- |||||||||| The Jarisch-Herxheimer reaction to second line drug for Syphilis (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2298;
Despite of availability of treatment syphilis remains exists in a sporadic form in India. My case report is an important study because very few cases are reported about Jarisch-Herxheimer Reaction in Secondary Syphilis after treatment with azithromycin.
- |||||||||| doxycycline / Generic mfg., ivermectin topical / Generic mfg., isotretinoin oral / Generic mfg.
SMAE modulates the the Angiopoietin (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2178;
When needed : topical ivermectin (192 weeks- , 9,1% of total weeks), doxycycline 100 mg (54 weeks -, 2,6% of total) and isotretinoin low dose (50 weeks -, 2,4% of total) were prescribed); no signs of incompatibility with SAME SMAE were observed. SMAE may contribute to the long term maintenance of vascular homeostasis in rosacea prone skin.
- |||||||||| Zeven (dalbavancin) / RaQualia, AbbVie
Dalbavancin for the treatment of severe hidradenitis suppurativa (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2162;
SMAE may contribute to the long term maintenance of vascular homeostasis in rosacea prone skin. He was currently on treatment with adalimumab subcutaneous ( sc) injection of 80 mg every 14 days for his Crohn
- |||||||||| doxycycline / Generic mfg.
Journal: Adjuvant Topical Interferon Alpha 2b for the Treatment of Monkeypox Ocular Manifestations. (Pubmed Central) - Aug 29, 2023
Alternative and efficacious treatment options for Mpox ocular manifestations are needed to prevent further disease progression and sequelae in countries with no access to the gold-standard therapy. Topical interferon alpha 2b and oral doxycycline have shown adequate response as shown with this patient.
- |||||||||| tetracycline / Generic mfg.
Journal: A portable test strip fabricated of luminescent lanthanide-functionalized metal-organic frameworks for rapid and visual detection of tetracycline antibiotics. (Pubmed Central) - Aug 29, 2023
Upon exposure to TCs, significant luminescence quenching of ATUC excited at 255 nm was observed due to the inner filter effect (IFE) and photo-induced electron transfer (PET), and the established strategy has a detection limit (LOD) of 11.0, 20.1, 9.1, and 22.5 nM for TC, CTC, OTC, and DOX, respectively. More importantly, given its portability and conspicuous luminescence color gradation variation, a portable test strip based on ATUC was manufactured and the results could be distinguished immediately by the naked eye and smartphone analysis, allowing for on-site rapid quantitative assay of TCs, not only in the laboratory but also in a point-of-care setting.
- |||||||||| doxycycline / Generic mfg.
Journal: Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency. (Pubmed Central) - Aug 29, 2023
Here we provide a variety of novel results, as generated on a methodologically extended basis, and present a concept for the codetermination of viral replication efficiency through these kinase activities: (i) cyclin H expression, in various human cell types, is substantially upregulated by strains of HCMV including the clinically relevant HCMV Merlin; (ii) vCDK/pUL97 interacts with human cyclin H in both HCMV-infected and plasmid-transfected cell systems; (iii) a doxycycline-inducible shRNA-dependent knock-down (KD) of cyclin H significantly reduces pUL97 activity (qSox in vitro kinase assay); (iv) accordingly, pUL97 in vitro kinase activity is seen significantly increased upon addition of recombinant cyclin H; (v) as a point of specific importance, human CDK7 activity shows an increase by vCDK/pUL97-mediated trans-stimulation (whereas pUL97 is not stimulated by CDK7); (vi) phosphosite-specific antibodies indicate an upregulated CDK7 phosphorylation upon HCMV infection, as mediated through a pUL97-specific modulatory effect (i.e. shown by pUL97 inhibitor treatment or pUL97-deficient viral mutant); (vii) finally, an efficient KD of cyclin H in primary fibroblasts generally results in an impaired HCMV replication efficiency as measured on protein and genomic levels. These results show evidence for the codetermination of viral replication by vCDK/pUL97, cyclin H and CDK7, thus supporting the specific importance of cyclin H as a central regulatory factor, and suggesting novel targeting options for antiviral drugs.
- |||||||||| thapsigargin / University of Nottingham, Pirbright Institute
Journal: Context-dependent effects of CCN2 on ?-cell mass expansion and indicators of cell stress in the setting of acute and chronic stress. (Pubmed Central) - Aug 28, 2023
CCN2 induction in isolated islets treated with thapsigargin ex vivo resulted in upregulation of the gene encoding the Nrf2 transcription factor, a master regulator of antioxidant genes, suggesting that CCN2 further activates this pathway in the presence of cell stress. These studies indicate that the potential of CCN2 to induce ?-cell mass expansion is context-dependent and that the presence of ?-cell stress does not ensure ?-cell proliferation in response to CCN2.
