doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  cephalexin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Antimicrobial stewardship: Prescribing across the primary care health professions. (Pubmed Central) -  Jun 7, 2023   
    The proportional higher increase in antibiotic use by non-medical prescribers is a concern. To reduce inappropriate use of antibiotics and antimicrobial resistance, educational strategies targeted at all medical and non-medical prescribers are needed to align prescribing with current best practice within the scope of practice of respective prescribers.
  • ||||||||||  Nuzyra (omadacycline) / Paratek
    Journal:  Antimicrobial susceptibility of Clostridioides difficile to omadacycline and comparator antimicrobials. (Pubmed Central) -  Jun 6, 2023   
    This novel method of drug delivery can effectively lead to the repurposing of traditional Doxycycline as a potential adjunct treatment for managing the cytokine storm in the lungs in COPD and viral infections. Among 200 contemporary C. difficile isolates, there were no notable elevations in the in vitro omadacycline MIC, indicating a high level of activity towards C. difficile in comparison with commonly used antimicrobials for CABP and ABSSSI.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Developmental impairments of craniofacial bone and cartilage in transgenic mice expressing FGF10. (Pubmed Central) -  Jun 5, 2023   
    To test this hypothesis, we used a tet-on doxycycline-inducible transgenic mouse model (FGF10 Tg) to overexpress Fgf10 from embryonic day 12.5...We found an alternative splicing variant of Fgfr2-IIIb with a predicted translation product lacking the transmembrane domain, and suggesting a soluble form of FGFR2-IIIb (sFGFR2-IIIb), differentially expressed in some of the craniofacial bones and cartilages. Thus, excessive FGF10 may perturb signal transduction of the FGF-FGFR, leading to craniofacial skeletal abnormalities in FGF10 Tg mice.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Journal:  Comparative Assessment of the Effect of Three Various Local Drug Delivery Medicaments in the Management of Chronic Periodontitis. (Pubmed Central) -  Jun 5, 2023   
    Local administration of antibacterial agents in continued or regulated delivery arrangement is employed to augment the actions of nonsurgical periodontal management, and it may be likely to attain gingival well-being by eliminating the requirement for invasive methods with the aid of local drug delivery arrangements. Chosen elimination or prohibition of microbial pathogens with locally administered antibacterial agents coupled with SRP is an efficient move toward treatment of chronic periodontitis.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Dexamethasone and doxycycline functionalized nanoparticles enhance osteogenic properties of titanium surfaces. (Pubmed Central) -  Jun 5, 2023   
    This study provides key insights into the further development of heterogeneous metallic oxides-carbon catalysts for antibiotic-containing wastewater treatment. DoxNPs and DexNPs were able to stimulate osteoblasts differentiation when applied on titanium surfaces, being considered potential inducers of osteogenic environment when performing regenerative procedures around titanium dental implants.
  • ||||||||||  doxycycline / Generic mfg., sirolimus / Generic mfg.
    Journal, Oncolytic virus, IO biomarker:  Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. (Pubmed Central) -  May 31, 2023   
    The switches are applied to enable inducible expression of fusogenic proteins, dose-controlled delivery of toxic cytokines, and chemical regulation of VV replication. This toolbox enables the precise modulation of transgene circuitry in VV-vectored oncolytic virus design.
  • ||||||||||  doxycycline / Generic mfg.
    Trial initiation date:  Investigation of Laser Assisted Drug Delivery of NanoDOX (clinicaltrials.gov) -  May 30, 2023   
    P2,  N=12, Recruiting, 
    Oral doxycycline 40 Initiation date: Apr 2023 --> Jul 2023
  • ||||||||||  Neurobrucellosis: two cases presenting with optic neuropathy and myelitis (Foyer 3B, 3rd Floor) -  May 29, 2023 - Abstract #EPNS2023EPNS_554;    
    Brucellosis and neurobrucellosis are often overlooked because manifestations are variable and nonspecific, and risk factors like contact or food consumption may be absent. Several weeks' diagnostic delay in our cases after acute presentation with cranial nerve involvement and severe myelitis emphasizes the importance of awareness.
  • ||||||||||  Journal:  Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. (Pubmed Central) -  May 29, 2023   
    This was seen most prominently in emtricitabine and lamivudine; but also, sulfamethoxazole, trimethoprim, sulfadiazine, clindamycin, ciprofloxacin, ofloxacin, and doxycycline. Urban water fingerprinting (UWF) data triangulation with prescription datasets showed good correlations for several antimicrobial agents (AAs) (e.g., clindamycin, clarithromycin, ofloxacin, and doxycycline)...For example, tetracycline was not reported in available prescription statistics, but was detected at an average of 18.4
  • ||||||||||  Journal:  Performance of a Pilot-Scale Continuous Flow Ozone-Based Hospital Wastewater Treatment System. (Pubmed Central) -  May 27, 2023   
    Clarithromycin was more readily removed than the other antimicrobials (81-91%), and no clear removal trend was observed for ampicillin. Our findings provide a better understanding of the environmental management of hospital wastewater and enhance the effectiveness of disinfection wastewater treatment systems at medical facilities for mitigating the discharge of pollutants into aquatic environments.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Evaluation of Alternative Doxycycline Antibiotic Regimes in an Inhalational Murine Model of Q Fever. (Pubmed Central) -  May 27, 2023   
    Pre-exposure prophylaxis or post-exposure treatment at the resolution of clinical signs did not improve outcomes. These are the first studies to experimentally evaluate different doxycycline treatment regimens for Q fever and illustrate the need to explore the efficacy of other novel antibiotics.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg.
