nimodipine / Generic mfg. 
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 49 Diseases   11 Trials   11 Trials   798 News 


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  • ||||||||||  Pivlaz (clazosentan) / Idorsia, Sosei
    Journal:  Pharmacotherapy in SAH: Clinical Trial Lessons. (Pubmed Central) -  Jan 20, 2024   
    However, extensive research is currently underway to identify novel substances with magnesium sulphate, cilostazol, clazosentan and fasudil, demonstrating promising results...Statins may benefit some patients by reducing the incidence of vasospasm and delayed ischemic events. As several clinical trials are underway, it is expected that in the years to come, more therapeutic options will be added to the attending physician's armamentarium.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  The Laboratory Origins of Nimodipine in Cerebral Vasospasm. (Pubmed Central) -  Jan 20, 2024   
    As several clinical trials are underway, it is expected that in the years to come, more therapeutic options will be added to the attending physician's armamentarium. No abstract available
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  The Cell Permeant Phosphopetpide (Pubmed Central) -  Jan 16, 2024   
    No abstract available Therapeutic options after SAH are currently limited to hemodynamic optimization and nimodipine, which have limited clinical efficacy...Using a single cisterna magna injection rat model of SAH, we demonstrated that intravenous administration of low-dose VP3 after SAH improved neurologic deficits for up to 14
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Risks of nimodipine dose reduction during the high-risk period for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. (Pubmed Central) -  Jan 13, 2024   
    'Poor WFNS grade' and 'reduced nimodipine dose' were identified as independent risk factors for DCI-related infarction while 'older age,' 'poor WFNS grade,' and 'reduced nimodipine dose' were associated with unfavorable outcome at 3 months after discharge. Nimodipine dose reduction during the high-risk period of DCI and CVS between days 5 and 10 after hemorrhage might abrogate the positive prognostic effects of nimodipine and should be critically evaluated.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Nimodipine in treatment of bipolar disorder (Pubmed Central) -  Dec 26, 2023   
    Due to its pronounced ability to penetrate the blood-brain barrier, it has a selective effect on brain neurons and has a vasodilating, antihypertensive and normotimic effect. Nimodipine blocks LTCC channels in brain neurons, thereby influencing synaptic plasticity, transmitter release and excitation-transcription coupling, which makes it possible to influence various clinical conditions with pathology in the area of affect, including bipolar disorders with ultra-rapid cycling, and also, in cases with high resistance and intolerance to other mood stabilizers.
  • ||||||||||  aspirin / Generic mfg., nimodipine / Generic mfg.
    Review, Journal:  Contrast-medium injury of spinal cord after cerebral angiography using nonionic contrast agents: A case report and literature review. (Pubmed Central) -  Dec 24, 2023   
    Nimodipine blocks LTCC channels in brain neurons, thereby influencing synaptic plasticity, transmitter release and excitation-transcription coupling, which makes it possible to influence various clinical conditions with pathology in the area of affect, including bipolar disorders with ultra-rapid cycling, and also, in cases with high resistance and intolerance to other mood stabilizers. Given the grave outcomes of CIS, like limb paralysis, breathing difficulties, and even fatality, it is imperative to remain cautious about this complication, even with the use of modern, less harmful contrast agents.
  • ||||||||||  nifedipine immediate release / Generic mfg., nimodipine / Generic mfg.
    Journal:  High-throughput nanoscale crystallization of dihydropyridine active pharmaceutical ingredients. (Pubmed Central) -  Dec 21, 2023   
    This approach allowed 288 individual crystallization experiments to be performed in parallel on each molecule, resulting in rapid access to crystals and subsequent crystal structures for all six dihydropyridines, as well as revealing a new solvate polymorph of nifedipine (1,4-dioxane solvate) and the first known solvate of nimodipine (DMSO solvate). This work further demonstrates the power of modern high-throughput crystallization methods in the exploration of the solid-state landscape of active pharmaceutical ingredients to facilitate crystal form discovery and structural analysis by single-crystal X-ray diffraction.
  • ||||||||||  nimodipine (GTX-104) / Acasti Pharma
    Trial completion date, Trial primary completion date:  STRIVE-ON: Safety and Tolerability of GTX-104 Compared With Oral Nimodipine in Patients With aSAH (clinicaltrials.gov) -  Dec 5, 2023   
    P3,  N=100, Recruiting, 
    Nimodipine has been useful in differentiating the diagnosis of FV resulting from mechanical thrombectomy and other potential causes, such as iatrogenic dissection or residual clot. .
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Study on the Nasal Drug Delivery System of NMD Liposomes In Situ Thermosensitive Gel. (Pubmed Central) -  Nov 21, 2023   
    WZYD attenuates EBI after SAH by activating Nrf2/HO-1 signaling through SIRT6-mediated H3K56 deacetylation, suggesting its therapeutic potential for SAH treatment. Nimodipine (NMD) is a 1,4-dihydropyridine calcium antagonist that is effective in the prevention and treatment of cerebral arterial vasospasm and cerebral ischemic injury caused by subarachnoid hemorrhage...Meanwhile, the NMD liposome gel formulation achieved sustained release over 56
  • ||||||||||  aspirin / Generic mfg., nimodipine / Generic mfg.
