- |||||||||| nimodipine / Generic mfg., paracetamol / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: SYNAPSE: Measuring Blood Flow in the Brain After Epileptic Activity (clinicaltrials.gov) - Feb 5, 2020
P2, N=33, Recruiting,
The majority of fatal cases in our report occurred in women, with over half of those cases during the puerperium period. Not yet recruiting --> Recruiting | Trial completion date: Oct 2020 --> Oct 2021 | Trial primary completion date: Oct 2020 --> Oct 2021
- |||||||||| Nimotop (nimodipine) / Bayer
Delayed Vasospasm in Traumatic Subarachnoid Hemorrhage () - Jan 21, 2020 - Abstract #AAN2020AAN_1655;
Mechanism is poorly understood but thought to be due to inflammatory cascade triggered by hemoglobin degradation. More studies on the predictors, outcomes and treatment of vasospasm following tSAH are needed.
- |||||||||| Nimotop (nimodipine) / Bayer
Ruptured Spinal Aneurysm as a Complication of Post-Partum Angiopathy () - Jan 21, 2020 - Abstract #AAN2020AAN_1489;
In the presence of unexplained SHA and/or SC dysfunction, spinal SHA needs to be considered. If present, SA ought not systematically be attributed to epidural anesthesia and spinal angiography should be obtained.
- |||||||||| Eporon (epoetin alfa biosimilar) - Dong / A, Nimotop (nimodipine) / Bayer
Preclinical, Journal: Effects of intrathecal verapamil on cerebral vasopasm in experimental rat study. (Pubmed Central) - Jan 16, 2020
Proactive and preventive strategies such as oral nimodipine and endovascular rescue therapies can reduce the morbidity and mortality associated with CV. Our findings suggest that intrathecal verapamil can prevent vasospasm, oxidative stress, and apoptosis after experimental subarachnoid hemorrhage.
- |||||||||| nimodipine / Generic mfg., choline alfoscerate / Generic mfg.
Trial completion: CONIVAD: Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment (clinicaltrials.gov) - Jan 13, 2020
P2, N=62, Completed,
The present work may provide some scientific references for selecting the appropriate mesoporous silica carrier for a specific drug. Active, not recruiting --> Completed
- |||||||||| nimodipine microparticles (EG-1962) / Edge Therap
Clinical, P3 data, Journal: Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)]. (Pubmed Central) - Jan 11, 2020
P3
Data on safety, rescue therapy, delayed cerebral infarction, and health economics will be collected. Trail registration NCT02790632.
- |||||||||| Nimotop (nimodipine) / Bayer
Clinical, Journal: Vasospasm and delayed cerebral ischemia after uneventful clipping of an unruptured intracranial aneurysm - a case report. (Pubmed Central) - Jan 8, 2020
Cerebral vasospasm as a cause of ischemic stroke after uneventful surgery for a UIA seems to be a rare but possibly underestimated etiology that demands particular attention with respect to providing appropriate treatment. In future, it may be prudent to perform follow-up transcranial ultrasonography testing after the clipping of a UIA, especially considering the availability of potentially neuroprotective medications like nimodipine.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: How signals of calcium ions initiate the beats of cilia and flagella. (Pubmed Central) - Jan 1, 2020
We propose a new scenario based on the polyelectrolyte properties of cellular microtubules (MTs) such that dynamic influx of Ca ions provides the initiation and synchronization of dynein sliding along microtubules. We also point out the possible interplay between tubulin polyglutaminated C-termini and localized pulses of Ca ions along microtubules.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. (Pubmed Central) - Dec 25, 2019
In the thalamus, there was a significant decrease in the amplitude of low frequency fluctuations (ALFF) in resting state functional MRI and an apparent increase of grey matter volume in hypoxia, with the ALFF partially normalized towards normoxia baseline with nimodipine. This study provides further evidence that the brain response to acute hypoxia is mediated by calcium, and importantly that manipulation of intracellular calcium flux following hypoxia may reduce cerebral cytotoxic oedema.
