- |||||||||| doxycycline / Generic mfg.
Journal: Self-Propelled PLGA Micromotor with Chemotactic Response to Inflammation. (Pubmed Central) - May 15, 2021
The movement behavior in the presence of hydrogen peroxide is confirmed by nanoparticle tracking analysis. An in vitro model is designed and confirmed the response efficiency and directional control of the micromotors toward phorbol esters-stimulated macrophages.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Primary cutaneous marginal zone lymphoma treated with doxycycline in a pediatric patient. (Pubmed Central) - May 15, 2021
He was started on doxycycline and experienced a near-complete response. Given the favorable side effect profile of doxycycline and the indolent nature of PCMZL, we believe doxycycline is a possible therapy for PCMZL pediatric patients who have widely disseminated cutaneous disease.
- |||||||||| doxycycline / Generic mfg.
Journal: Neurotransmission through dopamine D1 receptor is required for aversive memory formation and Arc activation in the cerebral cortex. (Pubmed Central) - May 15, 2021
Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment...Knockdown of D1R expression following Dox treatment resulted in impaired performance in the passive avoidance test and was associated with a decrease in dVenus expression in the cerebral cortex (visual, somatosensory, and motor cortices), but not the hippocampus, compared with control mice without Dox treatment. These findings indicate that D1R-mediated dopaminergic transmission is critical for aversive memory formation, specifically by influencing Arc expression in the cerebral cortex.
- |||||||||| doxycycline / Generic mfg.
Journal: Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradation. (Pubmed Central) - May 15, 2021
Statement of significance Application of Zn-doped nanoparticles on acid etched dentin reduced biofilm formation and viability at the resin-dentin interface due to both remineralization and antibacterial properties. Doxycycline-doped nanoparticles also diminished oral biofilm viability, but did not remineralize the resin-dentin interface.
- |||||||||| doxycycline / Generic mfg.
Journal: Paired wavelength relevance as spectrophotometric strategy for evaluation the potency of medicine affecting human health. (Pubmed Central) - May 15, 2021
Paired wavelength relevance as spectrophotometric strategy was carried for simultaneous analysis of unresolved bands of doxycycline hydrochloride (DOX) and tylosin tartrate (TYT) as an example of veterinary binary mixture...The outcomes were matched statistically with those of the authorized systems; Student's t-test, F-test, and One-way ANOVA, presenting acceptable values and no momentous change with accuracy. The procedures can be considered useful for the quantitative analysis.
- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes. (Pubmed Central) - May 15, 2021
These in vitro studies demonstrated that doxycycline, in addition to inhibiting MMP, also modulated AL-induced autophagy in cardiomyocytes and provide potential insights for future therapeutic targets for AL-induced proteotoxicity. Novel therapies for cardiotoxicity and heart failure in AL cardiac amyloidosis remain an important unmet need.
- |||||||||| doxycycline / Generic mfg.
Journal: Antimicrobial and Anti-inflammatory Thermo-reversible Hydrogel for Periodontal Delivery. (Pubmed Central) - May 15, 2021
This study aimed to formulate an antimicrobial and anti-inflammatory treatment option, by incorporating doxycycline (DOX) and/or lipoxin A (LXA) into 0.5 wt% thermo-reversible polyisocyanopeptide (PIC)...In addition, PIC-DOX and PIC-DOX+LXA improved gingival clinical attachment by 0.6 mm compared with conventional periodontal treatment alone (i.e. mechanical debridement). In conclusion, the thermo-reversible PIC hydrogel is a safe and effective vehicle for periodontal drug delivery.
- |||||||||| doxycycline / Generic mfg., naproxen / Generic mfg.
Clinical, Journal: Chronic seronegative spondyloarthropathy following acute Mycoplasma pneumoniae infection in a human leukocyte antigen B27-positive patient: a case report. (Pubmed Central) - May 15, 2021
In our patient, M. pneumoniae infection may represent a random event, or it might be a necessary factor for the development of reactive arthritis, asymmetric proximal myopathy, and sacroiliitis, always in combination with the appropriate genetic background. Extrapulmonary manifestations of M. pneumoniae may occur even in the complete absence of respiratory symptoms, and the diagnosis of unusual complications, such as reactive arthritis, requires high clinical suspicion and extensive investigation.
- |||||||||| dapsone / Generic mfg., rifampicin / Generic mfg., cefuroxime / Generic mfg.
