- |||||||||| Biomarker, Journal, PD(L)-1 Biomarker, IO Biomarker: What's new in oncodermatology? (Pubmed Central) - Jun 15, 2019
We also have a new anti-BRAF + anti-MEK combination: encorafenib + binimetinib with a good benefit/risk ratio and a particularly favorable safety profile as compared with existing similar combinations. Major steps forward were obtained for locally advanced Merkel cell carcinoma and squamous cell carcinoma with anti-PDL-1 avelumab and anti-PD1 cemiplimab respectively.
- |||||||||| Libtayo (cemiplimab-rwlc) / Regeneron
Biomarker, Enrollment closed, Trial completion date, PD(L)-1 Biomarker, IO biomarker: An Exploratory Tumor Biopsy-driven Study to Understand the Relationship Between Biomarkers and Clinical Response in Patients With Head and Neck Cancer Receiving REGN2810 (Anti-PD-1) (clinicaltrials.gov) - May 20, 2019 P1, N=33, Active, not recruiting, N=130 --> 225 Recruiting --> Active, not recruiting | Trial completion date: May 2020 --> Dec 2020
- |||||||||| Libtayo (cemiplimab) / Sanofi, Regeneron
Journal: Cemiplimab effective in cutaneous SCC. (Pubmed Central) - May 17, 2019 Trial primary completion date: Apr 2019 --> Dec 2019 No abstract available
- |||||||||| Libtayo (cemiplimab-rwlc) / Regeneron
Enrollment open: CASE: CemiplimAb Survivorship Epidemiology (clinicaltrials.gov) - Apr 16, 2019 P=N/A, N=350, Recruiting, Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- |||||||||| Libtayo (cemiplimab-rwlc) / Regeneron
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, IO biomarker: EMPOWER-lung 4: A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer (clinicaltrials.gov) - Apr 8, 2019 P2, N=28, Active, not recruiting, Trial completion date: Jul 2022 --> Feb 2023 | Trial primary completion date: Jul 2022 --> Feb 2023 Recruiting --> Active, not recruiting | N=252 --> 28 | Trial completion date: Jan 2022 --> Apr 2020 | Trial primary completion date: Jan 2022 --> Apr 2020
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Clinical, Clinical guideline, Review, Journal, Adverse events, Checkpoint inhibition: Management of Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitor Therapy: a Minireview of Current Clinical Guidelines. (Pubmed Central) - Apr 2, 2019 Herein, we review the mechanisms of irAEs and strategies for management of irAEs and highlight similarities as well as differences among clinical guidelines from the National Comprehensive Cancer Network, American Society of Clinical Oncology, Society for Immunotherapy of Cancer, and European Society for Medical Oncology. Understanding these similarities and key differences will facilitate the development and implementation of a practice site-specific plan for the management of irAEs.
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Trial completion date, Trial primary completion date: A Study of Isatuximab-based Therapy in Participants With Lymphoma (clinicaltrials.gov) - Mar 12, 2019 P1/2, N=130, Recruiting, Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2018 --> Jun 2021 Trial completion date: Jun 2022 --> Jan 2023 | Trial primary completion date: Jun 2022 --> Jan 2023
- |||||||||| Libtayo (cemiplimab-rwlc) / Regeneron
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, Monotherapy: EMPOWER-Lung 2: REGN2810 (Anti-PD-1 Antibody), Platinum-based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in Patients With Lung Cancer (clinicaltrials.gov) - Mar 6, 2019 P3, N=5, Active, not recruiting, Trial completion date: Jun 2022 --> Jan 2023 | Trial primary completion date: Jun 2022 --> Jan 2023 Recruiting --> Active, not recruiting | N=585 --> 5 | Trial completion date: Mar 2023 --> Nov 2020 | Trial primary completion date: Mar 2023 --> Nov 2020
- |||||||||| Libtayo (cemiplimab-rwlc) / Regeneron
Biomarker, Enrollment closed, Trial completion date, Trial primary completion date, PD(L)-1 Biomarker, IO biomarker: An Exploratory Tumor Biopsy-driven Study to Understand the Relationship Between Biomarkers and Clinical Response in Melanoma Patients Receiving REGN2810 (Anti-PD-1) (clinicaltrials.gov) - Jan 11, 2019 P1, N=50, Active, not recruiting, N=182 --> 266 | Trial completion date: Jun 2020 --> Aug 2021 Recruiting --> Active, not recruiting | Trial completion date: Jun 2020 --> Oct 2019 | Trial primary completion date: Jun 2019 --> Mar 2019
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