- |||||||||| doxycycline / Generic mfg.
Journal: Disseminated adult xanthogranuloma successfully treated with doxycycline. (Pubmed Central) - Aug 22, 2023
Further analysis, especially modeling studies, are needed to evaluate strategies aiming to reduce doxycycline intake (PEP/PrEP versus repeated targeted therapies) and improve sexual health outcomes within the community. No abstract available
- |||||||||| Journal: Never forget ocular syphilis: A case series from a single tertiary centre. (Pubmed Central) - Aug 22, 2023
As adjunctive therapy to systemic antibiotics, oral corticosteroids in three patients and intravitreal ceftazidime (2.25 mg/0.1 mL) injections in one patient were administered. In conclusion, ocular syphilis is a re-emerging phenomenon; prompt diagnosis and proper antibiotic treatment can prevent serious ocular complications.
- |||||||||| doxycycline / Generic mfg.
Journal, Combination therapy: Efficacy of supramolecular salicylic acid in combination with doxycycline in the treatment of acne. (Pubmed Central) - Aug 21, 2023
The overall incidence of adverse reactions was significantly lower in the experimental group versus control group (5.71% vs. 17.14%, P<0.05). Supramolecular salicylic acid in combination with doxycycline in the treatment of patients with acne is an optimal option, as it could better promote acne regression, reduce the level of depression and reduce the patient's self-perceived burden.
- |||||||||| doxycycline / Generic mfg.
Journal: Imaging telomerase reverse transcriptase expression in oligodendrogliomas using hyperpolarized ?-[1-C]-gluconolactone. (Pubmed Central) - Aug 21, 2023
Doxycycline-inducible TERT silencing abrogated 6-PG production from hyperpolarized ?-[1-C]-gluconolactone in oligodendroglioma cells, consistent with the loss of G6PD activity...These results indicate that hyperpolarized ?-[1-C]-gluconolactone reports on TERT expression and early response to therapy in oligodendrogliomas. Our studies identify a novel agent for imaging tumor proliferation and treatment response in oligodendroglioma patients.
- |||||||||| doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Brucellosis in Pediatric Populations: An 11-Year Cohort Study. (Pubmed Central) - Aug 18, 2023
Pediatric brucellosis is an acute febrile disease often associated with rheumatologic complaints. Patients 8-18 years of age also presented with headache, weight loss, and night sweats.
- |||||||||| Nplate (romiplostim) / Amgen, Kyowa Kirin, Abthrax (raxibacumab) / Emergent Biosolutions
Review, Journal: United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism. (Pubmed Central) - Aug 18, 2023
For bioterrorism-associated anthrax, the FDA approved five antibiotics (doxycycline, penicillin-G, levofloxacin, moxifloxacin, and ciprofloxacin), two monoclonal antibodies (obiltoxaximab and raxibacumab), one polyclonal antitoxin (Anthrax Immune Globulin Intravenous) and two vaccines (Anthrax Vaccine Adsorbed and Anthrax Vaccine Adsorbed with an adjuvant)...Two potential mass public health disasters are aerosolized anthrax dissemination and radiological incidents. Five agents authorized for anthrax emergencies only have FDA approval for this indication, five antibiotics have FDA approvals as antibiotics for common infections and for bacillus anthrax, and four agents have regulatory approvals for supportive care for cancer and for radiological incidents.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Review, Journal: Pemphigoid diseases in older adults (Pubmed Central) - Aug 18, 2023
Patients are best managed in centers experience with the management of pemphigoid diseases. Updated national and international guidelines for the diagnosis and treatment of bullous pemphigoid and mucous membrane pemphigoid have recently been published.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Observational data, Journal: Scrub Typhus in Children: A Prospective Observational Study in a Tertiary Care Hospital in Eastern India. (Pubmed Central) - Aug 18, 2023
Conclusions Even in the absence of eschar, scrub typhus should be suspected in any febrile child who experiences clinical signs of meningoencephalitis syndrome, capillary leakage, skin rash, conjunctival congestion, LRTI, AKI, lymphadenopathy, hepatosplenomegaly, thrombocytopenia, and liver dysfunction in the post-monsoon season. Strong clinical suspicion and prompt anti-scrub drug administration go a long way in preventing or decreasing the morbidity and mortality of the same.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: Efficacy of Topical Azithromycin versus Systemic Doxycycline in Treatment of Meibomian Gland Dysfunction. (Pubmed Central) - Aug 17, 2023
Meibomian gland dysfunction (MGD) could be treated effectively with oral doxycycline and topical azithromycin by improving symptoms, clinical signs, and stabilization of tear film. Moreover, the topical azithromycin group seemed to be superior over the oral doxycycline group in improving the quality of tear film in the short term, having fewer side effects, more compliance, and better tolerability.
