- |||||||||| Treatment Strategies for Ultra-Resistant Schizophrenias (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_934;
Electroconvulsive therapy seems to be the only non-pharmacological technique with enough data to support its efficacy in ultra-resistant cases of schizophrenia. Other neuromodulatory techniques, like tDCS, are still in early phase of investigation, and psychotherapy does not have enough evidence to support its efficacy.
- |||||||||| memantine / Generic mfg.
[VIRTUAL] INHIBITION OF AMYLOID ΒETA PROTEIN AGGREGATION BY SELF-ASSEMBLING NANOPARTICLES OF MEMANTINE-ALPHA LIPOIC ACID CONJUGATE (EXHIBITION HALL) - Jan 6, 2020 - Abstract #AATADPD2020AAT_ADPD_782;
Self-assembled MEM-ALA nanoparticles were successfully prepared and the DLS curve of nanoparticles were found to be unimodal distribution with an average hydrodynamic diameter of 124.2 ± 2.05 nm and polydispersity index of 0.19 ± 0.04 which was in concurrence with FE-SEM analysis. Conclusions In summary, study demonstrated that self-assembled MEM-ALA nanoparticles inhibited the formation of β-amyloid1-42 fibrils and showed better effects than MEM alone.
- |||||||||| memantine / Generic mfg.
Clinical, Journal: Predementia neurocognitive impairment in the elderly (Pubmed Central) - Jan 5, 2020
Later this state named as mild cognitive impairment (MCI) is considered as prodromal phase of demented disease. Up to date studies allow us consider MCI as an integral part of the complex structure of overlapping syndromes ('pre-cognitive impairment'), the allocation of which have not only theoretical, but also pragmatic meaning, allow us, on the one hand, to plan clinical trials series with various therapeutic targets, and, on the other hand, to form rational approach to the modern management of patients with MCI and pre-MCI in clinical practice.
- |||||||||| memantine / Generic mfg.
Journal: Small arms fire-like noise: Effects on hearing loss, gap detection and the influence of preventive treatment. (Pubmed Central) - Jan 4, 2020
As in the previous study, piribedil, memantine, and ACEMg treatment significantly reduced the noise-induced loss of ribbons, such that it was no longer significantly different from normal. However, it did not prevent development of the reduced gap detection indication of tinnitus in all treated noise exposed rats, reducing the incidence but not reaching significance.
- |||||||||| venlafaxine / Generic mfg., memantine / Generic mfg.
Clinical, Review, Journal: Ineffective levels of transforming growth factors and their receptor account for old age being a risk factor for Alzheimer's disease. (Pubmed Central) - Jan 1, 2020
Alternative, possible reasons are discussed but rejected because either those reasons may also affect young persons or because they cannot be validated in a clinical trial. The proposed hypothesis may be validated in persons with aMCI after raising their brain levels of TGF-β1 and 2 by using a combination of three drugs, lithium, memantine, plus either glatiramer or venlafaxine, and then assessing their progression to AD.
- |||||||||| memantine / Generic mfg.
Journal: A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. (Pubmed Central) - Dec 25, 2019
Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine...Moreover, most of these compounds have been predicted to be brain permeable. This set of biological properties makes them promising leads for further anti-Alzheimer drug development.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal, Combination therapy: Allograft of Sertoli Cell Transplantation in Combination with Memantine Alleviates Ischemia-Induced Tissue Damages in An Animal Model of Rat. (Pubmed Central) - Dec 25, 2019
This study shows that a combination of SCs and memantine caused a significant decrease in neurological defects, infarction volume, the permeability of the blood-brain barrier, and edema in comparison with the control group. Probably, memantine and SCs transplantation reduce the damage of cerebral ischemia, through the secretion of growth factors, anti-inflammatory cytokines, and antioxidant factors.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism. (Pubmed Central) - Dec 25, 2019
Corroborating the general thought that overactivation of the striatal N-methyl-D-aspartate receptor function might generate levodopa-induced dyskinesias and parkinsonism, our results suggest that a continuous intrastriatal MMT infusion can be beneficial for the management of Parkinson's disease with levodopa-induced dyskinesias. Our study also provides indications for the prototypic use of pharmacological deep-brain modulation through intracerebral infusion systems for treating medically intractable movement disorders.
