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114 Diseases |  |
151 Trials |
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151 Trials |  |
5480 News |  |
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- | doxycycline / Generic mfg.
Journal: Long-Term Doxycycline Therapy for Stable COPD: Do the Benefits Outweigh the Drawbacks? (Pubmed Central) - Sep 21, 2023
No abstract available
- | doxycycline / Generic mfg.
Journal: Microbiological Monitoring in Therapeutic Trials in COPD. (Pubmed Central) - Sep 21, 2023
No abstract available No abstract available
- | doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: NCI-2018-00630: Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions (clinicaltrials.gov) - Sep 21, 2023
P=N/A, N=208, Recruiting, Sponsor: M.D. Anderson Cancer Center
No abstract available Trial completion date: Dec 2022 --> Apr 2025 | Trial primary completion date: Dec 2022 --> Apr 2025
- | doxycycline / Generic mfg.
New trial: Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever (clinicaltrials.gov) - Sep 21, 2023
P=N/A, N=526, Not yet recruiting, Sponsor: Medical Corps, Israel Defense Force
- || doxycycline / Generic mfg.
Clinical, Retrospective data, Review, Journal: Safety of longer-term doxycycline use: A systematic review and meta-analysis with implications for bacterial STI chemoprophylaxis. (Pubmed Central) - Sep 21, 2023
Longer-term (8+ weeks) doxycycline use is generally safe and may be associated with minor side-effects. Further research is needed on the potential metabolic impact of longer-term doxycycline use.
- | trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
Journal: Prevalence of blood stream infections and associated factors among febrile neutropenic cancer patients on chemotherapy at Ocean Road Cancer Institute, Tanzania. (Pubmed Central) - Sep 20, 2023
Further research is needed on the potential metabolic impact of longer-term doxycycline use. The prevalence of FN among the cancer patients on chemotherapy in Tanzania is low but associated with drug-resistant bacteria.
- || doxycycline / Generic mfg., azithromycin / Generic mfg.
Review, Journal: Lyme Disease: An Overview. (Pubmed Central) - Sep 20, 2023
No vaccine is available and one episode of the disease will not confer life-long immunity; thus, preventive measures remain a priority. The concept of post-Lyme disease syndrome versus chronic Lyme disease remains contested for want of robust evidence favoring benefits of prolonged antibiotic therapy.
- | Journal: Isolation and identification of Chryseobacterium indologenes and its pathological changes in Pelodiscus sinensis. (Pubmed Central) - Sep 19, 2023
In conclusion, the pathogen causing the death of farmed P. sinensis was isolated and identified, and a drug-sensitive test was conducted. Our findings contribute to the future diagnosis and treatment of the disease.
- | doxycycline / Generic mfg.
Journal: Travel Medicine: Special Issues. (Pubmed Central) - Sep 18, 2023
Some prescriptions (eg, doxycycline for prophylaxis against leptospirosis) depend on the planned activities while abroad...The US State Department's website has resources that Americans traveling abroad should be familiar with, including information about the laws and customs of the destination country. It is important that travelers investigate the different insurance options or coverages before a trip, in case emergencies arise.
- | Journal: Characteristics of Biofilm-Forming Ability and Antibiotic Resistance of Cutibacterium acnes and Staphylococcus epidermidis from Acne Vulgaris Patients. (Pubmed Central) - Sep 18, 2023
Furthermore, although statistically not significant, some resistances were observed against clindamycin, erythromycin, and azithromycin. Consequently, the use of these three antibiotics should be judiciously regulated.
- | vancomycin / Generic mfg., ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Journal: Borrelia burgdorferi-A Bacterium Worthy of Consideration in Culture-Negative Prosthetic Joint Infection. (Pubmed Central) - Sep 18, 2023
The patient was switched to doxycycline and ceftriaxone for a total duration of 4 weeks, followed by a successful second-stage revision and remains asymptomatic after 1 year. Five cases of culture-negative prosthetic joint infections caused by the spirochete, Borrelia burgdorferi, have been reported in the orthopaedic literature.1-4 We present a sixth case, occurring in a 68-year-old woman in Northwestern Pennsylvania, 8 years after a primary right total knee arthroplasty.
- || tetracycline / Generic mfg.
Retrospective data, Review, Journal: Prevalence of Brucella melitensis and Brucella abortus tetracyclines resistance: A systematic review and meta-analysis. (Pubmed Central) - Sep 18, 2023
The prevalence of tetracycline and doxycycline resistance in Brucella was low (1.7%) but increased over time. This increase in tetracycline and doxycycline resistance highlights the need for further research to understand resistance mechanisms and develop more effective treatments.
- UTILITY OF ATRIAL FIBRILLATION IN CULTURE-NEGATIVE ENDOCARDITIS (Convention Center Exhibit Hall) - Sep 15, 2023 - Abstract #CHEST2023CHEST_5851;
- | doxycycline / Generic mfg.
Journal: Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP. (Pubmed Central) - Sep 15, 2023
The emergent ramR mutations were similar to those seen in circulating strains of K. pneumoniae. These findings suggest that we need to assess the effect of doxycycline PEP on resistance induction on a broader range of bacterial species than has hitherto been the case.
