- |||||||||| memantine / Generic mfg.
Review, Journal: Alzheimer's Disease and Stroke: A Tangled Neurological Conundrum. (Pubmed Central) - Jun 22, 2022
Therapeutic and management modalities already in use for AD were put together, and the possibility of early intervention in such patients benefitting cerebrovascular pathologies, particularly stroke-related, was explored. Prognostic differences between patients of stroke with and without AD were also reviewed, and how appropriate management can reduce the burden on health care settings when both present simultaneously was emphasized.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg., fluoxetine / Generic mfg.
Journal: Unraveling the Binding Mechanism of Alzheimer's Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches. (Pubmed Central) - Jun 19, 2022
Molecular docking further validated the fluorescence and ITC results and unfolded the mechanism that hydrogen bonding governs the binding of fluoxetine to irisin with a significant binding score, i.e., -6.3 kcal/mol. We believe that these findings provide a promising solution to fight against AD as well as a platform for further research to utilize irisin in the drug-delivery system for an effective therapeutic strategy.
- |||||||||| memantine / Generic mfg.
Journal, Combination therapy, Monotherapy: Tolerability of memantine monotherapy versus adding memantine as combination therapy. (Pubmed Central) - Jun 15, 2022
Therefore, as a patient progresses to moderate-severe stages of disease, we recommend switching CI monotherapy to memantine monotherapy as opposed to adding memantine as combination therapy for those patients on more than 10 other medications to increase tolerability. Given the limitations of a smaller sample size, variables such as severity of disease, renal and liver impairment as well as medication dosing were not significant predictors (Table 3) for those reporting side effects on combination therapy.
- |||||||||| memantine / Generic mfg.
Journal: Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex. (Pubmed Central) - Jun 14, 2022
These imaging results document an enhancement of neuronal Ca influx, hypoxemia, and ischemia with cocaine in the PFC of HIV-1 Tg rats that were attenuated by memantine pretreatment. Thus, the potential utility of memantine in the treatment of HAND and of cocaine-induced neurotoxicity deserves further investigation.
- |||||||||| Vyzulta (latanoprostene bunod) / Bausch Health, Nicox, Durysta (bimatoprost implant) / AbbVie
Review, Journal: Newer advances in medical management of glaucoma. (Pubmed Central) - Jun 11, 2022
Bimatoprost implants and travoprost punctum plugs attempt to ease chronic medication use in glaucoma patients...While there is some evidence to support the role of Brimonidine in neuroprotection, further research is needed to clarify the role of Memantine and Neurotrophins. Evidence for benefit from dietary supplementation with Alpha lipoic acid, Forskolin , and Ginko Biloba is limited.
- |||||||||| memantine / Generic mfg.
Review, Journal: Memantine in the Prevention of Radiation-Induced Brain Damage: A Narrative Review. (Pubmed Central) - Jun 11, 2022
This new understanding of WBRT-induced toxicity may represent the basis for further innovative trials. These studies should aim to: (i) evaluate in greater detail the cognitive effects and, more generally, the quality of life impairment during and immediately after WBRT; (ii) study the mechanisms producing these early effects; (iii) test in clinical studies, the modern and advanced WBRT techniques based on both hippocampal-sparing and hypothalamic-pituitary-sparing, currently evaluated only in planning studies; (iv) test new timings of antiglutamatergic drugs administration aimed at preventing not only late toxicity but also acute effects.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Retrospective data, Journal: Targeting the Beta-2-Adrenergic Receptor and the Risk of Developing Alzheimer's Disease: A Retrospective Inception Cohort Study. (Pubmed Central) - Jun 9, 2022
Dementia prescription practice was generally consistent with clinical guidelines in memory clinics in China, whereas the prescription of antidementia and psychotropic medication mainly depended on patients' clinical symptoms. These findings suggest that exposure to non-selective βAR antagonists is associated with an increased risk for developing AD whereas there may be a decreased risk for developing AD after exposure to selective β2AR agonists.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice. (Pubmed Central) - Jun 9, 2022
Finally, we confirmed that repeated administration of memantine at 1 mg/kg p.o. and propolis at 100 mg/kg p.o. for 8 weeks failed to restore the cognitive deficits in Kir6.2-/- mice. Our study demonstrates that propolis increases ATP contents and promotes the amelioration of cognitive deficits rescued by memantine via Kir6.2 channel inhibition in the CA1 region.
