nimodipine / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 49 Diseases   11 Trials   11 Trials   798 News 


«12345678910111213...1314»
  • ||||||||||  nimodipine / Generic mfg.
    Retrospective data, Review, Journal:  Update on intrathecal management of cerebral vasospasm: a systematic review and meta-analysis. (Pubmed Central) -  Apr 7, 2022   
    The authors support the use of intrathecal management in the prevention and rescue management of cerebral vasospasm. More randomized controlled trials are warranted to determine the best combination of pharmaceutical agents and administration route in order to formulate a standardized treatment approach.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Clinical Effect of Nimodipine Combined with Magnesium Sulfate on Pregnancy-Induced Hypertension Syndrome. (Pubmed Central) -  Apr 5, 2022   
    Compared with 14.58%, 12.50%, and 2.08% in the single drug group, the neonatal asphyxia rate, premature birth rate, and stillbirth rate in the combined group are 6.25%, 4.17%, and 0.00%, respectively, and the difference is not statistically significant (P > 0.05). Nimodipine combined with magnesium sulfate can effectively control blood pressure in patients with pregnancy-induced hypertension, reduce vascular endothelial damage, regulate the expression of HSP70, PTX3, and PLGF, and improve pregnancy outcomes without increasing adverse reactions.
  • ||||||||||  isradipine / Generic mfg., nimodipine / Generic mfg.
    Journal:  Dihydropyridines Potentiate ATP-Induced Currents Mediated by the Full-Length Human P2X5 Receptor. (Pubmed Central) -  Apr 2, 2022   
    We conclude that common dihydropyridines or four new derivatives of amlodipine are not suitable as hP2X5 antagonists, but amlodipine might serve as a lead for future synthesis to increase its affinity. Furthermore, a side effect of nimodipine therapy could be a stimulatory effect on inflammatory processes.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats. (Pubmed Central) -  Apr 1, 2022   
    Moreover, 400 mg/kg dose of three plants in conjugation (Group F) were found to be more effective in restoring the normal activities of all measured parameters than independent doses (Group C, D, E) and is comparable with standard drug nimodipine (Group G) clinically used for the treatment of multiple sclerosis. The present study, for the first time, reported the clinical evidence of N. hindustana, V. negundo, and A. albiflora against multiple sclerosis and concludes that all three plants showed remyelination as well neuroprotective effects which may be used as a potential natural neurotherapeutic agent against multiple sclerosis.
  • ||||||||||  nimodipine / Generic mfg.
    Retrospective data, Journal:  Quantitative electroencephalogram for prediction of delayed ischemia in subarachnoid haemorrhage. Report of one case (Pubmed Central) -  Mar 30, 2022   
    Pharmacological angioplasty with nimodipine was performed, with an excellent radiological response, although not clinical...A second therapeutic angiography was performed; the patient persisted with aphasia and left central facial paresis. The quantitative EEG analysis performed retrospectively showed a generalized reduction in the spectral edge frequency 95 (SEF95; meaning slowing in the EEG signal) at the fourth day of follow up, three days earlier than the clinical and imaging diagnosis of DCI was established.
  • ||||||||||  methylphenidate tablet / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
    Review, Journal:  Pharmacological Management of Apathy in Dementia. (Pubmed Central) -  Mar 23, 2022   
    Regarding FTD- and DLB-related apathy, initial studies with agomelatine and rivastigmine showed benefits, respectively...With regards to mixed populations, memantine, galantamine and gingko biloba showed effects on apathy in the AD plus VaD populations and nimodipine in the VaD plus mixed dementia populations...There should also be a consensus on using scales with high test/retest and interrater reliabilities to limit the inconsistencies between clinical trials. In conclusion, there are currently no US FDA-approved drugs that target apathy in dementia, so there is an ongoing need for the development of such drugs.
  • ||||||||||  verapamil / Generic mfg.
    PEDIATRIC CEREBRAL VASOSPASM ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1766;    
    Nimodipine was initiated along with hypervolemia and permissive hypertension for management of vasospasm, but intravenous milrinone and intrathecal (IT) nicardipine were added as adjunct therapies...Vasospasm resolved by week 2, after 3 treatments with IA verapamil and therapies were de-escalated...IT and IA vasodilator therapy are effective treatments for cerebral vasospasm secondary to bacterial meningitis. Single agent anti-platelet therapy should strongly be considered, given local hypercoagulability and risk of thrombosis.
  • ||||||||||  nimodipine / Generic mfg.
    SUBARACHNOID HEMORRHAGE ASSOCIATED WITH HOMOZYGOUS ALPHA-1 ANTITRYPSIN DEFICIENCY ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1713;    
    Treatment according to the stroke protocol was initiated with seizure prophylaxis, nimodipine, daily transcranial Doppler ultrasound and blood pressure management with systolic goals in the range of 120-150 mm of Hg...AAT deficiency and its association with an IA in the Asian population has not been established. Male Caucasian subarachnoid hemorrhage patients with emphysematous changes should be evaluated for AAT deficiency as a potential cause of the IA.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  Neferine Protects Against Brain Damage in Permanent Cerebral Ischemic Rat Associated with Autophagy Suppression and AMPK/mTOR Regulation. (Pubmed Central) -  Mar 18, 2022   
    We performed permanent cerebral ischemia in rats by middle cerebral artery occlusion (pMCAO) for 12 h with or without administration of neferine or nimodipine, a calcium (Ca) channel blocker...Neferine significantly attenuated the upregulation of autophagy-associated proteins such as LC3-II, beclin-1, and p62 as well as autophagosome formation, all of which were induced by pMCAO. Neferine exerted remarkable protection against cerebral ischemia, possibly via the regulation of autophagy mediated by the Ca-dependent AMPK/mTOR pathway.
