- |||||||||| doxycycline / Generic mfg.
Journal: REG? promotes mantle cell lymphoma cell apoptosis by downregulating NF-?B signaling. (Pubmed Central) - Mar 15, 2023
carrying pathogenic virulence and resistance genes, necessitating the application of biosecurity measures to prevent migratory birds from entering farms during their migration period. JEKO-1 cells stably transfected with a doxycycline-inducible Tet-On system expressed high levels of REG?...Stattic
- |||||||||| doxycycline / Generic mfg.
Journal: Lyme borreliosis (Pubmed Central) - Mar 15, 2023
LB treatment is mainly based on doxycycline for 14 to 28 days, depending on the clinical stage and manifestations, without demonstrated interest in prolonging it, even if symptoms persist...Attentive listening to the patient is essential. The prognosis of LB in the medium-term is favorable, especially if they beneficiate of an early management.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal, Adverse events: Long-term gastrointestinal adverse effects of doxycycline. (Pubmed Central) - Mar 14, 2023
GI adverse events, including esophagitis, are not rare with long-term use of oral doxycycline, particularly in older age and a higher dose of 200 mg/day. Future large and randomized studies are needed to compare the efficacy and safety of different doxycycline doses.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Journal: Neuro-Leptospirosis: Experience from a tertiary center of North India. (Pubmed Central) - Mar 14, 2023
Diagnosis of neuroleptospirosis should always be considered in patients with acute meningoencephalitis along with bacterial and viral encephalitis. Prognosis is good with early diagnosis and appropriate treatment.
- |||||||||| clodronate disodium / Generic mfg., doxycycline / Generic mfg.
Mesenchyme-derived inflammation results in macrophage recruitment and alters saccular stage lung development () - Mar 14, 2023 - Abstract #PAS2023PAS_4171;
Design/ We used a transgenic mouse model in which human IKK b (an upstream activator of NF- k B) is expressed in Tbx4-positive lung fibroblasts in a doxycycline (Dox) inducible manner (referred to as IKK b Tbx4 )...Depletion of macrophages with daily injections of intraperitoneal (IP) clodronate from PN 1-4 rescued the saccular lung phenotype in IKK b Tbx4 mice... Transgene activation in IKK b Tbx4 mice resulted in lung inflammation with increased mRNA expression of cytokines and chemokines and recruitment of macrophages (% macrophages/viable lung cells [mean
- |||||||||| Meningitis Masquerading as Migraine (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3276;
This questions whether the usage of oral doxycycline is as efficacious as IV antibiotics for neuroborreliosis in the USA. Further studies investigating oral doxycycline are needed in the U.S to answer this.
- |||||||||| hydrochlorothiazide / Generic mfg., doxycycline / Generic mfg.
Syndrome of Inappropriate Antidiuretic Hormone Secretion - A Rare Initial Presentation of Lyme Neuroborreliosis (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3274;
It was thought to be multifactorial due to SIADH and the use of hydrochlorothiazide...Ultimately, he was treated with doxycycline and discharged home...The mechanism of this phenomenon remains unclear; likely related to the inflammation cascade induced by CNS infection. Prompt recognition is critical for timely diagnosis and treatment.
- |||||||||| doxycycline / Generic mfg.
A Case of Facial Diplegia Secondary to Lyme Neuroborreliosis (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3273;
His symptoms gradually improved after treatment with doxycycline...However, facial diplegia is typically associated with an underlying systemic illness. Prompt identification of the disease aids in early treatment and management.
- |||||||||| prednisone / Generic mfg., doxycycline / Generic mfg., sirolimus / Generic mfg.
Case Study: A Heart Transplant Recipient with New, Severe Headache (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1852;
The patient received doxycycline for a 10-day course with improvement. Conclusions Identification of tick-borne disease in patients with a history of chronic immune suppression is necessary to avoid complications related to this relatively uncommon cause of infection.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg.
Neurobrucellosis Presenting With Isolated Intracranial Hypertension (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1824;
The evolution is favorable in more than 50% of cases after appropriate antibiotic therapy. Early diagnosis and appropriate management are important.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
From (Cat) Scratch: A Unique Presentation of CNS Bartonella Infection (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1459;
Two months before presenting to ED, her ophthalmologist increased her prednisone regimen to 80 mg daily due to concern for lupus retinitis...She was started on empiric therapy with ceftriaxone, ganciclovir, voriconazole, pyrimethamine, and sulfadiazine...She was started on doxycycline and rifampin and discharged home...We encourage evaluation for Bartonella infection if standard infectious workup is negative and there is no improvement with empiric treatment. Prompt diagnosis is important as treatment can improve morbidity and mortality.
