- |||||||||| doxycycline / generics, paclitaxel / generics, gemcitabine / generics
Preclinical, Journal: Establishment and Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to Gemcitabine. (Pubmed Central) - Apr 15, 2019
Next, based on a comparison between qRT-PCR and microarray data, a list of up-regulated genes in MT-CHC01R1.5 was selected and further confirmed in a primary cell culture obtained from an ICC patient resistant to GEM. In conclusion, we characterized a new GEM resistance ICC model that could be exploited either to study alternative mechanisms of resistance or to explore new therapies.
- |||||||||| doxycycline / generics
Journal: Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques. (Pubmed Central) - Apr 14, 2019
...We investigated the pathology associated with late disseminated Lyme disease (12 to 13 months after tick inoculation) in doxycycline-treated (28 days; 5 mg/kg, oral, twice daily) and untreated rhesus macaques...Borrelia antigen staining of probable spirochete cross-sections was also observed in heart, skeletal muscle, and near peripheral nerves of both treated and untreated animals. These findings support the notion that chronic Lyme disease symptoms can be attributable to residual inflammation in and around tissues that harbor a low burden of persistent host-adapted spirochetes and/or residual antigen.
- |||||||||| doxycycline / generics
Clinical, Review, Journal: How safe is doxycycline for young children or for pregnant or breastfeeding women? (Pubmed Central) - Apr 14, 2019
Review of the available data, however, suggests that this interpretation may be incorrect or at least premature. In conclusion, until more definitive data are developed, doxycycline should continue to be only selectively prescribed for young children and pregnant or breastfeeding women for whom alternative, safer antibiotics are not available, and courses of treatment should be of as short a duration as possible.
- |||||||||| ciprofloxacin / generics, doxycycline / generics
Journal: Enteropathogens and antibiotics (Pubmed Central) - Apr 11, 2019
The susceptibility pattern of the different bacteria determines the choice of the most appropriate treatment. The aim of this review is to analyse the current situation, developments, and evolution of resistance and multidrug resistance in these 4 enteric pathogens.
- |||||||||| Flagyl (metronidazole) / SLA
Journal: Papulopustular Rosacea: Response to Treatment with Oral Azithromycin. (Pubmed Central) - Apr 11, 2019
The aim of this review is to analyse the current situation, developments, and evolution of resistance and multidrug resistance in these 4 enteric pathogens. The findings of this pilot study suggest that oral azithromycin could be a very effective short-term and long-term treatment for RPP resistant to conventional treatment.
- |||||||||| doxycycline / generics
Clinical, Review, Journal: Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women. (Pubmed Central) - Apr 11, 2019
It is also important that future RCTs include adherence, CT resistance to antibiotic regimens, and risk of reinfection as outcomes to be measured. In addition, it is important to conduct a network meta-analysis in order to evaluate all those studies that included in one arm only the current antibiotic treatments for CT infection that are recommended by the updated clinical practice guidelines.
- |||||||||| doxycycline / generics
Journal: Alternative treatment strategies to accelerate the elimination of onchocerciasis. (Pubmed Central) - Apr 11, 2019
The choice of the ATS depends on the prevalences and intensities of infection with Onchocerca volvulus and Loa loa and on the relative cost-effectiveness of the strategies for the given epidemiological situation. Modelling can help select the optimal strategies, but field evaluations to determine the relative cost-effectiveness are urgently needed.
- |||||||||| doxycycline / generics, amoxicillin / generics
Clinical, Journal: Prevalence of Bordetella pertussis infection in children with chronic cough and its clinical features (Pubmed Central) - Apr 11, 2019
The presence of Bordetella pertussis infection in children with chronic cough should be taken seriously by clinicians, and children with chronic cough and Bordetella pertussis infection may not have the typical symptoms of pertussis and are mainly manifested as chronic cough. Amoxicillin may be an alternative drug for macrolide-resistant Bordetella pertussis infection.
