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- | Keral (dexketoprofen trometamol) / Menarini
Journal: Taste Masking of Dexketoprofen Trometamol Orally Disintegrating Granules by High-Shear Coating with Glyceryl Distearate. (Pubmed Central) - Feb 24, 2024
The coated granules were characterized for their morphology and solid-state properties by SEM, BET, XRPD, DSC, and NIR analyses. A human taste panel test confirmed the masking of DXKT taste in the selected batch granules.
- |||| Keral (dexketoprofen trometamol) / Menarini
Trial completion, Enrollment change: Dante: Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain (clinicaltrials.gov) - Aug 25, 2022
P4, N=544, Completed, Sponsor: Menarini International Operations Luxembourg SA
A human taste panel test confirmed the masking of DXKT taste in the selected batch granules. Recruiting --> Completed | N=816 --> 544
- ||||| Keral (dexketoprofen trometamol) / Menarini
New P4 trial: Dante: Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain (clinicaltrials.gov) - Dec 28, 2021
P4, N=816, Recruiting, Sponsor: Menarini International Operations Luxembourg SA
- |||| Keral (dexketoprofen trometamol) / Menarini
Trial completion: Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (clinicaltrials.gov) - Mar 24, 2021
P4, N=654, Completed, Sponsor: Menarini Group
Recruiting --> Completed | N=816 --> 544 Active, not recruiting --> Completed
- dexketoprofen/trometamol tablet / Menarini
[VIRTUAL] EVALUATION OF ORAL USE OF DEXKETOPROFEN/TRAMADOL IN ACUTE POSTOPERATIVE PAIN IN PATIENTS UNDERGOING TOTAL HIP REPLACEMENT WITH A MINIMALLY INVASIVE ANTERIOR APPROACH (AMIS) () - Aug 30, 2020 - Abstract #WIP2020WIP_393;
Fixed-dose combination of dexketoprofen and tramadol provides a com- prehensive multimodal approach for moderate to severe acute pain in patients undergoing unilateral total hip arthroplasty thanks to central analgesic effect, peripheral analgesic action and anti-inflammatory activity. The combination shows a good tolerability profile.
- || dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study. (Pubmed Central) - Jun 28, 2020
The combination shows a good tolerability profile. The agreed consensus statements may assist clinicians in applying the results of clinical studies and clinical experience to routine care settings, providing guidance for use of this new analgesic combination in moderate-to-severe post-operative and non-surgical acute pain.
- | dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Prospective, randomized comparative study of ultrasound-guided blocking of the lateral cutaneous branches of the intercostal nerves versus conventional analgesia in non-reconstructive breast surgery. (Pubmed Central) - Apr 10, 2020
The agreed consensus statements may assist clinicians in applying the results of clinical studies and clinical experience to routine care settings, providing guidance for use of this new analgesic combination in moderate-to-severe post-operative and non-surgical acute pain. In non-reconstructive breast surgery, performing a BRILMA block allows obtaining lower pain scores, which implies less need for rescue analgesics and a significant saving of tramadol in the study period.
- || dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). (Pubmed Central) - Feb 26, 2020
P4
In non-reconstructive breast surgery, performing a BRILMA block allows obtaining lower pain scores, which implies less need for rescue analgesics and a significant saving of tramadol in the study period. TRAM/DKP (75/25 mg) is effective and superior to TRAM/paracetamol (75/650 mg) in relieving moderate to severe acute pain following surgical removal of impacted lower third molar, with a faster onset of action, greater and durable analgesia, together with a favourable safety profile.
- || fentanyl citrate / Generic mfg., dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Ultrasound guided erector spinae plane block for postoperative analgesia after augmentation mammoplasty: case series (Pubmed Central) - Jan 11, 2020
At the postoperative 24th hour, the mean Numerical Rating Scale score was 1. The mean intravenous tramadol consumption was 70.8±15.3mg in the first 24 h. None of the patients had any complications related to erector spinae plane block.
- || dexketoprofen/trometamol tablet / Menarini
Spinal, TXA ev. LIA (ropi)+ TXA local. No drainage. Elastomeric pump (dexketoprofen/tramadol)+Paracetamol. Opiates (morfine) only rescue (Twitter) - Oct 13, 2019
- dexketoprofen/trometamol tablet / Menarini
Oh what a headache! () - Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1466;
No improvement with analgesic medication (naproxen 550 mg + tramadol 50 mg during a week)...Tretatment strategies include: dieta and weight loss, medications as diuretics, painkillersand surgery. It is an important disease to know by the physician in the emergency department.
- | dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Correction: Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). (Pubmed Central) - Jun 16, 2019
It is an important disease to know by the physician in the emergency department. No abstract available
- | dexamethasone / generics
Review, Journal: Prevention and treatment of postoperative pain after lumbar spine procedures: a systematic review. (Pubmed Central) - Apr 3, 2019
These include: the preoperative use of dexamethasone, that showed to be able to reduce pain at mobilization but not pain at rest and total morphine consumption; the use of gabapentinoids as part of a multimodal analgesic approach; safety and effectiveness of intraoperative use of ketamine, dexketoprofen, and tramadol. Finally, electrical nerve stimulation is gaining interest and is potentially suitable for the clinical needs.
- ||| Keral (dexketoprofen trometamol) / Menarini
Enrollment closed, Trial primary completion date: Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (clinicaltrials.gov) - Feb 10, 2017
P4, N=640, Active, not recruiting, Sponsor: Menarini Group
Finally, electrical nerve stimulation is gaining interest and is potentially suitable for the clinical needs. Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2016 --> Apr 2017
- ||||| Keral (dexketoprofen trometamol) / Menarini
New P4 trial: Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (clinicaltrials.gov) - May 19, 2016
P4, N=640, Recruiting, Sponsor: Menarini Group
- | Keral (dexketoprofen trometamol) / Menarini
New P1 trial: Comparative Bioavailability of Dexketoprofen Trometamol Oral Solution vs Tablet Formulations (clinicaltrials.gov) - Aug 6, 2014
P1, N=26, Completed, Sponsor: Menarini Group
- ||||||| Keral (dexketoprofen trometamol) / Menarini
Trial completion: Oral Treatment for Gynaecological Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (clinicaltrials.gov) - May 25, 2014
P3, N=606, Completed, Sponsor: Menarini Group
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2016 --> Apr 2017 Recruiting --> Completed
- | Keral (dexketoprofen trometamol) / Menarini
Trial completion: DAVID-art: Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (clinicaltrials.gov) - Feb 25, 2014
P3, N=641, Completed, Sponsor: Menarini Group
Recruiting --> Completed Recruiting --> Completed
- |||||||||| Keral (dexketoprofen trometamol) / Menarini
New P3 trial: Oral Treatment for Gynaecological Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (clinicaltrials.gov) - Jul 18, 2013
P3, N=600, Recruiting, Sponsor: Menarini Group
- || Keral (dexketoprofen trometamol) / Menarini
New P3 trial: DAVID-art: Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (clinicaltrials.gov) - Jul 16, 2013
P3, N=641, Completed, Sponsor: Menarini Group
- ||| Keral (dexketoprofen trometamol) / Menarini
Enrollment change: DEX-TRA 02: Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain (clinicaltrials.gov) - Jan 10, 2012
P2, N=745, Completed, Sponsor: Menarini Group
Recruiting --> Completed N=600 --> 745
- |||| Keral (dexketoprofen trometamol) / Menarini
Trial completion: DEX-TRA 02: Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain (clinicaltrials.gov) - Jan 10, 2012
P2, N=745, Completed, Sponsor: Menarini Group
N=600 --> 745 Recruiting --> Completed