memantine / Generic mfg. 
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  • ||||||||||  risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg., quetiapine / Generic Mfg.
    Patterns of Lewy body dementia diagnosis and treatment in Florida (Les Muses, Level 3) -  Sep 24, 2019 - Abstract #MDSCongress2019MDS_1678;    
    African-Americans account for a lower percent of LBD cases than the proportion of African-Americans (17%) in Florida suggesting LBD may be underdiagnosed in this population [1]. Opportunities to improve care include diagnosis amongst racial/ethnic minorities and decreased use of inappropriate antipsychotics.
  • ||||||||||  memantine / generics
    Memantine induced dyskinesia in Alzheimer’s disease (Agora 2 West, Level 2) -  Sep 24, 2019 - Abstract #MDSCongress2019MDS_1185;    
    This study was supported by grant projects from the Ministry of Health of the Czech Republic – AZV 15-31984A and AZV NV18-04-00346, by European Regional Development Fund – Project ENOCH (No. Z.02.1.01/0.0/0.0/16_019/0000868) and by Institutional Support MZ CR – RVO FNOL 2019
  • ||||||||||  memantine / generics
    Memantine and 3D gait analysis in patient with Parkinson’s disease: an observer-blind randomized clinical trial (Agora 3 West, Level 3) -  Sep 24, 2019 - Abstract #MDSCongress2019MDS_801;    
    Z.02.1.01/0.0/0.0/16_019/0000868) and by Institutional Support MZ CR – RVO FNOL 2019 Apparently, the use of memantine is a promising direction of correction of disturbances of gait in PD by improving the glutamatergic transition from the striatum to specific areas of the cerebral cortex involved in the control of gait, and a larger placebo-controlled clinical study is warranted.
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
    A novel anti-EGFR antibody HLX07 for potential treatment of squamous cell carcinoma of the head and neck (Exhibition area) -  Sep 17, 2019 - Abstract #ESMOAsia2019ESMO_ASIA_438;    
    P1, P1/2
    These findings support the initiation of a phase 1b/2 study of HLX07 plus chemotherapy in advanced solid tumours with the longest follow-up time of over 275 days as of 20-June-2019. Additionally, HLX07 is currently under safety and efficacy investigation combined with anti-PD-1 antibody, HLX10, in squamous cell carcinoma of head and neck.Legal entity responsible for the study: Shanghai Henlius Biotech, Inc.; Taiwan Henlix Biotech Co., Ltd.
  • ||||||||||  memantine / generics
    Clinical, Journal:  Study on bioequivalence of two memantine tablet formulations in healthy Indonesian subjects. (Pubmed Central) -  Sep 16, 2019   
    Additionally, HLX07 is currently under safety and efficacy investigation combined with anti-PD-1 antibody, HLX10, in squamous cell carcinoma of head and neck.Legal entity responsible for the study: Shanghai Henlius Biotech, Inc.; Taiwan Henlix Biotech Co., Ltd. These results indicated that the two formulations of memantine were bioequivalent; therefore, they may be prescribed interchangeably.
  • ||||||||||  risperidone / Generic Mfg., Egis, carbamazepine / Generic Mfg.
    Journal:  Pharmacotherapy of Down Syndrome. (Pubmed Central) -  Sep 6, 2019   
    If ineffective, we use memantine or clozapine...We treat "regression" with symptoms of MDD± psychosis, with an antidepressant and an antipsychotic if needed. Randomized controlled trials of medications for co-morbid psychiatric disorders in DS are warranted.
  • ||||||||||  memantine / generics
    Journal:  Memantine mediates astrocytic activity in response to excitotoxicity induced by PP2A inhibition. (Pubmed Central) -  Sep 4, 2019   
    MN decreased glutamate uptake in the hippocampus and increased the release of S100B protein in the CSF in response to OKA neurotoxicity, which indicates a possible neurons-astrocyte coupling protective mechanism. These findings shed light on astrocytes as potential targets for treating neurological disorders associated with decreased PP2 A activity.
