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296 Diseases |  |
92 Trials |
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- metformin / Generic mfg.
COMBINING METFORMIN AND DRUG-LOADED KIDNEY-TARGETING MICELLES FOR POLYCYSTIC KIDNEY DISEASE () - Mar 28, 2023 - Abstract #ISNWCN2023ISN_WCN_1176;
0.0001. Conclusions Together, we show drug synergy using drug-loaded nanoparticles and free MET for the first time and present a novel nanomedicine-based combinatorial therapeutic approach for ADPKD with enhanced efficacy.
- | metformin / Generic mfg., letrozole / Generic mfg., pioglitazone / Generic mfg.
Journal: Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4?. (Pubmed Central) - Mar 27, 2023
Our findings hint at the value of HNF-4? in the treatment of PCOS by PIO, which could shed light on potential targets that may be used in treatments for PCOS with metabolic disorders.
- |||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Trial completion date, Trial primary completion date: Efficacy and Safety of Piemonte Association in the Treatment of Type II Diabetes Mellitus (clinicaltrials.gov) - Mar 27, 2023
P3, N=480, Not yet recruiting, Sponsor: EMS
in the treatment of PCOS by PIO, which could shed light on potential targets that may be used in treatments for PCOS with metabolic disorders. Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Sep 2023 --> Sep 2024
- | pioglitazone / Generic mfg.
Trial completion, Enrollment change, Trial completion date: Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA) (clinicaltrials.gov) - Mar 27, 2023
P1, N=16, Completed, Sponsor: Ohio State University
Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Sep 2023 --> Sep 2024 Recruiting --> Completed | N=36 --> 16 | Trial completion date: Jun 2023 --> Oct 2022
- High-dose Insulin Therapy in Management of Refractory Shock From Multiple Drug Overdose (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7915;
Management of vasodilatory shock with multiple pressors and other therapies, such as methylene blue, may not be adequate necessitating extracorporeal support. Our patient received > 10L/day and early CVVHD initiation was required to prevent fluid overload.
- pioglitazone / Generic mfg.
The Mitochondrial Protein Mitoneet and Its Involvement With Iron Homeostasis and Metabolic Regulation in Pulmonary Hypertension (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5367;
Our patient received > 10L/day and early CVVHD initiation was required to prevent fluid overload. These results highlight a potential role for mitochondrial iron manipulation in PH, indicate that platelet bioenergetics can reflect changes in PASMC metabolism, and suggest novel mechanisms for therapeutic intervention.
- | pioglitazone / Generic mfg.
Journal: Pioglitazone inhibits oxidative stress, MMP-mediated inflammation and vascular dysfunction in high glucose-induced human saphenous vein grafts. (Pubmed Central) - Mar 24, 2023
These results highlight a potential role for mitochondrial iron manipulation in PH, indicate that platelet bioenergetics can reflect changes in PASMC metabolism, and suggest novel mechanisms for therapeutic intervention. Pioglitazone may contribute to the prevention of restenosis and maintaining vascular function in HSV grafts of DM patients undergoing CABG.
- | memantine / Generic mfg.
Journal: A novel approach to repositioning memantine for metabolic syndrome-induced steatohepatitis: Modulation of hepatic autophagy, inflammation, and fibrosis. (Pubmed Central) - Mar 24, 2023
Pioglitazone may contribute to the prevention of restenosis and maintaining vascular function in HSV grafts of DM patients undergoing CABG. The hepatoprotective effect of memantine against steatohepatitis is mediated, at least partly, through conserving hepatic autophagy along with anti-inflammatory, antioxidant, and anti-fibrotic effects.
- | Ocaliva (obeticholic acid) / Intercept, pioglitazone / Generic mfg.
Journal: Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in nonalcoholic fatty liver disease. (Pubmed Central) - Mar 21, 2023
The models developed were sufficiently sensitive to characterize the longitudinal change for three different drug interventions. These data support continued validation of these proteomic models to enable a "liquid biopsy"-based assessment of NAFLD.
- | BIBR1532 / Boehringer Ingelheim, LY294002 / Eli Lilly
Journal: Activation of PPAR-? prevents TERT-mediated pulmonary vascular remodeling in MCT-induced pulmonary hypertension. (Pubmed Central) - Mar 21, 2023
Activation of PPAR-? prevents pulmonary arterial remodeling through Akt/c-Myc/TERT axis suppression.
