nimodipine / Generic mfg. 
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  • ||||||||||  nimodipine / Generic mfg.
    Journal, IO biomarker:  The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification. (Pubmed Central) -  Jul 10, 2023   
    The Sprague-Dawley (SD) rats were divided into sham, model, low-dose (5?g/kg, i.g.), high-dose (20?g/kg, i.g.), and nimodipine (20?mg/kg, i.g.) groups once daily for 7?days...Furthermore, HGWD decreased the levels of HIF-1A, VEGFA, Bax, cleaved caspase-3, p-MAPK1, and p-c-Jun while increasing the expression of p-PI3K, p-AKT1, and Bcl-2. This study initially elucidated the mechanism of HGWD anti-IS, which contributed to the further promotion and secondary development of HGWD in clinical practice.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Bibliometric analysis of acupuncture and moxibustion treatment for mild cognitive impairment. (Pubmed Central) -  Jul 3, 2023   
    The hotspots in Chinese literature were "needling, treatment, electric acupuncture, nimodipine, cognitive training" and other clinical research directions...In the future, strengthening effective communication and cooperation among institutions, especially international cooperation, is essential for conducting high-quality research on acupuncture for MCI. This will help obtain high-level evidence and improve the output and translation of research results.
  • ||||||||||  donepezil / Generic mfg., nimodipine / Generic mfg., piracetam / Generic mfg.
    Retrospective data, Review:  Efficacy of acupuncture and pharmacological therapies for vascular cognitive impairment with no dementia: a network meta-analysis. (Pubmed Central) -  Jul 3, 2023   
    For the secondary outcome, electroacupuncture plus nimodipine was considered to be the most effective intervention (P = 42.70%), followed by manual acupuncture plus nimodipine (P = 30.62%) and manual acupuncture (P = 28.89%), whereas nimodipine ranked the least efficacious intervention (P = 44.56%)...The combination of acupuncture and drug therapy had a tendency to perform better than monotherapy in terms of clinical outcomes. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=331718, identifier: CRD42022331718.
  • ||||||||||  nimodipine / Generic mfg.
    Trial completion, Enrollment change, Trial completion date:  Cognitive Effects of Nimodipine in Patients With Schizophrenia (clinicaltrials.gov) -  Jun 23, 2023   
    P1,  N=18, Completed, 
    Although Ketamine and Nimodipine have shown promise in the treatment and prevention of CSDs in SAH, further research is needed to determine the therapeutic potential of these as well as other agents. Suspended --> Completed | N=30 --> 18 | Trial completion date: Jan 2024 --> May 2023
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  NimoTop or NimoStop? (Pubmed Central) -  Jun 21, 2023   
    Suspended --> Completed | N=30 --> 18 | Trial completion date: Jan 2024 --> May 2023 No abstract available
  • ||||||||||  nimodipine / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Stellate Ganglion Block as Adjuvant Therapy to ca Channel Blocker (clinicaltrials.gov) -  Jun 13, 2023   
    P2,  N=40, Completed, 
    Our pharmacovigilance database analysis showed a significant association between the use of intravenous DCCIs and hypoxia. Not yet recruiting --> Completed | Trial completion date: Nov 2024 --> Jan 2023 | Trial primary completion date: Oct 2024 --> Dec 2022
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Bath-related headache: a case report. (Pubmed Central) -  Jun 8, 2023   
    Bath-related headache is a thunderclap primary headache disorder with a benign prognosis, but its recognition requires awareness to differentiate it from subarachnoid hemorrhage. It warrants inclusion in the International Classification of Headache Disorders.
  • ||||||||||  Review:  Capsular warning syndrome and its clinical awareness and therapeutic approach: two case reports and a systematic review of the literature. (Pubmed Central) -  Jun 1, 2023   
    The first patient had six events of right hemiparesis with recovery in 10-30 min; after MRI and digital subtraction angiography (DSA), he received apixaban and clopidogrel; however, a day after admission, he developed ischemic infarction with partial recovery...After MRI and DSA with an intra-arterial infusion of nimodipine, oral aspirin, and ticagrelor, he presented another event-developing stroke and was discharged with partial recovery...Our cases fit with the description of patients with partial recovery and risk factors (hypertension, diabetes, and smoking) in male patients. There is a lack of evidence regarding the best treatment option; dual antiplatelet therapy and anticoagulation therapy are strong contenders for a favorable result.
  • ||||||||||  nimodipine / Generic mfg.
    Clinical improvement of a toddler with COVID-19 focal cerebral arteriopathy possibly due to intra-arterial nimodipine (Foyer 3B, 3rd Floor) -  May 29, 2023 - Abstract #EPNS2023EPNS_78;    
    The present report describes a toddler with FCA most likely induced by SARS-CoV-2 infection who showed significant clinical improvement that may be related to injection of intra-arterial nimodipine. The efficacy and safety of intra-arterial nimodipine administration by well trained invasive neuroradiologists warrants further investigation.To our knowledge, this is the first reported use of nimodipine in this setting.
