 |
49 Diseases |  |
11 Trials |
|
11 Trials |  |
798 News |  |
| 12345678910111213...1314» |
- | tadalafil / Generic mfg.
Preclinical, Journal: The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining. (Pubmed Central) - Sep 27, 2024
These findings suggest that while tadalafil may not directly prevent endothelial cell death like nimodipine, its neuroprotective properties hint at its potential utility in DCI treatment. Further research involving a broader range of apoptosis-related proteins is recommended to enhance our understanding in this area.
- | Kalydeco (ivacaftor) / Vertex
Journal: Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism. (Pubmed Central) - Sep 27, 2024
In conclusion, this paper presented the results of studies investigating the interaction between these drugs and ivacaftor in vitro and in vivo. The objective is to provide a rationale for the safety of ivacaftor in combination with other drugs.
- | nimodipine / Generic mfg.
Journal: Iatrogenic arterial vasospasm during mechanical thrombectomy requiring treatment with intra-arterial nimodipine might be associated with worse outcomes. (Pubmed Central) - Sep 9, 2024
Arterial vasospasm occurring during the MT procedure and requiring intra-arterial nimodipine administration was associated with worse outcomes, especially in case of intracranial vasospasm. Although this study cannot formally differentiate whether the negative consequences were due to the vasospasm itself, or nimodipine administration or both, there might be an important signal toward a substantial clinical impact of iatrogenic vasospasm during MT.
- | venlafaxine / Generic mfg., morphine sulphate / Generic mfg.
Journal: Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain. (Pubmed Central) - Sep 2, 2024
Our data showed that the simultaneous use of venlafaxine with calcium channel blockers could increase the acute analgesic effects of morphine and reduce the induction and expression of tolerance to it. Also, the preventive and protective roles of simultaneous administration of venlafaxine and calcium channel blockers on morphine-induced mitochondrial oxidative stress and damage during the tolerance test were achieved.
- | nimodipine / Generic mfg.
Journal: Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery. (Pubmed Central) - Aug 26, 2024
Also, the preventive and protective roles of simultaneous administration of venlafaxine and calcium channel blockers on morphine-induced mitochondrial oxidative stress and damage during the tolerance test were achieved. Pharmacokinetic results showed that after transnasal administration, the AUC(0-?) of the R8-modified nimodipine liposomal gel was 11.662
- | verapamil / Generic mfg., nimodipine / Generic mfg., milrinone / Generic mfg.
Journal: Use of dual intraventricular vasodilators for refractory cerebral vasospasm in a pediatric patient with traumatic subarachnoid hemorrhage: A case report. (Pubmed Central) - Aug 22, 2024
Pharmacokinetic results showed that after transnasal administration, the AUC(0-?) of the R8-modified nimodipine liposomal gel was 11.662 This case illustrates the potential benefit of using dual IVT vasodilators to improve outcomes for pediatric patients with refractory cerebral vasospasm.
- | nimodipine / Generic mfg.
Journal: RCVS: case-study and role of substance abuse, Covid and psychotropic drugs (Pubmed Central) - Aug 20, 2024
He was given nimodipine with rapid and full symptom remission. We aim to highlight this rare, but important, neurological syndrome and its various psychiatric risk factors.
- | nimodipine / Generic mfg.
Journal: Exploring postictal recovery with acetaminophen or nimodipine: A randomized-controlled crossover trial. (Pubmed Central) - Aug 20, 2024
Pretreatment with acetaminophen or nimodipine did not alleviate symptoms and signs of the postictal state. Systematic study of the postictal state after ECT-induced seizures is feasible.
- | nimodipine / Generic mfg.
Journal, Metastases: Letter to the editor: "Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia". (Pubmed Central) - Aug 14, 2024
Emphasizing the need for personalized medicine, it advocates for integrating genetic screening and advanced monitoring techniques to tailor treatments to individual patient profiles. This approach could significantly improve clinical outcomes by optimizing drug efficacy and minimizing adverse effects.
- || nimodipine / Generic mfg.
Review, Journal: When transfusion causes a splitting headache: A case report and rapid review of transfusion-associated reversible cerebral vasoconstriction syndrome. (Pubmed Central) - Aug 14, 2024
Transfusion-associated RCVS (TA-RCVS) typically presents with thunderclap headaches and one or more systemic (hypertension, nausea/vomiting) or neurologic (seizure, stroke, visual changes) symptoms within a week after red blood cell transfusion. Treatment of RCVS is based on blood pressure control; a recent study suggested that early use of nimodipine could shorten the disease course.
- | donepezil / Generic mfg., nimodipine / Generic mfg.