  • ||||||||||  memantine / generics, bromocriptine / generics, amantadine / generics
    Review, Journal:  Antipsychotic-induced motor symptoms in schizophrenic psychoses-Part 2 : Catatonic symptoms and neuroleptic malignant syndrome (Pubmed Central) -  Sep 1, 2019   
    ...Although there is no established treatment of ACS (here designated as a specific subtype of catatonic symptoms), an attempt should be made with benzodiazepines and memantine can also be helpful...The medicinal treatment with benzodiazepines, bromocriptine, amantadine, dantrolene and/or ECT is also advocated...In conclusion, the abovementioned clinical syndromes must be rapidly recognized and treated. Early recognition and treatment of these movement disorders can under certain circumstances be lifesaving and favorably influence the later clinical outcome.
  • ||||||||||  memantine / generics
    Clinical, Journal:  Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? (Pubmed Central) -  Sep 1, 2019   
    Although impulsivity did not predict subjective response to low-dose alcohol, the results suggest that small amounts of alcohol can produce a range of subjective effects, even among heavy drinkers. Future studies would benefit by examining subjective response across a range of BACs among both light and heavy drinkers.
  • ||||||||||  Afinitor (everolimus) / Novartis
    Review, Journal:  Identifying mutations in epilepsy genes: Impact on treatment selection. (Pubmed Central) -  Aug 30, 2019   
    Everolimus, an mTOR inhibitor approved for the treatment of focal seizures associated with tuberous sclerosis complex, is an example of a medication targeting the etiological mechanisms of the disease. Several treatments aimed at correcting specific pathogenic defects responsible for rare genetic epilepsies are currently in development, and range from traditional small molecules to novel approaches involving peptides, antisense oligonucleotides, and gene therapy.
  • ||||||||||  memantine / generics
    Journal:  Response of zebrafish larvae to mild electrical stimuli: a 96-well setup for behavioural screening. (Pubmed Central) -  Aug 28, 2019   
    We demonstrate how TVB enables the simulation of systems effects caused by pathogenetic molecular candidate mechanisms in human virtual brains. The combination of the described electrode clips for stimulus delivery and behavioural tracking allows for the use of zebrafish larvae in a new array of medium to high throughput applications.
  • ||||||||||  memantine / generics
    Living alone with dementia: related use of drugs () -  Aug 27, 2019 - Abstract #AEC2019AEC_98;    
    This study explores medication differences between people with dementia living alone, or living with an informal caregiver, or people with dementia living in care homes in Northern Ireland. Data from over 25,000 people with dementia from national databases in Northern Ireland are retrospectively analysed. The results will inform health care professionals and practices about the effect of living arrangements in prescribing medication for dementia and comorbidities.
  • ||||||||||  Comtan (entacapone) / Novartis, Orion Corp
    Trial completion date, Trial primary completion date:  Treatment of Orthostatic Intolerance (clinicaltrials.gov) -  Aug 21, 2019   
    P1/2,  N=150, Active, not recruiting, 
    These findings confirmed the effectiveness of N- and C-terminal modifications on cell viability and CPPs internalization. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  memantine / generics
    Review, Journal:  New treatment modalities in Alzheimer's disease. (Pubmed Central) -  Aug 17, 2019   
    ...Routinely used acetylcholinesterase inhibitors and memantine seem to slow disease progression only to a limited extend...Here, we review the studies about the new treatment modalities in AD with a classification based on their main targets, specifically pathologic structures of the disease, amyloid and tau, neural network dysfunction with special interest to the regulation of gamma oscillations, and attempts for the restoration of neural tissue via regenerative medicine. Additionally, we describe the evolving modalities related to gut microbiota, modulation, microglial function, and glucose metabolism.
