memantine / Generic mfg. 
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  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Probiotics as potential therapeutic options for Alzheimer's disease. (Pubmed Central) -  Oct 14, 2021   
    As for probiotics, a total of 13 studies employed single-strain probiotic, and the rest studies used multi-strain probiotics (ranged from 2 to 9 probiotic strains), 4 used probiotic-fermented milk or probiotic-fermented soybean, 2 studies used engineered probiotic strain, and 4 studies focused on the combined effect of probiotics with AD drug memantine, selenium, or exercise...•A total of 35 associated studies consisted of 26 animal model studies and 9 human studies were included. •Most studies found that probiotic administration conferred neuroprotective benefits and could attenuate cognitive deficits.
  • ||||||||||  memantine / Generic mfg.
    Preclinical, Journal:  In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat. (Pubmed Central) -  Oct 13, 2021   
    PQ10, a phosphodiesterase-10 inhibitor, significantly enhanced the TBS-induced LTP response, but did not change the PPF response. Overall, the results confirm the strain-dependent differences in the form of synaptic plasticity, replicate earlier plasticity results, and report effective protocols that generate a relatively subthreshold margin of LTP induction and maintenance, which are suitable for pharmacology in the LE rat strain mainly used in cognitive studies.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Chronic kidney disease and cognitive impairment. (Pubmed Central) -  Oct 7, 2021   
    Anticholinesterase drugs and memantine should be used with caution in patients with CKD, as most of these drugs accumulate due to a low glomerular filtration rate. Due to the poor prognosis of patients with NCD and ESRD treated by dialysis or kidney transplantation, a cognitive assessment should be proposed in older patients with severe CKD in order to discuss the initiation and type of renal replacement therapy with both patients and caregivers.
  • ||||||||||  memantine / Generic mfg.
    Preclinical, Journal:  Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice. (Pubmed Central) -  Oct 2, 2021   
    In WT mice, memantine treatment, which does not alter NMDAR function, upregulated synaptic genes and downregulated ECM genes; memantine-treated WT mice also exhibited a reverse-ASD pattern. Therefore, early chronic treatment of Shank2-KO mice with memantine alters expression of chromatin, mitochondria, ECM, actin, and ASD-related genes.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Memantine can protect against inflammation-based cognitive decline in geriatric depression. (Pubmed Central) -  Oct 1, 2021   
    P4
    In this exploratory analysis, the addition of memantine to escitalopram provided a protective effect on executive functioning in older depressed adults. Future studies are needed to replicate the association of cytokine markers to antidepressant and neuroprotective treatment-related change in cognition in geriatric depression.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Targets for migraine treatment: beyond calcitonin gene-related peptide. (Pubmed Central) -  Oct 1, 2021   
    The hypothalamus has also been implicated in migraine pathophysiology: the potential role of orexins in migraine is discussed. Acid-sensing ion channels, as well as amylin-blocking drugs, may also become migraine treatments in the future: more research is warranted.
  • ||||||||||  Aduhelm (aducanumab) / Eisai, Biogen
    Journal:  Aducanumab (Aduhelm) for Alzheimer's disease. (Pubmed Central) -  Sep 29, 2021   
    Future work will further characterize FENM's mechanism of action with the goal of clinical development. No abstract available
  • ||||||||||  memantine / Generic mfg.
    Journal:  A top 5 list for French general practice. (Pubmed Central) -  Sep 26, 2021   
    All the items selected have a negative risk-benefit balance and are frequently prescribed by French general practitioners. This list differs from other top five lists for general practice, reflecting the local medical culture.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Current and evolving treatment strategies for the Alzheimer disease continuum. (Pubmed Central) -  Sep 23, 2021   
    In October 2019, the AD community was re-invigorated by unexpected news that a Biologics License Application will be submitted for aducanumab to treat AD. This article explores the current state of biomarker-driven drug development across the AD continuum and reviews investigational drugs in phase 2/3 clinical development for AD.
  • ||||||||||  memantine / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action. (Pubmed Central) -  Sep 22, 2021   
    Finally, we establish that Idiopathic Pulmonary Fibrosis shares several involved genes, biological pathways and candidate inhibiting-drugs with Dupuytren's Disease, IgG4-related Disease, Systemic Sclerosis and Cystic Fibrosis. We propose that treatments for these fibrotic diseases should be jointly pursued.
  • ||||||||||  memantine / Generic mfg.
    Enrollment closed:  Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer (clinicaltrials.gov) -  Sep 22, 2021   
    P2,  N=56, Active, not recruiting, 
    We propose that treatments for these fibrotic diseases should be jointly pursued. Enrolling by invitation --> Active, not recruiting
  • ||||||||||  memantine / Generic mfg.