  • ||||||||||  nimodipine / Generic mfg.
    A case of cerebral vasculitis mimicking RCVS (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3321;    
    She was diagnosed with RCVS and put on nimodipine, however patient continued to complain about headache and a second MRI showed an asymptomatic ischemic lesion... Although TCHs rarely characterizes headache in cerebral vasculitis and often addresses towards other etiologies, this case emphasizes the need of a comprehensive differential diagnosis of all possible underlying causes, in order to not miss potentially treatable conditions.
  • ||||||||||  nimodipine / Generic mfg.
    Reversible focal neurologic deficits as a complication of diagnostic cerebral angiogram (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2832;    
    Given the temporal course, we suspect focal hypoperfusion due to cerebral vasospasm as the likely etiology, possibly attributable to iodinated contrast agent. Further studies are needed to clarify whether this represents an entity separate from previously described CIE, where contrast staining and cerebral edema are seen on neuroimaging.
  • ||||||||||  atorvastatin / Generic mfg., nimodipine / Generic mfg.
    Subarachnoid Hemorrhage and Cerebral Edema Caused by Disseminated Coccidiomycosis: A Case Report ([VIRTUAL]) -  Mar 6, 2022 - Abstract #AAN2022AAN_2080;    
    Although aneurysmal rupture is a common culprit for nontraumatic subarachnoid hemorrhage, in this case there was sufficient evidence that the aneurysm found on imaging did not explain the patient’s presentation, and another underlying pathology should be sought. With appropriate treatment, this patient had a good outcome.
  • ||||||||||  verapamil / Generic mfg.
    Journal:  Calcium Channel Antagonists for Mood Disorders. (Pubmed Central) -  Mar 4, 2022   
    Medications that antagonize hyperactive intracellular signaling warrant more interest than they have received in psychiatry. Further experience will clarify the applications of these medications alone and in combination with more established mood stabilizers.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis. (Pubmed Central) -  Feb 26, 2022   
    Nimodipine was well tolerated and crossed the blood brain barrier, as expected, but there was no effect on Aβ accumulation or on the relative amount of neuritic dystrophy, as assessed by either immunoblot, dot blot or immunofluorescence imaging of Aβ42 and dystrophic neurite marker LAMP1. While we conclude that nimodipine treatment is not likely to improve amyloid pathology or decrease neuritic dystrophy in AD, it is worth noting that nimodipine did not worsen the phenotype suggesting its use is safe in AD patients.
  • ||||||||||  nimodipine / Generic mfg.
    Retrospective data, Journal:  Nimodipine reduces delayed cerebral vasospasm after intracranial tumor surgery: A Retrospective Study. (Pubmed Central) -  Feb 25, 2022   
    Preoperative and postoperative the MCA velocities were compared, revealing a significant change in the normal saline group but not in the nimodipine group. Nimodipine markedly improves prognosis and significantly reduces ischemia secondary to delayed CVS after intracranial tumor surgery, as well as the risks of mortality and morbidity.
  • ||||||||||  flunarizine / Generic mfg., nimodipine / Generic mfg.
    Journal:  Safety and efficacy of nimodipine combined with flunarizine in patients with angioneurotic headache. (Pubmed Central) -  Feb 19, 2022   
    Nimodipine markedly improves prognosis and significantly reduces ischemia secondary to delayed CVS after intracranial tumor surgery, as well as the risks of mortality and morbidity. Nimodipine combined with flunarizine can better promote the recovery of patients with angioneurotic headache and improve their quality of life.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  L-type calcium channel subtypes mediating hypothalamic dysfunction caused by amyloid-beta. (Pubmed Central) -  Feb 4, 2022   
    These results suggest that Ca 1.2 does not have a significant role in amyloid-beta mediated dysfunction of hypothalamic arcuate NPY neurons and that Ca 1.3 is likely the major target of amyloid-beta in these neurons. Future studies modulating Ca 1.3 in hypothalamic neurons will help elucidate the mechanisms underlying hypothalamic dysfunction caused by amyloid-beta pathology and its therapeutic potential in AD.
  • ||||||||||  nimodipine / Generic mfg.
    Review, Journal:  The Potential Role of Neuromodulation in Subarachnoid Hemorrhage. (Pubmed Central) -  Jan 29, 2022   
    DCI has a complex pathogenesis, making the unique anatomical distribution and pleiotropic capabilities of various types of neuromodulation a promising field of study. We may be at the cusp of a breakthrough in the use of these techniques for the treatment of this stubbornly difficult disease.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Crystal morphology tuning and green post-synthetic modification of metal organic framework for HPLC enantioseparation. (Pubmed Central) -  Jan 19, 2022   
    The homochiral Co-MOF-74-L-Tyr CSP gave superior enantioseparation performance for the eight chiral drugs and drug intermediates, such as nitrendipine, nimodipine, benzoin, 2,2'-furoin and bi-2-naphthol to the commercial columns under normal phase condition...Furthermore, the Co-MOF-74-L-Tyr packed column was successfully applied to detect the product N-1-(1-naphthyl)ethyltosylamide (HR-8) in the asymmetric reductive amination reaction. The size/morphology-controlled synthesis coupled with the green post-synthetic modification approach paves the way to fabricate target chiral MOFs with pre-designed functional groups, which is an effective complement for the preparation of CSPs in chiral chromatography.
  • ||||||||||  nimodipine / Generic mfg.
    Review, Journal:  Aneurysmal Subarachnoid Hemorrhage: the Last Decade. (Pubmed Central) -  Jan 14, 2022   
    In fact, much of SAH management is derived from studies in other patient populations. Therefore, further study of complications, including DCI and other medical complications, is needed to optimize outcomes for this fragile patient population.