- | pioglitazone / Generic mfg.
New P4 trial: PREVALENT: The Role of Pioglitazone in Vascular Transcriptional Remodeling (clinicaltrials.gov) - Mar 20, 2023
P4, N=20, Not yet recruiting, Sponsor: University of Campinas, Brazil
- || pioglitazone / Generic mfg.
Review, Journal: Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials. (Pubmed Central) - Mar 15, 2023
Vitamin E and pioglitazone are efficacious for NASH resolution; however, their benefits must be weighed against the reported risks...Furthermore, therapeutic agents targeting NASH pathogenesis, including bile acid signaling, insulin resistance, and lipid metabolism, are in various phases of clinical development. In this article, we review the benefits and drawbacks of current pharmacotherapy and the efficacy of upcoming treatments for NASH.
- | pioglitazone / Generic mfg.
Enrollment closed: PIOGAS: Pioglitazone for Idiopathic Gastroparesis (clinicaltrials.gov) - Mar 15, 2023
P1, N=10, Active, not recruiting, Sponsor: Johns Hopkins University
In this article, we review the benefits and drawbacks of current pharmacotherapy and the efficacy of upcoming treatments for NASH. Recruiting --> Active, not recruiting
- | pioglitazone / Generic mfg.
Journal: Synergistic effects of PI3K inhibition and pioglitazone against acute promyelocytic leukemia cells. (Pubmed Central) - Mar 14, 2023
Recruiting --> Active, not recruiting This study sheds light on the significance of the PI3K/Akt pathway in APL cell sensitivity to pioglitazone and proposed that the presence of the PI3K inhibitor in the therapeutic regimen containing pioglitazone could be promising in the treatment of this malignancy.
- || pioglitazone / Generic mfg.
el tema es que para realmente dar un salto cualitativo debemos confiar en una justicia que hoy tiene bajísima credibilidad por sus propios actos. (Twitter) - Mar 13, 2023
- | pioglitazone / Generic mfg.
Journal: Synthesis, in-Silico studies and biological evaluation of pyrimidine based thiazolidinedione derivatives as potential anti-diabetic agent. (Pubmed Central) - Mar 9, 2023
This study sheds light on the significance of the PI3K/Akt pathway in APL cell sensitivity to pioglitazone and proposed that the presence of the PI3K inhibitor in the therapeutic regimen containing pioglitazone could be promising in the treatment of this malignancy. It reduced the level of blood glucose to 145.2
- | pioglitazone / Generic mfg.
Journal: Curcumin and 10-undecenoic acid as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. (Pubmed Central) - Mar 9, 2023
It reduced the level of blood glucose to 145.2 The most promising phytochemicals were curcumin, pioglitazone hydrochloride, and 10-undecenoic acid...Inhibition of LasI/LasR QS system was 21% by curcumin (at 200
- || Byetta (exenatide) / AstraZeneca
Clinical, Retrospective data, Review, Journal: The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis. (Pubmed Central) - Mar 9, 2023
CC?+?MET?+?PIO should be recommended as the optimal therapeutic strategy to improve pregnancy outcomes. However, none of the above treatments had a beneficial effect on clinical pregnancy in obese PCOS.
- || pioglitazone / Generic mfg.
Marie Curie defendió el feminismo con sus actos y apoyó los movimientos políticos en esa dirección. atribuirle una frase que intenta desvirtuar el feminismo en su nombre es ofensivo. (Twitter) - Mar 8, 2023
- | pioglitazone / Generic mfg.
Trial initiation date, Trial primary completion date: Quantifying Hepatic Mitochondrial Fluxes in Humans (clinicaltrials.gov) - Mar 8, 2023
P4, N=60, Recruiting, Sponsor: The University of Texas Health Science Center at San Antonio
However, none of the above treatments had a beneficial effect on clinical pregnancy in obese PCOS. Initiation date: Feb 2022 --> Nov 2022 | Trial primary completion date: Feb 2026 --> Mar 2027
- | Bilessglu (chiglitazar) / Chipscreen
New P1 trial: Study on the Efficacy and Safety of Chiglitazar Sodium in PCOS With T2DM (clinicaltrials.gov) - Mar 8, 2023
P1, N=142, Enrolling by invitation, Sponsor: Affiliated Hospital of Nantong University
- | pioglitazone / Generic mfg.
