leucovorin calcium / Generic mfg. 
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 424 Diseases   807 Trials   807 Trials   14372 News 


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  • ||||||||||  leucovorin calcium / Generic mfg., fluorouracil topical / Generic mfg.
    Clinical, Journal:  Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers. (Pubmed Central) -  Mar 23, 2018   
    From 1996 to 2002, 119 patients received an adjuvant 4-drug chemotherapy regimen of 5-fluorouracil, leucovorin, MMC, and dipyridamole with chemoradiation on 2 consecutive trials (trials A and B)...This is the first study to report long-term outcomes of MMC with 5-fluorouracil-based adjuvant chemoradiation in periampullary cancers. Because MMC may be considered in DNA repair-deficient carcinomas, randomized trials are needed to determine the true benefit of adjuvant MMC.
  • ||||||||||  monalizumab (IPH2201) / AstraZeneca, Innate, Imfinzi (durvalumab) / AstraZeneca
    Enrollment change, Trial completion date, Trial primary completion date, PD(L)-1 Biomarker, IO biomarker, Metastases:  A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors (clinicaltrials.gov) -  Mar 22, 2018   
    P1,  N=280, Recruiting, 
    Not yet recruiting --> Recruiting N=215 --> 280 | Trial completion date: Oct 2019 --> Jan 2022 | Trial primary completion date: Oct 2019 --> Jan 2022
  • ||||||||||  Trial completion date, Trial primary completion date, Combination therapy, IO biomarker:  Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma (clinicaltrials.gov) -  Mar 21, 2018   
    P2,  N=6, Active, not recruiting, 
    Trial completion date: Apr 2018 --> Aug 2018 | Trial primary completion date: Apr 2018 --> Aug 2018 Trial completion date: Apr 2019 --> Jun 2021 | Trial primary completion date: Mar 2017 --> Jun 2020
  • ||||||||||  5-fluorouracil / Generic mfg., oxaliplatin / Generic mfg.
    Trial completion, Metastases:  Neo-adjuvant Chemoradiation With Oxaliplatin/5-FU in Rectal Cancer (clinicaltrials.gov) -  Mar 20, 2018   
    P2,  N=27, Completed, 
    Trial completion date: Apr 2019 --> Jun 2021 | Trial primary completion date: Mar 2017 --> Jun 2020 Recruiting --> Completed
  • ||||||||||  oxaliplatin / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
    Trial completion date, Trial primary completion date:  Preoperative Folfirinox, Radiation Therapy for Resectable Adenocarcinoma of the Pancreas (clinicaltrials.gov) -  Mar 20, 2018   
    P2,  N=34, Active, not recruiting, 
    Recruiting --> Completed Trial completion date: Jun 2019 --> Jun 2021 | Trial primary completion date: Jun 2019 --> Jun 2020
  • ||||||||||  Biomarker, Trial completion date, Trial primary completion date, MSi-H Biomarker, PD(L)-1 Biomarker:  MODUL: A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC) (clinicaltrials.gov) -  Mar 16, 2018   
    P2,  N=1400, Recruiting, 
    Trial completion date: Dec 2017 --> Dec 2018 | Trial primary completion date: Nov 2017 --> Jun 2018 Trial completion date: Oct 2020 --> Dec 2021 | Trial primary completion date: May 2017 --> May 2019
  • ||||||||||  pegilodecakin (LY3500518) / Eli Lilly
    Trial completion date, Trial primary completion date:  A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors (clinicaltrials.gov) -  Mar 15, 2018   
    P1,  N=350, Active, not recruiting, 
    Trial completion date: Jun 2018 --> Dec 2019 | Trial primary completion date: Dec 2017 --> Dec 2018 Trial completion date: Mar 2018 --> Mar 2020 | Trial primary completion date: Feb 2018 --> Feb 2020
  • ||||||||||  Bylantra (devimistat) / Cornerstone Pharma, Ono Pharma
    Trial initiation date, Combination therapy, Metastases:  CPI-613 in Combination With Modified FOLFIRINOX in Patients With Locally Advanced Pancreatic Cancer (clinicaltrials.gov) -  Mar 15, 2018   
    P2,  N=45, Not yet recruiting, 
    Trial completion date: Mar 2018 --> Mar 2020 | Trial primary completion date: Feb 2018 --> Feb 2020 Initiation date: Feb 2018 --> Aug 2018
  • ||||||||||  Onivyde (nanoliposomal irinotecan) / Servier, Ipsen
    Enrollment open:  Post Marketing Surveillance Study for ONIVYDE (clinicaltrials.gov) -  Mar 15, 2018   
    P=N/A,  N=78, Recruiting, 
    Initiation date: Feb 2018 --> Aug 2018 Not yet recruiting --> Recruiting
  • ||||||||||  New P1 trial, Metastases:  Short-course Radiotherapy (5 (clinicaltrials.gov) -  Mar 14, 2018   
    P1,  N=9, Not yet recruiting, 
  • ||||||||||  Cyramza (ramucirumab) / Eli Lilly
    Trial completion, Trial completion date, Combination therapy, Metastases:  A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRI (clinicaltrials.gov) -  Mar 8, 2018   
    P2,  N=29, Completed, 
    Not yet recruiting --> Recruiting | Initiation date: Mar 2018 --> Feb 2018 Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Feb 2018
  • ||||||||||  Avastin (bevacizumab) / Roche
    Trial primary completion date, Metastases:  Escalated Dose of Irinotecan in mCRC (clinicaltrials.gov) -  Mar 8, 2018   
    P=N/A,  N=320, Recruiting, 
    Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Feb 2018 Trial primary completion date: Dec 2017 --> Dec 2018