    Journal:  Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease. (Pubmed Central) -  Sep 18, 2021   
    Computational drug repositioning analyses of expression changes within the disease-associated networks retrieved known Alzheimer disease drugs (e.g., memantine) as well as biologically meaningful drug categories (e.g., glutamate receptor antagonists). Our results improve the biological interpretation of genetic data for Alzheimer disease and provide a list of potential antidementia drug repositioning candidates for which the efficacy should be investigated in functional validation studies.
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation. (Pubmed Central) -  Sep 11, 2021   
    Several drugs have been used in aphasia pharmacotherapy, but evidence from clinical studies suggest that only nootropic agents, donepezil and memantine, may improve the prognosis of aphasia. This article is an overview on the current state of knowledge related to post-stroke aphasia pharmacology, rehabilitation, and future trends.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP). (Pubmed Central) -  Sep 11, 2021   
    Furthermore, our experiments indicated that ethanol withdrawal (7 days withdrawal after 10 days ethanol administration) down-regulated the CNR1 (encoding CB1), GRIN1/2A (encoding GluN1 and GluN2A subunit of the NMDA receptor) genes expression in the prefrontal cortex and dorsal striatum, but up-regulated these in the hippocampus, confirming the involvement of these receptors in ethanol rewarding effects. Thus, our results show that the endocannabinoid system is involved in the motivational properties of ethanol, and glutamate may control cannabinoid induced relapse into ethanol seeking behavior.
  • ||||||||||  Comtan (entacapone) / Novartis, Orion Corp
    Trial completion date, Trial primary completion date:  Treatment of Orthostatic Intolerance (clinicaltrials.gov) -  Sep 8, 2021   
    P1/2,  N=150, Active, not recruiting, 
    Thus, our results show that the endocannabinoid system is involved in the motivational properties of ethanol, and glutamate may control cannabinoid induced relapse into ethanol seeking behavior. Trial completion date: Dec 2022 --> Dec 2025 | Trial primary completion date: Dec 2022 --> Dec 2025
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Preventive treatments to slow substantia nigra damage and Parkinson's disease progression: a critical perspective review. (Pubmed Central) -  Sep 3, 2021   
    The integration of neuro-immune, antioxidant, and nutritional approaches to treatment should afford better neuroprotection, including by attenuating neuroinflammation, nitro-oxidative stress, mitochondrial dysfunction, and neurodegenerative processes. Future research should clarify the efficacy, and interactions, of nicotine receptor agonists, gut microbiome-derived butyrate, melatonin, and NSAIDs in the treatment of PD.
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Alzheimer's disease: targeting the glutamatergic system. (Pubmed Central) -  Sep 1, 2021   
    We explore how the reported benefits of BCAA supplementation or restriction in improving cognitive function in other neurological diseases may have potential application in AD. Given that memantine, the glutamate receptor agonist, shows clinical relevance it is now timely to research related pathways, an understanding of which could identify novel approaches to treatment of AD.
  • ||||||||||  memantine / Generic mfg., amantadine / Generic mfg.
    Review, Journal:  Potential for the Repurposing of Adamantane Antivirals for COVID-19. (Pubmed Central) -  Aug 22, 2021   
    Amantadine and memantine are widely employed for the treatment of neurodegenerative diseases and a pathophysiologic link between the antiviral and anti-Parkinson actions of amantadine has been entertained. Case reports involving 23 patients with reverse transcription polymerase chain reaction-confirmed coronavirus disease 2019 (COVID-19) and a range of co-morbidities including type 2 diabetes mellitus, Parkinson's disease, multiple sclerosis and severe cognitive impairment reveal significant potential benefits of amantadine and memantine for the prevention and/or treatment of coronavirus disease 2019 and its neurological complications.
  • ||||||||||  memantine / Generic mfg.
    Trial completion date, Trial primary completion date:  MIND: Local Study of Akatinol Memantine in VaD in Russia (clinicaltrials.gov) -  Aug 19, 2021   
    P3,  N=126, Recruiting, 
    Our study provides unique data about dementia management in European primary care for the benefit of national and international stakeholders. Trial completion date: Jul 2021 --> Dec 2022 | Trial primary completion date: Jul 2021 --> Dec 2022
  • ||||||||||  memantine / Generic mfg.
    Journal:  Activation of N-methyl-D-aspartate receptor regulates insulin sensitivity and lipid metabolism. (Pubmed Central) -  Aug 18, 2021   
    To assess the role of NMDAR in insulin sensitivity and lipid metabolism, we tested the effects of Memantine (an NMDAR antagonist) and NMDA (an NMDAR agonist) on mice fed with HFD or standard chow diet...The PPARα activity reduction induced by NMDAR activation was reversibly mediated by ERK1/2 signaling. These findings revealed that targeting NMDAR might be a promising therapeutic strategy for metabolic syndrome in obesity.