- |||||||||| doxycycline / generics
Journal: The role of DOCK10 in the regulation of the transcriptome and aging. (Pubmed Central) - Apr 10, 2019
...To investigate whether DOCK10 is involved in regulation of the transcriptome, changes in the gene expression profiles (GEPs) were studied by microarray in three cellular models: DOCK10 expression induced by doxycycline (dox) withdrawal in a stable inducible HeLa clone, DOCK10 expression induced by transient transfection of 293T cells, and wild type (WT) versus KO mouse spleen B cells (SBC)...These results indicate a role for Dock10 in senescence. These novel roles of DOCK10 in the regulation of the transcriptome and aging deserve further exploration.
- |||||||||| doxycycline / generics
Journal: Simplified inducible system for Trypanosoma brucei. (Pubmed Central) - Apr 9, 2019
Furthermore we have adapted the pTbFIX plasmid to perform RNAi experimentation. Lethal phenotypes, including α-tubulin and those corresponding to the enolase and clathrin heavy chain genes, were successfully recapitulated in procyclic and bloodstream parasites thus showing the versatility of this new tool.
- |||||||||| doxycycline / generics, meropenem / generics
Journal: Melioidosis: misdiagnosed in Nepal. (Pubmed Central) - Apr 9, 2019
In addition, the microbiologist should be trained to correctly identify B. pseudomallei as it is often confused for other Burkholderia species. The organism responds only to specific antibiotics; therefore, correct and timely diagnosis becomes crucial for better outcomes.
- |||||||||| doxycycline / generics
Journal: Antioxidant and immune-enhancing effects of probiotic Lactobacillus plantarum 200655 isolated from kimchi. (Pubmed Central) - Apr 9, 2019
...plantarum 200655 did not produce β-glucuronidase and was sensitive to ampicillin, tetracycline, chloramphenicol, and doxycycline...RAW 264.7 cells treated with L. plantarum 200655 produced more nitric oxide, induced nitric oxide synthase, and cytokine related to immune-enhancing effects such as interleukin-1β and interleukin-6. Therefore, L. plantarum 200655 could be useful as a probiotic strain for older people.
- |||||||||| doxycycline / generics
Journal: Successful treatment of Ureaplasma-induced hyperammonemia syndrome post-lung transplant. (Pubmed Central) - Apr 7, 2019
...This case report describes an individual post-lung transplant, treated emperically with doxycycline along with other measures to lower ammonia levels, at the time hyperammonemia with encephalopathy was recognized...Ureaplasma species were subsequently identified using 16S ribosomal RNA gene PCR/sequencing of pleural fluid, and by culture of bronchoalveolar (BAL) fluid. This case provides further support for empiric treatment of Ureaplasma species upon recognition of hyperammonemia syndrome post-lung transplant.
- |||||||||| doxycycline / generics
Journal: Chlamydia ascites: a call for sexually transmitted infection testing. (Pubmed Central) - Apr 7, 2019
Doxycycline was prescribed for a diagnosis of pelvic inflammatory disease exudative ascites. Since discharge, she has completed her antibiotic course and reports resolution of all symptoms without recurrence of ascites.
- |||||||||| doxycycline / generics
Journal: Haemoplasmosis in cats: European guidelines from the ABCD on prevention and management. (Pubmed Central) - Apr 5, 2019
Treatment with doxycycline for 2-4 weeks is usually effective for M haemofelis-associated clinical disease (but this may not clear infection). Little information is currently available on the antibiotic responsiveness of ' Candidatus M haemominutum' and ' Candidatus M turicensis'.
- |||||||||| doxycycline / generics
Journal: Silencing of cyt-c4 led to decrease of biofilm formation in Aeromonas hydrophila. (Pubmed Central) - Apr 5, 2019
Silencing cyt-c4 led to deficiencies in biofilm formation, adhesion, drug resistance and pathogenicity of A. hydrophila, which suggests that cyt-c4 plays crucial role in the biofilm formation and virulence mechanisms of A. hydrophila. GEN: gentamycin; SDZ: sulfadiazine; AK: amikacin; P: penicillin; CFP: cefoperazone; LEV: levofloxacin; MH: minocycline; FFC: florfenicol; TE: tetracycline; AMP: ampicillin; KAN: kanamycin; STR: streptomycin; SXT: sulfamethoxazole/trimethoprim; DO: doxycycline; OT: Oxytetracycline.
