- |||||||||| doxycycline / Generic mfg.
Preclinical, Review, Journal: Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies. (Pubmed Central) - Aug 12, 2024
However, although promising, the use of this substance requires standardization in application methods and adopted concentrations, allowing for more direct comparisons between studies. Furthermore, long-term studies are interesting to conduct, ensuring biocompatibility and complete understanding of long-term effects on dental materials.
- |||||||||| tetracycline / Generic mfg.
Journal: Enhancing outer membrane permeability of tetracycline antibiotics in P. aeruginosa using TOB-CIP conjugates. (Pubmed Central) - Aug 12, 2024
The structure-activity relationship investigation indicates that the flexible hydrophobic C12 carbon-chain linker in TOB-CIP conjugate 1a is an optimal potentiator of tetracyclines against tetracycline-resistant and -susceptible strains of P. aeruginosa. Furthermore, conjugate 1a consistently synergized with the 3rd generation tetracycline, eravacycline, in P. aeruginosa PAO1 in the presence of up to 25% fetal bovine serum (FBS).
- |||||||||| doxycycline / Generic mfg.
Journal: A Splenic Infarct in Scrub Typhus: A Rare Entity. (Pubmed Central) - Aug 12, 2024
The case of a 68-year-old male with fever and abdominal discomfort, ultimately diagnosed with both scrub typhus and splenic infarct, illustrates the importance of recognizing splenic infarction as a potential complication of scrub typhus, particularly in areas where the disease is prevalent. The patient was promptly diagnosed and managed with a favorable outcome.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Japanese spotted fever in an area endemic to SFTS virus: Case report and review of the literature. (Pubmed Central) - Aug 9, 2024
In all areas where tick-borne diseases are endemic, include SFTS-epidemic areas, we recommend using the Weil-Felix test to screen for potential rickettsiosis in patients presenting with fever and thrombocytopenia with or without rash in primary healthcare settings, as well as simultaneous testing for the SFTS virus and spotted fever group rickettsioses sequence. Additionally, mNGS sequencing should be used to confirm the diagnosis and provide information for epidemiological investigations in patients who are suspected of having spotted fever group rickettsiosis.
- |||||||||| doxycycline / Generic mfg., spironolactone / Generic mfg.
Trial primary completion date, HEOR: Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne (clinicaltrials.gov) - Aug 9, 2024
P4, N=400, Recruiting,
Additionally, mNGS sequencing should be used to confirm the diagnosis and provide information for epidemiological investigations in patients who are suspected of having spotted fever group rickettsiosis. Trial primary completion date: Jul 2025 --> Dec 2025
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Primaxin (cilastatin/imipenem) / Abbott
Journal, Nontuberculous mycobacteria: Screening, epidemic trends and drug sensitivity analysis of nontuberculous mycobacteria in a local area of China. (Pubmed Central) - Aug 8, 2024
NTM strains are highly sensitive to amikacin, clarithromycin, rifabutin, moxifloxacin, and rifampicin. These findings can guide diagnosis, treatment strategies, and drug selection for NTM disease in Anhui Province.
- |||||||||| hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
Journal: Infective Endocarditis Due to Q Fever From a Tick Bite: A Case Report. (Pubmed Central) - Aug 8, 2024
Fevers resolved with doxycycline and hydroxychloroquine. Our case highlights that suspicion for Q fever should be maintained in patients presenting to the hospital with fevers of unknown origin for prompt recognition and appropriate treatment.