    Posterior Spinal Artery Aneurysm Resulting in Acute Paraplegia () -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_838;    
    Posterior spinal artery aneurysm is a rare but life threatening condition that is typically due to vascular malformations. They can lead to further complications such as acute subarachnoid hemorrhage and paraplegia as seen in the case of this patient.
  • ||||||||||  riluzole / Generic mfg., nimodipine / Generic mfg.
    Postnatal development of  (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_3778;    
    These data suggest a developmental shift in the magnitude of rhythmogenic ionic currents and the expression of corresponding ion channels. Findings from this study will inform future experiments to reveal essential mechanisms of locomotor rhythmogenesis in mature spinal locomotor circuitry.
  • ||||||||||  nimodipine / Generic mfg.
    L-type calcium channel mediates pre-tangle tau-induced neuronal degeneration in the locus coeruleus: a pilot study (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_2188;    
    The preliminary result showed that pre-tangle tau elevates LTCC, and chronic nimodipine administration rescued spatial and olfactory behavioral deficiencies induced by pre-tangle tau. Our data support the involvement of Ca2+ in AD and suggest that therapeutics targeted at the LTCC-mitochondria-LC pathway could be beneficial in AD intervention.
  • ||||||||||  nimodipine / Generic mfg.
    NMDAR ca2+ flux and LTCC voltage-dependent conformational change cooperate locally and sequentially to signal to the nucleus (WCC 207A) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_1387;    
    LTCC V?C is required for NMDA-induced CaMKII mobilization and pCREB increases, which is blocked by the addition of LTCC-blocker nimodipine to prevent the conformational change...Studies are currently under way to investigate the temporal dynamics of protein-protein interactions between CaMKII and either LTCC or NMDAR using FRET imaging. Together, our findings provide a molecular basis for how NMDAR and LTCC may cooperate to drive long-term synaptic changes.
  • ||||||||||  nimodipine / Generic mfg.
    Journal, Heterogeneity:  Novel Insights into Pathophysiology of Delayed Cerebral Ischemia: Effects of Current Rescue Therapy on Microvascular Perfusion Heterogeneity. (Pubmed Central) -  Oct 28, 2023   
    This study evaluates the effect of multimodal rescue therapy (intra-arterial nimodipine administration and elevation of blood pressure) on MTT and cvMTT during DCI in aneurysmal subarachnoid haemorrhage (aSAH) patients...The combined multimodal rescue therapy was effective in addressing the general microvascular perfusion impairment but did not affect the mechanisms underlying microvascular perfusion heterogeneity. This highlights the need for research into new therapeutic approaches that also target these pathophysiological mechanisms of DCI.
  • ||||||||||  nimodipine / Generic mfg., memantine / Generic mfg., citicoline / Generic mfg.
    Review:  The efficacy and safety of post-stroke cognitive impairment therapies: an umbrella review. (Pubmed Central) -  Sep 11, 2023   
    Our study demonstrated that ACEI inhibitors (Donepezil) and NMDA antagonists (Memantine), EGB761, and acupuncture are the ADL and BI, MoCA, and neurological function deficit medication/therapy, respectively, for patients with PSCI. Clinical Trial Registration: https://inplasy.com/inplasy-2022-11-0139/; Identifier: INPLASY2022110139.
  • ||||||||||  nimodipine / Generic mfg.
    Journal:  Nimodipine Reduces Microvasospasms After Experimental Subarachnoid Hemorrhage. (Pubmed Central) -  Sep 8, 2023   
    Our results show that nimodipine reduces the formation of microvasospasms, thus, shedding new light on the mode of action of a drug routinely used for the treatment of SAH for >3 decades. Furthermore, L-type Ca2+ channels may be involved in the pathophysiology of microvasospasm formation.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  Osmundacetone alleviates cerebral ischemia-reperfusion injury in rats. (Pubmed Central) -  Sep 8, 2023   
    Rats were respectively given nimodipine (NI), low dose (L-DHBAc) and high dose (H-DHBAc) Osmundacetone, and they were killed under anesthesia after 24 hours of reperfusion...The effect of H-DHBAc was similar to those of NI. These results suggest that DHBAc could mitigate damage to brain tissue in rats with cerebral I/R injury.
  • ||||||||||  nimodipine / Generic mfg.
    Preclinical, Journal:  Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis. (Pubmed Central) -  Aug 29, 2023   
    Sprague-Dawley rats were randomly assigned to the following groups (n?=?10) and administered intragastrically once a day for 7 consecutive days: sham, model, nimodipine (24?mg/kg), styrax-L (0.1?g/kg), styrax-M (0.2?g/kg) and styrax-H (0.4?g/kg)...Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.