- |||||||||| pioglitazone / Generic mfg.
Preclinical, Journal: The effects of the voglibose on non-alcoholic fatty liver disease in mice model. (Pubmed Central) - Aug 13, 2022
After 10 weeks, mice in the HFHFr group were randomly assigned to one of three groups: HFHFr diet with vehicle, HFHFr with voglibose, or HFHFr with pioglitazone...In the in vitro experiment, reducing the influx of glucose into hepatocytes significantly reduced steatosis and de novo lipogenesis even in the presence of sufficient fructose and fat, demonstrating that the mechanism of voglibose could be effective in treating HFHFr diet-induced NAFLD. These results indicate that voglibose improves HFHFr diet-induced NAFLD by suppressing hepatic de novo lipogenesis.
- |||||||||| sirolimus / Generic mfg., pioglitazone / Generic mfg.
Journal: T-2 toxin and its cardiotoxicity: New insights on the molecular mechanisms and therapeutic implications. (Pubmed Central) - Aug 12, 2022
Antioxidant supplementation (e.g., catalase, vitamin C, and selenium), induction of autophagy (e.g., rapamycin), blockade of inflammatory signaling (e.g., methylprednisolone) or treatment with PPAR-γ agonists (e.g., pioglitazone) may provide protective effects against these detrimental cardiac effects caused by T-2 toxin. We believe that our review provides new insights in understanding T-2 toxin exposure-induced cardiotoxicity and fuels effective prevention and treatment strategies against this important food-borne toxin-induced health problems.
- |||||||||| pioglitazone / Generic mfg.
Preclinical, Journal, IO biomarker: Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. (Pubmed Central) - Aug 10, 2022
TMP (20, 40, and 80 mg/kg) and Pioglitazone (10 mg/kg) were administered for 4 weeks...Furthermore, treatment with TMP increased BDNF, p-Akt, and p-CREB levels, normalized cholinergic dysfunction, and suppressed oxidative, inflammatory, and apoptotic markers in the hippocampus. Collectively, our results suggest that the TMP may be an effective neuroprotective agent in alleviating type 2 diabetes-associated cognitive deficits.
- |||||||||| Byetta (exenatide) / AstraZeneca
Journal: T2DM Subgroups and Response to Glucose-lowering Therapy: Results from EDICT and Qatar Study. (Pubmed Central) - Aug 5, 2022
Distinct metabolic phenotypes characterize different T2DM clusters and differential responses to glucose-lowering therapies. Participants with severe insulin deficiency respond better to agents that preserve beta-cell function, while, surprisingly, patients with severe insulin resistance did not respond favourably to insulin sensitizers.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo, Ocaliva (obeticholic acid) / Intercept, Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
Review, Journal: Nonalcoholic fatty liver disease and osteoporosis: a potential association with therapeutic implications. (Pubmed Central) - Aug 5, 2022
If an association between NAFLD and osteoporosis is established, a medication that could target both diseases would be a great advancement. This review summarized the main experimental and clinical evidence on the potential association between NAFLD and osteoporosis and focused on treatment considerations derived from this potential association.
- |||||||||| pioglitazone / Generic mfg.
Journal: A nem alkoholos zsírmájbetegség és a 2-es típusú cukorbetegség. (Pubmed Central) - Aug 4, 2022
Until now, the use of pioglitazone and vitamin E has only been recommended by guidelines for selected patient groups with biopsy-proven NASH...Orv Hetil. 2022; 163(22): 855-862.
- |||||||||| pioglitazone / Generic mfg.
Journal: Pioglitazone, Bladder Cancer and the Presumption of Innocence. (Pubmed Central) - Jul 31, 2022
This evidence cannot justify its low clinical administration, especially in the present era of individualised treatment strategies. Definite clarification of this issue is imperative and urgently anticipated from future high quality and rigorous pharmacoepidemiologic research, keeping in mind its unique mechanism of action and its significant pleiotropic effects.
- |||||||||| pioglitazone / Generic mfg.
Journal: Central vs site outcome adjudication in the IRIS trial. (Pubmed Central) - Jul 29, 2022
The estimate of treatment effects were larger with the updated stroke definition. There may be benefit of central adjudication for events with specific features, such as shorter symptom duration or normal brain imaging.
- |||||||||| pioglitazone / Generic mfg.