- |||||||||| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Double blaKPC-2 copies quadrupled minimum inhibitory concentration of ceftazidime-avibactam in hospital-derived Klebsiella pneumoniae. (Pubmed Central) - Aug 8, 2024
Our case highlights that suspicion for Q fever should be maintained in patients presenting to the hospital with fevers of unknown origin for prompt recognition and appropriate treatment. The Kpn_XM9 was resistant to amikacin, aztreonam, ticarcillin/clavulanic acid, piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, tobramycin, ciprofloxacin, levofloxacin, doxycycline, minocycline, tigecycline, colistin, and trimethoprim/sulfamethoxazole; it was barely susceptible to CZA with a minimum inhibitory concentration of 8/4
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: A Mouse Model for Conditional Expression of Activated ?-Catenin in Epidermal Keratinocytes. (Pubmed Central) - Aug 7, 2024
Following short-term doxycycline intake during the telogen resting phase, the adult K5: CAT bigenic develops enlarged pilosebaceous units that expand deep into the dermis, an expansion usually observed during the anagen growth phase...Joining a small group of mouse models for conditional ?-catenin signaling, our K5: CAT mouse model will be particularly useful in identifying those molecular mediators of ?-catenin that are responsible for initiating and maintaining these phenotypic responses in the K5: CAT skin. Such studies are predicted to shed more light on ?-catenin signaling in epidermal epithelial morphogenesis, hair follicle cycling, and hair growth pathologies.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: A novel microfluidic tool for the evaluation of local drug delivery systems in simulated in vivo conditions. (Pubmed Central) - Aug 6, 2024
Chitosan scaffolds loaded with different concentrations of doxycycline were used for evaluating our device...Specifically, in the case of continuous flow, the quantity of the released drug is much higher due to the higher driving force for diffusion (concentration gradient). Overall, the proposed microfluidic tool proved to be ideal for evaluating LDD systems, as the in vivo microenvironment can be replicated in a better way than with currently used standard systems.
- |||||||||| Fraxiparine (nadroparin) / Aspen Pharma, Nuzyra (omadacycline) / Paratek
Journal: Severe community-acquired pneumonia caused by Chlamydia abortus in China: a case report. (Pubmed Central) - Aug 6, 2024
In the local hospital, she was initially diagnosed with community-acquired pneumonia and treated with piperacillin-tazobactam for 4 days...There, her condition continued to worsen despite continued treatment with the high-flow nasal cannula and omadacycline...The doctors in the ICU again adjusted the treatment, this time to meropenem along with mechanical ventilation; they also instituted methylprednisolone, ulinastatin, nadroparin calcium, and human immunoglobulin...Subsequent mNGS suggested the presence of C. abortus, sequence number 5072; we therefore discontinued the meropenem and implemented a combination of doxycycline and moxifloxacin...mNGS is uniquely suited for the early detection of this unusual infection. The combination of doxycycline and quinolones has been shown to be effective in severe pneumonia caused by C. abortus.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
Atypicals cases of mediterranean spotted fever in morocco (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5211;
Systemic manifestations: neurological, digestive and cutaneous vasculitis are atypical and can be life threatening. Hence the importance of a good knowledge of dermatological semiology that allows an early diagnosis in order to institute an effective treatment.
- |||||||||| Finding the culprit: rosacea mimickers in the context of corticosteroid-induced rebound (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5131;
The particularity of the case is the difficult differential diagnosis of the initial rash. As periorificial dermatitis is a well known mimicker of rosacea, with similar treatment regimen, is difficult to establish the original rash, mainly in the context of topical corticoid long term use, which can produce for both rebounds, and also corticosteroid-induced rosacea-like dermatitis.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg., minocycline / Generic mfg.
A meta-analysis of effectiveness on antibiotic prophylaxis for sexually transmitted infections in people with high-risk sexual behaviors (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5096;
This study summarized preliminarily the evidence that antibiotic prophylaxis for bacterial STIs in people with high-risk sexual behaviors was effective and acceptable. Pre-exposure prophylaxis using azithromycin could lower the incidence rates of both gonorrhea and chlamydial infection; post-exposure prophylaxis using doxycycline could reduce the incidence rates of gonorrhea, chlamydial infection, and syphilis.
- |||||||||| A Frequently Underestimated Condition: Case Report of Alopecia Secondary to Syphilis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5086;
The patient displayed not only clinical signs of syphilis but also complex dermatological conditions exacerbated by the bacterial infection. This case underscores the need for careful evaluation and ongoing monitoring, emphasizing the importance of comprehensive differential diagnosis and a personalized treatment approach.
