pioglitazone / Generic mfg. 
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 296 Diseases   92 Trials   92 Trials   3449 News 


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  • ||||||||||  pioglitazone / Generic mfg.
    Review, Journal:  Metabolic Mechanisms Connecting Alzheimer's and Parkinson's Diseases: Potential Avenues for Novel Therapeutic Approaches. (Pubmed Central) -  Jul 6, 2022   
    Examination of anti-diabetic therapies in preclinical models and in some observational clinical studies have suggested effectiveness of the first generation insulin sensitizer pioglitazone in both AD and PD...The mechanisms involve modification of autophagy, inflammation, and cell differentiation in various cell types including neurons, glia, macrophages, and endothelium. These observations have implications for the understanding of the general pathology of neurodegeneration and suggest general therapeutic approaches to disease modification.
  • ||||||||||  pamapimod (RO4402257) / Roche
    Journal:  Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern. (Pubmed Central) -  Jul 2, 2022   
    Both drugs showed similar antiviral potency across several cultured cell types and similar antiviral activity against SARS-CoV-2 Wuhan type, and the VoCs Alpha, Beta, Gamma, Delta, and Omicron. These data support the combination of pamapimod and pioglitazone as a potential therapy to reduce duration and severity of disease in COVID-19 patients, an assumption currently evaluated in an ongoing phase II clinical study.
  • ||||||||||  pioglitazone / Generic mfg.
    Review, Journal:  Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury. (Pubmed Central) -  Jun 28, 2022   
    To achieve the protective impact of PG the following was required: (1) stimulating PPARγ; (2) decreasing oxidative stress; (3) decreasing nuclear factor kappa B (NF-κB), interleukin 6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and C-C motif chemokine ligand 20 (CCL20) expression; (4) limiting the increase in the number of activated microglia; and (5) reducing mitochondrial dysfunction. The findings indicate that when PIG is used clinically, it may serve as a neuroprotective anti-inflammatory approach in TBI.
  • ||||||||||  BIBR1532 / Boehringer Ingelheim, LY294002 / Eli Lilly
    Journal:  PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT. (Pubmed Central) -  Jun 23, 2022   
    Inhibition of Akt with LY294002, knockdown of c-MYC by siRNA or suppression of telomerase activity with BIBR1532 repressed PDGF-induced PASMC proliferation and migration. Furthermore, activation of peroxisome proliferator-activated receptor γ (PPARγ) with pioglitazone suppressed PDGF-induced TERT expression and telomerase activation, leading to inhibition of PASMC proliferation and migration.
  • ||||||||||  pioglitazone / Generic mfg.
    Preclinical, Journal:  Anti-hyperglycemic effects of Eryngium billardierei F. Delaroche extract on insulin-resistance HepG2 cells in vitro. (Pubmed Central) -  Jun 11, 2022   
    We conclude that diosmetin protects neuroblastoma cells against AGEs-induced ER injury via multiple mechanisms and may be a potential option for AD. The obtained data indicated that 1 mg/mL E. billardierei might have an anti-insulin resistance effect on insulin-resistance HepG2 cells in vitro and could be a promising candidate with anti-hyperglycemic properties for diabetes treatments.
  • ||||||||||  pioglitazone / Generic mfg., telmisartan / Generic mfg.
    Preclinical, Journal, IO biomarker:  Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats. (Pubmed Central) -  Jun 9, 2022   
    Telmisartan (TEL) is an angiotensin II type 1 receptor blocker and a partial activator of peroxisome proliferator-activated receptor-gamma (PPARγ), which regulates inflammatory and apoptotic pathways...The PPARγ effect of TEL was affirmed by using the PPARγ agonist pioglitazone (PIO), and the antagonist GW9662...Interestingly, co-treatment with GW9662 partially revoked the beneficial effects of TEL. These findings recommend that TEL improves motor and cognitive performance, while reducing neuronal inflammation and apoptosis in 3-NP-induced neurotoxicity via a PPARγ-dependent mechanism.
  • ||||||||||  pioglitazone / Generic mfg.
    Enrollment open:  Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention (clinicaltrials.gov) -  Jun 9, 2022   
    P2,  N=60, Recruiting, 
    These findings recommend that TEL improves motor and cognitive performance, while reducing neuronal inflammation and apoptosis in 3-NP-induced neurotoxicity via a PPARγ-dependent mechanism. Not yet recruiting --> Recruiting
  • ||||||||||  pioglitazone / Generic mfg.
