- |||||||||| Journal: Emergency department utilization in Veterans with spinal cord injuries & disorders. (Pubmed Central) - Sep 11, 2024
Overall, more than half of Veterans with SCI/D required an ED visit during the five-year study period and over one third of Veterans in each fiscal year required an ED visit. Interventions to target prevention of ED visits and subsequent hospitalizations could focus on these areas.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: A novel mouse model for hepatocyte-specific apoptosis-induced myeloid cell-dominant sterile liver injury and repair. (Pubmed Central) - Sep 11, 2024
After subcutaneous administration of a single dose of doxycycline (5 mg/kg, Dox) to 3xTg-iHAP mice, we observed a complete histological spectrum of sterile liver wound-healing responses: asymptomatic hepatocyte apoptosis at 8 h, necrotic liver injury and sterile inflammation at 48 h, followed by hepatocyte mitosis and regeneration within 7 days...Together, we established a novel mouse model of injury and regeneration induced by hepatocyte apoptosis. This tool provides a robust in vivo platform for studying the pathophysiology of sterile liver inflammation, regeneration, and new therapeutic interventions for liver diseases.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Journal: A case of Bartonella vinsonii endocarditis. (Pubmed Central) - Sep 11, 2024
Valuing the combination of multiple auxiliary diagnostic methods and improving the application of m-NGS in the detection of unknown pathogens can compensate for the current limitations in the diagnosis of Bartonella. Early diagnosis and treatment are extremely important for Bartonella endocarditis.
- |||||||||| cefepime hydrochloride / Generic mfg., vancomycin / Generic mfg., doxycycline / Generic mfg.
UNRAVELING THE ENIGMA: TRACING THE ORIGINS OF A LETHAL ENCOUNTER WITH STREPTOCOCCAL TOXIC SHOCK SYNDROME (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6998;
Vasopressors, broad spectrum antibiotics - Vancomycin, Cefepime, and Doxycycline were started. Our case report signifies the critical importance of swift and accurate diagnosis and treatment in optimizing outcomes for STSS patients, a task made more challenging by overlapping clinical presentations with severe pneumonia, pneumothorax and intra-abdominal pathology.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg., voriconazole / Generic mfg.
BRINGING IT BACK TO THE RESPIRATORY TRACT: A CASE OF DISSEMINATING ASPERGILLUS FUMIGATUS TO THE THORACIC SPINE AND LUNG (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6994;
One month before this hospitalization, she was diagnosed with vertebral osteomyelitis, treated with a prolonged course oral Doxycycline and Ciprofloxacin...She was ultimately discharged on a six-month course of Voriconazole for Pulmonary Aspergillosis complicated by superimposed bacterial pneumonia, and rib and vertebral osteomyelitis... This case demonstrates that IPA does not discriminate against immunocompetent hosts and that severe invasive infection can result even with intact host immune defense mechanisms.
- |||||||||| PLEURAL ACTINOMYCOSIS IN A YOUNG WOMAN PRESENTING AS CULTURE NEGATIVE MULTILOCULATED PLEURAL EFFUSION: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6590;
Pleural actinomycosis is an insidious onset illness that can be culture negative and present subtly with anorexia, mimicking malignancies and tuberculosis. A strong suspicion for actinomycosis must be maintained for chronic unexplained pleural effusions and pulmonary consolidations, and treatment with penicillin begun while awaiting cultures and pathology.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg., atovaquone / Generic mfg.
STEALTHY INVADERS: UNMASKING HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN LYME AND BABESIOSIS COINFECTION (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6575;
Our case uniquely demonstrates HLH triggered by Lyme and babesiosis coinfection despite a low babesiosis parasitemia burden. This emphasizes the need for vigilance for HLH beyond established severity criteria in tick-borne illness, potentially allowing earlier intervention and improved outcomes.
