doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  ceftriaxone / Generic mfg., cefuroxime / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Antibacterial drugs for Lyme disease. (Pubmed Central) -  May 26, 2021   
    No abstract available No abstract available
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Tetracycline as an inhibitor to the SARS-CoV-2. (Pubmed Central) -  May 25, 2021   
    These RBD residues also engage in significant hydrogen bonding with the human receptor ACE2. The ability to preclude cell infection complements the anti-inflammatory and cytokine suppressing capability of tetracycline; this may reduce the duration of ICU stays and mechanical ventilation induced by the coronavirus SARS-CoV-2.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential. (Pubmed Central) -  May 25, 2021   
    In this work, we combined two types of amorphous silica: bioglass and doxycycline-loaded mesoporous silica MCM-41 into the form of spherical granules (pellets) as a bifunctional bone drug delivery system...The progressive biomimetic apatite formation on the surface of the pellets was observed. No cytotoxic effect of pellets towards human osteoblasts was noticed.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors. (Pubmed Central) -  May 22, 2021   
    We establish 2,135 hESC lines, representing three clones each of 714 doxycycline (Dox)-inducible genes including 481 TFs, and obtain 26,998 microscopic cell images and 2,174 transcriptome datasets-RNA sequencing (RNA-seq) or microarrays-48 h after the presence or absence of Dox...TFs are also characterized by their ability to induce differentiation of hESCs into specific cell lineages. These analyses help to provide a way of classifying TFs and identifying specific sets of TFs for directing hESC differentiation into desired cell types.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Bilateral Vestibulopathy in Neuroborreliosis. (Pubmed Central) -  May 22, 2021   
    This is the first case report of bilateral vestibulopathy likely caused by neuroborreliosis. Although neurotologic involvement is an uncommon complication in this condition, clinicians should consider a vestibular testing battery when addressed by patient's history and bedside vestibular findings.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Systematic quantification of the anion transport function of pendrin (SLC26A4) and its disease-associated variants. (Pubmed Central) -  May 20, 2021   
    We established HEK293T-based stable cell lines that express pendrin missense variants in a doxycycline-dependent manner, and systematically determined their anion transport activities with high accuracy in a 96-well plate format using a high throughput plate reader...We also found that some of these putative missense variants disrupt normal mRNA splicing. Our comprehensive experimental approach helps determine the pathogenicity of each pendrin variant, which should guide future efforts to benefit patients.
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
    Clinical, Journal:  Evaluation of a Comprehensive Skin Toxicity Program for Patients Treated With Epidermal Growth Factor Receptor Inhibitors at a Cancer Treatment Center. (Pubmed Central) -  May 20, 2021   
    The Skin Toxicity Evaluation Protocol With Panitumumab trial found reduced incidence of skin toxicity and quality of life impairment with preemptive use of doxycycline hyclate, topical corticosteroids, moisturizers, and sunscreen, demonstrating the benefit of prophylactic treatment for skin toxicity...From 2012 to 2017, preemptive tetracycline use (13 of 29 [45%] to 30 of 42 [71%]; P = .02) and topical corticosteroid use (2 of 29 [7%] to 24 of 42 [57%]; P < .001) increased and topical antibiotic use (23 of 29 [79%] to 18 of 42 [43%]; P = .002) decreased...Patients prescribed prophylactic treatment were 94% less likely to require a first rescue treatment for rash (adjusted odds ratio, 0.06; 95% CI, 0.02-0.16; P < .001), 74% less likely to require a second rescue treatment for rash (adjusted odds ratio, 0.26; 95% CI, 0.08-0.83; P = .02), and 79% less likely to experience a cetuximab dose change or interruption (adjusted odds ratio, 0.21; 95% CI, 0.06-0.81; P = .02) than patients not prescribed prophylactic treatment, adjusting for treatment site and year. Dermatologists can add value to oncology care by raising awareness of appropriate treatment options and increasing adherence to evidence-based prophylaxis protocols for EGFRi-associated rash, which is associated with decreased interventions and toxicity-associated chemotherapy interruptions.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Adaptive resistance evolution of V. cholerae to doxycycline associated with spontaneous mutation. (Pubmed Central) -  May 20, 2021   
    Dxycycline stress also induced co-resistance to colistin antibiotic, a last resort drug to treat extensively drug resistant bacteria. The study illustrates a possible mechanism of doxycycline selected resistance in V. cholerae for the first time and doxycycline selected co-resistance which warrants strict restrictions on the indiscriminate use of antibiotics.