    Preclinical, Journal:  Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment. (Pubmed Central) -  May 27, 2023   
    SorA changed gut microbial composition during intraperitoneal application only and did neither alter the vaginal microbiota in mice nor affect growth of human-derived lactobacilli. Additional dose escalations and/or pharmaceutical modifications will be needed to optimize application of SorA and to reach sufficient anti-chlamydial activity in vivo.
  • ||||||||||  Journal:  Distribution and Characterization of Typical Antibiotics in Water Bodies of the Yellow River Estuary and Their Ecological Risks. (Pubmed Central) -  May 26, 2023   
    The ecological risk evaluation of 14 antibiotics in the Yellow River Estuary watershed showed that clarithromycin and doxycycline hydrochloride were present at medium-risk levels, and lincomycin hydrochloride, sulfamethoxazole, methomyl, oxifloxacin, enrofloxacin, sulfadiazine, roxithromycin, sulfapyridine, sulfadiazine and ciprofloxacin were present at low-risk levels in the samples collected from water bodies of the Yellow River Estuary. This study provides novel, beneficial information for the assessment of the ecological risk presented by antibiotics in the Yellow River Estuary water bodies and provides a scientific basis for future antibiotic pollution control in the Yellow River Basin.
  • ||||||||||  doxycycline / Generic mfg.
    Journal, Combination therapy:  Spatio-temporal control of targeted gene expression in combination with CRISPR/Cas and Tet-On systems in Medaka. (Pubmed Central) -  May 25, 2023   
    Next, using transgenic Medaka for establishing the Tet-On system by KI, we demonstrated that doxycycline administration for four or more days by feeding can be a stable and efficient method to achieve expression of the transduced reporter gene in adult fish. From these analyses, we propose an optimized approach for a spatio-temporal gene-expression system in the adult stage of Medaka and other small fishes.
  • ||||||||||  doxycycline / Generic mfg., Nerlynx (neratinib) / Puma, Knight Therap, Pierre Fabre
    Journal:  HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers. (Pubmed Central) -  May 22, 2023   
    We aimed to identify proteins that bound to HER3 upon inhibition of the HER family with the pan-HER inhibitor neratinib in HER2+ breast cancer cells...To examine the role of NMIIA in HER2+ breast cancer, we modulated NMIIA levels in BT474 and MDA-MB-453 cells using doxycycline inducible shRNA targeting MYH9...In addition, loss of MYH9 suppresses cell growth, proliferation, migration, and invasion. Our data reveals that NMIIA regulates HER3 and loss of NMIIA reduces HER2+ breast cancer growth.
  • ||||||||||  Takecab (vonoprazan) / Takeda, Phathom Pharma
    Journal:  The efficacy and mechanism of vonoprazan-containing triple therapy in the eradication of Helicobacter pylori. (Pubmed Central) -  May 22, 2023   
    P=N/A
    Our data reveals that NMIIA regulates HER3 and loss of NMIIA reduces HER2+ breast cancer growth. Enrolled patients confirmed to be infected with H. pylori were randomly divided into four groups: VPZ + doxycycline + furazolidone, VPZ + doxycycline + amoxicillin, esomeprazole (EPZ) + bismuth + doxycycline + furazolidone, and EPZ + colloidal bismuth + doxycycline + amoxicillin for 14
  • ||||||||||  doxycycline / Generic mfg., sulphadiazine / Generic mfg.
    Journal:  The impact of antibiotic residues on resistance patterns in leek at harvest. (Pubmed Central) -  May 22, 2023   
    This could be due to a shift in soil microbiota induced by the addition of lincomycin. The results of this study indicate that consumption of leek carries a low risk of exposure to antibiotic residues or antibiotic resistance to doxycycline, sulfadiazine or lincomycin.
  • ||||||||||  doxycycline / Generic mfg.
    Observational data, Retrospective data, Journal:  Rickettsioses imported by travellers and migrants to Spain attended in the (Pubmed Central) -  May 22, 2023   
    Doxycycline should be considered in the empiric treatment of imported fever of travellers coming from those areas or who have engaged in high-risk activities. There is a need to improve access to molecular diagnosis of rickettsiosis in Spain.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation. (Pubmed Central) -  May 20, 2023   
    Here, we generated a human inducible pluripotent stem cell (hiPSC) model with a doxycycline dose-dependent MLL-AF9 expression...Our system allows for careful chemically controlled and stepwise in vitro hiPSC-derived differentiation under serum-free and feeder-free conditions. For a disease that currently lacks effective precision medicine, our system provides a novel entry-point into exploring potential novel targets for personalized therapeutic strategies.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  SOX1 Functions as a Tumor Suppressor by Repressing HES1 in Lung Cancer. (Pubmed Central) -  May 16, 2023   
    Knockdown of SOX1 by the withdrawal of doxycycline partly restored the malignant phenotype of inducible SOX1-expressing NSCLC cells...Furthermore, we performed phenotypic rescue experiments to prove that overexpression of HES1-FLAG in SOX1-expressing H1299 cells partly reversed the tumor-suppressive effect. Taken together, these data demonstrated that SOX1 acts as a tumor suppressor by directly inhibiting HES1 during the development of NSCLC.