Retrospective data, Journal: The Impact of Combined Application of Donepezil and Nimodipine on Patients with Comorbid Cerebral Small Vessel Disease and Cognitive Dysfunction: Efficacy and Influence on Nutritional Status. (Pubmed Central) - Aug 12, 2024
It can significantly lower the Hcy and hs-CRP levels and improve the nutritional status without increasing the frequency of adverse reactions. In addition, for CSVD patients with cognitive dysfunction, age, course of disease, MoCA score, HR, SBP, DBP, drinking history, and medication regimen are risk factors impacting patient prognosis, while SBP, DBP, and medication regimen are independent risk factors.
- | Simulect (basiliximab) / Novartis
Journal: Reversible cerebral vasoconstriction syndrome post-cardiac transplantation: a therapeutic dilemma: case report. (Pubmed Central) - Aug 10, 2024
Reversible cerebral vasoconstriction syndrome is rare after orthotopic heart transplantation. Until now,
- Eyevinal (ibudilast) / MediciNova
Ibudilast, a Phosphodiesterase Inhibitor, Alleviates Huntington's Disease Pathology through Neuroinflammation Modulation and Signaling Pathway Regulation in a Rat Model (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_647;
Nimodipine (12 mg/kg, orally) was used as a positive control drug. These findings provide clear evidence of the neuroprotective, neurotrophic, and memory-enhancing effects of IBD as a therapeutic agent for managing HD pathology in a rat model.
- nimodipine / Generic mfg.
Single-Dose Calcium Channel Blocker Toxicity in a Patient with Severe Liver Disease (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4978;
Her shock resolved with early identification and treatment of CCB toxicity. This case highlights the unique pharmacokinetic properties of nimodipine, the potential for CCB toxicity secondary to a single dose of nimodipine in patients with advanced liver disease, and the increased risk for CCB toxicity inherent to concomitant use of cytochrome P450 (CYP450) inhibitors in high-risk patients.
- nitroprusside / Generic mfg., nimodipine / Generic mfg.
Anesthesia for Extra-Intracranial Bypass Surgery for a Giant Brain Aneurysm with Fisher Grade IV SAH (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4473;
Two temporary clippings were performed, lasting 33 and 43 minutes. Postoperatively, she exhibited a moderate right hemiparesis and aphasia but fully recovered and was discharged on the 16th day.
- hydroxocobalamin (vit B12) / Generic mfg.
ALL THAT AND A BAG OF B12: FIVE PRESSOR REFRACTORY VASOPLEGIC SHOCK TREATED WITH HIGH-DOSE HYDROXOCOBALAMIN (Convention Center Exhibit Hall: Rapid Fire Area 2D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_4817;
High dose hydroxocobalamin (Cyanokit) is a minimal risk, effective salvage agent for vasoplegia in distributive shock, including in sepsis and calcium channel blocker overdose. It should be considered in patients with catecholamine resistant shock.
- | nimodipine / Generic mfg.
Preclinical, Journal: Tongqiao Yizhi granule repress the nuclear factor kappa-b/nucleotide oligomerization domain-like receptors 3/caspase-1 pyroptosis pathway in the hippocampus to counter vascular dementia in rats. (Pubmed Central) - Jul 31, 2024
It should be considered in patients with catecholamine resistant shock. TQYZKL inhibits neuronal pyroptosis in the hippocampus of VaD rats by regulating nuclear factor kappa-B/NLRP3/caspase-1 signaling pathway, thus exerting a therapeutic effect on VaD in the rats.
- | nimodipine / Generic mfg.
Journal, Metastases: Letter to the editor: "Beyond nimodipine: Advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia". (Pubmed Central) - Jul 31, 2024
TQYZKL inhibits neuronal pyroptosis in the hippocampus of VaD rats by regulating nuclear factor kappa-B/NLRP3/caspase-1 signaling pathway, thus exerting a therapeutic effect on VaD in the rats. No abstract available
- | nimodipine / Generic mfg.
Preclinical, Journal: Nimodipine attenuates neuroinflammation and delayed apoptotic neuronal death induced by trimethyltin in the dentate gyrus of mice. (Pubmed Central) - Jul 31, 2024
In addition, nimodipine significantly attenuated TMT-induced microglial activation and delayed apoptosis of dentate granule neurons. Our results suggest that L-VGCC blockade attenuates neuroinflammation and delayed neurotoxicity following TMT-induced convulsions through the regulation of astroglial phenotypic changes by promoting ERK signaling.
- | nimodipine / Generic mfg.