- |||||||||| fexofenadine / Generic mfg., pregabalin / Generic mfg., doxycycline / Generic mfg.
Paraneoplastic pruritus in lymphoid malignancies (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4731;
It is essential to evaluate such patients thoroughly. Clinical findings like fever, weight loss and lymphadenopathy are important clues to detect a lymphoproliferative neoplasm.
- |||||||||| hydroxychloroquine / Generic mfg., tacrolimus topical / Generic mfg., doxycycline / Generic mfg.
Tattoo complications in Finland: A series of 70 patients (2016-2024) (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4634;
We observe an increase in cases of granulomas within black tattoos, while cases of allergy to red shades remains stable. This could be a fortuitous finding resulting from a bias of recruitment.
- |||||||||| hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
Granulomatous cheilitis of Miescher: a rare entity (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4465;
The etiology of GC is still unknown. Several postulated factors include, Genetic Chromosome 9p11, Immunologic factors
- |||||||||| dapsone / Generic mfg.
Resolution of prurigo pigmentosa on dapsone (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4438;
Dapsone represents an alternative therapy in patients with allergy to tetracyclines and it is as effective as tetracyclines in inducing a clinical remission. In addition, modifying patients
- |||||||||| doxycycline / Generic mfg.
Melkersson-Rosenthal syndrome improvement with intralesional corticosteroids and doxycycline (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4401;
MRS is a rare neuro-mucocutaneous disorder that presents as orofacial swelling, facial palsy, and fissured tongue and can be oligosymptomatic or monosymptomatic. It has been postulated to be associated with genetic, allergic, infectious, and immunologic factors, but none have been proven.
- |||||||||| doxycycline / Generic mfg., isotretinoin / Generic mfg.
Weight reduction melts off long standing confluent and reticulated papillomatosis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4343;
The relationship between weight loss and subsequent clearance of the disease highlights the possible association between obesity and the underlying pathogenesis of CRP. Further studies and observations are recommended in future.
- |||||||||| doxycycline / Generic mfg.
A Rare Case of Prurigo Pigmentosa in North Afric (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4281;
It is characterized by progression in three phases: an initial phase with the appearance of urticarial plaques, followed by the formation of vesicular and papular lesions, and then a late phase with pigmented macules arranged linearly. Treatment mainly relies on cyclines.
- |||||||||| tofacitinib / Generic mfg.
Recalcitrant and widespread granuloma annulare successfully managed with tofacitinib (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4239;
Over the initial treatment period of four years, the interventions listed below offered little or no benefit: doxycycline, PUVA, doxepin, topical corticosteroids, hydroxychloroquine, tacrolimus 0.1% ointment, acitretin, mepacrine, ciclosporin, dapsone, pentoxifylline, hydroxycarbamide, fumaric acid esters, methotrexate, potassium iodide, rituximab, isotretinoin and mycophenolate mofetil. Upon treatment with infliximab, she showed promising improvement in her GA...This resulted in major impact on patient
- |||||||||| metronidazole topical / Generic mfg., doxycycline / Generic mfg.
Cortico-induced fulminant rosacea: learning the lesson again ! (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4229;
Most patients with fulminant rosacea have no previous history of papules or pustules. In our patient, papulo-pustular lesions were treated as rosacea, and the application of dermocorticoids was incriminated in the aggravation towards a fulminant form.
- |||||||||| Coexistence of follicular lichen planus with nail involvement and erosive oral lichen planus (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4198;
Our patient debuted with an initial form of follicular lichen planus with nail involvement, later adding oral mucosa lesions which pathological anatomy was consistent with erosive oral lichen planus. We highlight the importance of clinical suspicion and the value of pathological anatomy to confirm the entity, in order to install treatment as early as possible.
