- |||||||||| V404 / Roche
Journal: Fine Mapping of Lr49 Using 90K SNP Chip Array and Flow-Sorted Chromosome Sequencing in Wheat. (Pubmed Central) - Mar 3, 2020
Adult plant resistance gene Lr49 was previously mapped on the long arm of chromosome 4B of cultivar VL404 and flanked by microsatellite markers barc163 (8.1 cM) and wmc349 (10.1 cM), neither of which was sufficiently closely linked for efficient marker assisted selection...Testing of the linked markers on 75 Australian and 90 European cultivars with diverse genetic backgrounds showed that sunKASP_21 was most strongly associated with Lr49. Our results also show that the Lr49 genomic region contains structural variation relative to the reference stock Chinese Spring, possibly an inverted genomic duplication, which introduces a new set of challenges for the Lr49 cloning.
- |||||||||| V404 / Roche
Journal: A rapidly changing jet orientation in the stellar-mass black-hole system V404 Cygni. (Pubmed Central) - May 1, 2019
Our findings suggest that the dynamics of the precessing inner accretion disk could play a role in either directly launching or redirecting the jets within the inner few hundred gravitational radii. Similar dynamics should be expected in any strongly accreting black hole whose spin is misaligned with the inflowing gas, both affecting the observational characteristics of the jets and distributing the black-hole feedback more uniformly over the surrounding environment.
- |||||||||| V404 / Roche
Trial primary completion date: Safety and Preliminary Efficacy Study of V404 PDS in Uveitis (clinicaltrials.gov) - Sep 26, 2016
P1/2, N=7, Terminated,
Similar dynamics should be expected in any strongly accreting black hole whose spin is misaligned with the inflowing gas, both affecting the observational characteristics of the jets and distributing the black-hole feedback more uniformly over the surrounding environment. Trial primary completion date: Mar 2015 --> Oct 2014
- |||||||||| V404 / Roche
Enrollment change, Trial termination: Safety and Preliminary Efficacy Study of V404 PDS in Uveitis (clinicaltrials.gov) - Mar 7, 2015
P1/2, N=7, Terminated,
Trial primary completion date: Mar 2015 --> Oct 2014 N=20 --> 7 | Recruiting --> Terminated; Study terminated due to unacceptable frequency of drug related adverse events
|