Review, Journal: Current treatment of non-alcoholic fatty liver disease. (Pubmed Central) - Jul 24, 2022
Apart from lifestyle modifications such as weight loss, a Mediterranean diet and physical activity, only a few NAFLD-specific pharmacological treatment options such as Vitamin E and Pioglitazone are considered by current international guidelines...Finally, knowledge about treating complications of end-stage liver disease due to NASH becomes an increasingly important cornerstone in the treatment of the broad disease spectrum of NAFLD. In this review, we summarize currently available and future treatment options for patients with NAFLD that may help internal medicine specialists treat the complete clinical spectrum of this highly prevalent liver disease.
- |||||||||| pioglitazone / Generic mfg.
Journal: Transgressions of innate moral codes - transgressions in service of the Self. (Pubmed Central) - Jul 23, 2022
An important theme throughout this paper concerns humanity's ongoing hunger to expiate guilt through the practices of scapegoating, sin-eating and confession. While these practices promise redemption, each seriously fails through their reluctance to address the unconscious recognition and consequences of transgressions.
- |||||||||| pioglitazone / Generic mfg.
Preclinical, Journal: Role of insulin resistance and the gut microbiome on urine oxalate excretion in ob/ob mice. (Pubmed Central) - Jul 23, 2022
We then compared urine oxalate excretion in ob/ob mice before and after leptin replacement or pioglitazone treatment, two maneuvers that reduce insulin resistance in ob/ob mice...Unexpectedly, we found that when food intake was carefully matched between ob/ob and wild type mice, the amount of 24-h urine oxalate excretion did not differ between the two mouse strains, suggesting that ob/ob mice excrete more urine oxalate because of hyperphagia. Since the level of urine oxalate excretion in wild type mice in our study was higher than those reported in prior studies, future work will be needed to standardize the measurement of urine oxalate and to define the range of urine oxalate excretion in wild type mice so that accurate and valid comparisons can be made between wild type mice and ob/ob mice or other mouse models.
- |||||||||| Byetta (exenatide) / AstraZeneca
Journal, Combination therapy: FGF21 Contributes to Metabolic Improvements Elicited by Exenatide and Pioglitazone in Patients with Type 2 Diabetes. (Pubmed Central) - Jul 20, 2022
Since the level of urine oxalate excretion in wild type mice in our study was higher than those reported in prior studies, future work will be needed to standardize the measurement of urine oxalate and to define the range of urine oxalate excretion in wild type mice so that accurate and valid comparisons can be made between wild type mice and ob/ob mice or other mouse models. Alterations in the plasma FGF21 profile may contribute to the beneficial metabolic effects of pioglitazone and exenatide in human patients with T2D.
- |||||||||| trazodone ER / Generic mfg., pioglitazone / Generic mfg.
PK/PD data, Journal: Influence of trazodone on the pharmacodynamics and pharmacokinetics of pioglitazone. (Pubmed Central) - Jul 19, 2022
Trazodone apparently produced pharmacokinetic interaction with pioglitazone which might be by attenuating the metabolism of pioglitazone. Therefore, care should be taken in simultaneous therapy with pioglitazone and trazodone.
- |||||||||| metformin / Generic mfg., pioglitazone / Generic mfg., spironolactone / Generic mfg.
SPIOMET4HEALTH: a 4-Arm Trial to Test the Effects of Lifestyle Intervention plus either Placebo, or Pioglitazone (PIO) , or Spironolactone-Pioglitazone (SPIO) , or Spironolactone-Pioglitazone-Metformin (SPIOMET) in Adolescent Girls and Young Women with PCOS () - Jul 16, 2022 - Abstract #ENDO2022ENDO_2184;
Treatment's effectivity will be primarily judged by the change in ovulation rates, besides measures of androgens, body composition, insulin sensitivity, and quality of life. The SPIOMET4HEALTH project will deliver the first results of an international study evaluating the efficacy, tolerability and safety of SPIOMET to treat PCOS.
- |||||||||| pioglitazone / Generic mfg.
Preclinical, Journal: Role of olmesartan in ameliorating diabetic nephropathy in rats by targeting the AGE/PKC, TLR4/P38-MAPK and SIRT-1 autophagic signaling pathways. (Pubmed Central) - Jul 15, 2022
The F/Fr/STZ-induced diabetic rats were orally treated with either OM (10 mg/kg) or pioglitazone (10 mg/kg); as a standard drug daily for four consecutive weeks...Finally, OM protected against type 2 diabetes-related nephropathy complications by altering inflammatory pathways, oxidative, fibrotic, and autophagic processes triggered by renal glucose overload. This study shows that OM has a reno-protective effect against DN in rats by inhibiting the AGE/PKC, TLR4/P38-MAPK, and SIRT-1 autophagic signaling pathways.