  • ||||||||||  nimodipine / Generic mfg.
    Trial primary completion date:  Cognitive Effects of Nimodipine in Patients With Schizophrenia (clinicaltrials.gov) -  May 15, 2023   
    P1,  N=30, Suspended, 
    The efficacy and safety of intra-arterial nimodipine administration by well trained invasive neuroradiologists warrants further investigation.To our knowledge, this is the first reported use of nimodipine in this setting. Trial primary completion date: Jan 2024 --> May 2023
  • ||||||||||  Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
    Journal:  VIsion Salvage Using Intra-Ophthalmic Arterial Alteplase Combine with Nimodipine in Central Retinal Artery Occlusion (VISION). (Pubmed Central) -  May 2, 2023   
    There were also asymptomatic thromboembolic events in 2 patients (22.2%) after the intervention procedure, without any morbidity or mortality. The use of selective intra-ophthalmic arterial combined nimodipine and alteplase was efficacious in improving BCVA at 1 month for patients with non-arteritic CRAO presenting between 24 hours from onset, with minor adverse events but no serious adverse events.
  • ||||||||||  nimodipine / Generic mfg.
    Review, Journal:  Cerebral Vasospasm: Practical Review of Diagnosis and Management. (Pubmed Central) -  Mar 27, 2023   
    However, with the equipment we have, it has been possible to improve the outcome, even if it is still not ideal, in patients who develop vasospasm. Several studies are in the final stages to improve the outcome of this unfortunately frequent condition.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Enhanced dissolution rate of nimodipine through ?-lactoglobulin based formulation. (Pubmed Central) -  Mar 20, 2023   
    Nimodipine combined with atorvastatin calcium could significantly improve the clinical symptoms in patients with CVS after SAH, which would be beneficial, safe, and effective for the patient's recovery. Surprisingly, the ASD formulated with BLG at 17.5% DL demonstrated an even higher drug release (C, 643
  • ||||||||||  nimodipine / Generic mfg., milrinone / Generic mfg.
    Treatment of Refractory Vasospasm after Aneurysmal Subarachnoid Hemorrhage: What else could we do for our patients? A Case Report and Systemic Literature Review (Both in-person and online) -  Mar 12, 2023 - Abstract #AAN2023AAN_2683;    
    Current guidelines recommend using nimodipine and maintaining euvolemia to prevent vasospasm, with hypertension induction and cerebral angioplasty and/or selective intra-arterial vasodilator therapy for its treatment...The patient fully recovered following treatment which included management recommendations per guidelines, milrinone for inducing hypertension, intrathecal nicardipine, and bilateral stellate ganglion block (SCG)...Conclusions A variety of complementary therapies are available and could be used in the management of refractory vasospasm. Although these are alternative therapies, they are efficacious in managing this condition, and physicians should be aware of these options.
  • ||||||||||  dantrolene / Generic mfg.
    Preclinical, Journal:  Dantrolene Significantly Improves Cerebral Blood Flow in a Rat Model of Hemorrhagic Vasospasms. (Pubmed Central) -  Mar 7, 2023   
    Altogether, our results indicate that 2.5 mg/kg dantrolene significantly reduces BFV in the MCA without altering systemic hemodynamic parameters to a similar extent than the highest dose of nimodipine or the combination of dantrolene and the lowest dose of nimodipine. Therefore, dantrolene may provide a promising alternative to lower the risk, or partially revert, CVSP.
  • ||||||||||  pravastatin / Generic mfg., nimodipine / Generic mfg.
    PK/PD data, Review, Journal:  Potential Pharmacokinetic Interactions of Common Cardiovascular Drugs and Selected European and Latin American Herbal Medicines: A Scoping Review. (Pubmed Central) -  Feb 11, 2023   
    The adenosine-modulating drugs could be considered for repurposing based on predicted effects on AR activation. as per the preclinical data reviewed here, we encourage more clinical research on whether drugs with apparently very low interaction risk, such as pravastatin, nadolol, and nimodipine/nitrendipine, may help prevent HDI when statins, beta blockers, and calcium channel blockers, respectively, are prescribed for long-term treatments.
  • ||||||||||  nimodipine / Generic mfg., paracetamol / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  SYNAPSE: Measuring Blood Flow in the Brain After Epileptic Activity (clinicaltrials.gov) -  Jan 26, 2023   
    P2,  N=34, Active, not recruiting, 
    On the whole, the findings of the present study suggest that the combined use of IT nimodipine with IV admission for patients post-aSAH who developed severe CV is a safe procedure that may prevent permanent neurological deterioration and delay unfavorable ischemic incidents. Recruiting --> Active, not recruiting | Trial completion date: Oct 2022 --> Mar 2023 | Trial primary completion date: Oct 2022 --> Dec 2022
  • ||||||||||  dexamethasone / Generic mfg., nimodipine / Generic mfg.
