leucovorin calcium / Generic mfg. 
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  • ||||||||||  5-fluorouracil / Generic mfg.
    Preoperative chemotherapy flot vs dox in patients of locally advanced gastric adenocarcinoma (Exhibition / Poster Area) -  Oct 9, 2022 - Abstract #ESMOAsia2022ESMO_Asia_647;    
    Background Flot (5-fluorouracil, leucovorin, oxaliplatin and docetaxel) is the standard regimen for perioperative chemotherapy in locally advanced gastric cancer...This study compares it with dox (docetaxel, oxaliplatin and capecitabine) - a daycare regimen, as capecitabine has already been proven non-inferior to 5-fluorouracil in advanced gastric cancer...Conclusions The radiological response to chemotherapy post flot or dox regimen is not statistically different. Dox maybe considered as an alternative regimen to flot in neoadjuvant chemotherapy in locally advanced gastric cancer patients with the advantage being a daycare procedure, requiring less resources and manpower.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Asparlas (calaspargase pegol-mknl) / Servier, Takeda, Leadiant Biosci
    Enrollment open, Pan tumor:  Venetoclax Basket Trial for High Risk Hematologic Malignancies (clinicaltrials.gov) -  Oct 6, 2022   
    P1,  N=92, Recruiting, 
    Although there is no standard NAT regimen for patients with pancreatic cancer, postoperative chemotherapy following NAT and resection appears to be associated with improved OS for patients with node-positive disease. Not yet recruiting --> Recruiting
  • ||||||||||  leucovorin calcium / Generic mfg.
    Combined Preserving Fertility Treatment of Women with Cervical Pregnancy () -  Oct 6, 2022 - Abstract #AAGL2022AAGL_883;    
    The results of our study suggest that resectoscopic removal of embryo preceded by cytostatic therapy with methotrexate and leucovorin allows to preserve fertility in women with early cervical pregnancy. In cases of chorion invasion into the cervix and myometrium SUAE following resectoscopy appears to be a treatment of choice.
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
    Addition of losartan to FOLFORINOX and chemoradiation downregulates pro-invasion and immunosuppression-associated genes in locally advanced pancreatic cancer (Hall C) -  Oct 6, 2022 - Abstract #SITC2022SITC_1765;    
    P2
    Background Adding losartan to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC)...These findings suggest that losartan potentiates the benefit of FFX+CRT by reducing immunosuppression and invasion, and thus, may help overcome resistance to immunotherapy. Ethics Approval The study was approved by institutional review board (IRB) of Mass General Brigham (IRB protocol number: 2022P001372).
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
    IL-1 blockade prevents cardiac toxicity and improves immunotherapy efficacy in mouse models of pancreatic cancer (Hall C) -  Oct 6, 2022 - Abstract #SITC2022SITC_1548;    
    Conclusions Using a translationally relevant mouse model, we discovered that IL-1b mediates ICB-induced cardiotoxicity, which is the most fatal type of irAE in ICB-treated cancer patients. In addition, we found that IL-1b blockers, which are already used in the clinic for other indications[FD1] , may both reduce adverse events and enhance the antitumor effects triggered by immunotherapy.
  • ||||||||||  STC-1010 / Brenus Pharma
    EFFICACY STUDY OF STC-1010 ANTITUMOR VACCINE ASSOCIATED WITH STANDARD CHEMOTHERAPIES ON MC 38 SYNGENEIC COLON CANCER TUMOR MODEL (Hall C) -  Oct 6, 2022 - Abstract #SITC2022SITC_1487;    
    We report efficacy results of three (3 CL-S) cell lines S=stimulated by irradiation and heat shock versus three cell lines (6 CL-S) physically and chemically stimulated (irradiation, heat shock and chemotherapies), both haptenized (H) and administrated with immunostimulant (IS=cyclophosphamide and mGM-CSF) associated w/o to standard chemotherapy FOLFOX or FOLFIRI...Conclusions This third preclinical study confirms efficacy and safety of Brenus STC vaccine stimulated and haptenized alone or with standard chemotherapies associated to immunostimulant. This significant anticancer effect in mice could be explained by mobilization of CD3, CD8, CD4 T cells within the tumors and oriented M1 macrophage immune responses.
  • ||||||||||  methotrexate / Generic mfg.