- |||||||||| Flagyl (metronidazole) / SLA, clarithromycin / Generic mfg., Omeprazole RBX (omeprazole) / Generic mfg.
Journal: Repurposing Dihydropyridines for Treatment of Helicobacter pylori Infection. (Pubmed Central) - Dec 22, 2019
Oral treatments with 100 mg/kg/day of marketed formulations of Nimodipine or Nitrendipine in combination with omeprazole significantly reduced the H. pylori gastric colonization in mice. The results presented here support a novel therapeutic solution for treatment of antibiotic-resistant H. pylori infections.
- |||||||||| Nimotop (nimodipine) / Bayer
Advanced Neurocritical Care Management of Subarachnoid Hemorrhage and Delayed Cerebral Ischemia (Room 502 A) - Dec 21, 2019 - Abstract #ISC2020ISC_128;
Other major developments in SAH include a plethora of promising new treatments for the prevention and treatment of vasospasm and delayed cerebral ischemia, including Milrinone and intraventricular Nimodipine...From a neurocritical care standpoint, strategies for fluid and hemodynamic management of the SAH patient have evolved dramatically as we realize that traditional measures of volume status such as filling pressures fail to predict fluid responsiveness and new, less invasive technology, such as bedside ultrasound and transpulmonary thermodilution, becomes available. The session would therefore focus on these recent changes and advances in SAH, rather than discussing well established concepts
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Sensitivity of a Continuous Hot-Melt Extrusion and Strand Pelletization Line to Control Actions and Composition Variation. (Pubmed Central) - Dec 20, 2019
The purpose of this work was to develop a robust hot-melt extrusion and strand pelletization process for manufacturing pellets with an immediate release (IR) of a poorly water-soluble active pharmaceutical ingredient (API), nimodipine...Near-infrared (NIR) spectroscopy was applied to monitor API content and the sensitivity of the residence time distribution (RTD) was investigated by means of tracer measurements. NIR-based API content monitoring and RTD models for material tracking were found to be at risk after processing melt with high HPMC content, due to a lack of purging by less viscous formulation compositions.
- |||||||||| nimodipine microparticles (EG-1962) / PDS Biotech
PK/PD data, Journal: Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage. (Pubmed Central) - Dec 8, 2019
P1/2
The CSF concentrations from EG-1962, however, were at least 2 orders of magnitude higher than those with oral nimodipine. These results supported a phase 3 study that demonstrated a favorable safety profile for EG-1962 but yielded inconclusive efficacy results due to notable differences in clinical outcome based on baseline disease severity.Clinical trial registration no.: NCT01893190 (ClinicalTrials.gov).
- |||||||||| Nimotop (nimodipine) / Bayer
PK/PD data, Preclinical, Journal: Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. (Pubmed Central) - Nov 21, 2019
The chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing with other four groups where the rats were administered one of the five anthraquinones, and there was no significant difference between the nimodipine group...Emodin, rhein, chrysophanol, and physcion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma exposure levels. (4) This experiment provides a certain preclinical basis for the study of anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the mechanism of interaction between anthraquinones.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Nimodipine-Induced Blood Pressure Changes Can Predict Delayed Cerebral Ischemia. (Pubmed Central) - Nov 20, 2019
A fall of 18 mmHg in SBP after Nimodipine administration showed a sensitivity of 82.4% and specificity of 92.3% for occurrence of DCI. An increase of MAP and DBP after aSAH and a heightened sensitivity to Nimodipine administrations may serve as additional biomarkers for early detection of evolving DCI.
- |||||||||| Nimotop (nimodipine) / Bayer
Review, Journal: Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review. (Pubmed Central) - Nov 19, 2019
In terms of safety, one study had no occurrences of associated bacterial meningitis and the other study had two reported cases of bacterial meningitis out of 50 among those who received intrathecal nicardipine. Limited studies on the use of intrathecal nicardipine following non-traumatic subarachnoid hemorrhage and lack of pooling of results for this review demonstrate the need for more research in this field.
- |||||||||| nimodipine / Generic mfg.
