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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
unesbulin (BMIi-1) / PTC Therap
SUNRISELMS, NCT05269355: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)	Active, not recruiting	2/3	360	Europe, Canada, US, RoW	Unesbulin, PTC596, Dacarbazine, DTIC, Placebo	PTC Therapeutics	Leiomyosarcoma	06/24	06/24
2022-000073-12: A PHASE 2/3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF UNESBULIN IN UNRESECTABLE OR METASTATIC, RELAPSED OR REFRACTORY LEIOMYOSARCOMA	Completed	2/3	345	Europe	unesbulin, DTIC, PTC596, Tablet, Powder for solution for injection/infusion	PTC Therapeutics, Inc., PTC THERAPEUTICS INC., PTC Therapeutics, Inc.	Leiomyosarcoma, Soft Tissue Sarcoma, Diseases [C] - Cancer [C04]
OU-SCC-PTC-001, NCT03206645: Unesbulin in Women With Ovarian Cancer Receiving Neoadjuvant Chemotherapy	Completed	1	27	US	Unesbulin, PTC596	University of Oklahoma, PTC Therapeutics	Ovarian Cancer	08/21	03/24
NCT03761095: A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)	Completed	1	41	US	Unesbulin, PTC596, Dacarbazine, DTIC	PTC Therapeutics	Leiomyosarcoma	02/24	02/24
NCT03605550: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma	Active, not recruiting	1	64	US	PTC596, Radiotherapy	Nationwide Children's Hospital, PTC Therapeutics	High Grade Glioma, Diffuse Intrinsic Pontine Glioma	03/24	03/29