- |||||||||| memantine / Generic mfg.
Journal: Association of cognitive enhancers and incident seizure risk in dementia: a population-based study. (Pubmed Central) - Jun 8, 2022
Our findings suggest no immediate increase in seizure risk is associated with cholinesterase inhibitor use, although the risk of seizure in patients with dementia did increase after one year of continued medication intake. Further study is required to obtain confirmatory results on the seizure-related safety of cognitive enhancers in patients with dementia.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Journal: A comprehensive computational perspective in drug discovery for Alzheimer's disease. (Pubmed Central) - Jun 8, 2022
This chapter considers a wide range targets for Alzheimer's disease and current advances in the discovery of disease inhibitors. And also brief in-silico studies were highlighted and included to know how the theoretical lead is achievable in AD medication discovery.
- |||||||||| Journal: Protocol for a Pragmatic Trial of Pharmacotherapy Options Following Unsatisfactory Initial Treatment in OCD (PROCEED). (Pubmed Central) - Jun 4, 2022
P2
China is uniquely positioned to recruit sufficiently large sample sizes of treatment-naïve OCD patients to compare different pharmacotherapy options; data from the proposed trial promises to help inform current clinical practice guidelines by providing important information about optimal pharmacotherapy choice for those who demonstrate no response or response but no remission to first line pharmacotherapy. The trail was registered on 27 August 2020 in ClinicalTrials.gov (https://register.clinicaltrials.gov/) (NCT04539951).
- |||||||||| memantine / Generic mfg.
Biomarker, Journal: Pharmacogenetics of Donepezil and Memantine in Healthy Subjects. (Pubmed Central) - May 30, 2022
In conclusion, we did not observe any significant association of the SNPs analyzed with memantine and donepezil pharmacokinetics or ADRs. Current evidence on memantine and donepezil pharmacogenetics does not justify their inclusion in pharmacogenetic guidelines.
- |||||||||| memantine / Generic mfg.
Journal: Virtual Therapy with the NMDA Antagonist Memantine in Hippocampal Models of Moderate to Severe Alzheimer's Disease, in Silico Trials. (Pubmed Central) - May 30, 2022
In contrast, the number of virtual spikes (spikes) of severe AD of the hippocampus was significantly lower, at 1461.8 (95% CI, 1196.2-1727.4), versus those treated with the 10 µM dose, at 2734.5 (95% CI, 2369.8-3099.2), and the 30 µM dose, at 3748.9 (95% CI, 3219.8-4278.0). The results of the analysis of secondary endpoints, interspike intervals and frequencies changed statistically significantly relative to the placebo; The results of the in silico study confirm that memantine monotherapy is effective in the treatment of moderate to severe Alzheimer's disease, as assessed by various neuronal parameters.
- |||||||||| memantine / Generic mfg.
Review, Journal: Primary Palliative Care in Dementia. (Pubmed Central) - May 29, 2022
Excellent primary palliative care also involves discussion of deprescribing medications of uncertain benefit such as long term use of cholinesterase inhibitors and memantine and being vigilant in the monitoring of pain with its relationship to behavioral disturbance in patients with dementia...Caregiver burden is high for patients with dementia and comprehensive care should also address this burden and implement reduction strategies. When these aspects of care are particularly complex or initial managements strategies fall short, palliative care specialists can be an important additional resource not only for the patient and family, but for the care team struggling to guide the way through a disease with innumerable challenges.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Biomarker, Review, Journal: Pharmacogenetic studies in Alzheimer disease. (Pubmed Central) - May 29, 2022
Potential pharmacogenetic biomarkers for AD have been identified; however, it is still necessary to conduct further research into other populations and to identify new biomarkers. This information could assist in predicting patient response to these drugs and contribute to better treatment decision-making in a context as complex as ageing.