Journal: Validation of a Diet-Induced Macaca fascicularis Model of Nonalcoholic Steatohepatitis with Dietary and Pioglitazone Interventions. (Pubmed Central) - Mar 7, 2023
Both weight loss induced by DSCR and treatment with pioglitazone improve the histological features of NASH in a diet-induced cynomolgus monkey model. This model provides a translational preclinical model for testing novel NASH therapies.
- | pioglitazone / Generic mfg.
Journal: Pioglitazone Discontinuation in Patients with Nonalcoholic Steatohepatitis (NASH) Is Associated with Disease Recurrence. (Pubmed Central) - Mar 7, 2023
This model provides a translational preclinical model for testing novel NASH therapies. No abstract available
- | pioglitazone / Generic mfg.
Preclinical, Journal: Dysregulated glycolysis underpins high-fat-associated endometrial decidualization impairment during early pregnancy in mice. (Pubmed Central) - Mar 6, 2023
However, pioglitazone treatment improved glycolysis and alleviated defective decidualization. In conclusion, obesity-induced endometrial glycolysis modifications and key glycolytic enzyme downregulation during early pregnancy might cause abnormal decidualization, leading to an unsustainable pregnancy.
- | pioglitazone / Generic mfg.
Journal: Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes. (Pubmed Central) - Mar 3, 2023
Rats were divided into 4 groups as control (saline treated healthy rats), positive control (pioglitazone treated diabetic rats), diabetic control (untreated diabetic rats) and AI leaves extract treated diabetic rats...Biochemical investigation revealed that AI leaves extract treat diabetes via improving the levels of fasting insulin and HbA1c and a significant decrease in CK and SGPT levels were observed in AI leaves treated diabetic rats. So, AI besides treating diabetes, helps in lowering the risk of co-occurring diabetic diseases and found effective in lowering neuropsychological decline observed in type 2 diabetes.
- | Piqray (alpelisib) / Novartis
New P1 trial, Metastases: A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer. (clinicaltrials.gov) - Mar 3, 2023
P1, N=30, Recruiting, Sponsor: Rambam Health Care Campus
- || pioglitazone / Generic mfg.
Clinical, Retrospective data, Review, Journal: Comparative efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists, pioglitazone and vitamin E for liver histology among patients with nonalcoholic fatty liver disease: systematic review and pilot network meta-analysis of randomized controlled trials. (Pubmed Central) - Mar 2, 2023
GLP-1 receptor agonists were as effective as pioglitazone and vitamin E for liver histology among patients with NAFLD. GLP-1 receptor agonists might be considered as an alternative or complementary treatment in future clinical practice.
- | metformin / Generic mfg., pioglitazone / Generic mfg., Byetta (exenatide) / AstraZeneca
Journal: Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity. (Pubmed Central) - Mar 2, 2023
Metformin or exenatide treatment could prevent the degradation of insulin receptor substrate-1 protein by reducing the effect of suppressors of cytokine signaling-1 and suppressors of cytokine signaling-3 proteins, especially in the liver tissue. In addition, exercise can play a role as a complementary therapy by reducing suppressors of cytokine signaling-1 and suppressors of cytokine signaling-3 proteins in visceral adipose tissue.
- || Duvie (lobeglitazone) / Chong Kun Dang, pioglitazone / Generic mfg., Januvia (sitagliptin) / Merck (MSD)
Retrospective data, Review, Journal: Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis. (Pubmed Central) - Mar 2, 2023
In addition, exercise can play a role as a complementary therapy by reducing suppressors of cytokine signaling-1 and suppressors of cytokine signaling-3 proteins in visceral adipose tissue. The current evidence makes lobeglitazone unlikely to replace pioglitazone as the preferred thiazolidinedione in T2DM.
- | pioglitazone / Generic mfg., rosiglitazone / Generic mfg.
Journal: Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis. (Pubmed Central) - Mar 2, 2023
These findings establish a novel regulatory mechanism for viral replication. The inhibition of ACSL4 by ferroptosis inhibitors can reduce viral yields of enteroviruses and coronaviruses, including SARS-CoV-2, implying that ACSL4-mediated ferroptosis is a promising therapeutic target for viral diseases.
- | pioglitazone / Generic mfg.
