Ongoing

4

120

Europe

ACTRAPID, ACTRAPID, ACTRAPID, ACTRAPID

Oxford Radcliffe Hospitals NHS Trust

Those admitted to the Intensive Care Unit for treatment and likely to remain on the unit for longer than 5 days.

 

 

Ongoing

4

50

Europe

NovoRapid, Actrapid, NovoRapid®,, Actrapid®, NovoRapid®,, Actrapid®

Herz-, Thorax- und Gefäßchirurgische Anästhesie und Intensivmedizin

Therapy of hyperglycemia by intravenously applied insulin is going to be investigated.Hyperglycemia is very common in hospitalized, critically ill patients, even if they have not previously had diabetes. Studies have established that in-hospital hyperglycemia is associated with higher mortality and morbidity. Therefore, careful monitoring and therapy of hyperglycemia have become standard in the ICU and include treatment with continuous infusion of insulin.

 

 

Ongoing

4

16

Europe

Detemir (Levemir®), NPH insulin (Insulatard®), Actrapid, EU/1/04/278/005, EU/1/02/233/003, Actrapid 100 IU/ml EU/1/02/230/003, Insulin detemir, Human insulin NPH insulatard, Insulin actrapid, Insulin detemir, Human insulin NPH insulatard, Insulin actrapid

University of Surrey, Flinders University

Obstructive sleep apnoea

 

 

Ongoing

4

100

Europe

Apidra SoloStar, Lantus SoloStar, Actrapid Innolet, Insulatard FlexPen, Apidra SoloStar, Lantus SoloStar, Actrapid Innolet, Insulatard FlexPen

Endocrinology and Nutrition Unit. Hospital Universitari Bellvitge., Endocrinology and Nutrition Unit. Hospital Universitari Bellvitge.

Pacients receiving enteral nutrition and who present hyperglycemia. Pacientes tratados con nutrición enteral y que presenten hiperglicemia.

 

 

Ongoing

4

240

Europe

Actrapid, Actrapid, Actrapid

Royal Brompton & Harefield NHS Trust

Atrial Fibrillation following Coronary Artery Bypass Grafting operation.

 

 

Not yet recruiting

4

120

Europe

Actrapid, CICLOSPORINA A

Barbara Burgos-Blasco, Hospital Clinico San Carlos

Dry eye disease Enfermedad del ojo seco, Dry eye disease Ojo seco, Diseases [C] - Eye Diseases [C11]

 

 

Ongoing

3

37

Europe

NovoNorm 0.5 mg, Actrapid Penfill 100UI/ml, NovoNorm 1 mg, NovoNorm 2 mg, NovoNorm 0.5 mg, Actrapid Penfill 100UI/ml, NovoNorm 1 mg, NovoNorm 2 mg, NovoNorm 0.5 mg, Actrapid Penfill 100UI/ml, NovoNorm 1 mg, NovoNorm 2 mg

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)

Patients atteints de mucoviscidose, chez lesquels un diagnostic de diabète a été fait par hyperglycémie provoquée orale (HGPO)

 

 

Ongoing

3

810

Europe

Metformin, Glibenclamide, Tablet, Injection, Metformin, Glibenclamide, Insulin: including - fast acting, analog: NovoRapid, Humalog, Apidra - short acting, human: Actrapid, Humuline Regular, Insuman Rapid - medium long acting, human: Insulatard, Humuline NPH, Insuman Basal - long acting analog: Lantus, Levemir

University Medical Center Utrecht, ZonMw

The medical condition to be investigated in this trial is gestational diabetes with insufficient glycemic control by means of dietary adjustments and thus an indication for addiotional pharmacological treatment. In deze trial wordt het ziektebeeld diabetes gravidarum onderzocht, waarbij er met dieetaanpassingen onvoldoende glucosecontrole is bereikt en er dus indicatie is voor aanvullende farmacologische behandeling., Gestational diabetes, also known as gestational diabetes mellitus, is a condition in which women without previously diagnosed diabetes exhibit high blood glucose (blood sugar) levels during pregnancy. Zwangerschapssuikerziekte, ook wel zwangerschapsdiabetes, is een aandoening waarbij vrouwen waarbij niet al eerder suikerziekte is vastgesteld, tijdens de zwangerschap hoge bloedsuikerwaardes hebben., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]

 

 

Active, not recruiting

2

700

Europe

intensive insulin therapy (Actrapid IV to normoglycemia), Actrapid IV to normoglycemia, conventional insulin therapy (Actrapid IV only for excessive hyperglycemia), Actrapid IV only for excessive hyperglycemia

Greet Van den Berghe

Critical Illness

02/08

06/23

Not yet recruiting

2

10

Europe

Actrapid, Concentrate for solution for infusion, Actrapid

Bispebjerg Hospital, University of Copenhagen, University of Copenhagen

Insulin-induced increased heart rate, blood pressure and cardiacoutput Insulin induceret stigning i puls, blodtryk og minutvolumen, Changes in heart rate, blood pressure, and cardiac function caused byinsulin. Insulins ændringer i puls, blodtryk og hjertes pumpefunktion, Diseases [C] - Injuries, poisonings, and occupational diseases [C21]

 

 

Recruiting

2

90

US

Intranasal Insulin, Novolin R

Mclean Hospital

Psychosis, Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder

01/24

01/24

Recruiting

2

80

RoW

Semaglutide, Rybelsus, Intranasal insulin, Actrapid, Semaglutide placebo, Intranasal insulin placebo

Rutgers, The State University of New Jersey, Alzheimer's Association

Alzheimer Disease, Mild Cognitive Impairment, Metabolic Syndrome

12/27

12/28

Completed

1

40

US

Insulin, Regular, Human, Novolin R, Placebo, Saline

Pennington Biomedical Research Center, Nutrition Obesity Research Center

Insulin

06/22

06/22

Withdrawn

1

16

US

Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Octreotide Acetate IV, Glucagon, Glucagon IV, Human Growth Hormone, Omnitrope, Dexamethasone Oral, Dexamethasone, [6,6-2H2] D-glucose, D2-glucose, D2G, 20% D-glucose (aq), D20W, BOOST Plus, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer, Normal saline, NaCl IV, Human albumin, Human albumin IV

Columbia University, Albert Einstein College of Medicine, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease, Overweight and Obesity

11/25

03/26

Not yet recruiting

1

36

US

Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Glucagon, Growth Hormone, Human, Omnitrope, Zomacton, 20% D-glucose (aq), D20W, [6,6-2H2] D-glucose, D2-glucose, D2G, [1-13C1] sodium acetate, 13C-acetate, C13A, Nestle BOOST Plus, KIND Bar, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer

Columbia University, University of California, Berkeley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Insulin Resistance, Hyperinsulinemia, Metabolic Dysfunction Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease, Prediabetic State, Obesity

Recruiting

N/A

24

 

NW Cheung

Diabetes mellitus