Trial completion date, Trial primary completion date: Cognitive Effects of Nimodipine in Patients With Schizophrenia (clinicaltrials.gov) - Nov 11, 2019
P1, N=30, Recruiting,
The warming-promotion needling can improve the learning and memory ability in VD rats, which may be related to its effects in up-regulating the expression of nAChR su-bunits in the hippocampus. Trial completion date: Oct 2019 --> Oct 2020 | Trial primary completion date: Oct 2019 --> Oct 2020
- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Migraine Headache Prophylaxis. (Pubmed Central) - Nov 10, 2019
Acebutolol, oxcarbazepine, lamotrigine, and telmisartan are ineffective...The complementary treatments petasites, feverfew, magnesium, and riboflavin are probably effective. Nonpharmacologic therapies such as relaxation training, thermal biofeedback combined with relaxation training, electromyographic feedback, and cognitive behavior therapy also have good evidence to support their use in migraine prevention.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Modulation of brain ACE and ACE2 may be a promising protective strategy against cerebral ischemia/reperfusion injury: an experimental trial in rats. (Pubmed Central) - Nov 2, 2019
Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p.o.), and three xanthenone treatments (0.5, 1, and 2 mg/kg/day, 15 days, s.c.) groups...Histopathologically, both agents showed mild degenerative changes and necrosis of neurons in cerebral cortex and hippocampus compared with I/R control group. Modulation of brain RAS, either through suppression of the classic ACE pathway or stimulation of its antagonist pathway ACE2, may be a promising strategy against cerebral I/R damage.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: The role of alkalinization-induced Ca2+ influx in sperm motility activation of a viviparous fish Redtail Splitfin (Xenotoca eiseni). (Pubmed Central) - Oct 18, 2019
Major channel blockers known to inhibit Ca2+ influx (NiCl2, ruthenium red, GdCl3, SKF-96365, nimodipine, verapamil, methoxyverapamil, mibefradil, NNC 55-0396, ω-Conotoxin MVIIC, bepridil, and 2-APB) failed to inhibit Ca2+ influx, except for CdCl2, which partially inhibited the influx. We propose a novel mechanism for motility regulation of fish sperm: an alkaline environment in the female reproductive tract opens Ca2+ channels in the sperm plasma membrane without osmotic shock, and the Ca2+ influx functions as a second messenger to activate motor proteins controlling flagella movement.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular ma. (Pubmed Central) - Oct 17, 2019
Furthermore, type II collagen (COL2A1) expression was not detected (p < 0.05). The risk that a drug prescribed by a clinician in an innocuous manner to treat a patient by relieving the symptoms of a disease may affect the proliferation, differentiation, and viability of other cells and/or tissues at the molecular level, beyond its known side effects or adverse events, should not be forgotten.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer's Disease Associated Tau by Manipulation of L-Type Ca Channels. (Pubmed Central) - Sep 27, 2019
By using the Ca reporter GCaMP6f, we observed changes in Ca signaling when tau was expressed in these neurons, an effect that could be blocked by the L-type Ca channel antagonist nimodipine or reversed by RNAi knock-down of the L-type channel gene...Together, our Ca imaging and memory experiments suggest that expression of the 0N4R isoform of human tau increases the number of L-type Ca channels in the membrane resulting in changes in neuronal excitability that can be ameliorated by RNAi knockdown or pharmacological blockade of L-type Ca channels. This highlights a role for L-type Ca channels in tauopathy and their potential as a therapeutic target for AD.
- |||||||||| Nimotop (nimodipine) / Bayer
Journal: Differential contribution of Ca2+ sources to day and night BK current activation in the circadian clock. (Pubmed Central) - Sep 26, 2019
In contrast, dantrolene causes a significant decrease in BK current at night, suggesting that nighttime BK activation is driven by ryanodine receptor (RyR)-mediated Ca release...Finally, inhibition of LTCCs, but not RyRs, eliminates BK inactivation, but the BK β2 subunit was not required for activation of BK current by LTCCs. These data reveal a dynamic coupling strategy between BK channels and their Ca2+ sources in the SCN, contributing to diurnal regulation of SCN excitability.
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