doxycycline / Generic mfg. 
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  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Journal:  Whipple's disease presenting as weight gain and constipation in a Chinese woman. (Pubmed Central) -  May 13, 2023   
    A prolonged course of antibiotics may be required due to slow clinical response as documented by serial imaging in our case. The possibility of IRIS should be considered in patients with breakthrough fever during treatment of Whipple's disease.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  In silico analysis and molecular docking studies of natural compounds of Withania somnifera against bovine NLRP9. (Pubmed Central) -  May 12, 2023   
    In silico docking analysis revealed Withanolide B had the highest binding affinity score of -10.5 kcal/mol, whereas, among control drugs, doxycycline hydrochloride was most effective (-10.3 kcal/mol)...Thus, in the present situation, it is important to identify bioactives with the potential to combat inflammatory diseases and provide strength and immunity to the host. However, there is still a need to study in vitro and in vivo to further support these findings.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Thyroid Cancer Presenting as Aspiration Pneumonia (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_2531;    
    Retrosternal or ectopic thyroid tumors can present as euthyroid state without obvious enlargement of the normal thyroid gland. A meticulous clinical evaluation should include the differential diagnosis of retrosternal goiter or ectopic thyroid with cancer when treating patients who preset with sign and symptoms concerning for mediastinal disease.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Stress Induced AIPB Expression in Triple Negative (ER-/PR-/Her2-) Breast Tumors Reduces Estradiol (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_1090;    
    The model was used on engineered triple-negative tumor cells which conditionally overexpress AIPB with the addition of tetracycline...On addition of doxycycline, the estradiol level was further decreased to 47 ng/ml, which is about 29.4%...Aromatase is absent in triple-negative breast cancer, so we conclude aromatase independent action AIPB in these triple-negative tumorigenic cells plays a crucial role in estradiol synthesis. With our current data, we can suggest a model in which stimulating higher expression of AIPB in patients can provide them with better and longer lives.
  • ||||||||||  doxycycline / Generic mfg.
    Reproductive And Metabolic Characterization of Mice Overexpressing CYP17 in Ovarian Theca Cells (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_846;    
    To achieve this, a Triple mutant (TM) mouse was developed using the doxycycline inducible tet- on system, which involved RTTA, Cyp17 Cre and teto operator specifically inserted into CYP17 gene (purpose- double secure CYP17 specifically expressed in theca cells)...Comprehensive Laboratory Animal Monitoring System (CLAMS) did not show any changes in the Respiratory Exchange Ratio, heat production and ambulatory movement. These studies show a unique strategy to develop an endogenous excess testosterone producing transgenic mice with decreased fertility.
  • ||||||||||  doxycycline / Generic mfg.
    Somatic mutations in the zinc transporter ZnT1 cause primary aldosteronism (W-183C) -  May 11, 2023 - Abstract #ENDO2023ENDO_14;    
    Functional studies of the mutant SLC30A151_57del variant in a doxycycline-inducible adrenal cell system revealed pathologic Na+ influx caused by the mutant...This resulted in an increase in cytosolic Ca2+ activity, which stimulated CYP11B2 mRNA expression and aldosterone production. Collectively, these data implicate the first-in-field zinc transporter mutations as a dominant driver of aldosterone excess in PA.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Review, Journal:  An Update on Gonorrhea and Chlamydia. (Pubmed Central) -  May 11, 2023   
    Test of cure is indicated in persons at risk for reinfection or during pregnancy. Future directions include identifying effective strategies for prevention.
  • ||||||||||  ribavirin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Development of a recombinant reporter Getah virus for antiviral drug screening assays. (Pubmed Central) -  May 10, 2023   
    It was also found that the compound, doxycycline, showed an inhibitory effect on GETV replication...The reporter viruses will contribute to the assessment of viral replication and proliferation, tracking and elucidating of alphavirus-host interactions. In addition, they will help in the screening of potential antiviral compounds.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Pediatric Brucellosis: A Challenging Diagnosis-Case Report. (Pubmed Central) -  May 10, 2023   
    Brucella is an intracellular pathogen affecting multi-systems of the human body; thus, the treatment is started with antimicrobials that have penetrative effects on a cell. The treatment can be adjusted based on the age group and the complication of the symptoms.
  • ||||||||||  doxycycline / Generic mfg.
    New P4 trial:  DOXY-PEP: Doxy-Post-exposure Prophylaxis (clinicaltrials.gov) -  May 10, 2023   
    P4,  N=40, Not yet recruiting, 
  • ||||||||||  Journal:  Electrochemical properties of roots determine antibiotic adsorption on roots. (Pubmed Central) -  May 8, 2023   
    The soybean roots performed strong adsorption ability compared with the maize and wheat roots driven by the variations in root electrochemical properties. This study demonstrates the significance of electrochemical interactions between antibiotics and roots in plant-soil system and can contribute to the more accurate risk assessment and effective pollution control of antibiotics.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Peripheral vs. Core Body Temperature as Hypocretin/Orexin Neurons Degenerate: Exercise Mitigates Increased Heat Loss. (Pubmed Central) -  May 8, 2023   
    In the current study, we measured subcutaneous (T) and core (T) body temperature as well as activity in a conditional transgenic mouse strain that allows the inducible ablation of Hcrt/Ox-containing neurons by removal of doxycycline (DOX) from their diet (orexin-DTA mice)...Our results suggest that ablation of Hcrt/Ox-containing neurons results in elevated heat loss, likely through reduced sympathetic vasoconstrictor tone, and that exercise may have some therapeutic benefit to patients with narcolepsy, a disorder caused by Hcrt/Ox deficiency. Acute changes in body temperature may facilitate prediction of cataplexy onset and lead to interventions to mitigate its occurrence.