- |||||||||| doxycycline / generics
Journal: Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance. (Pubmed Central) - Apr 5, 2019
...In order to study regulatory functions of Hsp90 in C. auris, we placed HSP90 under the control of a doxycycline-repressible promoter to enable transcriptional repression...Finally, we discovered that C. auris transitions from yeast to filamentous growth in response to Hsp90 inhibition, accompanied by global transcriptional remodeling. Overall, this work provides a novel insight into mechanisms regulating azole resistance in C. auris and uncovers a distinct developmental program regulated by Hsp90.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, cefuroxime / Generic mfg.
Isothermal microcalorimetry is highly applicable for real-time detection of Staphylococcus aureus biofilm tolerance or resistance towards antibiotics (HALL I) - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_4230;
Using this system, the sensitivity of 5 methicillin-sensitive S. aureus (MSSA) and 5 methicillin-resistant S. aureus (MRSA) strains was determined towards: flucloxacillin, cefuroxime, cefotaxime, gentamycin, clindamycin, erythromycin, rifampicin, vancomycin, linezolid, levofloxacin, fusidic acid, co-trimoxazole, and doxycycline. Microcalorimetry allows monitoring the development of tolerance or resistance of S. aureus biofilms toward antibiotics in a fast and reliable way.
- |||||||||| doxycycline / Generic mfg., Pierre Fabre
A retrospective study of British military Q fever cases from Helmand, Afghanistan in 2008-2015 (Arena 2) - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3933;
Doxycycline 200mg daily for 2 weeks was given to 70 cases (81%) and the median time from onset of symptoms to receiving doxycycline was 5.5 days (range 0-324 days)... Smoking may be a risk factor for developing acute Q fever (which has been described previously) and delayed empirical antibiotic treatment may be a risk factor for QFS.
- |||||||||| doxycycline / Generic mfg., Pierre Fabre
Unexpected incidence of anaplasmosis in returning travelers with fever (HALL K) - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3659;
Among tick-borne pathogens, Anaplasma spp may be underreported and should be included in the differential diagnosis of returning travelers with undifferentiated fever. Doxycycline might be considered as empirical treatment of patients with undifferentiated non-malarial fever.
- |||||||||| ciprofloxacin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, amoxicillin / Generic mfg.
Impact of antibiotic treatment guidelines on prescribing in primary care clinics in Yangon, Myanmar () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3347;
The largest reduction in DDDs is likely to be attributable to reduced course length, particularly for respiratory tract infections, in keeping with the guideline. Introduction of antibiotic guidelines in primary care settings in low and middle-income countries can reduce the volume of antibiotics prescribed with potential secondary impacts to reduce the risk of developing antimicrobial resistance and reduce costs.
- |||||||||| ciprofloxacin / Generic mfg., fluconazole / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
Genital tract infections in reproductive age women of a psychiatric hospital () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3245;
Doxycycline suggests a better therapeutic option for the treatment of these genital tract infections. Relevant experience on that field of research dictates sensitivity testing as an important factor for a successful therapy.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, amoxicillin / Generic mfg.
Review on national treatment guidelines for sexually-transmitted infections in the western Pacific region () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3207;
However, continued efforts are needed to adopt optimal regimens based on the updated resistance data particularly for gonorrhea by strengthening of the existing surveillance system. Stable supply and procurement of BPG and an effective alternative regimen for syphilis in people with penicillin allergy and pregnant women are also needed.
- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
Brucella spondylodiscitis: risk factors of neurologically-complicated forms () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_3192;
Neurological complications in BSPD are frequent, causing therapeutic difficulties and high rate of sequelae. The most important determinant of prognosis are early diagnosis and timely treatment.
- |||||||||| ciprofloxacin / Generic mfg., doxycycline / Generic mfg., Pierre Fabre, Garamycin (gentamicin sulfate) / Generic mfg.
Can antimicrobial peptides influence bacteria's resistance profile? A pilot study with enterococci obtained from dogs with periodontal disease () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_2616;
Results show the importance of MPC and MSW determinations to guarantee an antimutant dosing strategy, allowing to establish accurate treatment protocols based on appropriate antimicrobial doses. To our knowledge, this is the first report of nisin’s MPC and MSW determination regarding canine enterococci, being a relevant step in the R&D of new antimicrobial compounds, both in human and veterinary medicine.
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