nimodipine / Generic mfg. 
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  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Characterization of nimodipine amorphous nanopowder prepared by quenching cooling combined with wet milling and spray drying. (Pubmed Central) -  Nov 16, 2022   
    The dissolution study showed that the dissolution rate of NMD in NMD-NAP was improved about 5 times that of pure NMD and 3 times that of nimodipine nanocrystalline (NMD-NC), indicating the combination of nano size and amorphous form produced a synergistic effect that could significantly increase the dissolution rate of NMD. Due to the significantly improved solubility and good industrial feasibility of the prepared NMD-NAP, the preparation of insoluble drugs into amorphous nanopowders is an effective method to improve the solubility of insoluble drugs and has good application prospects.
  • ||||||||||  donepezil / Generic mfg., nimodipine / Generic mfg.
    Retrospective data, Review, Journal:  Acupuncture and Related Therapies for the Cognitive Function of Alzheimer's Disease: A Network Meta-Analysis. (Pubmed Central) -  Nov 2, 2022   
    The comprehensive ranking results show that ACU+training and ACU have the highest ranking probability. ACU+Training and ACU may be the best therapies to improve the cognitive function of patients with mild to moderate AD, while the combination of acupuncture-related therapies and other therapies has a higher overall benefit.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  The Combination of Individual Herb of Mi-Jian-Chang-Pu Formula Exerts a Synergistic Effect in the Treatment of Ischemic Stroke in Rats. (Pubmed Central) -  Nov 1, 2022   
    108 adult male Sprague-Dawley rats were randomly and equally divided into 9 groups, including sham group (N, vehicle), middle cerebral artery occlusion (MCAO) model group (M, vehicle), positive group (P, 36 mg/kg/day nimodipine), crocin I (A1, 40 mg/kg/day), β-asarone (B1, 15 mg/kg/day), crocin I + β-asarone (A1B1, 55 mg/kg/day), C. sativus (A, 580 mg/kg/day), A. tatarinowii (B, 480 mg/kg/day), and C. sativus + A...The pharmacokinetic parameters further verified the above results that MJCPF could synergistically promote drug absorption greater than others. Our integrated pharmacodynamics, metabolomics, and pharmacokinetic approach reveals the synergistic effect of MJCPF on treatment of IS, which powerfully contribute to the understanding of scientific connotation of TMC formula.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Devastating delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. (Pubmed Central) -  Nov 1, 2022   
    Blood pressure instability was defined as nimodipine-induced blood pressure drops, dosage adjustments, or the use of blood pressure drugs before onset of DCI...The vast majority of these patients had blood pressure instability. Future studies are needed to investigate if a reduction in the number and extent of blood pressure fluctuations decreases the incidence of devastating DCI.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Notch Signaling Mediates Radiation-Induced Smooth Muscle Cell Hypermuscularization and Cerebral Vasculopathy. (Pubmed Central) -  Oct 29, 2022   
    Radiation-induced cerebral vasculopathy showed bead-like shape and increased contractile state. Inhibition of Notch signaling by N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester effectively attenuated vasculopathy and relieved cognitive impairment, suggesting Notch signaling as a therapeutic target for the treatment of RIBI.
  • ||||||||||  nimodipine / Generic mfg., cilostazol / Generic mfg.
    Trial completion date, Trial primary completion date:  Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH) (clinicaltrials.gov) -  Oct 28, 2022   
    P4,  N=120, Recruiting, 
    Inhibition of Notch signaling by N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester effectively attenuated vasculopathy and relieved cognitive impairment, suggesting Notch signaling as a therapeutic target for the treatment of RIBI. Trial completion date: Oct 2023 --> Jul 2024 | Trial primary completion date: Oct 2022 --> Jan 2024
  • ||||||||||  chlorogenic acid / Jiuzhang Biotech
    Journal:  The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. (Pubmed Central) -  Oct 28, 2022   
    Gallic acid, salidroside, chlorogenic acid, ethyl gallate, ferulic acid and tetrahydropalmatine detected by HPLC-MS showed good interaction and binding with HIF-1α/EPO/VEGFA. Our study demonstrated the mechanisms of JCT anti-ICS associated with the activation of the HIF-1α/EPO/VEGFA pathway, which provided a pharmacological basis for expanding the clinical application and some scientific ideas for further research into the material basis JCT anti-ICS.
  • ||||||||||  nimodipine / Generic mfg.