- |||||||||| doxycycline / Generic mfg., ivermectin topical / Generic mfg., isotretinoin / Generic mfg.
Granulomatous rosacea - from the clinical picture to therapy (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4165;
All patients develop retinoic dermatitis, which does not require drug withdrawal or dose adjustment and is managed by the administration of emollients. Undesirable events requiring dose adjustment - dyslipidemia and conjunctivitis - are formed in a small number of patients and do not require drug withdrawal.
- |||||||||| Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen
atypically afebrile gomm-button disease provoked by bbv152 (covaxin) sars-cov-2 vaccination. (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4115;
Patient was treated with Oral Corticosteroids , colchicine and doxycycline. It emphasizes the need for sharing the knowledge and experience on the subject of Gomm-Button disease, its variable and atypical clinical manifestations and the possible provoking factors and underlying causes to facilitate prompt daignosis and introduction of appropiate treatment.
- |||||||||| doxycycline / Generic mfg.
Pityriasis lichenoides et varioliformis acuta: a diagnostic challenge (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4098;
The patient was started on doxycycline 100 mg/day and betamethasone 0.05% cream twice daily, with a presumptive diagnosis of PLEVA... This case highlights the clinical and histological findings of PLEVA, because in order to provide an accurate diagnosis and an appropriate treatment, it is essential for dermatologists to be familiar with this entity, its differential diagnosis and the spectrum of pytiriasis lichenoides.
- |||||||||| hydroxychloroquine / Generic mfg., pentoxifylline / Generic mfg., doxycycline / Generic mfg.
Cutaneous Granulomatous Dermatitis in an Immunocompetent Adult Associated with Wild-Type Rubella Virus (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4092;
Atypical granulomatous dermatitis has been reported with rubella virus, which is thought to be a potential antigenic trigger. Inflammatory granulomas have been most commonly associated with vaccine-derived rubella virus in immunocompromised patients but more recently have been observed in immunocompetent patients and with wild type.
- |||||||||| doxycycline / Generic mfg.
Lymphogranuloma venereum: two clinical cases (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4084;
It is rare infections that can cause the greatest difficulties in diagnosis. Lymphogranuloma venereum can occur in different populations and geographic locations, and timely diagnosis and treatment makes it possible to prevent further spread of infection and the development of complications.
- |||||||||| A Case of Atypical Demodicosis Revealing HIV-Associated Immunodepression (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4044;
A few cases of DD have been reported in HIV-infected individuals, most often at the AIDS stage or with a CD4 lymphocyte count below 200 per mm3, as was the case with our patient. Therefore, some authors have considered DD as an opportunistic ectoparasitosis.
- |||||||||| Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie
Challenges in Diagnosing Pyoderma Gangrenosum with Mycobacterium fortuitum Infection (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4041;
We present a difficult case of PG after a trauma in a 42-year-old woman undergoing treatment with Infliximab. Identification of Mycobacterium fortuitum in cultures can be a contaminant and clinical response must be closely monitored in order to obtain an accurate diagnosis.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
Emerging spotted fever Rickettsioses in Morocco (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4037;
35 patients presented a febrile cutaneous eruption 48 hours after the tick, leading to hospitalization and treatmented by antibiotic: doxycycline +/- ciprofloxacin ( for cases with neurological involvment. Because rickettsial diseases have a wide geographical distribution, recognition of symptoms is essential to initiate rapid treatment to avoid a fatal outcome.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
Neurological damage due to rickettsiosis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4036;
The neurological complications of rickettsial disease are becoming increasingly frequent. Knowledge of the cutaneous and extra-cutaneous clinical picture lead to an early clinical diagnosis and an appropriate treatment to avoid a fatal outcome.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Borreliosis mimicking Gilbert's Pityriasis Rosea (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3998;
Doxycycline is the medication of choice as it works by interfering with the metabolism of bacteria, preventing their proliferation and progression. Furthermore, for local reactions that can cause edema, itching and erythema, antihistamines and corticosteroids can be used.
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