- |||||||||| saridegib oral (IPI 926 oral) / Infinity Pharma
Trial completion, Enrollment change, Trial initiation date, Trial primary completion date, Metastases: FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma (clinicaltrials.gov) - Aug 8, 2017 P1, N=15, Completed, Trial primary completion date: Jul 2017 --> Jan 2021 Recruiting --> Completed | N=21 --> 15 | Initiation date: Nov 2014 --> Aug 2011 | Trial primary completion date: Nov 2017 --> Dec 2012
- |||||||||| Avastin (bevacizumab) / Roche
Journal: Phase II Study of Modified FOLFOX6 With Bevacizumab in Metastatic Gastroesophageal Adenocarcinoma. (Pubmed Central) - Aug 3, 2017 First-line mFOLFOX6 with bevacizumab for metastatic gastroesophageal adenocarcinoma was well tolerated and associated with longer PFS and OS compared with historical data from similar populations treated without bevacizumab. Our results suggest that the addition of bevacizumab to mFOLFOX6 may provide clinical benefit in American patients with metastatic gastroesophageal adenocarcinoma, a finding consistent with previous studies of first-line bevacizumab in combination with chemotherapy for this disease.
- |||||||||| erlotinib / Generic mfg., Onivyde (nanoliposomal irinotecan) / Servier, Ipsen, Takeda, Abraxane (albumin-bound paclitaxel) / BMS, Otsuka
Journal: Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. (Pubmed Central) - Jul 29, 2017 For second-line therapy, gemcitabine plus NAB-paclitaxel should be offered to patients with first-line treatment with FOLFIRINOX, an ECOG PS 0 to 1, and a favorable comorbidity profile; fluorouracil plus oxaliplatin, irinotecan, or nanoliposomal irinotecan should be offered to patients with first-line treatment with gemcitabine plus NAB-paclitaxel, ECOG PS 0 to 1, and favorable comorbidity profile, and gemcitabine or fluorouracil should be offered to patients with either an ECOG PS 2 or a comorbidity profile that precludes other regimens. Additional information is available at www.asco.org/guidelines/MetPC and www.asco.org/guidelineswiki.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Oncaspar liquid (pegaspargase) / Servier
Enrollment open, Trial primary completion date: DFCI 16-001: Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents (clinicaltrials.gov) - Jul 28, 2017 P3, N=400, Recruiting, Although differences were nonsignificant, IC plus cetuximab seemed to be the least effective and most toxic of the three regimens tested. Not yet recruiting --> Recruiting | Trial primary completion date: May 2021 --> Dec 2021
- |||||||||| Avastin (bevacizumab) / Roche
Trial primary completion date, Metastases: AXEPT: A Phase III Study of 2nd-line XELIRI (clinicaltrials.gov) - Jul 27, 2017 P3, N=650, Active, not recruiting, Not yet recruiting --> Recruiting | Trial primary completion date: May 2021 --> Dec 2021 Trial primary completion date: Jan 2017 --> Nov 2017
- |||||||||| Otrexup (methotrexate) / Halozyme, Rituxan (rituximab) / Roche
Trial primary completion date: Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma (clinicaltrials.gov) - Jul 21, 2017 P2, N=28, Recruiting, Trial primary completion date: Jan 2017 --> Nov 2017 Trial primary completion date: Jul 2018 --> Jul 2019
- |||||||||| 5-fluorouracil / Generic mfg., metformin / Generic mfg., leucovorin calcium / Generic mfg.
Trial primary completion date, Metastases: Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer (clinicaltrials.gov) - Jul 19, 2017 P2, N=43, Recruiting, Trial primary completion date: Jul 2018 --> Jul 2019 Trial primary completion date: Apr 2017 --> Oct 2017
- |||||||||| simmitecan / HaiHe Biopharma, Shanghai Inst. of Materia Medica
Enrollment change, Trial primary completion date, Monotherapy, Metastases: Study to Evaluate the Safety, Tolerability, Preliminary Efficacy and Pharmacokinetics of Simmitecan Monotherapy and Combination in Patients With Advanced Solid Tumors (clinicaltrials.gov) - Jul 17, 2017 P1, N=243, Recruiting, Recruiting --> Completed | Trial primary completion date: Oct 2017 --> Jul 2017 N=158 --> 243 | Trial primary completion date: Oct 2018 --> Dec 2020
- |||||||||| dilpacimab (ABT-165) / AbbVie
Enrollment closed, Trial primary completion date, Metastases: A Study of ABT-165 in Subjects With Solid Tumors (clinicaltrials.gov) - Jul 13, 2017 P1, N=90, Active, not recruiting, N=204 --> 257 | Trial primary completion date: Jun 2017 --> Nov 2015 Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2018 --> Feb 2018
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