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Review, Journal: Probiotics as potential therapeutic options for Alzheimer's disease. (Pubmed Central) - Oct 14, 2021 As for probiotics, a total of 13 studies employed single-strain probiotic, and the rest studies used multi-strain probiotics (ranged from 2 to 9 probiotic strains), 4 used probiotic-fermented milk or probiotic-fermented soybean, 2 studies used engineered probiotic strain, and 4 studies focused on the combined effect of probiotics with AD drug memantine, selenium, or exercise...•A total of 35 associated studies consisted of 26 animal model studies and 9 human studies were included. •Most studies found that probiotic administration conferred neuroprotective benefits and could attenuate cognitive deficits.
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Journal: Chronic kidney disease and cognitive impairment. (Pubmed Central) - Oct 7, 2021 Anticholinesterase drugs and memantine should be used with caution in patients with CKD, as most of these drugs accumulate due to a low glomerular filtration rate. Due to the poor prognosis of patients with NCD and ESRD treated by dialysis or kidney transplantation, a cognitive assessment should be proposed in older patients with severe CKD in order to discuss the initiation and type of renal replacement therapy with both patients and caregivers.
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Preclinical, Journal: Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice. (Pubmed Central) - Oct 2, 2021 In WT mice, memantine treatment, which does not alter NMDAR function, upregulated synaptic genes and downregulated ECM genes; memantine-treated WT mice also exhibited a reverse-ASD pattern. Therefore, early chronic treatment of Shank2-KO mice with memantine alters expression of chromatin, mitochondria, ECM, actin, and ASD-related genes.
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Journal: Memantine can protect against inflammation-based cognitive decline in geriatric depression. (Pubmed Central) - Oct 1, 2021 P4 In this exploratory analysis, the addition of memantine to escitalopram provided a protective effect on executive functioning in older depressed adults. Future studies are needed to replicate the association of cytokine markers to antidepressant and neuroprotective treatment-related change in cognition in geriatric depression.
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Journal: Targets for migraine treatment: beyond calcitonin gene-related peptide. (Pubmed Central) - Oct 1, 2021 The hypothalamus has also been implicated in migraine pathophysiology: the potential role of orexins in migraine is discussed. Acid-sensing ion channels, as well as amylin-blocking drugs, may also become migraine treatments in the future: more research is warranted.
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Journal: Aducanumab (Aduhelm) for Alzheimer's disease. (Pubmed Central) - Sep 29, 2021 Future work will further characterize FENM's mechanism of action with the goal of clinical development. No abstract available
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Journal: A top 5 list for French general practice. (Pubmed Central) - Sep 26, 2021 All the items selected have a negative risk-benefit balance and are frequently prescribed by French general practitioners. This list differs from other top five lists for general practice, reflecting the local medical culture.
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Journal: Current and evolving treatment strategies for the Alzheimer disease continuum. (Pubmed Central) - Sep 23, 2021 In October 2019, the AD community was re-invigorated by unexpected news that a Biologics License Application will be submitted for aducanumab to treat AD. This article explores the current state of biomarker-driven drug development across the AD continuum and reviews investigational drugs in phase 2/3 clinical development for AD.
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Journal: Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease. (Pubmed Central) - Sep 18, 2021 Computational drug repositioning analyses of expression changes within the disease-associated networks retrieved known Alzheimer disease drugs (e.g., memantine) as well as biologically meaningful drug categories (e.g., glutamate receptor antagonists). Our results improve the biological interpretation of genetic data for Alzheimer disease and provide a list of potential antidementia drug repositioning candidates for which the efficacy should be investigated in functional validation studies.
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Clinical, Journal: Gender Disparities in Anti-dementia Medication Use among Older Adults: Health Equity Considerations and Management of Alzheimer's Disease and Related Dementias. (Pubmed Central) - Sep 14, 2021 Healthcare providers should be aware of gender disparities in receiving anti-dementia medications among patients with ADRD, and the need to plan programs of care to support both women and men. Future approaches to finding barriers of prescribing, receiving and, adhering to anti-dementia medications by gender should include differences in longevity, biology, cognition, social roles, and environment.
