- |||||||||| doxycycline / Generic mfg.
Nephrotic Syndrome and Hepatitis in Secondary Syphilis () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_681;
NS and SH can co-occur in setting of SS. A test of treatment approach can be considered even in the setting of PCN allergy in patients with stable renal function.
- |||||||||| Weil's Disease in Rochester: A Case Report () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_661;
High degree of suspicion in patients with known risk factors is crucial for diagnosis. This highlights the importance of obtaining a comprehensive medical history, including social aspects, and consulting other relevant services when a clinical diagnosis proves elusive.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg.
A Rash Revealing the Etiology of Hyponatremia () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_513;
Atypical presentations demand consideration, as in this SIADH case with Lyme neuroborreliosis. Even symptoms seemingly unrelated to hyponatremia, like rashes or constipation, may offer crucial diagnostic threads, underscoring the significance of comprehensive evaluation in such cases.
- |||||||||| tetracycline / Generic mfg.
Journal: Investigating the cause of increased tetracycline-resistant Neisseria gonorrhoeae in England, 2016-20. (Pubmed Central) - Mar 22, 2024
Even symptoms seemingly unrelated to hyponatremia, like rashes or constipation, may offer crucial diagnostic threads, underscoring the significance of comprehensive evaluation in such cases. Frequent screening of GBMSM at higher risk of STIs, such as those on pre-exposure prophylaxis (PrEP) leading to/and increased use of doxycycline for the treatment of diagnosed infections, may account for the increase in TetR in N. gonorrhoeae.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline-Induced Intracranial Hypertension Presenting as Unilateral Pulsatile Tinnitus. (Pubmed Central) - Mar 22, 2024
Shortly after transitioning to oral doxycycline and erythromycin eye ointment, she noted left-sided PT...Clinicians should maintain a high index of suspicion for all types of intracranial hypertension (idiopathic and secondary), even in patients with a lower BMI. Current and prior medications should be reviewed when considering the etiology of intracranial hypertension.
- |||||||||| Trikafta (elexacaftor/tezacaftor/ivacaftor) / Vertex
Life threatening infection with a highly resistant Achromobacter xylosoxidans strain (Exhibition and Poster Area) - Mar 22, 2024 - Abstract #ECFS2024ECFS_443;
In addition to oseltamivir i.v. therapy with Pip/Taz and Tobramycin was started...In this regard doxycycline (18 days iv, 21 days oral) was added...Moreover on day 20 under mero/col/doxy we started Trikafta off label which was well tolerated. Life threatening pulmonary infection with highly resistant A. xylosoxidans species in CF can be successfully treated with meropenem and colistin i.v. This case shows that the synergistic and bactericidal effect in vitro was essential in vivo as well.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: Improvement of Clinical Findings, Meibography and Tear Film Parameters in Pediatric Ocular Rosacea Patients After a Standard Treatment Protocol. (Pubmed Central) - Mar 21, 2024
The standard treatment protocol involved warm compresses, eyelid hygiene, preservative-free sodium hyaluronate eye drops (administered four times daily), topical azithromycin 1.5% (twice daily for 3?days), topical steroids (loteprednol 0.5%, four times daily for 2?weeks), and either doxycycline 100?mg/day for 14?days or oral suspension of azithromycin 10?mg/kg for 3?days followed by an additional three-day course of treatment administered 10?days later (for patients above and below 14?years of age, respectively). Meibomian gland loss area also significantly improved post-treatment (27.4?
- |||||||||| doxycycline / Generic mfg.
Journal, Adverse events, CAR T-Cell Therapy, IO biomarker: Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects. (Pubmed Central) - Mar 20, 2024
A Tet-On doxycycline-inducible CAIX expressing cell line was established to mimic various CAIX densities, providing coverage from CAIX-high skrc-59 tumor cells to CAIX-low MMNK-1 cholangiocytes...Moreover, in an RCC orthotopic mouse model, G9 CAR-T cells showed enhanced tumor control compared to G250. In summary, G9 has successfully mitigated OTOT side effects and in doing so has made CAIX a druggable immunotherapeutic target.
