- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Journal: Dementia care in diverse older adults in the Deep South and the rest of the United States. (Pubmed Central) - Feb 4, 2022
ADRD specialist and drug utilization is relatively low in both DS and non-DS, with no significant R/E differences. Research should continue to examine factors that may drive medical care decisions of older adults with ADRD in US regions with different socio-economic and medical resource contexts.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: Systematic review of pharmacological interventions for people with Lewy body dementia. (Pubmed Central) - Feb 4, 2022
We list evidence-based recommendations for the pharmacological management of DLB and PDD, and propose specific clinical guidelines for improving their clinical management. Supplemental data for this article can be accessed online at https://doi.org/10.1080/13607863.2022.2032601 .
- |||||||||| memantine / Generic mfg.
Journal: Preservation of cognitive function after brain irradiation. (Pubmed Central) - Feb 4, 2022
Supplemental data for this article can be accessed online at https://doi.org/10.1080/13607863.2022.2032601 . Future studies are required to evaluate the impact of memantine in different types of radiation therapy procedures and its effects on quality of life of brain metastatic survivors.
- |||||||||| memantine / Generic mfg., amantadine / Generic mfg.
Journal: Better language through chemistry: Augmenting speech-language therapy with pharmacotherapy in the treatment of aphasia. (Pubmed Central) - Feb 2, 2022
Although no medications are currently approved for the treatment of aphasia by the United States Food and Drug Administration, numerous candidate mechanisms for pharmaceutical manipulation continue to be identified based on our evolving understanding of the neurometabolic experience of stroke recovery across molecular, cellular, and functional levels of inquiry. This chapter will review evidence for catecholaminergic, glutamatergic, cholinergic, and serotonergic drug therapies and discuss future directions for both candidate drug selection and pharmacotherapy practice in people with aphasia.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease. (Pubmed Central) - Jan 29, 2022
In this review we updated the recent development of new therapeutics that regulate neurotransmitters, inflammation, lipid metabolism, autophagy, microbiota, circadian rhythm, and disease-modified genes for AD in preclinical research and clinical trials. It is to emphasize the importance of early diagnosis and multiple-target intervention, which may provide a promising outcome for AD treatment.
- |||||||||| memantine / Generic mfg.
Review, Journal: Memantine and its benefits for cancer, cardiovascular and neurological disorders. (Pubmed Central) - Jan 28, 2022
In addition, these receptors may play a role in cardiovascular disorders. In this review, we focus on the most recent findings for memantine with respect to its pharmacological effects in a range of diseases, including inflammatory disorders, cardiovascular diseases, cancer, neuropathy, as well as retinopathy.
- |||||||||| memantine / Generic mfg.
Journal, IO biomarker: Effect of memantine on the survival of an ischemic random skin flap and the underlying mechanism. (Pubmed Central) - Jan 28, 2022
In this review, we focus on the most recent findings for memantine with respect to its pharmacological effects in a range of diseases, including inflammatory disorders, cardiovascular diseases, cancer, neuropathy, as well as retinopathy. Memantine can promote the survival of skin flap in rats by improving the blood supply, promoting angiogenesis, inhibiting the inflammatory response, and reducing ischemia-reperfusion injury.
- |||||||||| gabapentin / Generic mfg., memantine / Generic mfg.
Review, Journal: Oncologic causes of oculopalatal tremors: neurophysiology and treatment. (Pubmed Central) - Jan 26, 2022
Symptom control through medication management has had limited success attributed to poor response and medication intolerance. Surgical modalities like DBS may have an emerging role in OPT treatment by targeting dyssynchronous activity in the dentatorubro-olivary pathway.
- |||||||||| memantine / Generic mfg.
Retrospective data, Journal: Neuroprotective Effects of Novel Treatments on Acute Optic Neuritis-A Meta-Analysis. (Pubmed Central) - Jan 26, 2022
Larger randomized controlled trials with suitable outcome measures are warranted to evaluate the neuroprotective effects of novel treatments. Further studies should also tailor therapies to specific patient populations and investigate a more targeted treatment for acute optic neuritis.
