leucovorin calcium / Generic mfg. 
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 424 Diseases   807 Trials   807 Trials   14372 News 


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  • ||||||||||  BI 695502 (bevacizumab biosimilar) / Boehringer Ingelheim
    Trial completion date, Trial primary completion date, Metastases:  INVICTAN (clinicaltrials.gov) -  Feb 22, 2018   
    P3,  N=123, Active, not recruiting, 
    Trial primary completion date: Mar 2016 --> Nov 2012 Trial primary completion date: Jan 2019 --> Sep 2018 | Trial completion date: Jan 2019 --> Sep 2018
  • ||||||||||  spartalizumab (PDR001) / Novartis
    Enrollment open, Trial completion date, Trial primary completion date, Combination therapy, Metastases:  PDR001 in Combination With Bevacizumab and mFOLFOX6 as First Line Therapy in Patients With Metastatic MSS Colorectal Cancer (clinicaltrials.gov) -  Feb 20, 2018   
    P1,  N=92, Recruiting, 
    Trial primary completion date: Jan 2019 --> Sep 2018 | Trial completion date: Jan 2019 --> Sep 2018 Active, not recruiting --> Recruiting | Trial primary completion date: Jan 2021 --> Jun 2019 | Trial completion date: Jan 2021 --> Jun 2019
  • ||||||||||  Sotyktu (deucravacitinib) / BMS
    Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date:  A Study to Investigate BMS-986165 and Methotrexate in Healthy Male Patients (clinicaltrials.gov) -  Feb 19, 2018   
    P1,  N=12, Recruiting, 
    Not yet recruiting --> Recruiting | Initiation date: Sep 2017 --> Oct 2017 Not yet recruiting --> Recruiting | Trial completion date: Apr 2018 --> Apr 2018 | Initiation date: Jan 2018 --> Jan 2018 | Trial primary completion date: Apr 2018 --> Apr 2018
  • ||||||||||  methotrexate / Generic mfg.
    Clinical, Journal:  Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicity. (Pubmed Central) -  Feb 18, 2018   
    Nephrotoxicity is a possible complication of therapy with high-dose methotrexate with most instances comprising grade 1-2 toxicity. Male gender, low albumin, and administration of interacting drugs or furosemide during high-dose methotrexate clearance may predispose patients to nephrotoxicity.
  • ||||||||||  Alymsys (bevacizumab-maly) - Amneal, Pharmaceutical Libbs, Grupo Insud, Nichi / Iko, Stada
    Trial completion, Trial completion date, Trial initiation date:  Bioequivalence Study Bevacizumab Biosimilar (BEVZ92) Versus Bevacizumab (AVASTIN (clinicaltrials.gov) -  Feb 15, 2018   
    P1,  N=142, Completed, 
    Male gender, low albumin, and administration of interacting drugs or furosemide during high-dose methotrexate clearance may predispose patients to nephrotoxicity. Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Jun 2017 | Initiation date: Oct 2014 --> Oct 2014
  • ||||||||||  Xpovio (selinexor) / Karyopharm
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Metastases:  SENTINEL: Phase 1 Trial To Evaluate mFOLFOX6 With Selinexor In Patients With Metastatic Colorectal Cancer (clinicaltrials.gov) -  Feb 14, 2018   
    P1,  N=10, Completed, 
    N=10 --> 0 | Terminated --> Withdrawn Active, not recruiting --> Completed | N=27 --> 10 | Trial completion date: Apr 2018 --> Mar 2017 | Trial primary completion date: Jun 2017 --> Mar 2017
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, cetuximab biosimilar / CinnaGen
    Trial completion date, Trial primary completion date, Metastases:  Comparing Efficacy and Safety of Cetuximab (CinnaGen) Versus Erbitux (clinicaltrials.gov) -  Feb 14, 2018   
    P3,  N=234, Recruiting, 
    Trial primary completion date: Jul 2019 --> Mar 2020 | Trial completion date: Oct 2020 --> Oct 2021 Trial primary completion date: Feb 2018 --> Nov 2019 | Trial completion date: Nov 2018 --> Feb 2020
  • ||||||||||  Reolysin (pelareorep) / Oncolytics, Andrus Reo
    Trial completion date, Trial primary completion date, Combination therapy, Metastases:  Study of REOLYSIN (clinicaltrials.gov) -  Feb 12, 2018   
    P1,  N=32, Active, not recruiting, 
    Trial primary completion date: Feb 2018 --> Nov 2019 | Trial completion date: Nov 2018 --> Feb 2020 Trial primary completion date: Feb 2018 --> Oct 2018 | Trial completion date: Apr 2018 --> Dec 2018
  • ||||||||||  Reolysin (pelareorep) / Oncolytics, Andrus Reo
    Trial completion date, Trial primary completion date, PD(L)-1 Biomarker, Metastases:  Study of Pembrolizumab With REOLYSIN (clinicaltrials.gov) -  Feb 12, 2018   
    P1b,  N=9, Active, not recruiting, 
    Recruiting --> Active, not recruiting Trial primary completion date: Jan 2018 --> Oct 2018 | Trial completion date: Mar 2018 --> Dec 2018
  • ||||||||||  Avastin (bevacizumab) / Roche
    Trial primary completion date, Metastases:  Study of Vitamin D in Untreated Metastatic Colorectal Cancer (clinicaltrials.gov) -  Feb 9, 2018   
    P2,  N=120, Active, not recruiting, 
    Trial primary completion date: Jan 2018 --> Oct 2018 | Trial completion date: Mar 2018 --> Dec 2018 Trial primary completion date: Jul 2017 --> Mar 2018
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  A Study in Adults With Untreated Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Feb 9, 2018   
    P2,  N=100, Active, not recruiting, 
    Trial primary completion date: Jul 2017 --> Mar 2018 Trial primary completion date: Dec 2017 --> Dec 2018 | Trial completion date: Dec 2017 --> Dec 2018
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
    Trial primary completion date, Metastases:  FOLFIRI as Second Line Chemotherapy for Metastatic Esophageal Carcinoma (clinicaltrials.gov) -  Feb 5, 2018   
    P2,  N=35, Recruiting, 
    Recruiting --> Active, not recruiting Trial primary completion date: Sep 2017 --> Sep 2018
  • ||||||||||  5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg.
    Trial primary completion date:  A Study on the Timing of FOLFOX for Patients With Operable, Node Positive Rectal Cancer (clinicaltrials.gov) -  Feb 1, 2018   
    P2,  N=180, Active, not recruiting, 
    Trial primary completion date: Jan 2018 --> Jan 2020 | Trial completion date: Jul 2018 --> Jul 2020 Trial primary completion date: Dec 2017 --> May 2018
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, cetuximab biosimilar / CinnaGen
    Enrollment open, Metastases:  Comparing Efficacy and Safety of Cetuximab (CinnaGen) Versus Erbitux (clinicaltrials.gov) -  Jan 30, 2018   
    P3,  N=234, Recruiting, 
    Trial primary completion date: Dec 2017 --> Jun 2018 Not yet recruiting --> Recruiting
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group
    Enrollment open:  Phase I Study of the Combination of Apatinib and POF (clinicaltrials.gov) -  Jan 26, 2018   
    P1,  N=18, Recruiting, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
  • ||||||||||  Trial primary completion date, Surgery:  GCC 1324: Borderline Pancreas Study: FOLFIRINOX +SBRT (clinicaltrials.gov) -  Jan 19, 2018   
    P1,  N=20, Recruiting, 
    Trial primary completion date: Jan 2018 --> Jan 2019 Trial primary completion date: Dec 2017 --> Dec 2018