- |||||||||| doxycycline / Generic mfg.
Journal: Conditional expression of FumA in Aspergillus niger enhances synthesis of L-malic acid. (Pubmed Central) - Mar 20, 2024
Employing CRISPR-Cas9 technology, we performed a replacement of the fumA promoter with a doxycycline-induced promoter Tet...The progress in metabolic engineering and bioprocess optimization holds promise for expediting industrial L-malic acid synthesis via biological fermentation. Moreover, it carries implications for the biosynthesis of various other organic acids.
- |||||||||| Zokinvy (lonafarnib) / Eiger
Journal: Genetic and pharmacological modulation of lamin A (Pubmed Central) - Mar 20, 2024
By expressing a variety of LA mutants using a doxycycline-inducible system, and in conjunction with FTI, we demonstrate that the permanent farnesylation, and not the ?50AA, is solely responsible for progerin-induced cellular defects, as well as its rapid accumulation and slow clearance...Collectively, our study unravels the precise contributions of progerin's permanent farnesylation to its turnover and HGPS cellular phenotypes, and how FTI treatment ameliorates these. These findings are applicable to other diseases associated with permanently farnesylated proteins, such as adult-onset autosomal dominant leukodystrophy.
- |||||||||| Review, Journal: Antibiotics for treatment of leptospirosis. (Pubmed Central) - Mar 18, 2024
As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Review, Journal: Antibiotic prophylaxis for leptospirosis. (Pubmed Central) - Mar 18, 2024
We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis. (Pubmed Central) - Mar 17, 2024
Determination of the active form of MMP-8 (aMMP-8) in oral rinse fluid using off-the-shelf assays shows the highest potential. Despite reports about aMMP-8 and promising data on the role of MMP-8 in periodontal diagnosis, a clear determination of the usefulness of this enzyme requires further research.
- |||||||||| doxycycline / Generic mfg., gefitinib / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy. (Pubmed Central) - Mar 16, 2024
In addition, inhibition of autophagy by bafilomycin-A1 significantly abolished the effect of USP24-i-101 on maintaining genomic integrity, decreasing PD-L1 and inhibiting drug resistance acquired in chemotherapy or targeted therapy. In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner.
- |||||||||| doxycycline / Generic mfg.
Adherence Markers for Doxy-PEP in Plasma and Urine (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_1289;
We examined doxycycline (DOXY) concentrations in urine and plasma, two specimen types commonly collected for STI testing, following a single oral DOXY dose to identify objective adherence markers of Doxy-PEP dosing.Eleven male and 9 female participants provided blood and urine up to 7 days after receiving a 200 mg oral DOXY dose...We identified adherence measures after a single DOXY dose within a pharmacologic tail of 4 and 7 days in plasma and urine, respectively. The data will inform and enable adherence testing in clinical studies to better assess Doxy-PEP efficacy.
- |||||||||| doxycycline / Generic mfg.
Doxy-PEP Associated With Declines in Chlamydia and Syphilis in MSM and Trans Women in San Francisco () - Mar 16, 2024 - Abstract #CROI2024CROI_1236;
Other factors, including changes in screening and sexual practices (e.g., in response to mpox), may have contributed to observed trends. Future analyses are planned with extended post-period data to determine whether observed trends continue to align with citywide doxy-PEP uptake and to assess for demographic disparities in doxy-PEP uptake and STI incidence.
- |||||||||| doxycycline / Generic mfg.
Early Adopters: Implementation of Doxycycline Postexposure Prophylaxis in a Boston Health Center (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_593;
PrEP users were more likely to initiate doxyPEP than PLHIV, but most patients recently diagnosed with a bSTI had not received doxyPEP. The increased uptake among patients with private insurance compared to those with public insurance highlights the need for programs to facilitate doxyPEP access in an equitable manner.
- |||||||||| doxycycline / Generic mfg.
Objective Assessment of Doxycycline PEP Use Among Cisgender Women in Kenya (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_591;
Among young cisgender women taking HIV PrEP with a high prevalence and incidence of STIs, the use of doxycycline for STI prevention was overall low. Detection of doxycycline using objective measures was associated with older age and not having a primary sex partner.