Preclinical, Journal: Investigating the Therapeutic Effects of Nimodipine on Vasogenic Cerebral Edema and Blood-Brain Barrier Impairment in an Ischemic Stroke Rat Model. (Pubmed Central) - Jul 21, 2024
These results suggest that nimodipine may reduce cerebral edema and BBB breakdown caused by ischemia/reperfusion. This effect is potentially mediated through the reduction of MMP-9 and ICAM-1 levels and the enhancement of mitochondrial function.
- | nimodipine / Generic mfg.
Journal: Acupuncture Therapy Modulating "Du" Channel Attenuates Ischemic Stroke-induced Disorders by Modulating REST-mediated miR-21/PDCD4 Signaling Transduction. (Pubmed Central) - Jul 20, 2024
The disorders are then handled with the acupuncture with nimodipine as the positive control...The changes in miR-REST/21-3p contributed to the inhibition of PDCD4. Collectively, the findings in the current study highlight that miR-21-3p is associated with the anti-IS function of the acupuncture, which is mediated by the inhibition of REST.
- nimodipine / Generic mfg.
Observational data, Retrospective data, Journal: The impact of nimodipine combined with Ginkgo biloba extract on cognitive function and ADL scores in patients with Parkinson's disease: A retrospective study. (Pubmed Central) - Jul 19, 2024
However, after treatment, the observation group showed higher Mini-Mental State Examination and activities of daily living scores compared to the control group (P?<?.05). The combined treatment of nimodipine and Ginkgo biloba extract in patients with Parkinson's disease has a significant effect and can effectively improve cognitive function and enhance daily living abilities.
- || nimodipine / Generic mfg.
Review, Journal, Metastases: Beyond nimodipine: advanced neuroprotection strategies for aneurysmal subarachnoid hemorrhage vasospasm and delayed cerebral ischemia. (Pubmed Central) - Jul 5, 2024
However, the number of trials conducted is significantly lower than for nimodipine. Aneurysmal SAH-associated vasospasm remains an area of ongoing preclinical and clinical research where the search for new drugs or associations is critical.
- | nimodipine / Generic mfg.
Preclinical, Journal: Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations. (Pubmed Central) - Jul 1, 2024
The results demonstrate that nimodipine directly inhibits SD, independent of nimodipine's vascular effects. Therefore, the use of nimodipine may be extended to treat acute brain injuries where SD plays a central role in injury progression.
- | nimodipine / Generic mfg.
Journal: ?-asarone induces viability and angiogenesis and suppresses apoptosis of human vascular endothelial cells after ischemic stroke by upregulating vascular endothelial growth factor A. (Pubmed Central) - Jul 1, 2024
The study confirms that ?-asarone, like nimodipine, can ameliorate cerebral infarction and pathological damage...In vitro experiments affirmed that ?-asarone can induce viability and suppress apoptosis in OGD-mediated HMEC-1 cells and promote angiogenesis of OGD HMEC-1 cells by upregulating VEGFA. This establishes the potential for ?-asarone to be a latent drug for IS therapy.
- | nimodipine / Generic mfg.
Preclinical, Journal: Nimodipine Protects Vascular and Cognitive Function in an Animal Model of Cerebral Small Vessel Disease. (Pubmed Central) - Jun 24, 2024
Chronic treatment with nimodipine protects from strokes, and vascular and cognitive deficits in spontaneously hypertensive stroke-prone rat. Nimodipine may provide an effective preventive treatment for stroke and cognitive decline in cerebral small vessel disease.
- | nimodipine / Generic mfg.
Biomarker, Journal: Nimodipine-associated standard dose reductions and neurologic outcomes after aneurysmal subarachnoid hemorrhage: the era of pharmacogenomics. (Pubmed Central) - Jun 19, 2024
We describe the pharmacogenomic relationship of nimodipine dose reduction with clinical outcomes. These results have major implications for future individualized dosing of nimodipine in the era of precision medicine.
- nimodipine / Generic mfg.
Recurrent thunderclap headache post endovascular embolization of pial AV malformation () - Jun 18, 2024 - Abstract #AHS2024AHS_223;
Onyx material used for embolization of arteriovenous malformation may produce RCVS due to angiotoxic nature of its solvent dimethyl sulfoxide. Arteriovenous malformation with nidus formation with feeders from right posterior parietal branch of middle cerebral artery.
- | nimodipine / Generic mfg.
Journal: Diagnosis and endovascular management of vasospasm after aneurysmal subarachnoid hemorrhage - survey of real-life practices. (Pubmed Central) - Jun 17, 2024
Our study highlights the considerable heterogeneity among the neurointerventional community regarding vasospasm diagnosis and endovascular management. Randomized trials and guidelines are needed to improve standard of care, determine optimal management approaches and track outcomes.