- |||||||||| ketamine / Generic mfg., memantine / Generic mfg., dextromethorphan / Generic mfg.
Journal: Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy. (Pubmed Central) - Jan 19, 2022
Our study provides real-world evidence for the state of clinical practice related to PSD in Japan. Our finding contributes to the understanding of the phenotype-genotype correlations of patients with GRIN1 gene variants, provides a molecular mechanism underlying the actions of this variant, and explores therapeutic strategies for treating GRIN1-related neurological conditions.
- |||||||||| memantine / Generic mfg.
Journal: A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. (Pubmed Central) - Jan 18, 2022
These results, with the combined approach, suggested that autophagy-activating small molecules may improve proteinopathies by eliminating nonfunctional protein aggregates. ADK: adenosine kinase; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; BECN1: beclin-1; DDIT3/CHOP: DNA damage inducible transcript 3; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2S1/eIF2α: eukaryotic translation initiation factor 2 subunit alpha; ER: endoplasmic reticulum; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; FDA: Food and Drug Administration; GSH: glutathione; HD: Huntington disease; HSPA5/GRP78: heat shock protein family A (Hsp70) member 5; HTT: huntingtin; JAK: Janus kinase, MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MAP2K/MEK: mitogen-activated protein kinase kinase; MAP3K8/Tpl2: mitogen-activated protein kinase kinase kinase 8; MAPK: mitogen-activated protein kinase; MPP: 1-methyl-4-phenylpyridinium; MTOR: mechanistic target of rapamycin kinase; MTORC: MTOR complex; NAC: N-acetylcysteine; NGF: nerve growth factor 2; NMDA: N-methyl-D-aspartate; PCA: principal component analysis; PD: Parkinson disease; PDA: pancreatic ductal adenocarcinoma; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PMA: phorbol 12-myristate 13-acetate; PRKC/PKC: protein kinase C; ROCK: Rho-associated coiled-coil protein kinase; RR: ribonucleotide reductase; SIGMAR1: sigma non-opioid intracellular receptor 1; SQSTM1/p62: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TFEB: Transcription factor EB; TGFB/TGF-β: Transforming growth factor beta; ULK1: unc-51 like autophagy activating kinase 1; XBP1: X-box binding protein 1.
- |||||||||| memantine / Generic mfg.
Journal, Epigenetic controller: Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease. (Pubmed Central) - Jan 15, 2022
In this study, a series of novel phenothiazine-, memantine-, and 1,2,3,4-tetrahydro-γ-carboline-based HDAC6 inhibitors with a variety of linker moieties were designed and synthesized...Moreover, W5 promoted the differentiated neuronal neurite outgrowth, increased the mRNA expression of the recognized neurogenesis markers, GAP43, N-myc, and MAP-2. Therefore, W5 might be a good lead for the development of novel HDAC6 inhibitors targeting multi-facets of AD.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Memantine improves memory and hippocampal proliferation in adult male rats. (Pubmed Central) - Jan 14, 2022
There was a significant weight reduction in the DOX group in comparison to the control group, but MEM attenuated DOX-induced weight loss. Rats treated with DOX displayed a drop in memory, hippocampal proliferation, and weight compared to the MEM-treated group, whereas the co-administration of MEM with DOX protected memory, hippocampal proliferation, and doxorubicin-induced weight loss.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Memantine improves cognitive deficits via K channel inhibition in olfactory bulbectomized mice. (Pubmed Central) - Jan 14, 2022
Finally, improvement of cognitive deficits by memantine treatments was observed in OBX-operated Kir6.1 heterozygous (+/-) mice but not in OBX-operated Kir6.2 heterozygous (+/-) mice. Overall, our study demonstrates that memantine rescues OBX-induced cognitive deficits via Kir6.2 channel inhibition in the CA1 region.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice. (Pubmed Central) - Jan 4, 2022