  • ||||||||||  memantine / generics
    Journal:  CNB-001 reduces paraplegia in rabbits following spinal cord ischemia. (Pubmed Central) -  Aug 10, 2019   
    ...The improvements were similar to those produced by the uncompetitive N-methyl-D-aspartate receptor antagonist memantine...CNB-001 is a potential important novel treatment for spinal cord ischemia induced by aortic occlusion. All experiments were approved by the CSMC Institutional Animal Care and Use Committee (IACUC #4311) on November 1, 2012.
  • ||||||||||  donepezil / generics, memantine / generics, rivastigmine / generics
    Journal:  Diagnosis and Treatment of Cognitive Impairment in Parkinson's Disease (Pubmed Central) -  Aug 8, 2019   
    Cognitive impairment and motor symptoms in PD can be treated concurrently. Therefore, the correlation between motor and cognitive function should be considered when treating PD.
  • ||||||||||  iclepertin (BI425809) / Boehringer Ingelheim
    Enrollment closed, Enrollment change:  A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other (clinicaltrials.gov) -  Aug 7, 2019   
    P1,  N=8, Active, not recruiting, 
    Patient attrition and poor testing compliance remain significant problems in studies of cognitive function of brain metastases patients and further effort is needed to improve compliance with testing and sensitivity of patient-reported measures. Recruiting --> Active, not recruiting | N=16 --> 8
  • ||||||||||  memantine / generics
    Preclinical, Journal:  Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy. (Pubmed Central) -  Aug 3, 2019   
    Despite their side effects, cholinesterase (ChE) inhibitors remain the only approved drugs to treat Alzheimer's disease patients, along with the N-methyl-d-aspartate (NMDA) receptor antagonist memantine...Remarkably, in vitro results were in accordance with the starting hypothesis, showing a relative inactivity of the prodrug against DYRK1A and ChEs and a potent inhibition of ChEs by the oxidized form. Molecular docking and kinetic studies of ChE inhibition by the active compound are also discussed in this report.
  • ||||||||||  memantine / generics
    Preclinical, Journal:  Preclinical Models of Alzheimer's Disease: Relevance and Translational Validity. (Pubmed Central) -  Aug 3, 2019   
    These findings suggest that crocins counteract natural forgetting and may modulate different aspects of recognition memory, and that the combined use of crocins and memantine might represent a novel strategy to treat memory disorders. The only drugs currently approved for the treatment of Alzheimer's Disease (AD) are four acetylcholinesterase inhibitors and the NMDA antagonist memantine...This overview discusses the current animal models of AD in the context of both the controversies surrounding the causative role of amyloid in the disease and the need to develop validated models of cognitive function/dysfunction that more appropriately reflect the phenotype(s) of human aged-related dementias.
  • ||||||||||  memantine / generics
    Preclinical, Journal:  Rational design and implementation of a cucurbit[8]uril-based indicator-displacement assay for application in blood serum. (Pubmed Central) -  Aug 2, 2019   
    Therefore, a novel class of [2.2]paracyclophane-derived indicator dyes for the host CB8 was developed that possesses one of the highest host-guest affinities (K > 10 M in water) known in supramolecular host-guest chemistry, and which provides a large Stokes shift (up to 200 nm). The novel IDA was then tested for the detection of memantine in blood serum in a physiologically relevant sub- to low micromolar concentration range.
  • ||||||||||  memantine / generics
    Journal:  Abstracts from the 44th Annual Meeting of Japanese Society for Microcirculation. (Pubmed Central) -  Jul 31, 2019   
    Yokukansan is a traditional Japanese kampo medicine which was anciently used to reduce the irritability in children...Yokukansan is a traditional Japanese kampo medicine which was anciently used to reduce the irritability in children. Yokukansan is useful for prevention of abnormal glutamate release, and improvement of glutamate uptake with glutamate transporters.
  • ||||||||||  memantine / generics
    Journal:  Memantine Ameliorates Migraine Headache. (Pubmed Central) -  Jul 31, 2019   
    No severe adverse events and death were recorded during the study. Memantine (10 mg oral, once daily) is effective, well tolerated, and safe for patients with migraine.