- | Journal: Toxicologic analysis of 35 drugs in post mortem human blood samples with focus on antihypertensive and antiarrhythmic drugs. (Pubmed Central) - Jun 16, 2024
In addition, the method was specifically tested for the use in post mortem analysis. The applicability of our method was demonstrated by the analysis of two authentic human autopsy blood samples.
- | nimodipine / Generic mfg.
Journal: A Survey on Monitoring and Management of Cerebral Vasospasm and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: The Mantra Study. (Pubmed Central) - Jun 10, 2024
This survey demonstrated variability in monitoring and management strategies for DCI related to vasospasm after aSAH. These findings may be helpful in promoting educational programs and future research.
- | nimodipine / Generic mfg.
Journal: Nimodipine as Vasodilator in Guide Catheter Flush to Prevent Vasospasm During Endovascular Stroke Treatment. (Pubmed Central) - May 31, 2024
Prophylactic adding of nimodipine reduces the risk of vasospasm during EVT without affecting the clinical outcome. Patients with anterior circulation TVO experienced more vasospasm compared to posterior circulation TVO.
- | nimodipine / Generic mfg.
Preclinical, Journal: Effects of epimedium total flavone capsules on post-stroke cognitive impairment in rats (Pubmed Central) - May 30, 2024
The experimental results showed that epimedium total flavone capsules can improve the cognitive function of model rats, and the mechanism may be related to the regulation of the expression of p-I?B? and p-NF-?B proteins, so as to inhibit inflammatory response induced by ischemia-reperfusion.
- | nimodipine / Generic mfg.
Preclinical, Journal: 2-(4-Methylthiazol-5-yl) Ethyl Nitrate Hydrochloride Ameliorates Cognitive Impairment via Modulation of Oxidative Stress and Nuclear Factor Kappa B (NF-?B) Signaling Pathway in Chronic Cerebral Hypoperfusion-Associated Spontaneously Hypertensive Rats. (Pubmed Central) - May 25, 2024
Nimodipine was used as a positive control...Taken together, W1302 exhibited beneficial effects on complications in VaD with hypertension, which is involved in suppressing oxidative damage, and the inflammatory reaction might be mediated by an increase in NO release. Therefore, W1302 has therapeutic potential for the treatment of VaD caused by chronic cerebral hypoperfusion-associated spontaneous hypertension.
- | nimodipine / Generic mfg.
Journal: Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia. (Pubmed Central) - May 18, 2024
Therefore, W1302 has therapeutic potential for the treatment of VaD caused by chronic cerebral hypoperfusion-associated spontaneous hypertension. Male, 4-9-month-old C57BL/6 mice (n
- nimodipine / Generic mfg.
THE IMPACT OF ENTERAL NIMODIPINE ON ENDOTHELIAL CELL APOPTOSIS IN AN ANIMAL SUBARACHNOID HEMORRHAGE MODEL (Poster area) - Apr 27, 2024 - Abstract #ESOC2024ESOC_1235;
- || nimodipine / Generic mfg.
Review, Journal: Nimodipine prophylaxis in aneurysmal subarachnoid hemorrhage, a question of tradition or evidence: A scoping review. (Pubmed Central) - Apr 25, 2024
Available evidence demonstrates that nimodipine only reduces the risk for DCI-related death or vegetative state and that fixed-dose regimens favour all cause infarct and death independent of DCI. Contemporaneous studies assessing the benefit of nimodipine beyond death or vegetative states and applying individualized dosing are warranted.
- | nimodipine / Generic mfg.
Journal: Dissolving microneedles loaded with nimodipine for prevention of sleep disorders at a high altitude. (Pubmed Central) - Apr 16, 2024
The blockage of calcium ion overloading may be an important modulation mechanism. NDMNs are a promising and user-friendly formulation for the prevention of high-altitude sleep disorders.
- | nimodipine / Generic mfg.
Journal: Olfactory three needle regulates the proliferation of olfactory bulb neural stem cells and ameliorates brain injury after subarachnoid hemorrhage by regulating Wnt/?-catenin signaling. (Pubmed Central) - Apr 10, 2024
NDMNs are a promising and user-friendly formulation for the prevention of high-altitude sleep disorders. Sprague-Dawley (SD) rats were randomly divided into five groups: Sham, SAH group, SAH
- | nimodipine / Generic mfg.