- | tetracycline / Generic mfg.
Journal: An efficient deep eutectic magnetic nano gel for rapid ultrasound-assisted dispersive (Pubmed Central) - Sep 15, 2023
These findings suggest that we need to assess the effect of doxycycline PEP on resistance induction on a broader range of bacterial species than has hitherto been the case. Under obtained optimum conditions, the obtained linear ranges were 1.5-500 (
- | doxycycline / Generic mfg.
Journal: Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism. (Pubmed Central) - Sep 14, 2023
Functional studies of the SLC30A1 variant in a doxycycline-inducible adrenal cell system revealed pathological Na influx...This resulted in an increase in cytosolic Ca activity, which stimulated CYP11B2 mRNA expression and aldosterone production. Collectively, these data implicate zinc transporter alterations as a dominant driver of aldosterone excess in PA.
- | ambroxol oral / Generic mfg., doxycycline / Generic mfg.
Enrollment open: A Phase II pilot study to determine protocol feasibility, and potential efficacy for disease modification of combined Doxycycline and Ambroxol in Dementia with Lewy Bodies (EUDRACT) - Sep 13, 2023
P2, N=32, Recruiting, Sponsor: University of Sydney
Collectively, these data implicate zinc transporter alterations as a dominant driver of aldosterone excess in PA. Not yet recruiting --> Recruiting
- || ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Retrospective data, Review, Journal: Leptospirosis in India: a systematic review and meta-analysis of clinical profile, treatment and outcomes. (Pubmed Central) - Sep 13, 2023
Leptospirosis is associated with significant mortality in Indian settings. There is a need for studies focussing on treatment modalities.
- || doxycycline / Generic mfg.
Review, Journal: Lyme Disease and Post-treatment Lyme Disease Syndrome: Current and Developing Treatment Options. (Pubmed Central) - Sep 11, 2023
There is a need for studies focussing on treatment modalities. Searching on PubMed, Google Scholar, MEDLINE, and ScienceDirect
- | doxycycline / Generic mfg.
Journal: Effect of Scaling and Root Planing in Conjunction with Antimicrobial Therapy on Glycated Hemoglobin Levels in Type 2 Diabetes Mellitus Patients. (Pubmed Central) - Sep 11, 2023
Various studies have been showing the benefits of non-surgical periodontal therapy as a benefit for improving the overall glycemic status of the patient. Non-surgical mechanical periodontal therapy combined with systemic administration of antimicrobials such as doxycycline enhances the metabolic status of type 2 diabetes mellitus patients better than non-surgical mechanical periodontal therapy alone.
- | VS-4718 / Verastem
Journal: Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension. (Pubmed Central) - Sep 11, 2023
Non-surgical mechanical periodontal therapy combined with systemic administration of antimicrobials such as doxycycline enhances the metabolic status of type 2 diabetes mellitus patients better than non-surgical mechanical periodontal therapy alone. Increase in MMP-2 activity proteolyzes type I collagen in the aortas of 2K1C rats and contributes to activate FAK and induces VSMC proliferation during the initial phase of hypertension.
- | doxycycline / Generic mfg.
Journal: Influence of locally delivered doxycycline on the clinical and molecular inflammatory status of intrabony defects prior to periodontal regeneration: A double-blind randomized controlled trial. (Pubmed Central) - Sep 11, 2023
Increase in MMP-2 activity proteolyzes type I collagen in the aortas of 2K1C rats and contributes to activate FAK and induces VSMC proliferation during the initial phase of hypertension. Within the limitations of this study, sites treated with DOX showed improved clinical and molecular inflammatory parameters before surgery, as well as soft tissue healing 2?weeks after surgery.
- bortezomib / Generic mfg., melphalan / Generic mfg., doxycycline / Generic mfg.
Targeting DNMT3B impairs multiple myeloma cell proliferation and clonogenic capacity and enhances sensitivity to standard of care agents. (In Person) - Sep 10, 2023 - Abstract #IMW2023IMW_573;
Both the DNMT3B specific inhibitor Nanaomycin A (NA) and genetic knockdown using a doxycycline inducible shRNA against DNMT3B (shDNMT3B) were used to specifically target DNMT3B. Together, our findings provide for the first time evidence that DNMT3B could be a novel promising epigenetic target to overcome or delay relapse in MM.
- iberdomide (CC-220) / BMS
MAP4K2 inhibition reinforces sensitivity to iberdomide in RAS-mutated MM through a CRBN-independent mechanism (In Person) - Sep 10, 2023 - Abstract #IMW2023IMW_474;
Our findings demonstrate that MAP4K2 is a novel therapeutic target to bypass IMiDs resistance in RAS-mutated MM. Therefore, this approach will provide a strategy to manage relapsed or refractory patients with multi-drug resistance and RAS-mutated MM.
- inobrodib (CCS1477) / CellCentric
Transcriptional heterogeneity overcomes super-enhancer disrupting drug combinations in multiple myeloma (MM). (In Person) - Sep 10, 2023 - Abstract #IMW2023IMW_451;
P1/2
The overlap of P300 and IKZF1 binding sites provides a molecular explanation for the observed synergy between POM and EP300i. These data provide a strong preclinical rationale for the ongoing clinical trial of POM+CCS1477 (NCT04068597).
