pioglitazone / Generic mfg. 
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  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Mitochondrial aconitase ACO2 links iron homeostasis with tumorigenicity in non-small cell lung cancer. (Pubmed Central) -  Oct 11, 2022   
    Hence, ACO2 is identified as a regulator of iron homeostasis and mitoNEET is implicated as a target in aggressive NSCLC. Implications: Iron-sulfur-cluster associated proteins including mitochondrial aconitase ACO2, mitoNEET (encoded by CISD1), and iron response element binding protein 1 (IRP1; encoded by ACO1) are part of an "ACO2-Iron Axis" that regulates iron homeostasis and is a determinant of a particularly aggressive subset of NSCLC.
  • ||||||||||  pioglitazone / Generic mfg.
    Regulation of inflammatory response in cutaneous leishmaniasis patients through PPAR-gamma signaling (Convention Center - Room 605/610 (6th Floor); In-Person-Only) -  Oct 9, 2022 - Abstract #ASTMH2022ASTMH_2002;    
    Addition of PPAR-gamma ligands, Omega 3 fatty acids (EPA and DHA) or Pioglitazone, to lesion cells decreased the levels of IL-6, TNF and IL-1β without affecting parasites counts. Our results suggest that adjuvant topical treatment with Omega 3 fatty acids or Pioglitazone may be beneficial for CL patients.
  • ||||||||||  pioglitazone / Generic mfg.
    Review, Journal:  Neuroprotective and anti-inflammatory effects of pioglitazone on Parkinson's disease: A comprehensive narrative review of clinical and experimental findings. (Pubmed Central) -  Oct 7, 2022   
    As per suggestions of preclinical studies, the therapeutic effects of PG treatment include; increased life expectancy of neurons, decreased oxidative stress, halted microglial activity, lower inflammation [reduced NF-κB, COX-2, and iNOS], reduced mitochondrial dysfunction, rise in motor function [motor agility] and non-motor function [lowered cognitive dysfunction]. In conclusion, we determined that PG exerts neuroprotective and anti-inflammatory effects in PD models and it can be considered a potential therapeutic candidate for PD.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Pioglitazone in diabetic kidney disease: forgotten but not gone. (Pubmed Central) -  Sep 29, 2022   
    This paper explores the pathophysiological mechanisms governing its possible nephroprotective activity during a diabetic state. It also discusses its future role to ameliorate the global burden of DKD.
  • ||||||||||  imatinib / Generic mfg., pioglitazone / Generic mfg.
    Journal:  CML-313 Kinetics of CITED2 Gene Expression in Chronic Myeloid Leukemia Patients. (Pubmed Central) -  Sep 29, 2022   
    Adding pioglitazone to imatinib improved the patients' response and downregulate the overexpressed CITED2 gene. A longer follow-up is planned and needed to confirm the safety and efficacy of the combination.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets. (Pubmed Central) -  Sep 29, 2022   
    PPARγ ligands, including pioglitazone, are also used in the management of this disease...With a polypharmacology approach, we screened 51 ncRNAs which were causal to a subset of diseases related to MAFLD. This study revealed a subset of ncRNAs that could help in more clear and guided designation of preclinical and clinical studies to verify the therapeutic application of the revealed ncRNAs by manipulating the PPARs molecular mechanism in MAFLD.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Pioglitazone Mediates Cardiac Progenitor Formation through Increasing ROS Levels. (Pubmed Central) -  Sep 28, 2022   
    In addition, this antioxidant prevents the action of pioglitazone in increasing oxygen radicals as well as beating cardiomyocyte differentiation properties. In this case, it can be concluded that PPARγ is required to modulate ROS levels during cardiac differentiation.
  • ||||||||||  pioglitazone / Generic mfg.
    Enrollment change, Trial termination:  Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke (clinicaltrials.gov) -  Sep 15, 2022   
    P1/2,  N=1, Terminated, 
    We also used previously reported single-cell glomerular transcriptome profiles to deconvolute three glomerular cell lineages (podocytes, mesangial cells, and endothelial cells) from our whole-transcriptome data and compared the gene dysregulation within each glomerular cell type in the PAN+GC vs. N=50 --> 1 | Recruiting --> Terminated; Temporarily suspended due to Pandemic.