- |||||||||| THE MYSTERIOUS VISITOR: A CHILLING ENCOUNTER WITH ELIZABETHKINGIA MIRICOLA (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6435;
She received ampicillin-sulbactam for aspiration pneumonia, zoledronic acid for hypercalcemia, and promethazine/diphenhydramine for nausea...Levetiracetam was administered, and she was intubated for airway protection. Midazolam and propofol were started for analgosedation and she was transferred to our hospital for continuous electroencephalogram (EEG).Objective data at our facility: hypernatremia (146 mmol/L), normal anion gap acidosis (bicarbonate: 15 mmol/L, chloride: 120 mmol/L), severe hypocalcemia (6 mg/dL), normocytic anemia (hemoglobin: 8.9 g/dL), elevated lipase (239 U/L), and AKI (creatinine: 1.64 mg/dL)...leading to initiation of vancomycin, piperacillin-tazobactam and doxycycline...Susceptibility testing indicated resistance to piperacillin-tazobactam, tetracycline, cefepime, and sensitivity to ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole...Some research studies demonstrate resistance to beta lactam, monobactam, vancomycin, carbapenems, and aminoglycosides, with variable susceptibility to minocycline, trimethoprim-sulfmethoxazole, piperacillin-tazobactam and levofloxacin [10
- |||||||||| A CASE OF VIBRYO VULNIFICUS SEPTIC SHOCK IN LANDLOCKED NORTH GEORGIA (Convention Center Exhibit Hall: Rapid Fire Area 2A) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6391;
This case underscores the importance of maintaining a high index of suspicion for Vibrio vulnificus infection, particularly in patients with a history of seawater exposure or consumption of raw seafood. Prompt recognition and aggressive management are essential to mitigate morbidity and mortality.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
BREATHING NEW LIFE INTO RARE LUNG INFECTIONS: A SHIMOIDEI SAGA (Convention Center Exhibit Hall: Poster Area 1) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6305;
This case summarizes and adds to the literary evidence of responsible pathogens present within the scope of NTM. It is the hope that the body of evidence continues to grow in efforts to help clinicians and patients alike navigate this disease process.
- |||||||||| PROGRESSIVE PNEUMONIA IN A PATIENT WITH RENAL TRANSPLANT HISTORY (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6029;
She was empirically treated with doxycycline and augmentin, which did not improve her symptoms...Due to concern for cocci, she was empirically started on fluconazole by outpatient Pulmonary Medicine...Despite antibiotic coverage with zosyn and vancomycin, she continued to worsen...Susceptibilities demonstrated resistance to amikacin, tobramycin, trimethropin-sulfamethoxazole, and imipenem... Diagnosing Nocardia early can make the difference in preventing a fatal outcome.
- |||||||||| cefepime hydrochloride / Generic mfg., vancomycin / Generic mfg., doxycycline / Generic mfg.
AN ALMOST FATAL HIKE: SEPTIC SHOCK SECONDARY TO EHRLICHIA CHAFFEENSIS IN AN IMMUNOCOMPETENT HOST (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_5902;
Clinicians should have a heightened sense of suspicion for ehrlichioses in septic patients who have a history of outdoor exposures and laboratory evidence of leukopenia, thrombocytopenia, and elevated aminotransferase levels. Prompt initiation of doxycycline is crucial in these cases.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: An updated molecular diagnostic for surveillance of tetM in Neisseria gonorrhoeae. (Pubmed Central) - Sep 10, 2024
As doxy-PEP is incorporated into clinical practice, an urgent unanswered question is whether increased doxycycline use will drive tetracycline-class resistance in Neisseria gonorrhoeae . Here, we report an updated RT-PCR molecular diagnostic to detect the tetM gene that confers high-level tetracycline resistance in N. gonorrhoeae .
- |||||||||| Journal: A quantitative approach to measure and predict microbiome response to antibiotics. (Pubmed Central) - Sep 4, 2024
Here, we present a novel method to quantify and predict antibiotic-specific microbiome changes, implemented in a ready-to-use software package. This has the potential to be a critical tool to broaden our understanding of the relationship between the microbiome and antibiotics.
- |||||||||| Nuzyra (omadacycline) / Paratek
Journal: High Rates of Nonsusceptibility to Common Oral Antibiotics in Streptococcus pneumoniae Clinical Isolates From the United States (2019-2021). (Pubmed Central) - Sep 4, 2024
Streptococcus pneumoniae isolates from the United States (n = 1038; 2019-2021) were susceptible to omadacycline (99.8%), levofloxacin (99.7%), and ceftriaxone (98.1%), whereas doxycycline (80.2%), oral penicillin (63.5%), cefpodoxime (76.8%), and azithromycin (54.4%) activity was limited. Tet(M) did not affect omadacycline activity but altered activity of older tetracyclines including doxycycline, suggesting omadacycline is an important option for treatment of community-acquired bacterial pneumonia.
- |||||||||| tetracycline / Generic mfg.
Journal: Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxy-PEP-Eligible Population. (Pubmed Central) - Sep 4, 2024
In Staphylococcus aureus infections in men eligible for doxycycline post-exposure prophylaxis (doxy-PEP), tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for S. aureus multi-drug resistance, underscoring the importance of surveillance.