- |||||||||| pioglitazone / Generic mfg.
Trial completion date, Trial primary completion date: Pioglitazone Therapy Targeting Fatigue in Breast Cancer (clinicaltrials.gov) - Jul 13, 2022
P2, N=30, Recruiting,
This study shows that OM has a reno-protective effect against DN in rats by inhibiting the AGE/PKC, TLR4/P38-MAPK, and SIRT-1 autophagic signaling pathways. Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Apr 2022 --> Apr 2023
- |||||||||| pioglitazone / Generic mfg.
Review, Journal: Drug Repurposing by Tumor Tissue Editing. (Pubmed Central) - Jul 13, 2022
Novel preclinical approaches like functional assays testing drug combinations in tumor tissue are needed to select potential drugs for repurposing. The two-step drug repurposing procedure, namely establishing novel functional systems states in tumor tissues and consecutively providing novel target sites for approved drugs, facilitates the systematic identification of drug activities outside the scope of any original clinical drug approvals.
- |||||||||| Ocaliva (obeticholic acid) / Intercept, resmetirom (MGL-3196) / Madrigal Pharma, aldafermin (NGM282) / NGM Biopharma
Clinical, Retrospective data, Review, Journal: Pharmacotherapeutic Impact on Nonalcoholic Steatohepatitis Histology: A Systematic Review and Network Meta-analysis. (Pubmed Central) - Jul 13, 2022
Multiple interventions were found to improve individual histologic scores across secondary outcome analyses and are detailed below. This novel systematic review and network meta-analysis represents the most comprehensive investigation to date regarding the pharmacotherapeutic options for biopsy-proven NASH using current recommended histologic endpoints.
- |||||||||| metformin / Generic mfg., pioglitazone / Generic mfg.
Review, Journal: Diabetes mellitus and multiple myeloma; common features of two distinct entities. (Pubmed Central) - Jul 10, 2022
Further data are needed to examine the effect of all classes of antidiabetic medication on MM and its complications. A baseline assessment of risk factors for glucose intolerance and close monitoring of glucose levels during therapy is strongly suggested for patients with MM.
- |||||||||| pioglitazone / Generic mfg.
Oral long-acting menin inhibitor normalises type 2 diabetes in two rat models (Golgi Hall) - Jul 9, 2022 - Abstract #EASD2022EASD_503;
Materials and Rats were treated daily with BMF-219, vehicle, or pioglitazone for 16 days and analyzed for fasting and non-fasting blood glucose levels, insulin, c-peptide, and blood lipemic levels... Collectively, our data indicate the novel and marked potential of BMF-219 as an oral, long-acting treatment for T2DM.
- |||||||||| pioglitazone / Generic mfg., rosiglitazone / Generic mfg.
Preclinical, Journal: Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress. (Pubmed Central) - Jul 9, 2022
Interestingly, administration of POG or RSG dramatically reduced oxidative damage in the heart and aorta, as reflected by a decrease in MDA and increased activities of SOD, CAT, and thiol content. The results of this study showed that administration of POG or RSG decreased oxidative damage in the heart and aorta tissues induced by hypothyroidism in rats.
- |||||||||| pioglitazone / Generic mfg.
Preclinical, Journal: Co-Adjuvancy of Solasodine & CoQ10 Against High Fat Diet-Induced Insulin Resistance Rats Via Modulating IRS-I and PPAR-γ Proteins Expression. (Pubmed Central) - Jul 8, 2022
The goal of this study was to see if solasodine combined with coenzyme Q10 could help rats with insulin resistance caused by a high-fat diet (HFD) by regulating the expression of IRS-I and PPAR-γ proteins.One of the six groups (n=6) got a conventional diet for 16 weeks as a control (normal), the HFD was given to the other five groups for 16 weeks, which further classified as-one group as HFD control while others treated with pioglitazone (10 mg/kg), coenzyme Q10 (50 mg/kg), solasodine (50 mg/kg) and combination of solasodine and coenzyme Q10i.e. SDQ10 (total 50 mg/kg) for the last 4 weeks orally once daily...Besides, increasesthe antioxidant activity of superoxide dismutase and catalase and normalized the architecture of kidney, pancreas and adipose tissue as well astreatment with SDQ10 raised the level of p-IRS1 and PPAR-y protein in liver tissue. As a result, supplementing with solasodine and coenzyme Q10 reversed the effect of the HFD on p-IRS1 and PPAR-y protein in liver tissue while also alleviating insulin resistance symptoms.
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