    Journal, Surgery:  Cerebral vasospasm following subarachnoid hemorrhage: a rare complication after transsphenoidal surgery for pituitary macroadenoma. (Pubmed Central) -  Jan 11, 2023   
    High-dose dexamethasone (16 mg/day) was initiated and the patient became more alert (Glasgow 14)...Nevertheless, nimodipine 60 mg 4/4 h was initiated...Post-TSS subarachnoid hemorrhage and hemiparesis may be important clues indicating CVS and infarction. There is limited evidence in the literature regarding post-TSS CVS surveillance and treatment strategies which could have an impact on clinical decisions.
  • ||||||||||  Journal:  Exploration of treatments for subarachnoid hemorrhage. (Pubmed Central) -  Jan 3, 2023   
    In addition, certain drugs can enhance lymphatic flow and influence the recovery process, such as Dexmedetomidine, SSRIs, and DL-3-n-butylphthalide...Clinical trials have not yet provided conclusive evidence to support the use of magnesium or statins. Moreover, other agents such as calcium channel blockers, milrinone, hydrogen sulfide, exosomes, erythropoietin, cilostazol, fasudil, albumin, Eicosapentaenoic acid, corticosteroids, minocycline, and stellate ganglion blockade should be investigated further.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke. (Pubmed Central) -  Dec 13, 2022   
    In this experiment, 90 adult male Sprague-Dawley rats were randomly divided into the sham operation group (SHAM, vehicle), middle cerebral artery occlusion-reperfusion injury model group (MCAO/R, vehicle), positive control group (NMDP, 36 mg/kg/day nimodipine), and low (BMDL, 0.805 g/kg/day), moderate (BMDM, 1.61 g/kg/day), and high (BMDH, 3.22 g/kg/day) dosage of BMD prophylactic administration groups...UHPLC-QTOF-MS/MS-based serum and brain metabolomics analysis found a total of 53 differential metabolites between MCAO/R and SHAM groups, of which 30 were significantly regulated by BMD intervention, and further metabolic pathway analysis implied that the protective effects were mainly associated with amino acid and glycerophospholipid metabolisms. Our pharmacodynamic and metabolomic results revealed the neuroprotective effects of BMD on MCAO/R rats, and the underlying mechanisms were probably related to amino acid and glycerophospholipid metabolisms.
  • ||||||||||  nimodipine / Generic mfg.
    Journal, IO biomarker:  Effect of ethanol extract of Gastrodiae Rhizoma on mitochondrial dysfunction in cerebral ischemia-reperfusion injury (Pubmed Central) -  Dec 7, 2022   
    SD rats were randomly divided into a sham operation group(Sham), a model group(MCAO/R), low-and high-dose ethanol extract of GE groups(262.3 and 524.6 mg·kg~(-1)), and a nimodipine group(Nim, 15 mg·kg~(-1))...In addition, the ethanol extract of GE reduced the loss of MMP and the escape of Cyt C to the cytoplasm(P<0.05), reduced the number of TUNEL positive cells(P<0.01) accompanied by the decrease in Bax and the up-regulation of Bcl-2(P<0.01), and increased the level of ATP(P<0.01). In conclusion, GE ethanol extract has a protective effect against MCAO/R-induced mitochondrial dysfunction, and the mechanism may be related to the regulation of oxidative stress, maintenance of functional morphology of mitochondria, and inhibition of endogenous apoptosis.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Effects of dichloromethane extraction from Piper nigrum L. and P. longum L. on the expression of autophagy-related proteins in ischemic stroke. (Pubmed Central) -  Nov 27, 2022   
    Animals were administered with DF (50, 100, and 150mg/kg) or nimodipine (12mg/kg) 6h after pMCAO for 14 consecutive days via intragastric gavage...Western blot testing showed that at the molecular level, DF significantly suppressed ischemia-induced activated expression of LC3, Beclin1, Atg12, and Atg5. Overall, our study indicated that DF attenuated neuronal autophagy by suppressing the expression of autophagy-related proteins to generate neuroprotection effect for ischemic stroke.
  • ||||||||||  nimodipine / Generic mfg.
    Retrospective data, Journal:  Intravenous Nimodipine Versus Enteral Nimodipine: The Meta-analysis Paradox. (Pubmed Central) -  Nov 22, 2022   
    Overall, our study indicated that DF attenuated neuronal autophagy by suppressing the expression of autophagy-related proteins to generate neuroprotection effect for ischemic stroke. No abstract available