  • ||||||||||  sildenafil / Generic mfg., pioglitazone / Generic mfg.
    Journal:  Pharmaceutical agents for contractile-metabolic dysfunction after volumetric muscle loss. (Pubmed Central) -  Sep 14, 2022   
    There was minimal evidence that these benefits came from greater mitochondrial biogenesis and/or mitochondrial complex protein content, but could be due to greater enzyme activities levels for complex I and complex II. These findings suggest that formoterol treatment is candidate to pair with a rehabilitative approach to maximize functional improvements in VML-injured muscle.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling. (Pubmed Central) -  Sep 14, 2022   
    In addition, phosphorylated levels of NFκB were reduced by pioglitazone or FGF 10 treatment but raised by GW9662 administration in FGF 10-treated SNI rats. Our findings show that FGF 10 has analgesic effects in rats after peripheral nerve injury and justify the role of PPAR-γ/NFκB signaling in FGF 10-regulated anti-microgliosis.
  • ||||||||||  pioglitazone / Generic mfg.
    Review, Journal:  Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature. (Pubmed Central) -  Sep 14, 2022   
    Nonetheless, the current literature does demonstrate that pioglitazone promotes the function of PPAR receptors in ameliorating inflammation, oxidative stress, amyloidogenesis, and hypothyroidism, and enhancing neurogenesis, synaptic plasticity, and mitochondrial function. Therefore, these mechanisms of PPAR receptors warrant further investigation in order to establish the clinical applicability of pioglitazone in the treatment of cognitive disorders, such as PD and AD, and neuronal impairment in conditions such as diabetes.
  • ||||||||||  Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
    Enrollment open:  Efficacy and Safety of Dapagliflozin in Patients With Non-alcoholic Steatohepatitis (clinicaltrials.gov) -  Sep 14, 2022   
    P4,  N=160, Recruiting, 
    Therefore, these mechanisms of PPAR receptors warrant further investigation in order to establish the clinical applicability of pioglitazone in the treatment of cognitive disorders, such as PD and AD, and neuronal impairment in conditions such as diabetes. Not yet recruiting --> Recruiting
  • ||||||||||  pioglitazone / Generic mfg., ezetimibe / Generic mfg., clopidogrel / Generic mfg.
    Journal:  European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack. (Pubmed Central) -  Sep 13, 2022   
    In addition to the evidence-based recommendations, all or the majority of working group members supported: out-of-office BP monitoring; use of combination treatment for BP control; consideration of ezetimibe or PCSK9 inhibitors when lipid targets are not achieved; consideration of use of low-dose DOACs in addition to an antiplatelet in selected groups of people with coronary or peripheral artery disease and aiming for an HbA1c level of <53 mmol/mol (7%) in people with diabetes mellitus. These guidelines aim to standardise long-term pharmacological treatment to reduce the burden of recurrent stroke in Europe.
  • ||||||||||  pioglitazone / Generic mfg., rosiglitazone / Generic mfg.
    Journal:  Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation. (Pubmed Central) -  Sep 10, 2022   
    Treatment with pioglitazone (PGZ), a PPARγ ligand, increased survival from PR8 infection, decreased M1 macrophage gene expression, and increased PPARγ mRNA in lungs...To study mechanisms by which PPARγ/RXR transcription factors induce canonical M2a genes, WT mouse macrophages were treated with IL-4 in the absence or presence of rosiglitazone (RGZ; PPARγ ligand), LG100754 (LG; RXR ligand), or both...In PPARγ-deficient macrophages, IL-4 alone failed to induce Arg1 and Mrc1 gene expression; however, concurrent treatment with LG or RGZ + LG enhanced IL-4-induced Arg1 and Mrc1 expression, but to a lower level than in WT macrophages, findings confirmed in the murine alveolar macrophage cell line, MH-S. These findings support a model in which PPARγ/RXR heterodimers control IL-4-induced M2a differentiation, and suggest that PPARγ/RXR agonists should be considered as important tools for clinical intervention against influenza-induced ALI.
  • ||||||||||  pioglitazone / Generic mfg.