- |||||||||| Journal: Stability study of selected veterinary drug residues spiked into extracts from different food commodities. (Pubmed Central) - Aug 15, 2023
Those and the other drug analytes (ciprofloxacin, doxycycline, florfenicol amine, 2-amino-flubendazole, oxytetracycline, sulfadiazine, sulfadimethoxine, sulfamethazine, and trimethoprim) were mostly stable for a month in refrigerated extracts, especially at higher concentrations, but not in all cases. In practice, freezer storage of extract solutions was found to be acceptable for at least a month, with a few exceptions.
- |||||||||| doxycycline / Generic mfg.
Journal: A (Pubmed Central) - Aug 15, 2023
In practice, freezer storage of extract solutions was found to be acceptable for at least a month, with a few exceptions. After extensive diagnostic investigation to identify in particular hemato-oncological diseases, a
- |||||||||| Review, Journal: Public health concerns for food contamination in Ghana: A scoping review. (Pubmed Central) - Aug 14, 2023
The following deductions were made from the review: Highly contaminated food results in death, short to long term morbidity, economic loss, and threatens to displace Ghana's efforts at achieving the Sustainable Development Goals (SDG) 2. Thus, Government must resource key regulatory bodies to enhance their operational capacity, regulators must foster collaboration in monitoring and supervision of food vendors, and managers of food service outlets must provide adequate facilities to engender food safety culture.
- |||||||||| metformin / Generic mfg., doxycycline / Generic mfg.
Journal: Novel pharmacological approaches in abdominal aortic aneurysm. (Pubmed Central) - Aug 14, 2023
Recent preclinical studies have postulated new therapeutic targets and pharmacological strategies paving the way for the implementation of future clinical studies exploring these novel therapeutic strategies. This review summarises some of the most relevant clinical and preclinical studies in search of new therapeutic approaches for AAA.
- |||||||||| Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
Journal: Antibacterial Activity and Mechanism of Canagliflozin against Methicillin-Resistant Staphylococcus aureus. (Pubmed Central) - Aug 12, 2023
In conclusion, canagliflozin exhibits antibacterial activity against MRSA by affecting bacterial metabolism, inhibiting its biofilm formation, distorting the bacterial cell wall, and altering the gene expression of biofilm formation and its virulence. Our study reveals the antibacterial activity of canagliflozin against MRSA, providing a new reference for treating diabetic foot infections.
- |||||||||| doxycycline / Generic mfg.
Journal: New Approach for Studying of Isoforms and High-Homology Proteins in Mammalian Cells. (Pubmed Central) - Aug 12, 2023
Using this construct, we achieved the preferential expression of only one recombinant PHF10 isoform with a simultaneously reduced number of all endogenous isoforms. Our approach can be used to study the role of point mutations, the functions of individual domains and important sites, or to individually detect untagged isoforms with knockdown of all endogenous isoforms.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg.
Journal: Clinical efficacy of arthroscopy combined with irrigation and drainage in the treatment of brucellosis of the hip. (Pubmed Central) - Aug 10, 2023
Arthroscopic treatment of brucellosis in the hip joint not only preserves the joint fluid and lesion tissue for a clear diagnosis but also allows thorough removal of the infected and injured tissue during surgery. Hip arthroscopy combined with postoperative tube irrigation and drainage is an effective method for the diagnosis and treatment of brucellosis in the hip joint.
- |||||||||| doxycycline / Generic mfg.
Retrospective data, Journal: A retrospective study on antibacterial treatments for koalas infected with Chlamydia pecorum. (Pubmed Central) - Aug 9, 2023
Studies have reported the treatment efficacy of chloramphenicol and doxycycline, which are the two most commonly administered treatments in diseased koalas, in clinical settings...Of the koalas, 28.5% initially had no clinical signs but were PCR positive for C. pecorum. This study enables further understanding of the complex nature between chlamydial infection and response to antibacterial treatment.
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