- |||||||||| memantine / Generic mfg.
Clinical, Review, Journal: Cognitive symptoms of Alzheimer's disease: clinical management and prevention. (Pubmed Central) - Dec 22, 2019
Evidence for the efficacy of vitamin E supplementation and medical foods is weak but might be considered in the context of cost, availability, and safety in individual patients. Apparently promising disease-modifying interventions, mostly addressing the amyloid cascade hypothesis of AD, have recently failed to demonstrate efficacy so novel approaches must be considered.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Prophylactic potential of memantine against soman poisoning in rats. (Pubmed Central) - Dec 21, 2019
Despite its behavioural effects, memantine seems to be beneficial antidote when administered after soman, along with atropine/HI-6/diazepam therapy. Mechanism of the antidotal effect of memantine against soman poisoning appears to be a combination of AChE-protecting and NMDA receptor-blocking action.
- |||||||||| memantine / Generic mfg.
Novel Psychopharmacology of Asd with Focus on Adhd (Thurgood Marshall Ballroom) - Dec 12, 2019 - Abstract #APSARD2020APSARD_111;
Data from clinical trials including those targeting inattention and hyperactivity will be reviewed and updated information on recent findings involving old and new compounds will be summarized. The rate of adverse events observed in individuals with ASD will be discussed with a focus on data from medications targeting symptoms of ADHD.
- |||||||||| memantine / Generic mfg.
Adhd and Autism: New Insights on Their Relationship (Thurgood Marshall Ballroom) - Dec 12, 2019 - Abstract #APSARD2020APSARD_108;
The role of novel pharmacological interventions will be discussed including oxytocin, arginine vasopressin, N-Acetylcysteine, pregnenolone, and memantine...Learning Objective 2: Understand how longitudinal studies provide a new perspective on the overlap of ADHD and ASD. Learning Objective 3: Review the results of neuroimaging studies relevant to the comorbidity of ADHD and ASD Learning Objective 4: Discuss recent advances in the psychopharmacology of ASD, particularly regarding the treatment of inattention and impulsivity in those with ASD.
- |||||||||| quetiapine / Generic Mfg.
Preclinical, Review, Journal: Strategies for Treatment-Resistant Depression: Lessons Learned from Animal Models. (Pubmed Central) - Nov 29, 2019
Interestingly, these innovative therapies have mechanisms of action different from those of classic antidepressants. These effects are mainly related to the regulation of neurotransmitter activity, including general glutamate and increased connectivity, synaptic capacity, and neuroplasticity.
- |||||||||| donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Journal: Cholinesterase as a Target for Drug Development in Alzheimer's Disease. (Pubmed Central) - Nov 28, 2019
Herein, we describe the role of acetylcholine sterase (AChE) and related hypothesis in AD along with the pharmacological and chemical aspects of the available cholinesterase inhibitors. This chapter discusses the development of several congeners and hybrids of available cholinesterase inhibitors along with their binding patterns in enzyme active sites.
- |||||||||| memantine / Generic mfg.
Heterogeneous Clinical and Functional Features of GRIN2D-Related Developmental and Epileptic Encephalopathy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1264;
Conclustions Overall, our findings further emphasize the importance of functional and biochemical validation for each individual variant. The combination of a rapidly growing array of genomic sequencing data with functional evaluation of specific molecular mechanisms and potential rescue pharmacology in vitro may provide a better understanding of disease mechanism, diagnoses, as well as choice of precision medicine for a subset of severe pediatric neurodevelopmental diseases.
- |||||||||| memantine / Generic mfg.
Cathodal Direct Current Simulation Heterogeneously Modulates Cortical Excitability in Human Cortex Derived from Epilepsy Surgery (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_330;
Given that DCS-LTD and DCS-LTP depends on the activation of mGluR5- and NMDA-type glutamate receptors, respectively, we further tested the effect of an uncompetitive NMDAR antagonist, memantine, on the anatomy of DCS modulation of cortical excitability...However, the DCS plastic effects are not uniform throughout cortical layers, which may partly explain the incomplete efficacy of transcranial cathodal DCS in clinical trials. Since blocking NMDAR activity could facilitate DCS-LTD in human cortex in vitro, we suggest a therapeutic potential of NMDAR antagonists to augment transcranial cathodal DCS efficiency.