- | doxycycline / Generic mfg.
Journal: Case series of 12 Bartonella quintana endocarditis from the Southwest Indian Ocean. (Pubmed Central) - Sep 8, 2023
These data provide a strong preclinical rationale for the ongoing clinical trial of POM+CCS1477 (NCT04068597). Bartonella quintana is an important cause of infective endocarditis in the Comoros archipelago and should be suspected in patients with mitral valve dysfunction and BCN from this area.
- | Journal: Antibiotic sensitivity profile of bacterial isolates from stool samples among children below five years in Murang'a County, Kenya. (Pubmed Central) - Sep 7, 2023
Isolates were sporadically resistant to erythromycin, streptomycin, doxycycline, and ofloxacin. the high resistance rate of enteric Gram-negative bacterial pathogens in Murang
- | Journal: Distribution and antibiogram of Vibrio species from hospital wastewater in Southwest, Nigeria. (Pubmed Central) - Sep 7, 2023
The least resistance rate (17.4%) was observed against amikacin and cotrimoxazole...this study has shown that untreated hospital wastewater is a reservoir for diverse strains of multiply resistant Vibrio species. Therefore, it is essential to adequately treat hospital wastewater to eliminate these emerging pollutants and set up a monitoring scheme to evaluate the treatment plants' effectiveness to reduce the pollutants' impact on the environment and the population.
- | doxycycline / Generic mfg.
Journal: Antimicrobial resistance and molecular typing of Staphylococcus aureus isolates from raw milk in Hunan Province. (Pubmed Central) - Sep 7, 2023
The present findings indicate the need to increase production of the CP8 S. aureus vaccine in Hunan Province and strengthen resistance monitoring of t796-ST7 isolates with the prevalent molecular type of multi-drug resistant strains. The use of ?-lactam, macrolides, and lincosamides should be reduced; doxycycline, sulfonamides, and glycopeptides could be appropriately added to veterinary antibiotics to treat infectious diseases in dairy cows.
- | Enbrel (etanercept) / Pfizer, Amgen
Biomarker, Journal, IO biomarker: TNF-? induced extracellular release of keratinocyte high-mobility group box 1 in Stevens-Johnson syndrome/toxic epidermal necrolysis: Biomarker and putative mechanism of pathogenesis. (Pubmed Central) - Sep 7, 2023
HMGB1 release from TNF-? treated (
- In Vitro Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates 2012-2023, reference lab experience. (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3252;
- Zeven (dalbavancin) / RaQualia, AbbVie
Dalbavancin for challenging left ventricular assist device driveline infections (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3249;
- doxycycline / Generic mfg., azithromycin / Generic mfg.
Efficacy of Doxycycline Versus Azithromycin in Community Acquired Pneumonia (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3132;
- Antimicrobial Resistance Profile of Mycobacterium simiae and Treatment Trends from a Tertiary Care Center in Lebanon (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3125;
- Pancreatic Abscess in Disseminated Melioidosis (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2757;
- Granulomatous Mastitis: An Elusive Disease (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2743;
- Antibiotic Stewardship Practices in hospitalized patients with Dengue in South India (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2673;
- Missed Opportunities for Early Treatment and Prevention of Community Acquired Bacterial Meningitis (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2587;
- doxycycline / Generic mfg., azithromycin / Generic mfg., itraconazole / Generic mfg.
A Multicenter Open-Label Single-Arm Clinical Trial of Combination Therapy of Surgery, Itraconazole, Doxycycline, and Azithromycin for Vascular Pythiosis (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2575;
- Mycoplasma and Ureaplasma Septic Arthritis - A Diagnostic Challenge (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2516;
- Current Management of Osteoarticular Infections by Infectious Diseases Physicians: Results of an Emerging Infections Network (EIN) Survey (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2510;
- doxycycline / Generic mfg.
Efficacy of Doxycycline in Staphylococcal Prosthetic Joint Infection Treated with Debridement, Antibiotics and Implant Retention (DAIR) or Revision with Destination Spacer Placement (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2498;
- High Rates of Non-Susceptibility to Common Oral Antibiotics Among Streptococcus pneumoniae Clinical Isolates from the United States (2019-2021) (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2318;
- Impacts of an evidence-based, pre-populated order panel on antimicrobial prescribing trends in ambulatory patients with community-acquired pneumonia (204 AB) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2276;
- A previously healthy man with a five-day history of diffuse joint pain (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2232;
- A rare gram-negative skin soft tissue infection and bacterial meningitis: Case report of Chromobacterium violaceum (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2223;
- A rare gram-negative skin soft tissue infection and bacterial meningitis: Case report of Chromobacterium violaceum (Poster Hall B+C - Arena 4) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2218;
- Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes. (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_1991;
- Rickettsial Disease Outbreak in Northeastern Mexico: A 15-Month Epidemiological Analysis (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_1984;
- Distribution of Rickettsia species among hospitalized cases and ticks in Pavlodar region, Kazakhstan, 2019 (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_1980;