leucovorin calcium / Generic mfg. 
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 424 Diseases   809 Trials   809 Trials   14393 News 


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  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Biomarker, Enrollment change, Trial completion date, Trial termination, Trial primary completion date, Liquid biopsy, Biopsy:  PRIMUS002: Looking at 2 Neo-adjuvant Treatment Regimens for Resectable and Borderline Resectable Pancreatic Cancer (clinicaltrials.gov) -  May 24, 2022   
    P2,  N=31, Terminated, 
    Active, not recruiting --> Recruiting N=278 --> 31 | Trial completion date: Dec 2023 --> Aug 2021 | Recruiting --> Terminated | Trial primary completion date: Jan 2023 --> Aug 2021; Due to funding being withdrawn
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., gemcitabine / Generic mfg.
    Biliary-Related Events (BREs) in Pancreatic Cancer (PC) Patients (Pts) (Livestream Frontenac, CC, 1st Floor) -  May 22, 2022 - Abstract #MASCCISOO2022MASCC_ISOO_290;    
    Methods Retrospective evaluation of BREs in patients treated with FOLFIRINOX or Gemcitabine based treatments,in adjuvant and locally advanced settings at our Institution; from January 2016 to July 2020.SPSS was used for data analysis...Md follow-up time of 21months(m; [21.6-30.3],21 deaths seen(66%).The md overall survival (OS) of the population was 15m(8.7-21.3).A shorter OS related to BREs during chemotherapy(20vs11m,p=0.018) and hospital admissions(24vs9m,p=0.004).Biliary stent prior to starting chemotherapy associated to a shorter OS (p=0.846). Conclusions BREs lead to multiple hospital admissions, increasing mortality in PC Pts.Prophylactics strategies, such as antibiotics have been proposed in previous trials.Prospective studies are warranted.
  • ||||||||||  leucovorin calcium / Generic mfg., sulphadiazine / Generic mfg.
    THE SEQUELAE OF CONGENITAL TOXOPLASMOSIS – HOW FREQUENT? HOW SEVERE? () -  May 19, 2022 - Abstract #ESPID2022ESPID_1373;    
    CT was confirmed in 43 (14.9%) of which 37 (86%) presented sequelae at the end of follow up. 33 patients presented scars at fundoscopy (19 on macular area) and 24 with Central nervous system (CNS) manifestations (9 hydrocephalus, 18 CNS calcifications, 6 epilepsy, 8 microcephaly), and one child died during the follow up.
  • ||||||||||  OCULAR LESIONS IN AN ADOLESCENT – A CHALLENGING DIAGNOSIS () -  May 19, 2022 - Abstract #ESPID2022ESPID_950;    
    Learning Points/ Congenital toxoplasmosis may present at a later age and physicians should have a high level of suspicion. Adequate and timely treatment is paramount to minimize the risk of lifelong sight-threatening lesions.
  • ||||||||||  PERSISTENT NEUTROPENIA DUE TO CONGENITAL TOXOPLASMOSIS TREATMENT () -  May 19, 2022 - Abstract #ESPID2022ESPID_949;    
    He started pyrimethamine(1mg/kg/day), sulfadiazine(100mg/kg/day) and folinic acid(15mg/day, 3 times a week). Neutropenia (570neutrophils/mm3 ) was detected 7 weeks after treatment initiation.
  • ||||||||||  leucovorin calcium / Generic mfg., sulphadiazine / Generic mfg., pyrimethamine / Generic mfg.
    CONGENITAL TOXOPLASMOSIS: PREVENTION IS THE KEY () -  May 19, 2022 - Abstract #ESPID2022ESPID_929;    
    Learning Points/ This case underlines the importance of surveillance and screening programs for pregnant women, and how a multidisciplinary approach between pediatricians and gynecologists might be important to reduce the risk of vertical transmission. It also highlights the importance of early diagnosis and treatment, in order to reduce morbidity.
  • ||||||||||  leucovorin calcium / Generic mfg., sulphadiazine / Generic mfg., pyrimethamine / Generic mfg.
    CONGENITAL TOXOPLASMOSIS IN TWINS: CASE REPORT () -  May 19, 2022 - Abstract #ESPID2022ESPID_928;    
    The diagnosis and treatment in twin pregnancies does not differ from singleton pregnancies. Prevention of primary infection during susceptible pregnancies is essential
  • ||||||||||  Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
    P2 data, Clinical Trial,Phase II, Journal:  Phase II trial of nafamostat mesilate/gemcitabin/S-1 for unresectable pancreatic cancer. (Pubmed Central) -  May 18, 2022   
    These results suggest a need to improve accuracy of RAS analyses, especially in solid biopsies. NAM/GEM/S-1 therapy is safe and could be promising option for unresectable pancreatic cancer, especially for stage IV cancer.
  • ||||||||||  leucovorin calcium / Generic mfg.
    Journal:  A Case of UFT/LV-Induced Acute Liver Failure after Surgery for Sigmoid Colon Cancer (Pubmed Central) -  May 18, 2022   
    Oral uracil and tegafur plus Leucovorin(UFT/LV)therapy is one of the standard adjuvant chemotherapies for colorectal cancer, and is widely used without any serious adverse events...Two months later, the platelet count decreased markedly, but fortunately, no bleeding occurred. There has been no recurrence since 2 years after the surgery without any additional adjuvant therapy.