    Preclinical, Journal:  Regulation of Neuroinflammatory Signaling by PPARγ Agonist in Mouse Model of Diabetes. (Pubmed Central) -  Jun 5, 2022   
    The present study provided a potential theoretical basis and therapeutic target for the treatment of neuroinflammation associated with diabetes. Pioglitazone may provide a promising therapeutic strategy in diabetes patients with muffled of behavioral activity.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha. (Pubmed Central) -  Jun 4, 2022   
    Treatment with the peroxisome proliferator-activated receptor gamma (PPARγ) ligand, pioglitazone (PIO), improved EtOH-mediated decreases in oxidative phosphorylation...Further, PIO treatment diminished HIF-1α levels and reversed glycolytic shift following EtOH exposure. These studies support a critical role for HIF-1α in mediating the glycolytic shift in energy metabolism of AM during excessive alcohol use.
  • ||||||||||  pioglitazone / Generic mfg.
    Preclinical, Journal:  Role of PPAR-γ in diabetes-induced testicular dysfunction, oxidative DNA damage and repair in leptin receptor-deficient obese type 2 diabetic mice. (Pubmed Central) -  May 31, 2022   
    Pioglitazone-induced activation of PPAR-γ for 12 weeks in db/db obese diabetic mice increases bodyweights and reduces blood glucose levels, but PPAR-γ inhibition by 2-chloro-5-nitro-N-phenylbenzamide does not alter these parameters; instead, improves testis and epididymis weights and sperm count...The PPAR-γ modulation does not significantly affect the structural changes in the testis. The PPAR-γ stimulation aggravates diabetes-induced effects on testis, including oxidative DNA damage and BER proteins, but PPAR-γ inhibition marginally recovers these diabetic effects indicating the involvement of the receptor in the reproductive effects of diabetes.
  • ||||||||||  metformin / Generic mfg., pioglitazone / Generic mfg.
    Clinical, Review, Journal:  Personalizing Diabetes Management in Liver Transplant Recipients: The New Era for Optimizing Risk Management. (Pubmed Central) -  May 29, 2022   
    Pioglitazone may be harmful in patients combatting obesity or heart failure...This review thoroughly discusses the roles of these extra-glycemic effects and safety considerations in LTRs. Through weighing the risks and benefits, we conclude that alternatives to insulin should be strongly considered, when feasible, for personalized long-term management based on risk factors and co-morbidities.
  • ||||||||||  Journal:  Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration. (Pubmed Central) -  May 29, 2022   
    The repurposed drugs mitigated cerebral ischemic injury by PPARγ mediated downregulation of nods like receptor protein 3 inflammasomes (NLRP3), tumor necrosis factor-alpha (TNF-α), cyclooxygenase 2 (COX-2), nuclear factor kappa-light-chain-enhancer of activated B cells (p-NF-kB), and c-Jun N-terminal kinase (p-JNK). Our data demonstrated that rabeprazole and ethambutol have neuroprotective potential via modulating the cytoprotective stress response, increasing cellular survival, and balancing homeostatic processes, and so may be suitable for future research in stroke therapy.
  • ||||||||||  pioglitazone / Generic mfg.
    Preclinical, Journal:  Treatment of pilocarpine-induced epileptic seizures in adult male mice. (Pubmed Central) -  May 26, 2022   
    Finally, biochemical techniques were used to determine the levels of Malondialdehyde and Catalase activity, as well as Superoxide Dismutase and Glutathione Reductase in the hippocampus. The results of this investigation suggest that pioglitazone's antioxidant action may play a key role in its neuroprotective properties against pilocarpine-induced seizure neuronal damage.
  • ||||||||||  pioglitazone / Generic mfg.
    Trial completion date, Trial primary completion date:  Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients (clinicaltrials.gov) -  May 25, 2022   
    P4,  N=28, Recruiting, 
    The results of this investigation suggest that pioglitazone's antioxidant action may play a key role in its neuroprotective properties against pilocarpine-induced seizure neuronal damage. Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Apr 2022 --> Apr 2023
  • ||||||||||  Cyclurad (cycloserine/lurasidone) / NeuroRx
    Journal:  Treatment-resistant bipolar depression: concepts and challenges for novel interventions. (Pubmed Central) -  May 25, 2022   
    Although there is no consensus about the concept of TRBD, better clarification of the neurobiology associated with treatment non-response could help identify novel strategies. More research is warranted, mainly focusing on personalizing current treatments to optimize response and remission rates.