- |||||||||| doxycycline / Generic mfg.
Doxycycline Postexposure Prophylaxis to Prevent Trichomonas vaginalis Among Cisgender Women (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_590;
Randomization to the doxycycline PEP group was not associated with a decreased incidence of T. vaginalis infections among cisgender women taking oral PrEP in Kenya. Low use of doxycycline may have contributed to this null result, highlighting the need to explore its role in preventing T. vaginalis in future research.
- |||||||||| doxycycline / Generic mfg., amoxicillin / Generic mfg.
Jarisch-Herxheimer Reaction in Patients With Syphilis With or Without Prior Antibiotic Prophylaxis (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_587;
We identified 71 patients (75%) with a study-defined antibiotic exposure: 67 (94%) amoxicillin and 4 (6%) doxycycline. The observed overall low incidence of JHR, even lower in the early syphilis group (which accounted for a higher proportion of cases when compared to previous studies), could be attributable to antibiotic prophylaxis, although a relatively low RPR titer might also play a role.
- |||||||||| doxycycline / Generic mfg.
Increased Usage of Doxycycline for Young Children with Lyme Disease (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_2865;
Of the 1077 children with Lyme disease, 93 (8.6%) had early, 402 (39.0%) early-disseminated, and 564 (52.4%) late disease. Doxycycline treatment was more common for older children [492/594 (82.8%) >/= 8 years vs. 224/483 (46.4%) < 8 years; p < 0.001] and with early-disseminated disease [324/420 (77.1%) early-disseminated vs.
- |||||||||| doxycycline / Generic mfg.
TWO DIFFERENT ROLES OF THE CHROMATIN REMODELING COMPONENT ARID1A IN NEOPLASTIC TRANSFORMATION OF GASTRIC MUCOSA (103AB - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_8328;
The GCK or GCK-Arid1aKO mice were sacrificed at 2 to 24 weeks after the doxycycline treatment and immunostaining was performed to examine changes in both stomach corpus and antrum...In contrast, the GCK-Arid1aKO mice showed hyperplastic tumor formation in the antrum with severe fibrotic changes at 24 weeks, while the GCK stomachs did not develop any tumors in the antrum. Conclusions : Our study suggests that the Arid1a in two different types of gastric cells, gastric chief cells and antral stem cells, can independently lead to the metaplasia progression in the corpus or tumorigenesis in the antrum.
- |||||||||| tamoxifen / Generic mfg., doxycycline / Generic mfg.
YAP1 LICENSES DIFFERENTIATED CELLS TO RETURN TO THE CELL CYCLE IN PALIGENOSIS VIA NON-CANONICAL HIPPO PATHWAY REGULATION (101 - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_4450;
Our findings emphasize the vital role of YAP1 activity in paligenosis and provide a comprehensive description of upstream kinase regulation and downstream targets associated with YAP1 regulation during the paligenosis process. These findings contribute to a deeper understanding of gastric cancer initiation and provide potential avenues for targeted therapeutic interventions.
- |||||||||| metformin / Generic mfg., tamoxifen / Generic mfg., doxycycline / Generic mfg.
Review, Journal: Enhancing healthy aging with small molecules: A (Pubmed Central) - Mar 14, 2024
Furthermore, the review delves into emerging strategies that encourage mitochondrial biogenesis. Together, these interventions present a promising avenue for addressing age-related mitochondrial degradation, thereby setting the stage for the development of innovative treatment approaches to meet this extensive challenge.
- |||||||||| doxycycline / Generic mfg.
Journal: Detection of doxycycline by using a tapered droplet structure fiber sensor. (Pubmed Central) - Mar 13, 2024
By modifying the sensing region with a molecularly imprinted polymer film of DC, this sensor realizes the specific detection of DC and has a detection sensitivity of 58.81 pm/ppm for DC in a large concentration range of 0-300 ppm. This sensor can be used to detect DC microcontent in aqueous solutions in real time.
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