Journal, Combination therapy: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi. (Pubmed Central) - May 15, 2021
Dapsone, alone or in various combinations with doxycycline, rifampin and azithromycin produced a significant reduction in the mass and protective glycosaminoglycan layer and overall viability of B. burgdorferi biofilm forms. This in vitro study strongly suggests that dapsone combination therapy could represent a novel and effective treatment option against the biofilm form of B. burgdorferi.
- |||||||||| doxycycline / Generic mfg.
Clinical, Review, Journal: Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a systematic review protocol. (Pubmed Central) - May 15, 2021
There are many ways to treat RAS, such as pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low...The results will be reported in a peer-reviewed journal or disseminated in relevant conferences. DOI 10.17605/OSF.IO/QASUY.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Journal: 2020 European guideline on the management of syphilis. (Pubmed Central) - May 15, 2021
The 2020 edition of the European guideline on the management of syphilis is an update of the 2014 edition. Main modifications and updates include: -The ongoing epidemics of early syphilis in Europe, particularly in men who have sex with men (MSM) -The development of dual treponemal and non-treponemal point-of-care (POC) tests -The progress in non-treponemal test (NTT) automatization -The regular episodic shortage of benzathine penicillin G (BPG) in some European countries -The exclusion of azithromycin as an alternative treatment at any stage of syphilis -The pre-exposure or immediate post-exposure prophylaxis with doxycycline in populations at high risk of acquiring syphilis.
- |||||||||| doxycycline / Generic mfg.
Journal: Metabonomics reveals an alleviation of fitness cost in resistant E. coli competing against susceptible E. coli at sub-MIC doxycycline. (Pubmed Central) - May 15, 2021
Moreover, the alleviation of fitness cost for resistant bacteria competed with susceptible bacteria at 1 mg/L doxycycline was correlated with the downregulation of the biomarkers pyruvate and pilocarpine. Our study offered new insight into the metabolic mechanisms by which the fitness cost of resistant mutants was reduced at doxycycline concentrations as low as 1 mg/L and identified various potential metabolites to limit the spread of antimicrobial resistance in the environment.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: Darier sign in a teenager with primary cutaneous marginal zone lymphoma. (Pubmed Central) - May 15, 2021
An adolescent male presented with dermal nodules on the arms, legs, and back with a positive Darier sign, ultimately diagnosed as PCMZL. The nodules demonstrated a partial response to doxycycline in the setting of prior Lyme disease followed by a complete response to rituximab.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: A Case of Plasmodium falciparum Malaria Treated with Artesunate in a 55-Year-Old Woman on Return to Florida from a Visit to Ghana. (Pubmed Central) - May 15, 2021
Infectious disease consultation was obtained and an infusion of intravenous (IV) quinidine and IV doxycycline was emergently started due to the anticipated delay in obtaining artesunate...The parasitemia and acidosis started improving by the third day of therapy. CONCLUSIONS Given that artesunate is more effective, easier to dose, and more tolerable than quinidine, it is now the treatment of choice for severe malaria in the United States.
- |||||||||| ceftriaxone / Generic mfg., rifampicin / Generic mfg.
Journal: Brucellosis. (Pubmed Central) - May 15, 2021
Treatment is for 3-6 months with combination therapy including Doxycycline, Rifampicin and ceftriaxone. The main issue is prevention and better animal husbandry.
- |||||||||| doxycycline / Generic mfg.
Journal: Mediterranean spotted fever associated with leucocytoclastic vasculitis and acute pancraeatitis. (Pubmed Central) - May 15, 2021
He improved with doxycycline, but bipedal pitting oedema and punctate rash involving the soles/hands appeared...Palpable purpura is a rare important manifestation of Mediterranean spotted fever (MSF), due to either secondary leucocytoclastic vasculitis or associated Henoch-Schonlein purpura (HSP), which best explains the distribution of the rash, arthralgia, gastrointestinal symptoms, and microhaematuria not usually seen in R. conorii infections. Likewise, the patient's acute pancreatitis may be interpreted as a rare presentation of HSP or a seldom-encountered feature of MSF.
- |||||||||| doxycycline / Generic mfg.
Journal: Lawsonella clevelandensis: an emerging cause of vascular graft infection. (Pubmed Central) - May 15, 2021
The patient underwent surgical resection and replacement of infected graft, followed by 6 weeks of intravenous antibiotic therapy and then chronic suppression with doxycycline and cefadroxil. He was infection-free at last follow-up.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: Pemphigoid gestationis: a rare pregnancy dermatosis treated with a combination of IVIg and rituximab. (Pubmed Central) - May 15, 2021
She did not go into remission for 6 months post partum despite treatment with prednisolone 40 mg/day, doxycycline 100 mg two times per day and dapsone 100 mg/day. The patient went into remission following treatment with three courses of intravenous immunoglobulin 2 mg/kg/course and 2 doses of rituximab 1 g at a 2-week interval.