- |||||||||| doxycycline / Generic mfg.
Horner (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1287;
Patient was treated with oral doxycycline with resolution of symptoms...This case illustrates and localizes an isolated Horner's syndrome as a masquerading presentation of neuroborreliosis. Therefore, clinical suspicion and early recognition are important, especially in the setting of a convincing history, to prompt early diagnosis and initiation of treatment and to prevent disease progression.
- |||||||||| doxycycline / Generic mfg.
Journal: Ultra Low-Cost Doxycycline Sclerotherapy for Lymphatic Malformations in Rwanda. (Pubmed Central) - Mar 9, 2023
Although cyclosporine A also inhibits renal and hepatic clearance, these results strongly suggest that efflux pumps in the intestinal epithelium are involved in the regulation of tetracycline absorption from the gastrointestinal tract. No abstract available
- |||||||||| doxycycline / Generic mfg.
Journal: Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection. (Pubmed Central) - Mar 7, 2023
Our results highlight the need for antibiotic stewardship, especially in settings with no IDDs. Moreover, Chlamydial adhesion to Hela 229 cells was blocked in a dose-dependent manner and RB-to-EB differentiation was inhibited by physcion from 28 to 48 hpi.Post treatment,upregulation of LC3-II was in a dose-dependent manner, indicating physcion activated autophagy and bacterial clearance.To validate clinical efficacy,49 SPF chickens aged 21days were divided into 5 groups and infected intra-laryngeally with 0.2
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline serum protein binding in pigs reveals a relatively high free fraction. (Pubmed Central) - Mar 7, 2023
Analysis of the data using a non-linear mixed-effects model demonstrated linearity of plasma protein binding with a mean fu value of 31% and a relatively low inter-subject variability of approximately 10%. This new data showing that the free fraction is four times greater than what could have been anticipated from historical data is discussed in particular for the calculation of the PK/PD cut-offs, which are used to establish the clinical breakpoints for antimicrobial susceptibility testing.
- |||||||||| doxycycline / Generic mfg.
Journal: A Sex-Dependent Association Between Doxycycline Use and Development of Schizophrenia. (Pubmed Central) - Mar 4, 2023
Doxycycline exposure is associated with a sex-dependent effect on schizophrenia risk. The next steps are replication of the results in independent well-characterized population cohorts, as well as preclinical studies to investigate sex-specific effects of doxycycline on biological mechanisms implicated in schizophrenia.
- |||||||||| emricasan (IDN 6556) / Histogen, Amerimmune
The irreversible pan-caspase inhibitor emricasan is a potential host-directed immunotherapy against methicillin-resistant S. aureus (MRSA) skin infections in mice () - Mar 4, 2023 - Abstract #ISID2023ISID_1275;
When compared to placebo, all three groups, placebo plus doxycycline, emricasan plus doxycycline, and emricasan treated group, exhibited biological effect, with reduction of both the lesion size (*p=0.0277, ****p<0.0001, ****p<0.0001, respectively) and bacterial burden (***p=0.003, ****p<0.0001, ****p<0.0001, respectively). Collectively, pan-caspase inhibitor emricasan and emricasan plus doxycycline reduced both the lesion size and bacterial burden in vivo, and emricasan is a potential host-directed immunotherapy against MRSA skin infections in a preclinical mouse model.
- |||||||||| doxycycline / Generic mfg.
Optimizing virus-driven merkel cell carcinoma development in mice () - Mar 4, 2023 - Abstract #ISID2023ISID_758;
We recently generated the first mouse model of MCC by CreER- and doxycycline-inducible expression of the Merkel cell transcription factor ATOH1 in epidermal progenitors also expressing the MCPyV sTAg, tLTAg, and single-copy deletion of Trp53...Intriguingly, MCCs with low-level or undetectable TAg expression exhibited a full complement of MCC differentiation markers, including dot-like K20, synaptophysin, and chromogranin A, which were not detected in our earlier MCC model. These findings reveal the acquisition of a classic MCC phenotype in tumors with markedly reduced expression of one or both TAgs, raising the possibility that TAg dosage is a critical determinant of the MCC neuroendocrine tumor phenotype.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Cicatricial bullous pemphigoid and sjogren's syndrome: Case report in an elderly female () - Mar 4, 2023 - Abstract #ISID2023ISID_599;
These findings reveal the acquisition of a classic MCC phenotype in tumors with markedly reduced expression of one or both TAgs, raising the possibility that TAg dosage is a critical determinant of the MCC neuroendocrine tumor phenotype. The labs were consistent with staph aureus and COPD so she was prescribed doxycycline and later topical steroids, but her lesions persisted...She was diagnosed with Sjorgen
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-Term Diabetes Rat Model with Severe Hyperglycemia-Induced Oral Bone Loss. (Pubmed Central) - Mar 3, 2023
Additionally, sodium hypochlorite(NaClO)-activation of human-recombinant (rh) MMP-9 and its inhibition by treatment with 10?M CMC2.24, Doxycycline, and Curcumin were evaluated...This study also highlights the role of MMP-9 as an early/sensitive biomarker in the absence of change in any other biochemical parameter. CMC2.24 also inhibited significant activation of pro-MMP-9 by NaOCl (oxidant) adding to known mechanisms by which this compound treats collagenolytic/inflammatory diseases including periodontitis.