- |||||||||| donepezil / generics, memantine / generics, rivastigmine / generics
Clinical, Journal: Patterns of Dementia Treatment and Frank Prescribing Errors in Older Adults With Parkinson Disease. (Pubmed Central) - Nov 28, 2019
Dementia medication use by persons with Parkinson disease varies by race/ethnicity and sex; potentially inappropriate prescribing is common among those being treated for cognitive impairment and varies by race/ethnicity, sex, and geography. These findings may serve as national and local targets for improving care quality and outcomes for persons with Parkinson disease.
- |||||||||| memantine / generics
Clinical, Journal: Association of Antidementia Therapies With Time to Skilled Nursing Facility Admission and Cardiovascular Events Among Elderly Adults With Alzheimer Disease. (Pubmed Central) - Nov 23, 2019
This result was mainly driven by the lower risk of bradycardia and syncope observed for the memantine monotherapy group relative to both AChEI monotherapy (bradycardia: aHR, 0.88; 95% CI, 0.82-0.95; and syncope: aHR, 0.92; 95% CI, 0.86-0.97) and combination therapy (bradycardia: aHR, 0.89; 95% CI, 0.82-0.97; and syncope: aHR, 0.87; 95% CI, 0.83-0.94). Time to SNF admission did not differ across treatment groups, but memantine monotherapy was associated with a lower risk of cardiovascular events compared with both AChEI monotherapy and combination therapy with an AChEI and memantine.
- |||||||||| donepezil / generics, memantine / generics
Journal: Rural Disparities in Alzheimer's Disease-Related Community Pharmacy Care in the United States. (Pubmed Central) - Nov 19, 2019
We found disparities in AD-related services in community pharmacies located in more rural counties, wherein individuals with AD and their caregivers may face barriers to obtaining quality pharmaceutical care. There is a need to strengthen pharmacists' knowledge and improve pharmacy services to reduce disparities.
- |||||||||| temozolomide / Generic mfg., memantine / Generic mfg., mefloquine / Generic mfg.
Trial completion date, Trial primary completion date: Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy (clinicaltrials.gov) - Nov 15, 2019
P1, N=144, Active, not recruiting,
There is a need to strengthen pharmacists' knowledge and improve pharmacy services to reduce disparities. Trial completion date: Sep 2019 --> Sep 2022 | Trial primary completion date: Sep 2019 --> Sep 2022
- |||||||||| iclepertin (BI425809) / Boehringer Ingelheim
Trial completion: A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other (clinicaltrials.gov) - Nov 14, 2019
P1, N=16, Completed,
However, costs were slightly lower for moderate than for mild AD dementia, possibly reflecting the observed unusual trend of greater caregiver time and higher memantine use in patients with mild versus moderate AD dementia. Active, not recruiting --> Completed
- |||||||||| memantine / generics
Journal: Current approaches to the pharmacological treatment of Alzheimer's disease. (Pubmed Central) - Nov 11, 2019
Evidence for other pharmacological therapies is mixed or lacking. Behavioural and psychological symptoms of dementia (BPSD) are common in people with Alzheimer's disease and may respond to symptomatic pharmacological and non-pharmacological treatment.
- |||||||||| memantine / generics
Journal: In silico identification of critical proteins associated with learning process and immune system for Down syndrome. (Pubmed Central) - Nov 3, 2019
In the previous studies, the expression levels of 77 proteins obtained from normal genotype control mice and from trisomic Ts65Dn mice have been analyzed after training in contextual fear conditioning with and without injection of the memantine drug using statistical methods and machine learning techniques...Later, deep neural network, gradient boosting tree, support vector machine and random forest classification methods are implemented to identify the accuracy. It is observed that the selected feature subsets not only yield higher accuracy classification results but also are composed of protein responses which are important for the learning and memory process and the immune system.
- |||||||||| donepezil / generics, memantine / generics, rivastigmine / generics
Journal: Diagnosis and Management of Dementia: Review. (Pubmed Central) - Oct 31, 2019
Rivastigmine can be used to treat symptomatic Parkinson disease dementia...Causes of dementia can be diagnosed by medical history, cognitive and physical examination, laboratory testing, and brain imaging. Management should include both nonpharmacologic and pharmacologic approaches, although efficacy of available treatments remains limited.
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