- |||||||||| tetracycline / Generic mfg.
Journal: Determination of seven tetracyclines in milk by dissolvable layered double hydroxide-based solid-phase extraction coupled with high-performance liquid chromatography. (Pubmed Central) - May 15, 2021
Under optimized conditions, the method achieved low detection limits of 0.414-0.986 μg L-1 and quantification limits of 1.38-3.29 μg L-1, and good recoveries of 93.5-100% with intra- and inter-day RSDs of 0.498-4.08% and 1.23-10.0%, respectively. This method is convenient, accurate, sensitive, rapid, cost-effective, eco-friendly, and suitable for the determination of seven tetracycline antibiotics in milk samples.
- |||||||||| doxycycline / Generic mfg.
Journal: Scrub typhus with cerebral venous sinus thrombosis: a rare presentation. (Pubmed Central) - May 15, 2021
She responded to treatment with doxycycline, anticoagulants, antipyrectics and intravenous saline. Early identification of such atypical neurological involvement in scrub typhus was helpful in satisfactory outcome.
- |||||||||| doxycycline / Generic mfg., meropenem / Generic mfg., linezolid oral / Generic mfg.
Journal: Tropical pyomyositis in scrub typhus: a rare association. (Pubmed Central) - May 15, 2021
Patient was treated aggressively with parenteral antibiotics (linezolid, clindamycin and meropenem) and surgical debridement...After serological confirmation of scrub typhus, the patient was put on oral doxycycline and he had a dramatic improvement within next few days. To the best of our knowledge, this is probably the first reported case of tropical pyomyositis in association with scrub typhus.
- |||||||||| doxycycline / Generic mfg.
Journal: Drug-Based Gold Nanoparticles Overgrowth for Enhanced SPR Biosensing of Doxycycline. (Pubmed Central) - May 14, 2021
The study also examined the role of colloidal stability and growth of doxy-AuNPs in relation to the response-enhancement strategy based on doxy-AuNPs. Thus, the doxy-AuNPs-based SPR biosensor is an excellent platform for the detection of doxycycline and demonstrates a new biosensing scheme where the analyte can provide enhancement.
- |||||||||| doxycycline / Generic mfg.
Journal: Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NFκB signaling. (Pubmed Central) - May 14, 2021
We examined the role of Rcn3 in the alveolar inflammatory response by using mice with a selective deletion of Rcn3 in alveolar epithelial cells upon doxycycline administration...The studies conducted in MLE12 cells consistently showed that Rcn3 knockdown blunted the activations of NFκB signaling and NLRP3-dependent inflammasome upon LPS exposure. Collectively, these findings suggest a novel role for Rcn3 in regulating the alveolar inflammatory response to pulmonary infection via the NFκB/NLRP3/inflammasome axis and shed additional light on the mechanism of ARDS/ALI.
- |||||||||| Zarzio (filgrastim biosimilar) / Novartis
[VIRTUAL] IMPLICATIONS OF THE SPLICEOSOME MUTATION U2AF1 FOR THE EXPRESSION OF CIRCULAR RNA () - May 13, 2021 - Abstract #EHA2021EHA_1581;
Methods We analyzed RNAseq data from a transgenic mouse model with doxycycline-inducible U2AF1S34F/U2AF1WT expression.1 In addition, we generated total RNAseq data from FACS sorted CD34+ bone marrow cells from patients with MDS with U2AF1 mutation (3 S34 mutations, 3 Q157 mutations), along with 5 matched MDS controls without spliceosome mutations and 4 healthy controls...Furthermore, distinct circRNA expression profiles were seen for mutations at the S34 and Q157 loci. Further investigation of the biological mechanism by which U2AF1 mutation supports backsplicing, and profiling of a larger cohort of MDS patients, is merited.
- |||||||||| tetracycline / Generic mfg.
Journal: Perinatal exposure to tetracycline contributes to lasting developmental effects on offspring. (Pubmed Central) - May 13, 2021
Our results demonstrated that early life doxycycline exposure shifts the homeostatic baseline of prior exposed animals that may subsequently impact responses to experimental manipulations. These results highlight the gut microbiota as an important factor to consider in systems requiring methods of chronic antibiotic administration during pregnancy and critical periods of postnatal development.
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