- |||||||||| Nuzyra (omadacycline) / Paratek
Preclinical, Journal: Omadacycline is active in vitro and in vivo against ciprofloxacin-resistant Bacillus anthracis. (Pubmed Central) - Sep 4, 2024
Omadacycline treatment significantly increased survival compared with the vehicle control group and the ciprofloxacin treatment group. As antibiotic resistance rates continue to rise worldwide, omadacycline may offer an alternative PEP or treatment option against inhalation anthrax, including anthrax caused by antibiotic-resistant B. anthracis.
- |||||||||| ceftriaxone / Generic mfg.
Preclinical, Journal: Assessing novel partner antimicrobials to protect ceftriaxone against gonococcal resistance: An in vitro evaluation. (Pubmed Central) - Sep 3, 2024
As antibiotic resistance rates continue to rise worldwide, omadacycline may offer an alternative PEP or treatment option against inhalation anthrax, including anthrax caused by antibiotic-resistant B. anthracis. The low MICs of zoliflodacin and pristinamycin for the three ceftriaxone-resistant strains suggest that these antimicrobials could be used as partner drugs with ceftriaxone to reduce the probability of ceftriaxone resistance spreading in areas with a high prevalence of ceftriaxone resistance.
- |||||||||| doxycycline / Generic mfg.
Journal: Unusual case of prurigo pigmentosa on the upper extremities in an adolescent female: A rare presentation. (Pubmed Central) - Sep 3, 2024
The low MICs of zoliflodacin and pristinamycin for the three ceftriaxone-resistant strains suggest that these antimicrobials could be used as partner drugs with ceftriaxone to reduce the probability of ceftriaxone resistance spreading in areas with a high prevalence of ceftriaxone resistance. Treatment with oral doxycycline and discontinuation of the ketogenic diet
- |||||||||| Avastin (bevacizumab) / Roche
Journal: Sea-fan retinal neovascularization associated with rickettsial retinitis: a case report. (Pubmed Central) - Sep 2, 2024
Multimodal imaging including OCT, fluorescein angiography, and OCT-angiography, is highly useful for accurate diagnosis and reliable monitoring of the evolution of retinitis, retinal neovascularization, and other retinal changes. The use of a combination therapy with oral doxycycline and corticosteroids and intravitreal anti-VEGF can improve outcomes.
- |||||||||| doxycycline / Generic mfg.
Journal: Forget me not: The effect of doxycycline on human declarative memory. (Pubmed Central) - Sep 2, 2024
These results suggest that doxycycline can improve declarative learning and memory without having long term negative effects on other cognitive domains in healthy humans. Our results give hope to further investigate doxycycline in neuroprotective treatment applications.
- |||||||||| doxycycline / Generic mfg.
Journal: Infected Emphysematous Bullae of the Lung: A Diagnostic Challenge. (Pubmed Central) - Sep 1, 2024
This case underscores the importance of considering environmental factors and multidisciplinary collaboration in managing complex respiratory conditions. Further research is warranted to elucidate optimal management strategies for infected emphysematous bullae of the lung.
- |||||||||| Journal: Detection of Pharmaceutical Contamination in Amphipods of Lake Baikal by the HPLC-MS Method. (Pubmed Central) - Aug 31, 2024
Using the multiple reaction monitoring (MRM) mode mentioned in GOST International Technical Standards, we detected molecules, fragmented as amikacin, chlortetracycline, doxycycline, oxytetracycline, dimetridazole, metronidazole and spiramycin. Thus, we first revealed that invertebrates of Lake Baikal can uptake pharmaceutical contaminants in the environment.
- |||||||||| doxycycline / Generic mfg.
Journal: Antimicrobial and Hemostatic Diatom Biosilica Composite Sponge. (Pubmed Central) - Aug 31, 2024
The gelatin-based diatom biosilica composite with antibiotics had the ability to prevent bleeding and release the antibiotic over a longer time compared to gelatin sponge. These properties indicate its potential as a highly promising medical device for facilitating rapid healing following tooth extraction.
- |||||||||| doxycycline / Generic mfg.
Journal: Identification of Aeromonas veronii as the Pathogen Associated with Massive Mortality in Bronze Gudgeon (Coreius heterodon). (Pubmed Central) - Aug 31, 2024
WH10 was shown to be sensitive to compound sulfamethoxazoles, cefothiophene, doxycycline, and sulfamethoxazole...The reverse was noted for alkaline phosphatase, total protein, albumin, total cholesterol, and glucose. Thus, Aeromonas veronii is implicated as the causative agent of the mass mortality observed in bronze gudgeon, warranting further investigations into the diagnosis, epidemiology, prevention, and treatment of this infectious disease.
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