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Effective removal of tetracycline antibiotics from water by magnetic functionalized biochar derived from rice waste. (Pubmed Central) -  May 7, 2023   
    The estimated cost of preparing MF-CMS is 5.91 USD per kg, and 1?kg of MF-CMS (consuming 8?kg of waste rice) can approximately treat 0.55 tons of TCs wastewater. Overall, the magnetic biochar derived from starch-rich rice waste as an adsorbent has promising and effective for the removal of TCs from water, but also provides a new idea for the resourceful treatment of solid waste.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Development of a perfusion process for continuous lentivirus production using stable suspension producer cell lines. (Pubmed Central) -  May 6, 2023   
    Both stable packaging cell lines are based on an inducible Tet-off system, thus requiring doxycycline removal for initiation of the virus production...Remarkably, cell viabilities >90% were maintained at high cell densities without compromising productivity throughout the whole process, allowing to further extend the process time. Given its low effects of toxicity during virus production, the presented cell lines are excellent candidates to develop a fully continuous LV production process to overcome the existing bottlenecks in LV manufacturing.
  • ||||||||||  doxycycline / Generic mfg.
    SY22 : Strengthening sexual health: PEP, PrEP and vaccines for STIs (Plaza Level Auditorium/Channel 4) -  May 5, 2023 - Abstract #IASHIV2023IAS_HIV_580;    
    This session will explore these advances, identify evidence needed for implementation, and address how these interventions may be integrated into HIV prevention and treatment services. Participants will also discuss priorities for research and programmes to maximize benefit for those at greatest need.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    TUBULE CELL-DERIVED ANGIOPOIETIN-2 EXACERBATES INFLAMMATION AND IS DETRIMENTAL TO RENAL FIBROSIS (Focussed Oral Room 8) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1081;    
    Overall, these findings suggest that increased Angpt2 in tubule epithelial cells deteriorate renal fibrosis through detrimental inflammation. Further studies are necessary to explore the participating cellular components and pathogenic mechanisms.
  • ||||||||||  doxycycline / Generic mfg.
    KIDNEY TUBULE POLYPLOIDIZATION DURING PHYSIOLOGIC AGEING IN MICE (Focussed Oral Room 1) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_997;    
    In these mice, FUCCI2aR reporter is expressed by all TC after doxycycline hyclate induction... This study demonstrates the increase of TC polyploidization, which is associated with a progressive fibrosis, senescence and CKD development during physiologic kidney ageing in mice.
  • ||||||||||  rifampicin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Bartonella Neuroretinitis: There Is More to Cat Scratch Disease than Meets the Eye. (Pubmed Central) -  May 3, 2023   
    CONCLUSIONS Early recognition and treatment of Bartonella neuroretinitis is essential to prevent vision loss and shorten recovery time. The current standard of treatment is doxycycline and rifampin for 4 to 6 weeks, and a growing body of literature indicates the supplementation of corticosteroids with these antibiotics.
  • ||||||||||  Journal:  Determination of antibiotics during treatment of hospital wastewater using automated solid-phase extraction followed by UHPLC-MS: Occurrence, removal and environmental risks. (Pubmed Central) -  May 2, 2023   
    In this study, 15 selected antibiotics (amoxicillin, ampicillin, azithromycin, ciprofloxacin, doxycycline, erythromycin, gentamicin, metronidazole, norfloxacin, ofloxacin, penicillin, sulfamethoxazole, sulfapyridine, tetracycline and trimethoprim) were monitored in wastewater as it goes through sedimentation (primary and secondary), aeration and chlorination stages of a WWTP...Removal efficiencies during sedimentation were generally positive with doxycycline achieving 80 - 95.8%, while negative removal efficiencies were observed for penicillin V (-46.4 to -17.1%) and trimethoprim (-26.2 to -18.9%)...The recorded effluent concentrations ranging between 0.0130 and 0.383?ng/mL were translated to low potential for development of antibiotic resistance genes in the receiving environments while ecotoxicity risk was high for only amoxicillin, ampicillin and sulfapyridine. The study has provided an overview of the performance of common wastewater treatment processes in South Africa and hopes that more monitoring and environmental risk data can be made available towards drafting of antibiotic priority lists that cater for Africa.
  • ||||||||||  doxycycline / Generic mfg.
    Journal, CAR T-Cell Therapy, IO biomarker, Metastases, Viral vector:  Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells. (Pubmed Central) -  May 1, 2023   
    We generated previously the first all-in-one, transactivator-free, doxycycline (Dox)-responsive (Lent-On-Plus or LOP) lentiviral vectors (LVs) able to control transgene expression in human stem cells...We validated the LOPIs2 system by generating inducible CAR-T cells that selectively kill CD19+ cells in the presence of Dox. In summary, we describe here the first transactivator-free, all-one-one system capable of generating Dox-inducible ATMPs.