    Trial completion date, Trial primary completion date:  Cognitive Effects of Nimodipine in Patients With Schizophrenia (clinicaltrials.gov) -  Oct 27, 2022   
    P1,  N=30, Suspended, 
    Our study demonstrated the mechanisms of JCT anti-ICS associated with the activation of the HIF-1α/EPO/VEGFA pathway, which provided a pharmacological basis for expanding the clinical application and some scientific ideas for further research into the material basis JCT anti-ICS. Trial completion date: Jan 2023 --> Jan 2024 | Trial primary completion date: Jan 2023 --> Jan 2024
  • ||||||||||  nimodipine / Generic mfg.
    Retrospective data, Journal:  Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis. (Pubmed Central) -  Oct 25, 2022   
    Trial completion date: Jan 2023 --> Jan 2024 | Trial primary completion date: Jan 2023 --> Jan 2024  Nimodipine is effective in the treatment of SAH, lowering incidence of adverse reactions and therefore improving the prognosis of patients.
  • ||||||||||  nimodipine / Generic mfg.
    Nimodipine prevents spasticity and enables spontaneous motor recovery after cervical spinal cord injury (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_11310;    
    Our data indicate that early and prolonged treatment with nimodipine not only reduced the development of spasticity following injury but also resulted in a significant improvement in tissue preservation and motor recovery compared to vehicle control. Our results indicate that nimodipine is a potential pharmacological treatment to prevent the development of spasticity and promote functional recovery in a clinically relevant model of cervical spinal cord injury.
  • ||||||||||  nimodipine / Generic mfg.
    Amyloid beta 42 causes intracellular calcium dysregulation and arcuate neuropeptide Y (NPY) neuronal dysfunction by modulating CaV1.3 channels (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_9533;    
    Similar to our previous data, we found that in the presence of 100 nM Aβ42 the peak current of LTCC I-V curves in Cav1.3 Cre-/- ARC NPY neurons were shifted from a high voltage-threshold in the control to a low voltage-threshold, an effect reversed by the LTCC blocker nimodipine (NMD, 2 μM) (SP=-30 mV: Veh -172.4±114.9 pA, Aβ42 -615.7±138.8 pA, NMD -153± 196.5 pA, n=4-5, p<0.05)...These data support that Cav1.3 but not Cav1.2 is required for the pathological effects of Aβ42 on ARC NPY neurons. Future studies will be important in further elucidating the pathological role and therapeutic potential of modulating Cav1.3 in AD.
  • ||||||||||  lorazepam / Generic mfg., nimodipine / Generic mfg., carbamazepine / Generic mfg.
    Elucidating the mechanisms of transcranial ultrasound for modulation of human motor cortex. (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_7450;    
    These results provide the first assessment of the pharmacological mechanisms of TUS brain stimulation in human and will be conducive to the development of TUS as a potential treatment of neurological and psychiatric disorders, as well as a tool for the study of the brain. Data collection is ongoing and more subjects are being recruited, increasing sample size in time for the conference.
  • ||||||||||  nimodipine / Generic mfg.
    Spike-time-dependent plasticity of retinal input to Superior colliculus wide-field neurons (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_7280;    
    t-LTP response was block by bath application of both APV (an NMDA receptor antagonist) and nimodipine (a L-type Ca2+ channel blocker), whereas t-LTD was only blocked by nimodipine. These findings indicate that retinal input to the SC can undergo long-term synaptic plasticity, which may play a role in the habituation of behavioural responses to threatening stimuli.
  • ||||||||||  nimodipine / Generic mfg.
    NMDAR Ca2+ flux and LTCC voltage-dependent conformational change cooperate locally and sequentially to signal to the nucleus (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_6740;    
    LTCC VΔC is required for NMDA-induced CaMKII mobilization and pCREB increases, which is blocked by the addition of LTCC-blocker nimodipine to prevent the conformational change...This may translate to distinct roles for each channel in synaptic plasticity: NMDAR in driving CaMKII mobilization, and LTCC in sustaining it. Together, our findings provide molecular basis for how NMDAR and LTCC may cooperate to drive long-term synaptic changes.
  • ||||||||||  riluzole / Generic mfg., nimodipine / Generic mfg.
    An electrically-coupled glutamatergic spinal network for the generation of episodic rhythmicity (SDCC Halls B-H) -  Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_2050;    
    Moreover, selective blockers against persistent sodium (NaV1.6: 4,9, AH-TTX) or persistent calcium currents (ICaL: Nimodipine) had no effects on episodic activity...Considering these experimental results, we examined with a computational model how AMPA, NMDA, and electrical coupling can lead to the generation of episodic rhythmicity within spinal circuits. Our results suggest that NMDA receptors play a key role in the generation bursting activity within episodes.