- |||||||||| citicoline / Generic mfg.
Journal: An Overview of Combination Treatment with Citicoline in Dementia. (Pubmed Central) - May 26, 2022
In making decisions about discontinuing these drugs, clinicians should exercise caution, considering the evidence from existing trials along with other factors important to patients and their carers. Open, prospective studies are advised to confirm the utility of combination therapy with citicoline for the treatment of AD and MD.
- |||||||||| memantine / Generic mfg.
Review, Journal: The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer's Disease. (Pubmed Central) - May 21, 2022
The current pharmacological therapies are based mainly on the oldest hypotheses of the disease-cholinergic (drugs affecting the cholinergic system are available), the hypothesis of amyloid-β aggregation (an anti-amyloid drug was conditionally approved by the FDA in 2020), and one drug is an N-methyl-D-aspartate receptor (NMDAR) antagonist (memantine)...The problem of neuroinflammation, which may be the result of microbiota disorders, is also described. An important aspect of the work is the chapter on the treatment strategies for changing the microbiota, potentially protecting against the disease and alleviating its course in the initial stages.
- |||||||||| memantine / Generic mfg.
Journal: Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer's Disease. (Pubmed Central) - May 19, 2022
At present, acetylcholine esterase inhibitors and memantine (NMDAR antagonist) are the only approved therapy for the symptomatic management of AD...Recently developed promising compounds have been summarized in the article. Some of these MTDLs with balanced activity profiles against different targets have the potential to be developed as drug candidates for the treatment of AD.
- |||||||||| memantine / Generic mfg., piracetam / Generic mfg.
Journal: A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease. (Pubmed Central) - May 19, 2022
The present review focuses on the risk / protective factors and pathogenic mechanisms involved in AD. In addition to the existing symptomatic therapeutic approach, a diverse array of possible targets linked to pathogenic cascades have been re-investigated to envisage the pharmacotherapeutic strategies in AD.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer's Disease Predementia. (Pubmed Central) - May 18, 2022
Furthermore, both compounds enhanced working memory in 5XFAD mice and modified NMDAR and CREB signaling, which may prevent synaptic dysfunction and modulate neurodegenerative progression. Together, our data confirm that relevant models to LOAD, such as the AAV-AD rat, can provide a framework for a better understanding of the disease and accurate assessment of preventive treatments.
- |||||||||| dizocilpine (MK801) / Merck (MSD)
Journal: The role of NMDA receptors subunits in the progression of inflammatory breast cancer (IBC). (Pubmed Central) - May 14, 2022
These findings may be related to the high aggressiveness and the high rate of metastasis by IBC within the brain. Our results have high clinical relevance since having extensive knowledge of the role of NMDARs in IBC progression could complement therapeutic approaches for patients with IBC.
- |||||||||| memantine / Generic mfg.
Journal, IO biomarker: Effect of Bacopa Monnieri and Memantine in LPS-induced neuronal toxicity. (Pubmed Central) - May 14, 2022
Overall, both MN and BM show anti-amyloidogenic and antiapoptotic effect in neuronal cells. The present study suggests that BM can be considered as a potential adjuvant therapy for preventing or delaying the progression of neurodegeneration in AD.
- |||||||||| memantine / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: ClearMEMory: Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus (clinicaltrials.gov) - May 12, 2022
P2, N=80, Recruiting,
The present study suggests that BM can be considered as a potential adjuvant therapy for preventing or delaying the progression of neurodegeneration in AD. Suspended --> Recruiting | Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Jan 2022 --> Jun 2023
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