    Retrospective data, Journal:  Methotrexate toxicity in psoriasis-A multicentric retrospective study. (Pubmed Central) -  Oct 5, 2022   
    Patients must be counseled regarding course of the disease, drug regimen, and dreaded side effects prior to initiating the drug. In case the symptoms of toxicity appear, a prompt medical advice must be sought.
  • ||||||||||  Journal:  Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution. (Pubmed Central) -  Oct 4, 2022   
    We analyzed a custom single-nucleus RNA-seq dataset derived from 37 primary PDAC specimens (18 untreated, 14 neoadjuvant FOLFIRINOX + chemoradiotherapy, 5 neoadjuvant FOLFIRINOX + chemoradiotherapy + losartan)...While losartan and proton therapy were associated with reduced lymphatic ECs, these therapies also correlated with an increase in reactive EndMT. Thus, the development and inclusion of EndMT-inhibiting drugs (e.g., nintedanib) to a neoadjuvant chemoradiotherapy regimen featuring losartan and/or proton therapy may be most effective in depleting both lymphatic and reactive EndMT populations and potentially improving patient outcomes.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Nivolumab-related vanishing bile duct syndrome: A rare but important complication of immunotherapy () -  Oct 4, 2022 - Abstract #AGW2022AGW_344;    
    While immunotherapy-related hepatitis is common (up to 10% with monotherapy and 20–30% with combination immunotherapy; median time to onset of 8–12 weeks after initiation of immunotherapy), immunotherapy-related cholangitis is rare, with 53 cases reported in the literature in a recent meta-analysis and systematic review, equating to an incidence of 0.5–0.7%. Only 9% of patients had a complete response to immunosuppressive therapy, with 70% having partial response and 21% poor response.
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
    Drastic response to cetuximab in metastatic eccrine porocarcinoma with EGFR amplification (Summit 2) -  Oct 1, 2022 - Abstract #ESMOAsia2022ESMO_Asia_399;    
    As an initial chemotherapy, carboplatin and docetaxel were administered every 3 weeks...Based on this result, cetuximab (400 mg/m 2 once, then 250 mg/m 2 per week) in association with 5-FU/LV (200 mg/m 2 leucovorin, 400 mg/m 2 bolus fluorouracil, and 2400 mg/m 2 infusional fluorouracil per 2 weeks) were administered...Table 1. Comprehensive genomic profiling by FoundationOne ®CDx
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
    Multi-omics signature for identification of RAS wild-type colorectal cancer liver metastases sensitive to anti-EGFR therapy (Summit 2) -  Oct 1, 2022 - Abstract #ESMOAsia2022ESMO_Asia_336;    
    P4
    In this study, we aimed to develop and validate a multi-omics deep learning model to predict cetuximab efficacy in RAS wild type mCRC patients...Conclusions The multi-omic signature can serve as an intermediate surrogate marker of anti-EGFR treatment sensitivity and survival. The signature outperformed known biomarkers in providing an early prediction of treatment sensitivity and could be used to Ras wild type mCRC treatment decisions.
  • ||||||||||  leucovorin calcium / Generic mfg.
    Enrollment closed:  Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder (clinicaltrials.gov) -  Sep 30, 2022   
    P2,  N=134, Active, not recruiting, 
    The signature outperformed known biomarkers in providing an early prediction of treatment sensitivity and could be used to Ras wild type mCRC treatment decisions. Suspended --> Active, not recruiting
  • ||||||||||  Review, Journal:  Effective combinations of anti-cancer and targeted drugs for pancreatic cancer treatment. (Pubmed Central) -  Sep 29, 2022   
    Therefore, these characteristics of pancreatic cancer are potential targets for developing effective novel therapies. In this minireview, combinations of gemcitabine and targeted drugs to these characteristics, combinations of targeted drugs, combinations of natural products and anti-cancer agents, including gemcitabine, and combinations among natural products are discussed.
  • ||||||||||  Herceptin (trastuzumab) / Roche
    Journal:  First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal carcinoma. (Pubmed Central) -  Sep 29, 2022   
    In conclusion, FOLFOX+trastuzumab is similar to CF+trastuzumab in terms of the median OS, but it is more effective in terms of the median PFS in the first-line treatment of HER2-positive metastatic gastric and GEJ cancer. The choice of treatment should be made by considering the prominent toxicity findings of the chemotherapy regimens.