- |||||||||| doxycycline / Generic mfg.
Journal: Alterations in faecal microbiome and resistome in Chinese international travellers: a metagenomic analysis. (Pubmed Central) - Mar 3, 2023
CMC2.24 also inhibited significant activation of pro-MMP-9 by NaOCl (oxidant) adding to known mechanisms by which this compound treats collagenolytic/inflammatory diseases including periodontitis. Our study highlights travel to low- or middle-income countries, Africa or Southeast Asia, a long travel duration, or the use of ABHS or doxycycline as antimalarial prophylaxis as important risk factors for the acquisition/enrichment of ARGs during international travel.
- |||||||||| doxycycline / Generic mfg.
Journal: Introduction of a Geminin mScarlet Reporter into H2B-mTurq2 hiPSCs for Live-cell Imaging of Proliferation and Cell Cycling. (Pubmed Central) - Mar 2, 2023
We previously generated a doxycycline-inducible H2B-mTurq2 reporter in hiPSCs to track cells and study cell division and apoptosis...mScarletI fluorescence increased gradually from the S-phase through the M-phase of the cell cycle and was lost at the metaphase-anaphase transition. The resulting hiPSC reporter line generated, which we named ProLiving, is a valuable tool to study cell division and cell cycle characteristics in living hiPSC-derived cells.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Journal: Human case of Anaplasma phagocytophilum infection in Eastern Taiwan. (Pubmed Central) - Mar 2, 2023
Our findings indicate the presence of HGA on the main island of Taiwan. Precautions against tick bites should be taken when engaging in outdoor activities, and HGA should be considered by physicians in the differential diagnosis.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date, Head-to-Head: LEPTO3: Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) (clinicaltrials.gov) - Feb 28, 2023
P4, N=220, Not yet recruiting,
Once the study is completed, we will publish our findings in a peer-reviewed medical journal. Trial completion date: May 2023 --> Aug 2025 | Trial primary completion date: Apr 2023 --> Jul 2025
- |||||||||| fluorouracil topical / Generic mfg., doxycycline / Generic mfg.
Journal: A Case of Segmental Darier Disease. (Pubmed Central) - Feb 27, 2023
Doxycycline and pulsed dye laser have also been reported to be effective (2,9)...Although uncommon, segmental DD should be included in the differential diagnosis of dermatoses that follow Blaschko's lines. Treatment options include various topical and oral treatments, depending on disease severity.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Virulence and antimicrobial resistance characteristics assessment of Vibrio isolated from shrimp (Penaeus vannamei) breeding system in south China. (Pubmed Central) - Feb 27, 2023
But only 5 resistance genes were detected, which were strA (43.8 %), strB (11.7 %), QnrVC (2.9 %), sul2 (8.8 %) and Int4 (8.8 %), respectively, and the antimicrobial resistance genotypes were not previously correlated with their phenotypes. The relevant research results provide theoretical basis for epizootic tracking in aquatic system in China, and targeting its final risk in aquatic ecosystem and public health perspectives.
- |||||||||| doxycycline / Generic mfg.
Journal: Enhanced photocatalytic degradation performance of InO/g-CN composites by coupling with HO. (Pubmed Central) - Feb 27, 2023
The relevant research results provide theoretical basis for epizootic tracking in aquatic system in China, and targeting its final risk in aquatic ecosystem and public health perspectives. The catalytic oxidation efficiency of the antibiotic doxycycline was greatly improved when the as-prepared compound was coupled with hydrogen peroxide, and 88.2% of doxycycline was degraded within 80
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