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Review, Journal: Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation. (Pubmed Central) - Sep 11, 2021 Several drugs have been used in aphasia pharmacotherapy, but evidence from clinical studies suggest that only nootropic agents, donepezil and memantine, may improve the prognosis of aphasia. This article is an overview on the current state of knowledge related to post-stroke aphasia pharmacology, rehabilitation, and future trends.
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Journal: Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP). (Pubmed Central) - Sep 11, 2021 Furthermore, our experiments indicated that ethanol withdrawal (7 days withdrawal after 10 days ethanol administration) down-regulated the CNR1 (encoding CB1), GRIN1/2A (encoding GluN1 and GluN2A subunit of the NMDA receptor) genes expression in the prefrontal cortex and dorsal striatum, but up-regulated these in the hippocampus, confirming the involvement of these receptors in ethanol rewarding effects. Thus, our results show that the endocannabinoid system is involved in the motivational properties of ethanol, and glutamate may control cannabinoid induced relapse into ethanol seeking behavior.
- |||||||||| Comtan (entacapone) / Novartis, Orion Corp
Trial completion date, Trial primary completion date: Treatment of Orthostatic Intolerance (clinicaltrials.gov) - Sep 8, 2021 P1/2, N=150, Active, not recruiting, Thus, our results show that the endocannabinoid system is involved in the motivational properties of ethanol, and glutamate may control cannabinoid induced relapse into ethanol seeking behavior. Trial completion date: Dec 2022 --> Dec 2025 | Trial primary completion date: Dec 2022 --> Dec 2025
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Review, Journal: Preventive treatments to slow substantia nigra damage and Parkinson's disease progression: a critical perspective review. (Pubmed Central) - Sep 3, 2021 The integration of neuro-immune, antioxidant, and nutritional approaches to treatment should afford better neuroprotection, including by attenuating neuroinflammation, nitro-oxidative stress, mitochondrial dysfunction, and neurodegenerative processes. Future research should clarify the efficacy, and interactions, of nicotine receptor agonists, gut microbiome-derived butyrate, melatonin, and NSAIDs in the treatment of PD.
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Review, Journal: Alzheimer's disease: targeting the glutamatergic system. (Pubmed Central) - Sep 1, 2021 We explore how the reported benefits of BCAA supplementation or restriction in improving cognitive function in other neurological diseases may have potential application in AD. Given that memantine, the glutamate receptor agonist, shows clinical relevance it is now timely to research related pathways, an understanding of which could identify novel approaches to treatment of AD.
- |||||||||| memantine / Generic mfg., amantadine / Generic mfg.
Review, Journal: Potential for the Repurposing of Adamantane Antivirals for COVID-19. (Pubmed Central) - Aug 22, 2021 Amantadine and memantine are widely employed for the treatment of neurodegenerative diseases and a pathophysiologic link between the antiviral and anti-Parkinson actions of amantadine has been entertained. Case reports involving 23 patients with reverse transcription polymerase chain reaction-confirmed coronavirus disease 2019 (COVID-19) and a range of co-morbidities including type 2 diabetes mellitus, Parkinson's disease, multiple sclerosis and severe cognitive impairment reveal significant potential benefits of amantadine and memantine for the prevention and/or treatment of coronavirus disease 2019 and its neurological complications.
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Trial completion date, Trial primary completion date: MIND: Local Study of Akatinol Memantine in VaD in Russia (clinicaltrials.gov) - Aug 19, 2021 P3, N=126, Recruiting, Our study provides unique data about dementia management in European primary care for the benefit of national and international stakeholders. Trial completion date: Jul 2021 --> Dec 2022 | Trial primary completion date: Jul 2021 --> Dec 2022
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Journal: Activation of N-methyl-D-aspartate receptor regulates insulin sensitivity and lipid metabolism. (Pubmed Central) - Aug 18, 2021 To assess the role of NMDAR in insulin sensitivity and lipid metabolism, we tested the effects of Memantine (an NMDAR antagonist) and NMDA (an NMDAR agonist) on mice fed with HFD or standard chow diet...The PPARα activity reduction induced by NMDAR activation was reversibly mediated by ERK1/2 signaling. These findings revealed that targeting NMDAR might be a promising therapeutic strategy for metabolic syndrome in obesity.
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