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- | Kineret (anakinra) / SOBI, Affibody, PAS-IL-1Ra - XL / protein
Preclinical, Journal: PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. (Pubmed Central) - Sep 4, 2020
Surface plasmon resonance analyses revealed significant binding between PAS-IL‑1Ra and IL‑1R1, although with a slightly lower affinity than anakinra. These results validate PAS-IL‑1Ra as an active IL‑1 antagonist with marked in vivo potency and a significantly extended half-life compared with anakinra.