of MET inhibitor. Combined treatment with MET-TKI and HAI-2 suggested to consider as a candidate for new strong therapy for RCC.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: Using a gradient boosted model for case ascertainment from free-text veterinary records. (Pubmed Central) - Feb 27, 2023 Predictors that exerted the highest influence on the model included frequencies of "doxycycline", "flu", "sneezing", "doxybrom" and "ocular"...Case ascertainment is a crucial step for further epidemiological study of cat flu. Ultimately, this tool can be extended to other clinical procedures, conditions, and diseases such as intensive care treatment due to snake bites and tick paralysis, physical injuries such as orthopaedic fractures or chest injuries and labour-intensive infectious diseases like parvovirus, canine cough, and ringworm, all of which require prolonged quarantine and care.
- |||||||||| doxycycline / Generic mfg.
Journal: Formulation Development of Doxycycline-loaded Lipid Nanocarriers Using Microfluidics by QbD Approach. (Pubmed Central) - Feb 27, 2023 Compared to Doxy solution, this LN-Doxy has reduced in vitro cellular toxicity and significant therapeutic efficacy which was verified in a peritonitis animal model. These results show the feasibility of using microfluidic technology combined with QbD approach to develop the LN formulation with high loading efficiency for ionizable hydrophilic drugs.
- |||||||||| doxycycline / Generic mfg.
Journal: Nuclear envelope protein LBR protects the genome from chromosomal instability and tumorigenesis. (Pubmed Central) - Feb 27, 2023 Furthermore, doxycycline-induced conditional depletion of LBR significantly increased tumor volumes that form within the subcutaneous xenografts of mice...Interestingly, qPCR array-based gene expression profiling showed a significant upregulation of TRF1 upon LBR depletion. Remarkably, TRF1 knockdown in the background of LBR depletion maintains chromosomal stability, unraveling a novel mechanism involving LBR and TRF in the maintenance of chromosomal stability in colorectal cancer cells.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline to treat community-acquired pneumonia. (Pubmed Central) - Feb 27, 2023 Empirical treatment with doxycycline should be considered in returning travellers with undifferentiated fever and negative tests for malaria and dengue, particularly when presenting severe illness, predictive factors for rickettsiosis or no features of dengue. No abstract available
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Comparative study of doxycycline, sancycline, and 4-dedimethylamino sancycline (CMT-3) on epidermal melanogenesis. (Pubmed Central) - Feb 27, 2023 Our results demonstrate a unique structure-activity relationship (SAR) for the effects of these compounds on melanogenesis and support the conclusion that removal of the 4-dimethylamino moiety confers the selective capacity to suppress melanosome export. Collectively, these results indicate that CMT-3 might be a candidate for diminishing hyperpigmentation skin disorders.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis. (Pubmed Central) - Feb 25, 2023 The formulation F1, consisting of HPMC K4 combined with C940 in a ratio of 5:3, the most performing in vitro, was tested in vivo in experimentally-induced periodontitis and demonstrated its effectiveness in improving the clinical parameters and reducing the salivary levels of matrix metalloproteinase-8 (MMP-8). The prepared Doxy Hyc loaded mucoadhesive buccal film could be used as an adjuvant for the local treatment of periodontitis, ensuring prolonged release of the antibiotic after topical application.
- |||||||||| metronidazole oral / Generic mfg., doxycycline / Generic mfg.
Journal, Machine learning: Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques. (Pubmed Central) - Feb 25, 2023 Aucubin, Plantamajoside, Herbacetin, secoisolariciresinol diglucoside, Secoisolariciresinol Monoglucoside, and other various natural bioactive molecules of psyllium and linseeds have beneficial effects as they possess anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory properties. The anticipated research work is be a better alternative treatment for genital infections.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: ?ffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis (clinicaltrials.gov) - Feb 24, 2023 P2, N=90, Recruiting, Our work provides a better understanding of the potential mechanism of resistance to selinexor and a rationale for combining selinexor with eIF4E inhibitors for the treatment of MM. Trial completion date: Jan 2023 --> Apr 2024 | Trial primary completion date: Nov 2022 --> Jan 2024
- |||||||||| Xenleta (lefamulin oral) / Nabriva Therap, Sumitomo Pharma
Trial suspension: Lefamulin for M. Genitalium Treatment Failures (clinicaltrials.gov) - Feb 14, 2023 P1/2, N=40, Suspended, This inducible gene expression system using MAC remains useful for providing critical insights into appearance of TDP-43 pathology. Recruiting --> Suspended
- |||||||||| doxycycline / Generic mfg.
Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date: Investigation of Laser Assisted Drug Delivery of NanoDOX (clinicaltrials.gov) - Feb 14, 2023 P2, N=12, Recruiting, Recruiting --> Suspended Not yet recruiting --> Recruiting | Trial completion date: Jan 2023 --> Jan 2024 | Initiation date: Oct 2022 --> Apr 2023 | Trial primary completion date: Nov 2022 --> Nov 2023
- |||||||||| doxycycline / Generic mfg.