The blockage of N-methyl-d-aspartate receptors (NMDAR) by memantine reduced LPS-induced depression-like behaviors, NLRP3 inflammasome and astrocyte activation, and calpain-1 expression...Interestingly, LPS-induced expression of calpain-1 largely co-localized with GFAP, indicating the specific function of calpain-1 in astrocytes. Together, these data indicate that astrocytic Kir4.1 could regulate NMDAR/calpain-1 signaling axis, contributing to depression-like behaviors, likely through regulating NLRP3 inflammasome activation.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Memantine Modulates Oxidative Stress in the Rat Brain following Experimental Autoimmune Encephalomyelitis. (Pubmed Central) - Jan 4, 2022
Importantly, pharmacological inhibition of ionotropic NMDA glutamate receptors by their antagonist memantine improved the physical activity of EAE rats, alleviated neurological deficits such as paralysis of tail and hind limbs, and modulated oxidative stress parameters (MDA, -SH groups, SOD's). Furthermore, the current therapy aiming to suppress NMDAR-induced oxidative stress was partially effective when NMDAR's antagonist was administered at an early (asymptomatic) stage of EAE.
- |||||||||| memantine / Generic mfg.
Review, Journal: Diagnosis and differential diagnosis flow diagram of Chinese post-stroke aphasia types and treatment of post-stroke aphasia. (Pubmed Central) - Dec 30, 2021
This review introduced the use of memantine, piracetam, donepezil, etc. in PSA treatment, evaluated clinical studies conducted in China and abroad, investigated the mechanism of action related to the use of drugs in PSA treatment, and explored the therapeutic mechanism of rehabilitation training. It suggested the use drugs of memantine, piracetam, donepezil, etc. combine with non-pharmacotherapy and rehabilitation training in clinical studies on PSA treatment and also in practical settings.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: Multitarget Directed Ligand Approaches for Alzheimer's Disease: A Complete Review. (Pubmed Central) - Dec 22, 2021
The underlying mechanism might involve repression of nNOS ser1412 phosphorylation, as well as peroxynitrite-related MMP-9 and NLRP3 inflammasome activation. The review might be helpful for researchers working on multi target directed ligands against AD.
- |||||||||| memantine / Generic mfg.
Exclusive blockade of extrasynaptic NMDA receptors ameliorates chronic pain (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_4331;
To test this hypothesis, we developed AuM, a first-in-class exclusive antagonist of eNMDARs, by attaching memantine (M) to a gold (Au) oparticle, so that the resulting otherapeutic is too large to gain access to the synaptic cleft...CFA-inflamed animals treated with AuM right after the injury shows significant slowing down of allodynia progressing compared to saline-injected animals. In summary, our findings indicate the involvement of eNMDAR at different stages of chronic pain development and offer the opportunity to develop novel therapeutics to ameliorate the impact of nerve injury.; Grant Support: NASU Grant 0120U00 (NV); NASU Grant 0118U007345; NASU Grant 0116U004470 (NV); NeurANO Bioscience, a company that is involved in research and development of otherapeutics for neurological disorders (EM)
- |||||||||| gabapentin / Generic mfg., memantine / Generic mfg.
Theta-burst stimulation induces spinal cord long-term potentiation and pain hypersensitivity via α2δ-1-bound NMDARs (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_4157;
In addition, treatment with the NMDAR antagonist memantine or AP5, gabapentin, or α2δ-1Tat peptide diminished TBS-induced allodynia and hyperalgesia. These findings indicate that TBS induces pain hypersensitivity and LTP predomitly in spinal excitatory dorsal horn neurons via activation of α2δ-1-bound NMDARs.; Grant Support: NIH grant NS101880; NIH grant GM120844
- |||||||||| memantine / Generic mfg.
