- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline postexposure prophylaxis for prevention of sexually transmitted infections. (Pubmed Central) - Jan 14, 2024 Even so, much remains unknown about the long-term consequences of doxy-PEP, and several concerns, including the potential for the development of antibiotic resistance and disturbances to the microbiome, balance the benefits. This review highlights the history of antibiotic prophylaxis for sexually transmitted infections, and the rationale, current evidence, and future directions for doxy-PEP.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Homophobia in the provision of sexual health care in the UK. (Pubmed Central) - Jan 14, 2024 We consider national decisions made in the UK related to sexually transmitted infection prevention in gay, bisexual, and other men who have sex with men (GBMSM), with three specific examples-HIV pre-exposure prophylaxis, mpox (formerly known as monkeypox) vaccination, and doxycycline prophylaxis...GBMSM have been affected disproportionately by HIV, mpox, and bacterial sexually transmitted infections, and there is an ongoing unmet need for effective prevention. Denying access to public health interventions that meet these needs is unethical.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
Review, Journal: Brucella epididymo-orchitis: A single-center experience with a review of the literature. (Pubmed Central) - Jan 13, 2024 In the Middle East, brucellosis remains a concerning infectious disease. Early diagnosis, aimed at preventing abscess formation and other complications, takes first priority to avoid invasive interventions.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses. (Pubmed Central) - Jan 11, 2024 Suppressing this expression with doxycycline following an initial period of viral replication reduces toxicity to postsynaptic cells...Ex vivo whole-cell recordings at 5?weeks postinfection showed that the second-generation system perturbs input and source cells much less than the first-generation system. Finally, two-photon calcium imaging of labeled networks of visual cortex neurons showed that their visual response properties appeared normal for 10?weeks, the longest we followed them.
- |||||||||| doxycycline / Generic mfg.
Journal: CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy. (Pubmed Central) - Jan 10, 2024 Finally, two-photon calcium imaging of labeled networks of visual cortex neurons showed that their visual response properties appeared normal for 10?weeks, the longest we followed them. Our findings clarified the pivotal roles of the CRIP1/USP7/PA200 complex in ubiquitin-dependent proteasome degradation and autophagy maturation involved in the pathogenesis of MM.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg., minocycline / Generic mfg.
Review, Journal: 2023 Korean sexually transmitted infections treatment guidelines for Mycoplasma genitalium by KAUTII. (Pubmed Central) - Jan 10, 2024 In the Korean STIs guideline 2023, macrolide resistance-guided antimicrobial therapy was emphasized due to the increased prevalence of macrolide resistance worldwide. Therefore, in case of treatment failure or recurrence, a macrolide susceptibility/resistance test is required.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
Review, Journal: 2023 Korean Association of Urogenital Tract Infection and Inflammation guidelines for gonococcal infection. (Pubmed Central) - Jan 10, 2024 Doxycycline (100 mg twice daily for 7 days) is added if there is a possibility of co-infection with chlamydia...Patients with gonorrhea should have repeated examinations within three months at the exposure site because of a high risk of re-infection. A person diagnosed with gonorrhea should discuss the nature of the infection, the importance of informing partners, when sexual activity can resume, and how to reduce the risk of sexually transmitted infections.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model. (Pubmed Central) - Jan 9, 2024 A person diagnosed with gonorrhea should discuss the nature of the infection, the importance of informing partners, when sexual activity can resume, and how to reduce the risk of sexually transmitted infections. We conclude that DOX protects the liver and kidney against injury and dysfunction in a HS model and could be a strategy to reduce organ damage associated with ischemia-and-reperfusion injury.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response. (Pubmed Central) - Jan 9, 2024 Despite the change in microbiome composition, doxycycline treatment had minimal effect on basal transcriptional signatures of inflammation the brain or on the neuroimmune response to LPS challenge. Our findings suggest that central neuroimmune responses may be less affected by doxycycline at doses needed for transgene control than by antibiotic cocktails at doses used for experimental microbiome disruption.
- |||||||||| doxycycline / Generic mfg.
Journal: Achaete-scute family bHLH transcription factor 2 activation promotes hepatoblastoma progression. (Pubmed Central) - Jan 6, 2024 ASCL2 expression was induced in HepG2 cells using the Tet-On 3G system, which includes doxycycline...ASCL2 promoted the formation of malignant phenotypes in HepG2 cells, which may be correlated with the upregulation of the Wnt signaling pathway-, EMT-, and stemness-related genes. ASCL2 activation may therefore be involved in the progression of HB.
- |||||||||| Synflorix (10-valent pneumococcal conjugate vaccine) / GSK, Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India
THE IMPACT OF PCV10 ON PNEUMOCOCCAL POPULATION STRUCTURE IN KILIFI, KENYA: A WHOLE GENOME SEQUENCING ANALYSIS (Ballroom East) - Jan 4, 2024 - Abstract #ISPPD2024ISPPD_78; Conclusions Serotypes and GPSCs expansion after PCV10 introduction a potential concern as it poses a challenge to effective control of invasive pneumococcal transmission. Monitoring for vaccine uptake and an in-depth genomic analysis of these isolates would provide further insights.
- |||||||||| doxycycline / Generic mfg.