Quantitative investigation into potential counterfeit doxycycline (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_12263; Bromoethane-D5 and methanol were also identified at much lower spectrum match percentages. The FTIR methodology along with the HPLC analysis provide an in-depth examination and evaluation of a given doxycycline sample, which will help analyze and identify counterfeit and potentially harmful pharmaceuticals.
- |||||||||| Journal: Prevalence and contamination patterns of Listeria monocytogenes in Pleurotus eryngii (king oyster mushroom) production plants. (Pubmed Central) - Feb 13, 2023
The drug with the highest resistance is rifampicin (37.9%), followed by penicillin (24.1%) and ciprofloxacin (10.3%)...In accordance with these results, the control of L. monocytogenes should focus on the environmental materials, especially in the mycelium stimulation stage. However, effective Listeria monitoring programs will allow for the improved development of Listeria control measures to minimize cross-contamination in the processing of P. eryngii.
- |||||||||| clarithromycin / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Digestate from Agricultural Biogas Plants as a Reservoir of Antimicrobials and Antibiotic Resistance Genes-Implications for the Environment. (Pubmed Central) - Feb 12, 2023 The abundance of ARGs encoding resistance to beta-lactams, tetracyclines, sulfonamides, fluoroquinolones, macrolide-lincosamide-streptogramin antibiotics, and the integrase genes were determined in the analyzed samples...Their concentrations differed in digestates obtained from different substrates and in liquid and solid fractions (ranging from 62.8 ng/g clarithromycin in the solid fraction of sewage sludge digestate to 1555.9 ng/L doxycycline in the liquid fraction of cattle manure digestate)...In addition, high concentrations of integrase genes (10 to 10 copies/g) in the samples indicate that mobile genetic elements may be involved in the spread of antibiotic resistance. The study suggested that the risk of soil contamination with antibiotics, HMs, and ARGs is high in farms where digestate is used as fertilizer.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Tet-Regulated Expression and Optical Clearing for In Vivo Visualization of Genetically Encoded Chimeric dCas9/Fluorescent Protein Probes. (Pubmed Central) - Feb 12, 2023 We investigated doxycycline (Dox)-inducible (Tet-On) intracellular distribution of constructs encoding dCas9 orthologs from St...In vivo Dox-induction of mCherry-chimera expression occurred in tumor xenografts as early as 24 h post-induction and was visualized by using optical clearing (OC) of the skin. OC via topical application of gadobutrol enabled high-contrast imaging of FP expression in tumor xenografts due to a 1.1-1.2-fold increase in FI in both the red and green channels.
- |||||||||| doxycycline / Generic mfg.
Journal: Pathogenic tau decreases nuclear tension in cultured neurons. (Pubmed Central) - Feb 10, 2023 We first find that tau-dependent nuclear envelope invagination and relocalization of LInker of Nucleoskeleton and Cytoskeleton (LINC) complex components are conserved in a newly-developed neuroblastoma cell line that features doxycycline-inducible expression of a tau mutant associated with autosomal dominant frontotemporal dementia...Using this nuclear tension sensor, we find that induced expression of pathogenic tau is sufficient to decrease nuclear tension. This work provides the initial proof-of-concept evidence that pathogenic forms of tau alter nuclear tension, paving the way for the future study of altered nuclear mechanosensing in the context of tau-mediated neurodegenerative disorders.
- |||||||||| Epsolay (microencapsulated benzoyl peroxide cream 5%) - Sol / Gel
Journal: Epsolay - a benzoyl peroxide cream for rosacea. (Pubmed Central) - Feb 9, 2023 This work provides the initial proof-of-concept evidence that pathogenic forms of tau alter nuclear tension, paving the way for the future study of altered nuclear mechanosensing in the context of tau-mediated neurodegenerative disorders. No abstract available
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Doxycycline for Elbow Tendinopathy (clinicaltrials.gov) - Feb 8, 2023 P1, N=25, Active, not recruiting, No abstract available Trial completion date: Jan 2023 --> Nov 2023 | Trial primary completion date: Jan 2023 --> Nov 2023
- |||||||||| doxycycline / Generic mfg.
Mir-34a Modulates Outcomes After Experimental Stroke In Mice (Hall F, Poster Hall; P211) - Feb 7, 2023 - Abstract #ISC2023ISC_941; Transient middle cerebral artery occlusion (tMCAO) was performed on 6-month old doxycycline-induced miR-34aTG mice compared to wild-type (WT) controls...Our post-stroke behavioral study revealed that antagomir-34a significantly improved functional outcomes including motor function assessed by accelerated rotarod tests at 2 weeks post-stroke (p = 0.0046) and memory deficits assessed by Morris Water Maze tests at 4 weeks post-stroke (p = 0.0012). These data demonstrate that miR-34a plays an important role in modulating acute stroke outcomes and suggest that miR-34a may be a promising therapeutic target for stroke therapy.
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