Investigating temporal dynamics of vascular changes in Alzheimer's disease mouse model using optical coherence tomography (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_3388;
To determine whether vascular alteration affects cognitive function, we used 3 different drugs that are known to have vasodilating effect: one vasodilating drug, nicorandil, and one FDA-approved AD drug, memantine...For the change in diameter and blood flows for penetrating arterioles and venules, these two drug-administered groups again showed the similar tendency to that of WT group, implying that the vasodilating effect seems to be correlated with cognitive impairment. Overall, our finding supports that understanding the temporal dynamics of vascular alterations in relation to cognitive decline could serve as a basis for translational research aiming toward early diagnosis of AD.; Grant Support: R01AG067228
- |||||||||| memantine / Generic mfg.
NMDA receptor GluN3A subunit as a pathogenic regulator of sporadic Alzheimer’s disease (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_2887;
However, treatments based on this hypothesis, including the recent amyloid antibody Aduhelm, have not provided effective clinical therapies...Early treatment at the pre-clinical stage using the NMDAR antagonist memantine (MEM; 10 mg/kg/day, 3 months) prevented/attenuated symptoms in GluN3A KO mice...Our results support the "Ca 2+ hypothesis" of AD with the novel amyloid-independent mechanism that the deficiency of GluN3A alone causes a slight lifelong Ca 2+ dyshomeostasis that can lead to AD pathophysiology and amyloid pathology. The long-term GluN3A modulation of NMDARs signifies new therapeutic targets and possible preventive interventions for a sporadic type of AD.; Grant Support: NIH Grant NS099596; VA Grant RX001473; NIH Grant NS091585; AHA Grant 0840110N; NIH Grant NS057255
- |||||||||| memantine / Generic mfg.
The role of spreading depolarizations in the acute behavioral deficits associated with mild traumatic brain injury in mice (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_2530;
Collectively, these studies suggest that SDs play a key mechanistic role in the acute behavioral deficits associated with mTBIs. Understanding the cellular and physiological mechanisms underlying the acute behavioral deficits associated with mTBIs will identify particular targets for intervention and promote brain recovery and repair.; Grant Support: P20 GM109089/GM/NIGMS NIH HHS/United States
- |||||||||| dizocilpine (MK801) / Merck (MSD)
NMDA receptor subtype dependence and kinetics of membrane to channel inhibition by (+)-MK-801 (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1602;
Using GluN1/2A receptors and 10 µM MK-801, we found that MK-801 exits the membrane with a time constant of 7.06 ± 1.1 s, reflecting much slower kinetics than memantine. Overall, MK-801 MCI exhibits NMDAR subtype dependence and kinetic properties that shed light on the wide range of MCI characteristics that can be exhibited by NMDAR channel blockers.; Grant Support: NIH R01GM128195
- |||||||||| ketamine / Generic mfg., memantine / Generic mfg.
Regulation of NMDA receptor channel block by intracellular calcium (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1600;
Our experiments show that memantine inhibition of GluN1/2A receptors is dynamically regulated by fluctuations of [Ca 2+ ] i across both physiological and pathological ranges, and that memantine inhibition of a mixed population of native NMDARs containing both GluN2A- and GluN2B-containing receptors is [Ca 2+ ] i dependent. Thus, the [Ca 2+ ] i dependence of NMDAR inhibition by memantine has the potential to profoundly impact the effects of memantine on neuronal function.; Grant Support: NIH Grant F31NS113477; NIH Grant R01AG065594; NIH Grant T32NS007433
- |||||||||| memantine / Generic mfg.
The role of NMDA receptors subunits in the progression of inflammatory breast cancer (IBC). (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1500;
These findings may be related to the high aggressiveness and the high rate of metastasis by IBC within the brain. Our results have high clinical relevance since having extensive knowledge of the role of NMDARs in IBC progression could complement therapeutic approaches for patients with IBC.; Grant Support: R15 DA044500
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