  • ||||||||||  clindamycin phosphate / Generic mfg., doxycycline / Generic mfg.
    Clinical, Review, Journal:  Tubo-ovarian abscess in non-sexually active adolescent girls: a case series and literature review. (Pubmed Central) -  May 20, 2021   
    Given the large proportion of cases attributable to anaerobic gut flora, treatment with antibiotics with adequate anaerobic coverage is recommended. Surgical drainage is not always necessary, but is often needed for diagnostic purposes or in patients not clinically improving with conservative measures.
  • ||||||||||  doxycycline / Generic mfg.
    Clinical, Journal, Combination therapy:  Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial. (Pubmed Central) -  May 20, 2021   
    P3
    The results revealed that enrofloxacin, lincomycin, doxycycline, and oxytetracycline were detected in hen eggshell samples. Patients with mild-to-moderate COVID-19 infection treated with ivermectin plus doxycycline recovered earlier, were less likely to progress to more serious disease, and were more likely to be COVID-19 negative by RT-PCR on day 14.
  • ||||||||||  [VIRTUAL] National trends in outpatient antibiotic use in the United States (US): 2011 to 2018 () -  May 20, 2021 - Abstract #ECCMID2021ECCMID_3591;    
    Outpatient antibiotic prescribing has decreased in the national VA system, with an overall annual reduction of 3.9%, and a reduction in ciprofloxacin use of 12.6% per year.  This may be related to VA antibiotic stewardship programs. Despite reduced utilization of some antibiotics, use of the three most commonly prescribed outpatient antibiotics remained stable . Our study identified target areas for outpatient antibiotic stewardship activities to reduce unnecessary antibiotic use.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery. (Pubmed Central) -  May 20, 2021   
    Additionally, model drug doxycycline was either pre-mixed with dissolved bmSF molecules or pre-loaded into pre-made bmSF nanospheres at the same amount before their mixing and deposition...These results indicate that the dosage and kinetics of loaded drugs can be quantitatively tailored by altering nanosphere concentration and deposition time as main processing parameters. Overall, this study illustrates the strong potential of pre-defining coating architecture to facilitate control over drug delivery.
  • ||||||||||  metformin / Generic mfg., rifampicin / Generic mfg.
    Clinical, Journal:  Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria. (Pubmed Central) -  May 20, 2021   
    Moreover, synergetic studies showed that metformin enhanced the effect of the combined antibiotics, as these combinations provide either a synergistic or additive effect with significant reduction in the MIC. Metformin exerts an adjuvant antibacterial effect; thus, it could be a possible candidate as an adjuvant therapy to reduce antimicrobial resistance.
  • ||||||||||  doxycycline / Generic mfg.
    [VIRTUAL] Inflammatory response within the nervous system in Tat induced HIV-associated sensory neuropathy () -  May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_2210;    
    Previously, using the doxycycline (DOX) inducible HIV-1 Tat transgenic (iTat) mice, we showed that Tat expression induced neuropathy-like behaviors...Gene ontology term enrichment analysis of this gene cluster via the PantherGo tool further identified a set of genes (IL-6, MAPK2K4, IL-10, HRAS1, BCL2L1, RHOA, JUN, and CREB1) that prevent/inhibit neuronal cell death/apoptosis. In all, both upregulation of selected pro-inflammatory cytokines within DRG, and down regulation of inflammation-related, neuronal survival genes within the spinal cord, could contribute to Tat-mediated peripheral neuropathy.
  • ||||||||||  doxycycline / Generic mfg.
    [VIRTUAL] The Role of CD4+ Tissue Resident Memory Cells in Oncogene Driven Lung Adenocarcinoma () -  May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_956;    
    In this study, we used a genetically engineered mouse model (GEMM) of lung adenocarcinoma (LAC), with doxycycline-inducible oncogene mutation KRASG12D...To examine clinical relevance, we used the program KMplotter and found signatures of Trm and CD4+ Trm significantly correlated with increased survival in LAC patients. We intend to determine the functional relevance of these Th2-like CD4+ TRM cells in the tumour microenvironment.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Polymeric nanoparticles for endodontic therapy. (Pubmed Central) -  May 15, 2021   
    The effect of undoped NPs, zinc, calcium and doxycycline-doped NPs (Zn-NPs, Ca-NPs and D-NPs, respectively) was tested in radicular dentin...When using undoped NPs or Ca-NPs, deposition of minerals occurred, but radicular dentin was not mechanically reinforced. Therefore, application of Zn-NPs in endodontically treated teeth previous to the canal filling is encouraged.