Journal: Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade. (Pubmed Central) - Apr 2, 2024
Chronic L-type calcium channel blockade with nimodipine injections for 6 weeks normalized neuronal excitability and synaptic plasticity and rescued spatial learning deficiency in human tau pseudophosphorylated at 14 amino acid sites-infused rats. The early onset of L-type calcium channel-mediated pretangle tau pathology and rectification by nimodipine in our model have significant implications for preclinical Alzheimer's disease prevention and intervention.
- || Review, Journal: An updated systematic review of neuroprotective agents in the treatment of spinal cord injury. (Pubmed Central) - Apr 1, 2024
It is worth noting that different endpoints or additional subgroup analyses may potentially alter the conclusions of individual trials. Therefore, certain SCI grades may benefit more from these treatments than others, while the overall results may remain inconclusive.
- | nimodipine / Generic mfg.
Journal: Immediate angiographic control after intra-arterial nimodipine administration underestimates the vasodilatory effect. (Pubmed Central) - Mar 19, 2024
Therefore, certain SCI grades may benefit more from these treatments than others, while the overall results may remain inconclusive. Vessel dilation was more pronounced in delayed vs. immediate controls, with greater changes in spastic vessel segments (n?=?31: 113.5 (
- nimodipine / Generic mfg.
Delayed ischemic neurological deficit detection and management after aneurysmal subarachnoid hemorrhage: a seven-year retrospective monocentric study () - Mar 18, 2024 - Abstract #ISICEM2024ISICEM_995;
The difficulty with DIND remains early recognition and the high functional impact among people in their working years. In this study, vasopressors have been shown to be effective treatment strategies without evidence of increased complications/poor -outcome.
- levetiracetam / Generic mfg., nimodipine / Generic mfg.
Acute Subarachnoid Hemorrhage as a Result of Ruptured C1-C2 Cervical Spinal Arteriovenous Malformation: A Unique Case Report (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_4550;
Medical management included Mannitol, 3% saline, and Keppra for seizure prophylaxis, along with blood pressure control. NA
- nimodipine / Generic mfg.
Intraventricular Nimodipine vs. Oral Nimodipine in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_2033;
Intraventricular nimodipine demonstrates a marginal risk reduction of angiographic vasospasm but not delayed cerebral ischemia compared with oral nimodipine in patients with aSAH. However, it does not confer additional benefits in terms of eGCS or other adverse events.
- | nimodipine / Generic mfg.
Journal: Clinical Experience With a Dedicated Neurocritical Care Quality Improvement Program in an Academic Medical Center. (Pubmed Central) - Feb 22, 2024
However, it does not confer additional benefits in terms of eGCS or other adverse events. Hospital-acquired infections were in the form
- | nimodipine / Generic mfg.
Journal: Risk factors for poor outcome after aneurysmal subarachnoid hemorrhage in patients with initial favorable neurological status. (Pubmed Central) - Feb 20, 2024
Although cerebral infarction is a common complication in aSAH individuals with favorable initial clinical condition, >80% of these patients show favorable long-term outcome. The knowledge of outcome-relevant baseline characteristics might help to reduce the burden of further complications and poor outcome in aSAH patients who tolerated the initial bleeding event well.
- verapamil / Generic mfg., sildenafil / Generic mfg., nimodipine / Generic mfg.
What a Headache! Managing Refractory Vasospasm Following Acute Subarachnoid Hemorrhage (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5937;
The use of stellate ganglion blocks, intra-arterial verapamil, lidocaine drips and oral sildenafil have previously been described as viable options in these cases. Further studies and establishing said guidelines will assist in reduction of post-subarachnoid hemorrhage complications.
- acetazolamide / Generic mfg., nimodipine / Generic mfg., dexamethasone injection / Generic mfg.
Prone Positioning for ARDS: A Double-Edged Sword (San Diego Convention Center, Room 5A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_769;
She was started on intravenous dexamethasone and diamox...Only a superior hemianopic field deficit remained, and she was eventually discharged home with a course of nimodipine, steroid taper, and follow-up appointment with ophthalmology...Retinal vascular occlusions may be related to external ocular pressure, thrombosis, emboli, vasospasm, or local compression from adjacent atherosclerotic arteries, all exacerbated by prone positioning. Therefore, we hope this case further emphasizes the importance of standard eye care and protection in the ICU setting, especially with prone positioning to prevent catastrophic vision-threatening complications.
- || nimodipine / Generic mfg.
Clinical, Review: A systematic-search-and-review of registered pharmacological therapies investigated to improve neuro-recovery after a stroke. (Pubmed Central) - Feb 15, 2024
Only nimodipine for SAH had LOE A of benefit (systematic review and network meta-analysis)...The decision on their use must be guided by the clinical profile, neurological impairments, and target outcomes based on the available evidence. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=376973, PROSPERO, CRD42022376973.