Trial initiation date, Surgery: ENRICHPLUS: Safety and Suitability of Supplementing Early MIP Surgery (MIPS) of ICH With Pioglitazone (clinicaltrials.gov) - Mar 1, 2023
P2, N=20, Not yet recruiting, Sponsor: University of Maryland, Baltimore
The inhibition of ACSL4 by ferroptosis inhibitors can reduce viral yields of enteroviruses and coronaviruses, including SARS-CoV-2, implying that ACSL4-mediated ferroptosis is a promising therapeutic target for viral diseases. Initiation date: Jan 2023 --> Jul 2023
- | Victoza (liraglutide) / Novo Nordisk
Trial completion, Trial completion date, Trial primary completion date: Lean-DM: Targeting Beta-cell Failure in Lean Patients With Type 2 Diabetes (clinicaltrials.gov) - Feb 27, 2023
P4, N=57, Completed, Sponsor: University of Leeds
Initiation date: Jan 2023 --> Jul 2023 Not yet recruiting --> Completed | Trial completion date: Oct 2023 --> Oct 2022 | Trial primary completion date: Oct 2023 --> Oct 2022
- | pioglitazone / Generic mfg., rosuvastatin / Generic mfg.
Journal: Ball-Milling Preparation of the Drug-Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates Evaluation. (Pubmed Central) - Feb 25, 2023
Not yet recruiting --> Completed | Trial completion date: Oct 2023 --> Oct 2022 | Trial primary completion date: Oct 2023 --> Oct 2022 However, the coamorphous 2:1 form exhibited an improvement of 1.03 times with respect to pure PGZ
- || pioglitazone / Generic mfg.
El próximo día 27 espero tener el placer de acudir al Salón de Actos de la Avda. Séneca a escuchar vuestras sugerencias y explicar mis propuestas. (Twitter) - Feb 21, 2023
- | pioglitazone / Generic mfg.
Trial completion date, Trial primary completion date: Low-Dose Pioglitazone in Patients With NASH (AIM 2) (clinicaltrials.gov) - Feb 17, 2023
P2, N=166, Recruiting, Sponsor: University of Florida
However, the coamorphous 2:1 form exhibited an improvement of 1.03 times with respect to pure PGZ Trial completion date: Feb 2024 --> Aug 2027 | Trial primary completion date: Feb 2024 --> Aug 2027
- || Erleada (apalutamide) / J&J
Trial completion, Trial completion date: A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate Cancer (clinicaltrials.gov) - Feb 15, 2023
P1, N=23, Completed, Sponsor: Aragon Pharmaceuticals, Inc.
Trial completion date: Feb 2024 --> Aug 2027 | Trial primary completion date: Feb 2024 --> Aug 2027 Active, not recruiting --> Completed | Trial completion date: Oct 2023 --> Jan 2023
- pioglitazone / Generic mfg.
Enzymatic roles for MitoNEET in controlling cellular redox status (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_8891;
This includes glutathione (both oxidized and reduced), the reactive electrophiles 4-hydroxynonenal and 4-oxononenal, and the pharmaceutical pioglitazone. Taken together, these results will inform other scientists aiming to make future drugs that target mitoNEET.
- | Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Trial completion date, Trial primary completion date: Dapagliflozin Plus Pioglitazone in T1DM (clinicaltrials.gov) - Feb 13, 2023
P4, N=120, Recruiting, Sponsor: The University of Texas Health Science Center at San Antonio
Taken together, these results will inform other scientists aiming to make future drugs that target mitoNEET. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Jun 2023
- | pioglitazone / Generic mfg.
Journal: Arsenic: A Perspective on Its Effect on Pioglitazone Bioavailability. (Pubmed Central) - Feb 12, 2023
The results indicate that the substitution of Fe for As modifies the enzymatic function of CYP 3A4 and CYP 2C8 isoforms, altering the metabolic process of CYP 2D6 and CYP 3A4 in patients with T2DM. Consequently, the variation in metabolism alters the bioavailability of pioglitazone and the expected final effect.
- | metformin / Generic mfg., pioglitazone / Generic mfg.
Journal: Development of Capillary Zone Electrophoresis Method for the Simultaneous Separation and Quantification of Metformin and Pioglitazone in Dosage Forms; and Comparison with HPLC Method. (Pubmed Central) - Feb 12, 2023
A comprehensive comparison was then carried out for the analytical features of both methods CZE and HPLC. Comparable results were obtained with the advantage of reagent consumption and separation efficiency of CZE over HPLC and shorter analysis time by HPLC compared with CZE.
- | Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Enrollment open, Trial initiation date, Heterogeneity: DiaSpax: Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes (clinicaltrials.gov) - Feb 10, 2023
P=N/A, N=60, Recruiting, Sponsor: Karolinska Institutet
Comparable results were obtained with the advantage of reagent consumption and separation efficiency of CZE over HPLC and shorter analysis time by HPLC compared with CZE. Not yet recruiting --> Recruiting | Initiation date: Sep 2022 --> Feb 2023
- pioglitazone / Generic mfg.
Effect Of Pioglitazone On Recurrent Stroke Risk In Patients With Post-stroke Cognitive Impairment And Insulin Resistance: Subgroup Analysis Of IRIS Trial (Hall F, Poster Hall; MP26) - Feb 7, 2023 - Abstract #ISC2023ISC_1398;
These data indicate that simple cognitive testing after 3 months from stroke may serve as a precision medicine tool to identify patients at higher risk who may benefit from pioglitazone treatment. This approach can be tested in secondary stroke prevention clinical trials.
- Hidradenitis suppurativa and endocrinological comorbidities: a multidisciplinary, joint approach (Room 2) - Feb 2, 2023 - Abstract #EHSF2023EHSF_47;
Not only two new diagnoses of diabetes were made, but also oral antidiabetic drugs, lipid-lowering medications and antidepressants, which are not part of the usual dermatologic therapeutic armamentarium, were succesfuly introduced or adjusted. Taking care of metabolic disease in HS patients is important for the management of HS, but, above all, it is crucial to prevent major causes of morbidity and mortality in our patients.
- | pioglitazone / Generic mfg.
Preclinical, Journal: Pluchea indica Leaf Extract Alleviates Dyslipidemia and Hepatic Steatosis by Modifying the Expression of Lipid Metabolism-Related Genes in Rats Fed a High Fat-High Fructose Diet. (Pubmed Central) - Feb 2, 2023
They were then divided into four groups receiving distilled water, PIE (100 or 300 mg/kg/d), and pioglitazone (10 mg/kg/d) for a further six weeks, during which the HFFD was continued...In conclusion, PIE alleviates dyslipidemia and hepatic steatosis in HFFD rats plausibly by increasing insulin resistance and modifying the gene expression associated with lipid metabolism. PIE may be used as preventive nutrition for dyslipidemia and hepatic steatosis.
- | pioglitazone / Generic mfg.
Trial termination: Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin (clinicaltrials.gov) - Jan 30, 2023
P=N/A, N=6, Terminated, Sponsor: Oregon Health and Science University
PIE may be used as preventive nutrition for dyslipidemia and hepatic steatosis. Completed --> Terminated; Insufficient funds to continue.
- ||| pioglitazone / Generic mfg.
🗓️ El próximo lunes, 30 de enero, el Dr. @prat_aleix, investigador principal en @idibaps, impartirá la ponencia 'Test genómico HER2DX en #cáncerdemama HER2+: Update y utilidad clínica'. 🕐 16:30 h. 📍 Salón de Actos de INCLIVA. 📧 Confirma tu asistencia en eflores@incliva.es (Twitter) - Jan 27, 2023
- | vildagliptin / Generic mfg., pioglitazone / Generic mfg.
Journal: Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial. (Pubmed Central) - Jan 27, 2023
Presence of OHTG predicts greater glucose lowering by pioglitazone than vildagliptin. www.anzctr.org.au, identifier (ACTRN12618001907235).
- | pioglitazone / Generic mfg.
Journal: Supplemental Pioglitazone to Patients of CML with Suboptimal TKI Response: A Pragmatic Pilot Study. (Pubmed Central) - Jan 27, 2023
The addition of Pioglitazone was well tolerated. The online version contains supplementary material available at 10.1007/s12288-022-01561-x.
- || pioglitazone / Generic mfg.
Review, Journal: Can Pioglitazone be used for optimisation of clinical nutrition therapy in the critically ill patient?: A Systematic Review. (Pubmed Central) - Jan 27, 2023
The online version contains supplementary material available at 10.1007/s12288-022-01561-x. Pioglitazone therapy increases skeletal muscle insulin sensitivity, and can decrease intramuscular inflammation.