Journal: Acute myeloid leukemia with neutrophilic differentiation in a 12-year-old African lion (Panthera leo). (Pubmed Central) - Jan 4, 2024 AML is a rare, aggressive hematopoietic disorder in domestic cats, although it has not yet been reported in nondomestic cats. This is the first description of the clinicopathological, histological, and immunohistochemical features of AML with neutrophilic differentiation in an FeLV-negative African lion that lacked circulating blasts.
- |||||||||| doxycycline / Generic mfg.
Journal: The effect of doxycycline on canine neutrophil functions. (Pubmed Central) - Jan 3, 2024 In summary, doxycycline showed a concentration-dependent immunomodulatory property in canine PMNs with a reduced ROS production and increased NET-induction. This immunomodulatory effect resulted in a slightly increased elimination of a doxycycline-resistant Staphylococcus aureus by the doxycycline plasma concentrations achieved in dogs.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
DoxyPEP: Should We Worry About Antimicrobial Resistance? () - Jan 2, 2024 - Abstract #CROI2024CROI_64; In the field of STI prevention using doxycycline on-demand post-exposure prophylaxis (PEPdoxy), we are witnessing significant advances...However, efficacy against Neisseria gonorrhoeae (GC) varies according to tetracycline resistance rates within populations, with Europe showing higher resistance rates than the US...This presentation will give an overview of the available data on the impact of doxy-PEP strategies on the microbiota and the molecular mechanism conferring resistance. These studies on the microbiome and antimicrobial resistance surveillance for bacterial STIs should be continued over time to fully assess the impact of this strategy.
- |||||||||| doxycycline / Generic mfg.
Introduction to DoxyPEP: Understanding the Issues () - Jan 2, 2024 - Abstract #CROI2024CROI_63; Recent trials demonstrate that doxycycline post-exposure prophylaxis (doxy-PEP) significantly reduces the risk of chlamydia, syphilis, and gonorrhea in cisgender men and transgender women who have sex with men...Despite its potential benefits for STI risk reduction in some populations, several potential implications of doxy-PEP in the near and longer term merit consideration. This presentation will review current evidence to frame the knowns and unknowns about doxy-PEP, highlight the range of doxy-PEP guidance and position statements, discuss the basis for concerns about antimicrobial resistance, and introduce future considerations for implementation to maximize benefit and minimize harms related to doxy-PEP use.
- |||||||||| Journal: Vibrio species: development of EUCAST susceptibility testing methods and MIC and zone diameter distributions on which to determine clinical breakpoints. (Pubmed Central) - Jan 2, 2024
This presentation will review current evidence to frame the knowns and unknowns about doxy-PEP, highlight the range of doxy-PEP guidance and position statements, discuss the basis for concerns about antimicrobial resistance, and introduce future considerations for implementation to maximize benefit and minimize harms related to doxy-PEP use. We demonstrated the validity of using standard BMD and EUCAST disc diffusion methodology for AST of five Vibrio spp., and generated suitable data to allow EUCAST to determine clinical MIC and zone diameter breakpoints for five pathogenic Vibrio spp., including both non-toxigenic and toxigenic V. cholerae.
- |||||||||| clindamycin phosphate / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
Preclinical, Journal: In vitro activity of clindamycin, doxycycline, and trimethoprim/sulfamethoxazole against clinical isolates of ?-hemolytic Streptococcus spp. via BD Phoenix and broth microdilution. (Pubmed Central) - Dec 29, 2023 Susceptibility rates via BMD for TMP/SMX, clindamycin, and doxycycline were 100%, 85.5%, and 56.6%, respectively. TMP/SMX is a potential monotherapy agent for ?-hemolytic Streptococcus skin and soft tissue infections.
- |||||||||| Journal: Isolation and identification of antimicrobial susceptibility, biofilm formation, efflux pump activity, and virulence determinants in multi-drug resistant Pseudomonas aeruginosa isolated from freshwater fishes. (Pubmed Central) - Dec 28, 2023
Virulent genes oprL, toxA, exoS, and phzM were detected in 68.5, 68.5, 100, and 17.1% of isolates, respectively. The data suggested that P. aeruginosa harbours multiple resistance mechanisms and virulence factors that may contribute to antibiotic resistance and pathogenicity, and their distribution in fish culture facilities highlights the public health hazards of the food chain.
- |||||||||| Cubicin (daptomycin) / Merck (MSD), Zeven (dalbavancin) / RaQualia, AbbVie
Journal: Is Corynebacterium striatum an emerging prosthetic joint infection pathogen and how should it be treated? (Pubmed Central) - Dec 25, 2023 It is important for clinicians to be cognizant that this pathogen can have inducible high level daptomycin resistance and that daptomycin is likely not a reliable antibiotic for these infections. While vancomycin and linezolid are the traditional antibiotics to use in these infections, other antibiotics such as dalbavancin, may also have utility, but more research is needed to determine the effectiveness of this antibiotic in C. striatum infections.
- |||||||||| Avastin (bevacizumab) / Roche
Retrospective data, Review, Journal: Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis. (Pubmed Central) - Dec 25, 2023 Propranolol, timolol, tranexamic acid, tamoxifen, and estriol were effective treatments which offered benefits to HHT patients in epistaxis management. Adverse events of tranexamic acid, tacrolimus, propranolol, and estradiol should be concerned.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: STI pathogens in the oropharynx: update on screening and treatment. (Pubmed Central) - Dec 23, 2023 The transmission of gonorrhoea and chlamydia is still not fully understood. Further work will be required to evaluate the benefits and harms of reducing screening in high-prevalence populations.
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