  • ||||||||||  nimodipine / Generic mfg., milrinone / Generic mfg.
    Observational data, Journal:  Role of Nimodipine and Milrinone in Delayed Cerebral Ischemia. (Pubmed Central) -  Oct 6, 2022   
    We propose implications for clinical practice and patient management to minimize cerebral ischemia. In this single-center small study, patients in the IAN group had significantly less mortality compared with the IVM group in the management of DCI after aneurysmal SAH.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal, IO biomarker:  Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms. (Pubmed Central) -  Sep 30, 2022   
    The rats were divided into 6 groups: sham, permanent middle cerebral artery occlusion (pMCAO), pMCAO with neferine and nimodipine treatment...Neferine treatment also significantly decreased apoptosis, with a decrease in Bax and cleaved caspase-3 and an increase in Bcl-2. This study suggested that neferine had a neuroprotective effect on permanent cerebral ischemia in rats by diminishing oxidative stress and apoptosis.
  • ||||||||||  nimodipine / Generic mfg.
    Review, Journal:  Delayed cerebral ischemia after meningioma resection: Literature review and illustrative case. (Pubmed Central) -  Sep 29, 2022   
    This study suggested that neferine had a neuroprotective effect on permanent cerebral ischemia in rats by diminishing oxidative stress and apoptosis. The systematic literature review and the present case of DCI following resection of an olfactory meningioma suggested that the main etiologic factors causing this rare pathology are: 1) intraoperative subarachnoid hemorrhagic contamination; 2) microvascular manipulation; 3) and possible dysregulation of hypothalamic function.
  • ||||||||||  nimodipine / Generic mfg.
    COMPARISON OF COMPLICATIONS OF POST-COVID-19 IN PATIENTS WITH PARKINSONISM SYNDROME OF DIFFERENT GENESIS (Poster Station: 9) -  Sep 22, 2022 - Abstract #MDSCongress2022MDR_Congress_1143;    
    Group 3 (50 people) were patients with drug-induced parkinsonism who took drugs containing amlodipine or nimodipine from 1 to 5 years for hypertension... In our opinion, patients with Parkinson’s syndromes of different genesis who have undergone COVID-19 have a difference in complications that require different ways of treatment and rehabilitation.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Enhancement of nerve regeneration with nimodipine treatment after sciatic nerve injury. (Pubmed Central) -  Aug 24, 2022   
    Additionally, nimodipine treatment increases the mRNA levels of neurotrophic factors (BDNF and NGF), which are known to contribute to the regeneration of injured neurons. The impact of nimodipine in PNI recovery may be due to its stimulation of the CREB signaling pathway and suppression of pro-inflammatory factor production.
  • ||||||||||  nimodipine / Generic mfg.
    Review, Journal:  Targeting Hemoglobin to Reduce Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. (Pubmed Central) -  Aug 24, 2022   
    Aside from nimodipine, no therapeutic agents are available to reduce the incidence of DCI...Finally, we will address a recent novel device that is currently being tested, the Neurapheresis CSF Management System™. This is an automated dual-lumen lumbar drainage system that has an option to filter CSF and return it to the patient.
  • ||||||||||  nimodipine / Generic mfg.
    Trial completion date, Trial primary completion date:  Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration (clinicaltrials.gov) -  Aug 24, 2022   
    P=N/A,  N=30, Recruiting, 
    This is an automated dual-lumen lumbar drainage system that has an option to filter CSF and return it to the patient. Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2022 --> Jul 2023
  • ||||||||||  nimodipine / Generic mfg.
    Clinical, Review, Journal:  Updates on aneurysmal subarachnoid hemorrhage: is there anything really new? (Pubmed Central) -  Aug 22, 2022   
    However, despite the number of publications, the only treatments shown to be effective in adequate, well-controlled clinical trials are nimodipine and repair of the ruptured aneurysm. Thus, doubts about the optimal management of SAH still persist.
  • ||||||||||  donepezil / Generic mfg., nimodipine / Generic mfg.
    Clinical, Review, Journal:  A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia. (Pubmed Central) -  Aug 12, 2022   
    Donepezil hydrochloride combined with nimodipine had good efficacy in the treatment of patients with vascular dementia, mainly in terms of improving the Simple MMSE scores, the ability to use daily living scale (ADL) scores and the CDR, and the best results were obtained after 12 weeks of intervention. Such conclusion should be cautiously evaluated.