    Trial initiation date:  Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (clinicaltrials.gov) -  Aug 30, 2022   
    P1/2,  N=60, Recruiting, 
    In a middle-income country, pioglitazone presented a higher probability of being cost-effective followed by SGLT2i and then GLP-1A. Initiation date: Feb 2022 --> May 2022
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Enacting Treaty Rights through Restoring Shoshone Ancestral Foods on the Wind River Indian Reservation. (Pubmed Central) -  Aug 30, 2022   
    El Restoring Shoshone Ancestral Food Gathering (RSAFG) es un grupo comunitario que lidera los esfuerzos de base en la reserva wind river para recuperar los alimentos ancestrales shoshone y promover la soberanía alimentaria. La historia de la RSAFG promueve métodos equitativos, descolonizados y empoderados por la comunidad para recuperar los alimentos indígenas al compartir tres de los actos de descolonización de RSAFG: 1) promulgar los derechos de los tratados mediante la recolección de plantas tradicionales, 2) exigir asociaciones equitativas en la investigación basada en la comunidad, y 3) compartir la historia a través de la autoría radical a través de narrativas en capas.
  • ||||||||||  pioglitazone / Generic mfg.
    Review, Journal:  Secondary diabetes mellitus due to primary aldosteronism. (Pubmed Central) -  Aug 25, 2022   
    The superior efficacy of adrenalectomy in ameliorating glucose metabolism vs. mineralocorticoid receptor antagonists in clinical studies highlights the contribution of non-mineralocorticoid receptor-mediated mechanisms in the pathophysiologic process. The exact role of hypokalemia, the mechanisms linking mineralocorticoid excess with hepatic steatosis, and possible disease-modifying role of pioglitazone warrant further studies.
  • ||||||||||  Clinical guideline, Review:  AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. (Pubmed Central) -  Aug 25, 2022   
    BEST PRACTICE ADVICE 14: The therapeutic role of glucagon-like peptide-1 agonists and sodium-glucose cotransporter-2 inhibitors in the management of lean NAFLD is not fully defined and requires further investigation. BEST PRACTICE ADVICE 15: Hepatocellular carcinoma surveillance with abdominal ultrasound with or without serum α-fetoprotein twice per year is suggested in patients with lean NAFLD and clinical markers compatible with liver cirrhosis.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  The Small Molecule PPARγ Agonist GL516 Induces Feeding-Stimulatory Effects in Hypothalamus Cells Hypo-E22 and Isolated Hypothalami. (Pubmed Central) -  Aug 22, 2022   
    DA and 5-HT levels in the HypoE22 cell supernatants were analyzed through HPLC; an ex vivo study on isolated hypothalamic specimens challenged with scalar concentrations of GL516 (1-100 µM) and with pioglitazone (10 µM) was carried out...These results highlight the capability of GL516 to modulate neuropeptide pathways deeply involved in appetite control suggesting an orexigenic effect. These findings emphasize the potential use of GL516 as a promising candidate for therapeutical applications in neurodegenerative diseases associated with the reduction in food intake and stimulation of catabolic pathways.
  • ||||||||||  LY294002 / Eli Lilly
    Journal:  rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence. (Pubmed Central) -  Aug 18, 2022   
    Previous studies have confirmed that both recombinant human erythropoietin (rhEPO) and peroxisome proliferator-activated receptors γ (PPARγ) activator pioglitazone can protect senescent nerve cells, and their mechanisms involve enhancing cell antioxidant capacity and reducing cell apoptosis...Starting on the 11th day of culture, rhEPO, LY294002, and GW9662 were added for treatment...In conclusion, this study confirmed that rhEPO can upregulate the expression of PGC-1α and PPARγ in cells and the level of PPARγ protein in the nucleus to enhance the antioxidant capacity of cells and delay the senescence of nerve cells through the PI3K/Akt pathway. These findings will provide ideas for finding new targets for neuroprotection research and will also provide a theoretical basis and experimental evidence for rhEPO anti-aging research in neural cells.
  • ||||||||||  pioglitazone / Generic mfg.
    Journal:  Pioglitazone enhances proteinuria reduction in complicated pediatric nephrotic syndrome. (Pubmed Central) -  Aug 16, 2022   
    While confirmatory safety and efficacy studies are needed, these findings suggest pioglitazone (a non-immunosuppressive drug) may be useful to enhance proteinuria reduction in some children and young adults with complicated NS. A higher resolution version of the Graphical abstract is available as Supplementary information.